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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9F16

Structure of a homomeric LRRC8C point mutation disease mutant

Functional Information from GO Data
ChainGOidnamespacecontents
A0005225molecular_functionvolume-sensitive anion channel activity
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0015734biological_processtaurine transmembrane transport
A0015810biological_processaspartate transmembrane transport
A0016020cellular_componentmembrane
A0034214biological_processprotein hexamerization
A0034220biological_processmonoatomic ion transmembrane transport
A0034702cellular_componentmonoatomic ion channel complex
A0071470biological_processcellular response to osmotic stress
A0098656biological_processmonoatomic anion transmembrane transport
A0140361biological_processcyclic-GMP-AMP transmembrane import across plasma membrane
B0005225molecular_functionvolume-sensitive anion channel activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005783cellular_componentendoplasmic reticulum
B0005789cellular_componentendoplasmic reticulum membrane
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0015734biological_processtaurine transmembrane transport
B0015810biological_processaspartate transmembrane transport
B0016020cellular_componentmembrane
B0034214biological_processprotein hexamerization
B0034220biological_processmonoatomic ion transmembrane transport
B0034702cellular_componentmonoatomic ion channel complex
B0071470biological_processcellular response to osmotic stress
B0098656biological_processmonoatomic anion transmembrane transport
B0140361biological_processcyclic-GMP-AMP transmembrane import across plasma membrane
C0005225molecular_functionvolume-sensitive anion channel activity
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005783cellular_componentendoplasmic reticulum
C0005789cellular_componentendoplasmic reticulum membrane
C0005886cellular_componentplasma membrane
C0006811biological_processmonoatomic ion transport
C0015734biological_processtaurine transmembrane transport
C0015810biological_processaspartate transmembrane transport
C0016020cellular_componentmembrane
C0034214biological_processprotein hexamerization
C0034220biological_processmonoatomic ion transmembrane transport
C0034702cellular_componentmonoatomic ion channel complex
C0071470biological_processcellular response to osmotic stress
C0098656biological_processmonoatomic anion transmembrane transport
C0140361biological_processcyclic-GMP-AMP transmembrane import across plasma membrane
D0005225molecular_functionvolume-sensitive anion channel activity
D0005515molecular_functionprotein binding
D0005737cellular_componentcytoplasm
D0005783cellular_componentendoplasmic reticulum
D0005789cellular_componentendoplasmic reticulum membrane
D0005886cellular_componentplasma membrane
D0006811biological_processmonoatomic ion transport
D0015734biological_processtaurine transmembrane transport
D0015810biological_processaspartate transmembrane transport
D0016020cellular_componentmembrane
D0034214biological_processprotein hexamerization
D0034220biological_processmonoatomic ion transmembrane transport
D0034702cellular_componentmonoatomic ion channel complex
D0071470biological_processcellular response to osmotic stress
D0098656biological_processmonoatomic anion transmembrane transport
D0140361biological_processcyclic-GMP-AMP transmembrane import across plasma membrane
E0005225molecular_functionvolume-sensitive anion channel activity
E0005515molecular_functionprotein binding
E0005737cellular_componentcytoplasm
E0005783cellular_componentendoplasmic reticulum
E0005789cellular_componentendoplasmic reticulum membrane
E0005886cellular_componentplasma membrane
E0006811biological_processmonoatomic ion transport
E0015734biological_processtaurine transmembrane transport
E0015810biological_processaspartate transmembrane transport
E0016020cellular_componentmembrane
E0034214biological_processprotein hexamerization
E0034220biological_processmonoatomic ion transmembrane transport
E0034702cellular_componentmonoatomic ion channel complex
E0071470biological_processcellular response to osmotic stress
E0098656biological_processmonoatomic anion transmembrane transport
E0140361biological_processcyclic-GMP-AMP transmembrane import across plasma membrane
F0005225molecular_functionvolume-sensitive anion channel activity
F0005515molecular_functionprotein binding
F0005737cellular_componentcytoplasm
F0005783cellular_componentendoplasmic reticulum
F0005789cellular_componentendoplasmic reticulum membrane
F0005886cellular_componentplasma membrane
F0006811biological_processmonoatomic ion transport
F0015734biological_processtaurine transmembrane transport
F0015810biological_processaspartate transmembrane transport
F0016020cellular_componentmembrane
F0034214biological_processprotein hexamerization
F0034220biological_processmonoatomic ion transmembrane transport
F0034702cellular_componentmonoatomic ion channel complex
F0071470biological_processcellular response to osmotic stress
F0098656biological_processmonoatomic anion transmembrane transport
F0140361biological_processcyclic-GMP-AMP transmembrane import across plasma membrane
G0005225molecular_functionvolume-sensitive anion channel activity
G0005515molecular_functionprotein binding
G0005737cellular_componentcytoplasm
G0005783cellular_componentendoplasmic reticulum
