9F11

CryoEM structure of the F plasmid relaxosome with oriT DNA ss-27_+3ds+4_+143 and TraI its TE mode, derived from ss-27_+3ds+4_+143-R Locally-refined 3.68 A Map.

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0000976	molecular_function	transcription cis-regulatory region binding
C	0001216	molecular_function	DNA-binding transcription activator activity
C	0003677	molecular_function	DNA binding
C	0005829	cellular_component	cytosol
C	0006260	biological_process	DNA replication
C	0006310	biological_process	DNA recombination
C	0006351	biological_process	DNA-templated transcription
C	0006355	biological_process	regulation of DNA-templated transcription
C	0006417	biological_process	regulation of translation
C	0009295	cellular_component	nucleoid
C	0009893	biological_process	positive regulation of metabolic process
C	0032993	cellular_component	protein-DNA complex
C	0043565	molecular_function	sequence-specific DNA binding
C	0045893	biological_process	positive regulation of DNA-templated transcription
C	1990177	cellular_component	IHF-DNA complex
D	0003677	molecular_function	DNA binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006260	biological_process	DNA replication
D	0006310	biological_process	DNA recombination
D	0006351	biological_process	DNA-templated transcription
D	0006355	biological_process	regulation of DNA-templated transcription
D	0006417	biological_process	regulation of translation
D	0043565	molecular_function	sequence-specific DNA binding
D	1990177	cellular_component	IHF-DNA complex
E	0003677	molecular_function	DNA binding
E	0005737	cellular_component	cytoplasm
F	0003677	molecular_function	DNA binding
F	0005737	cellular_component	cytoplasm
G	0003677	molecular_function	DNA binding
G	0005737	cellular_component	cytoplasm
H	0000166	molecular_function	nucleotide binding
H	0003677	molecular_function	DNA binding
H	0003678	molecular_function	DNA helicase activity
H	0003824	molecular_function	catalytic activity
H	0003917	molecular_function	DNA topoisomerase type I (single strand cut, ATP-independent) activity
H	0004386	molecular_function	helicase activity
H	0005524	molecular_function	ATP binding
H	0005737	cellular_component	cytoplasm
H	0016787	molecular_function	hydrolase activity
H	0016853	molecular_function	isomerase activity
H	0016887	molecular_function	ATP hydrolysis activity
H	0043139	molecular_function	5'-3' DNA helicase activity
H	0046872	molecular_function	metal ion binding

Functional Information from PROSITE/UniProt

site_id	PS00045
Number of Residues	20
Details	HISTONE_LIKE Bacterial histone-like DNA-binding proteins signature. GFgsFslhyRapRt.GrNPkT

Chain	Residue	Details
D	GLY47-THR66
C	GLY48-THR67

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"O-(5'-phospho-DNA)-tyrosine intermediate; for relaxase activity","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Active site: {"description":"Relaxase","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"14604527","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---