9F3V
RIP2K kinase domain dimer with bound compound 37 (N399), a speific NOD1 pathway inhibitor
This is a non-PDB format compatible entry.
Functional Information from GO Data
Functional Information from PROSITE/UniProt
| site_id | PS00108 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. LlHhDLKtqNILL |
| Chain | Residue | Details |
| A | LEU142-LEU154 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton acceptor => ECO:0000269|PubMed:9705938 |
| Chain | Residue | Details |
| A | ASP146 | |
| B | ASP146 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 |
| Chain | Residue | Details |
| A | LEU24 | |
| B | LEU24 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | LYS47 | |
| B | LYS47 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | MOD_RES: (Microbial infection) O-acetylthreonine; by Yersinia YopJ => ECO:0000269|PubMed:22520462 |
| Chain | Residue | Details |
| A | THR149 | |
| A | THR189 | |
| B | THR149 | |
| B | THR189 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:19369195 |
| Chain | Residue | Details |
| A | SER168 | |
| B | SER168 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 6 |
| Details | MOD_RES: Phosphoserine; alternate => ECO:0000269|PubMed:28545134 |
| Chain | Residue | Details |
| A | SER174 | |
| A | SER178 | |
| A | SER181 | |
| B | SER174 | |
| B | SER178 | |
| B | SER181 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by autocatalysis and LRRK2; alternate => ECO:0000269|PubMed:16824733, ECO:0000269|PubMed:27830463, ECO:0000269|PubMed:28545134 |
| Chain | Residue | Details |
| A | SER176 | |
| B | SER176 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:28545134 |
| Chain | Residue | Details |
| A | SER180 | |
| B | SER180 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | MOD_RES: (Microbial infection) O-acetylserine; by Yersinia YopJ => ECO:0000269|PubMed:22520462 |
| Chain | Residue | Details |
| A | SER183 | |
| B | SER183 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 4 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:18079694 |
| Chain | Residue | Details |
| A | LYS209 | |
| B | LYS209 |
