Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

9F16

Structure of a homomeric LRRC8C point mutation disease mutant

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005225	molecular_function	volume-sensitive anion channel activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0015734	biological_process	taurine transmembrane transport
A	0015810	biological_process	aspartate transmembrane transport
A	0016020	cellular_component	membrane
A	0034214	biological_process	protein hexamerization
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0034702	cellular_component	monoatomic ion channel complex
A	0045444	biological_process	fat cell differentiation
A	0071470	biological_process	cellular response to osmotic stress
A	0098656	biological_process	monoatomic anion transmembrane transport
A	0140361	biological_process	cyclic-GMP-AMP transmembrane import across plasma membrane
B	0005225	molecular_function	volume-sensitive anion channel activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005783	cellular_component	endoplasmic reticulum
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0015734	biological_process	taurine transmembrane transport
B	0015810	biological_process	aspartate transmembrane transport
B	0016020	cellular_component	membrane
B	0034214	biological_process	protein hexamerization
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0034702	cellular_component	monoatomic ion channel complex
B	0045444	biological_process	fat cell differentiation
B	0071470	biological_process	cellular response to osmotic stress
B	0098656	biological_process	monoatomic anion transmembrane transport
B	0140361	biological_process	cyclic-GMP-AMP transmembrane import across plasma membrane
C	0005225	molecular_function	volume-sensitive anion channel activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005783	cellular_component	endoplasmic reticulum
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0005886	cellular_component	plasma membrane
C	0006811	biological_process	monoatomic ion transport
C	0015734	biological_process	taurine transmembrane transport
C	0015810	biological_process	aspartate transmembrane transport
C	0016020	cellular_component	membrane
C	0034214	biological_process	protein hexamerization
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0034702	cellular_component	monoatomic ion channel complex
C	0045444	biological_process	fat cell differentiation
C	0071470	biological_process	cellular response to osmotic stress
C	0098656	biological_process	monoatomic anion transmembrane transport
C	0140361	biological_process	cyclic-GMP-AMP transmembrane import across plasma membrane
D	0005225	molecular_function	volume-sensitive anion channel activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005783	cellular_component	endoplasmic reticulum
D	0005789	cellular_component	endoplasmic reticulum membrane
D	0005886	cellular_component	plasma membrane
D	0006811	biological_process	monoatomic ion transport
D	0015734	biological_process	taurine transmembrane transport
D	0015810	biological_process	aspartate transmembrane transport
D	0016020	cellular_component	membrane
D	0034214	biological_process	protein hexamerization
D	0034220	biological_process	monoatomic ion transmembrane transport
D	0034702	cellular_component	monoatomic ion channel complex
D	0045444	biological_process	fat cell differentiation
D	0071470	biological_process	cellular response to osmotic stress
D	0098656	biological_process	monoatomic anion transmembrane transport
D	0140361	biological_process	cyclic-GMP-AMP transmembrane import across plasma membrane
E	0005225	molecular_function	volume-sensitive anion channel activity
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005783	cellular_component	endoplasmic reticulum
E	0005789	cellular_component	endoplasmic reticulum membrane
E	0005886	cellular_component	plasma membrane
E	0006811	biological_process	monoatomic ion transport
E	0015734	biological_process	taurine transmembrane transport
E	0015810	biological_process	aspartate transmembrane transport
E	0016020	cellular_component	membrane
E	0034214	biological_process	protein hexamerization
E	0034220	biological_process	monoatomic ion transmembrane transport
E	0034702	cellular_component	monoatomic ion channel complex
E	0045444	biological_process	fat cell differentiation
E	0071470	biological_process	cellular response to osmotic stress
E	0098656	biological_process	monoatomic anion transmembrane transport
E	0140361	biological_process	cyclic-GMP-AMP transmembrane import across plasma membrane
F	0005225	molecular_function	volume-sensitive anion channel activity
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005783	cellular_component	endoplasmic reticulum
F	0005789	cellular_component	endoplasmic reticulum membrane
F	0005886	cellular_component	plasma membrane
F	0006811	biological_process	monoatomic ion transport
F	0015734	biological_process	taurine transmembrane transport
F	0015810	biological_process	aspartate transmembrane transport
F	0016020	cellular_component	membrane
F	0034214	biological_process	protein hexamerization
F	0034220	biological_process	monoatomic ion transmembrane transport
F	0034702	cellular_component	monoatomic ion channel complex
F	0045444	biological_process	fat cell differentiation
F	0071470	biological_process	cellular response to osmotic stress
F	0098656	biological_process	monoatomic anion transmembrane transport
F	0140361	biological_process	cyclic-GMP-AMP transmembrane import across plasma membrane
G	0005225	molecular_function	volume-sensitive anion channel activity
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0005783	cellular_component	endoplasmic reticulum
G	0005789	cellular_component	endoplasmic reticulum membrane
G	0005886	cellular_component	plasma membrane
G	0006811	biological_process	monoatomic ion transport
G	0015734	biological_process	taurine transmembrane transport
G	0015810	biological_process	aspartate transmembrane transport
G	0016020	cellular_component	membrane
G	0034214	biological_process	protein hexamerization
G	0034220	biological_process	monoatomic ion transmembrane transport
G	0034702	cellular_component	monoatomic ion channel complex
G	0045444	biological_process	fat cell differentiation
G	0071470	biological_process	cellular response to osmotic stress
G	0098656	biological_process	monoatomic anion transmembrane transport
G	0140361	biological_process	cyclic-GMP-AMP transmembrane import across plasma membrane