G0005789cellular_componentendoplasmic reticulum membrane
G0005886cellular_componentplasma membrane
G0006811biological_processmonoatomic ion transport
G0015734biological_processtaurine transmembrane transport
G0015810biological_processaspartate transmembrane transport
G0016020cellular_componentmembrane
G0034214biological_processprotein hexamerization
G0034220biological_processmonoatomic ion transmembrane transport
G0034702cellular_componentmonoatomic ion channel complex
G0071470biological_processcellular response to osmotic stress
G0098656biological_processmonoatomic anion transmembrane transport
G0140361biological_processcyclic-GMP-AMP transmembrane import across plasma membrane
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues203
DetailsTopological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"36897307","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8DXN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DXO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DXP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DXQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DXR","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues96
DetailsTransmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"36897307","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8DXN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DXO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DXP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DXQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DXR","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues76
DetailsTransmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"36897307","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8DXN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DXO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DXP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DXQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DXR","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues84
DetailsTransmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"36897307","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8DXN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DXO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DXP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DXQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DXR","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues96
DetailsTransmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"36897307","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8DXN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DXO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DXP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DXQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DXR","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues92
DetailsRepeat: {"description":"LRR 1","evidences":[{"source":"UniProtKB","id":"Q8R502","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues88
DetailsRepeat: {"description":"LRR 2","evidences":[{"source":"UniProtKB","id":"Q8R502","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues80
DetailsRepeat: {"description":"LRR 3","evidences":[{"source":"UniProtKB","id":"Q8R502","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues84
DetailsRepeat: {"description":"LRR 4","evidences":[{"source":"UniProtKB","id":"Q8R502","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues92
DetailsRepeat: {"description":"LRR 5","evidences":[{"source":"UniProtKB","id":"Q8R502","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues66
DetailsRepeat: {"description":"LRR 7","evidences":[{"source":"UniProtKB","id":"Q8R502","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues44
DetailsRepeat: {"description":"LRR 8","evidences":[{"source":"UniProtKB","id":"Q8R502","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues46
DetailsRepeat: {"description":"LRR 9","evidences":[{"source":"UniProtKB","id":"Q8R502","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues44
DetailsRepeat: {"description":"LRR 10","evidences":[{"source":"UniProtKB","id":"Q8R502","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues46
DetailsRepeat: {"description":"LRR 11","evidences":[{"source":"UniProtKB","id":"Q8R502","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues44
DetailsRepeat: {"description":"LRR 12","evidences":[{"source":"UniProtKB","id":"Q8R502","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues42
DetailsRepeat: {"description":"LRR 13","evidences":[{"source":"UniProtKB","id":"Q8R502","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues44
DetailsRepeat: {"description":"LRR 14","evidences":[{"source":"UniProtKB","id":"Q8R502","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues42
DetailsRepeat: {"description":"LRR 15","evidences":[{"source":"UniProtKB","id":"Q8R502","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues42
DetailsRepeat: {"description":"LRR 16","evidences":[{"source":"UniProtKB","id":"Q8R502","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues46
DetailsRepeat: {"description":"LRR 17","evidences":[{"source":"UniProtKB","id":"Q8R502","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

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PDB entries from 2025-12-31

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