9F43
cryo-EM structure of human LST2 bound to human mTOR complex 1, focused on RAPTOR
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 62 |
| Details | ZN_FING: FYVE-type => ECO:0000255|PROSITE-ProRule:PRU00091 |
| Chain | Residue | Details |
| G | ASP817-PRO879 | |
| E | SER122 | |
| E | SER836 | |
| E | SER982 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00091 |
| Chain | Residue | Details |
| G | CYS823 | |
| G | CYS826 | |
| G | CYS839 | |
| G | CYS842 | |
| G | CYS847 | |
| G | CYS850 | |
| G | CYS869 | |
| G | CYS872 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| G | SER334 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| G | THR516 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by MAP2K => ECO:0000269|PubMed:19460345 |
| Chain | Residue | Details |
| G | SER586 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine; by MAP2K => ECO:0000269|PubMed:19460345 |
| Chain | Residue | Details |
| G | THR870 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:19460345 |
| Chain | Residue | Details |
| G | LYS87 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by PKA => ECO:0000269|PubMed:31112131 |
| Chain | Residue | Details |
| E | SER791 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by AMPK => ECO:0000269|PubMed:18439900, ECO:0000269|PubMed:37541260 |
| Chain | Residue | Details |
| E | SER792 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:19864431 |
| Chain | Residue | Details |
| E | SER855 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by MTOR => ECO:0000269|PubMed:19864431, ECO:0000269|PubMed:31530866, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| E | SER859 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by MAPK8, MTOR and NLK => ECO:0000269|PubMed:19864431, ECO:0000269|PubMed:22493283, ECO:0000269|PubMed:26588989, ECO:0000269|PubMed:31530866, ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| E | SER863 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| E | THR865 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by TBK1 => ECO:0000269|PubMed:19864431, ECO:0000269|PubMed:26588989, ECO:0000269|PubMed:31530866, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| E | SER877 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:30197302, ECO:0000269|PubMed:32561715 |
| Chain | Residue | Details |
| E | LYS1097 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 1 |
| Details | CARBOHYD: O-linked (GlcNAc) threonine => ECO:0000269|PubMed:37541260 |
| Chain | Residue | Details |
| E | THR700 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 3 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:35927303 |
| Chain | Residue | Details |
| E | LYS932 | |
| E | LYS948 |