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	168
Details	TRANSMEM: Helical; Name=1 => ECO:0000269\|PubMed:36897307, ECO:0007744\|PDB:8DXN, ECO:0007744\|PDB:8DXO, ECO:0007744\|PDB:8DXP, ECO:0007744\|PDB:8DXQ, ECO:0007744\|PDB:8DXR

Chain	Residue	Details
A	TRP23-VAL47
B	TRP23-VAL47
C	TRP23-VAL47
D	TRP23-VAL47
E	TRP23-VAL47
F	TRP23-VAL47
G	TRP23-VAL47

site_id	SWS_FT_FI2
Number of Residues	735
Details	TOPO_DOM: Extracellular => ECO:0000269\|PubMed:36897307, ECO:0007744\|PDB:8DXN, ECO:0007744\|PDB:8DXO, ECO:0007744\|PDB:8DXP, ECO:0007744\|PDB:8DXQ, ECO:0007744\|PDB:8DXR

Chain	Residue	Details
A	MET48-ALA124
E	SER285-HIS314
F	MET48-ALA124
F	SER285-HIS314
G	MET48-ALA124
G	SER285-HIS314
A	SER285-HIS314
B	MET48-ALA124
B	SER285-HIS314
C	MET48-ALA124
C	SER285-HIS314
D	MET48-ALA124
D	SER285-HIS314
E	MET48-ALA124

site_id	SWS_FT_FI3
Number of Residues	133
Details	TRANSMEM: Helical; Name=2 => ECO:0000269\|PubMed:36897307, ECO:0007744\|PDB:8DXN, ECO:0007744\|PDB:8DXO, ECO:0007744\|PDB:8DXP, ECO:0007744\|PDB:8DXQ, ECO:0007744\|PDB:8DXR

Chain	Residue	Details
A	LYS125-PHE144
B	LYS125-PHE144
C	LYS125-PHE144
D	LYS125-PHE144
E	LYS125-PHE144
F	LYS125-PHE144
G	LYS125-PHE144

site_id	SWS_FT_FI4
Number of Residues	819
Details	TOPO_DOM: Cytoplasmic => ECO:0000269\|PubMed:36897307, ECO:0007744\|PDB:8DXN, ECO:0007744\|PDB:8DXO, ECO:0007744\|PDB:8DXP, ECO:0007744\|PDB:8DXQ, ECO:0007744\|PDB:8DXR

Chain	Residue	Details
A	TRP145-TYR262
B	TRP145-TYR262
C	TRP145-TYR262
D	TRP145-TYR262
E	TRP145-TYR262
F	TRP145-TYR262
G	TRP145-TYR262

site_id	SWS_FT_FI5
Number of Residues	147
Details	TRANSMEM: Helical; Name=3 => ECO:0000269\|PubMed:36897307, ECO:0007744\|PDB:8DXN, ECO:0007744\|PDB:8DXO, ECO:0007744\|PDB:8DXP, ECO:0007744\|PDB:8DXQ, ECO:0007744\|PDB:8DXR

Chain	Residue	Details
A	VAL263-VAL284
B	VAL263-VAL284
C	VAL263-VAL284
D	VAL263-VAL284
E	VAL263-VAL284
F	VAL263-VAL284
G	VAL263-VAL284

site_id	SWS_FT_FI6
Number of Residues	168
Details	TRANSMEM: Helical; Name=4 => ECO:0000269\|PubMed:36897307, ECO:0007744\|PDB:8DXN, ECO:0007744\|PDB:8DXO, ECO:0007744\|PDB:8DXP, ECO:0007744\|PDB:8DXQ, ECO:0007744\|PDB:8DXR

Chain	Residue	Details
A	LEU315-TYR339
B	LEU315-TYR339
C	LEU315-TYR339
D	LEU315-TYR339
E	LEU315-TYR339
F	LEU315-TYR339
G	LEU315-TYR339

site_id	SWS_FT_FI7
Number of Residues	7
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:23186163

Chain	Residue	Details
A	SER212
B	SER212
C	SER212
D	SER212
E	SER212
F	SER212
G	SER212

site_id	SWS_FT_FI8
Number of Residues	7
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:Q498T9

Chain	Residue	Details
A	SER215
B	SER215
C	SER215
D	SER215
E	SER215
F	SER215
G	SER215

site_id	SWS_FT_FI9
Number of Residues	14
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN64
E	ASN70
F	ASN64
F	ASN70
G	ASN64
G	ASN70
A	ASN70
B	ASN64
B	ASN70
C	ASN64
C	ASN70
D	ASN64
D	ASN70
E	ASN64

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)