9F48
KS + AT di-domain of polyketide synthase 13 in Mycobacterium tuberculosis
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004312 | molecular_function | fatty acid synthase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006631 | biological_process | fatty acid metabolic process |
| A | 0006633 | biological_process | fatty acid biosynthetic process |
| A | 0016746 | molecular_function | acyltransferase activity |
| A | 0071770 | biological_process | DIM/DIP cell wall layer assembly |
| B | 0004312 | molecular_function | fatty acid synthase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006631 | biological_process | fatty acid metabolic process |
| B | 0006633 | biological_process | fatty acid biosynthetic process |
| B | 0016746 | molecular_function | acyltransferase activity |
| B | 0071770 | biological_process | DIM/DIP cell wall layer assembly |
Functional Information from PROSITE/UniProt
| site_id | PS00606 |
| Number of Residues | 17 |
| Details | KS3_1 Ketosynthase family 3 (KS3) active site signature. GPSvtIDtACSSSlvAI |
| Chain | Residue | Details |
| A | GLY278-ILE294 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Acyl-thioester intermediate; for beta-ketoacyl synthase activity => ECO:0000255|PROSITE-ProRule:PRU01348 |
| Chain | Residue | Details |
| A | CYS287 | |
| B | CYS287 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | ACT_SITE: For beta-ketoacyl synthase activity => ECO:0000255|PROSITE-ProRule:PRU01348 |
| Chain | Residue | Details |
| A | HIS423 | |
| A | HIS463 | |
| B | HIS423 | |
| B | HIS463 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | ACT_SITE: Acyl-ester intermediate; for acyltransferase activity => ECO:0000305|PubMed:22825853 |
| Chain | Residue | Details |
| A | SER801 | |
| B | SER801 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | ACT_SITE: For thioesterase-like activity => ECO:0000305|PubMed:25467124 |
| Chain | Residue | Details |
| A | SER1533 | |
| B | SER1533 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | MOD_RES: O-(pantetheine 4'-phosphoryl)serine => ECO:0000255|PROSITE-ProRule:PRU00258, ECO:0000269|PubMed:19436070 |
| Chain | Residue | Details |
| A | SER55 | |
| A | SER1266 | |
| B | SER55 | |
| B | SER1266 |
