9EOT

Structure of human ceramide synthase 6 (CerS6) bound to C16:0 (nanobody Nb02)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0016020	cellular_component	membrane
A	0046513	biological_process	ceramide biosynthetic process
A	0050291	molecular_function	sphingosine N-acyltransferase activity
C	0003677	molecular_function	DNA binding
C	0016020	cellular_component	membrane
C	0046513	biological_process	ceramide biosynthetic process
C	0050291	molecular_function	sphingosine N-acyltransferase activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	66
Details	TOPO_DOM: Lumenal => ECO:0000305|PubMed:29632068

Chain	Residue	Details
A	MET1-GLN34
C	MET1-GLN34

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site_id	SWS_FT_FI2
Number of Residues	200
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
A	ALA35-PHE55
C	VAL303-VAL323
A	LEU178-THR198
A	PHE205-ASN225
A	LEU263-VAL283
A	VAL303-VAL323
C	ALA35-PHE55
C	LEU178-THR198
C	PHE205-ASN225
C	LEU263-VAL283

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site_id	SWS_FT_FI3
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218

Chain	Residue	Details
A	ASN18
C	ASN18

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