9EOT
Structure of human ceramide synthase 6 (CerS6) bound to C16:0 (nanobody Nb02)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0016020 | cellular_component | membrane |
| A | 0046513 | biological_process | ceramide biosynthetic process |
| A | 0050291 | molecular_function | sphingosine N-acyltransferase activity |
| C | 0003677 | molecular_function | DNA binding |
| C | 0016020 | cellular_component | membrane |
| C | 0046513 | biological_process | ceramide biosynthetic process |
| C | 0050291 | molecular_function | sphingosine N-acyltransferase activity |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 34 |
| Details | Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"39528795","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8QZ6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8QZ7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9EOT","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 186 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"39528795","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8QZ6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8QZ7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9EOT","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 42 |
| Details | Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"39528795","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8QZ6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8QZ7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9EOT","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 88 |
| Details | Topological domain: {"description":"Lumenal","evidences":[{"source":"PubMed","id":"39528795","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8QZ6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8QZ7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9EOT","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 40 |
| Details | Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"39528795","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8QZ6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8QZ7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9EOT","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 36 |
| Details | Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"39528795","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8QZ6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8QZ7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9EOT","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 36 |
| Details | Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"39528795","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8QZ6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8QZ7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9EOT","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 44 |
| Details | Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"39528795","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8QZ6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8QZ7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9EOT","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 40 |
| Details | Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"39528795","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8QZ6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8QZ7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9EOT","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Nucleophile; for acyl transferase activity","evidences":[{"source":"PubMed","id":"39528795","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8QZ6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8QZ7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9EOT","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
