9EKB

Cryo-EM structure of apo-form human DNA polymerase delta

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000109	cellular_component	nucleotide-excision repair complex
A	0000166	molecular_function	nucleotide binding
A	0000731	biological_process	DNA synthesis involved in DNA repair
A	0000781	cellular_component	chromosome, telomeric region
A	0003676	molecular_function	nucleic acid binding
A	0003677	molecular_function	DNA binding
A	0003682	molecular_function	chromatin binding
A	0003684	molecular_function	damaged DNA binding
A	0003887	molecular_function	DNA-directed DNA polymerase activity
A	0004518	molecular_function	nuclease activity
A	0004527	molecular_function	exonuclease activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0006260	biological_process	DNA replication
A	0006261	biological_process	DNA-templated DNA replication
A	0006281	biological_process	DNA repair
A	0006287	biological_process	base-excision repair, gap-filling
A	0006297	biological_process	nucleotide-excision repair, DNA gap filling
A	0006974	biological_process	DNA damage response
A	0008270	molecular_function	zinc ion binding
A	0008296	molecular_function	3'-5'-DNA exonuclease activity
A	0008408	molecular_function	3'-5' exonuclease activity
A	0009411	biological_process	response to UV
A	0016020	cellular_component	membrane
A	0016740	molecular_function	transferase activity
A	0016779	molecular_function	nucleotidyltransferase activity
A	0016787	molecular_function	hydrolase activity
A	0019899	molecular_function	enzyme binding
A	0034061	molecular_function	DNA polymerase activity
A	0043625	cellular_component	delta DNA polymerase complex
A	0045004	biological_process	DNA replication proofreading
A	0046872	molecular_function	metal ion binding
A	0051536	molecular_function	iron-sulfur cluster binding
A	0051539	molecular_function	4 iron, 4 sulfur cluster binding
A	0055089	biological_process	fatty acid homeostasis
A	0070987	biological_process	error-free translesion synthesis
A	0071897	biological_process	DNA biosynthetic process
B	0003677	molecular_function	DNA binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0006260	biological_process	DNA replication
B	0006261	biological_process	DNA-templated DNA replication
B	0006271	biological_process	DNA strand elongation involved in DNA replication
B	0006281	biological_process	DNA repair
B	0006974	biological_process	DNA damage response
B	0016035	cellular_component	zeta DNA polymerase complex
B	0042276	biological_process	error-prone translesion synthesis
B	0043625	cellular_component	delta DNA polymerase complex
B	0071897	biological_process	DNA biosynthetic process
C	0000731	biological_process	DNA synthesis involved in DNA repair
C	0003887	molecular_function	DNA-directed DNA polymerase activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0006260	biological_process	DNA replication
C	0006261	biological_process	DNA-templated DNA replication
C	0006271	biological_process	DNA strand elongation involved in DNA replication
C	0006281	biological_process	DNA repair
C	0006297	biological_process	nucleotide-excision repair, DNA gap filling
C	0006298	biological_process	mismatch repair
C	0006974	biological_process	DNA damage response
C	0016035	cellular_component	zeta DNA polymerase complex
C	0030674	molecular_function	protein-macromolecule adaptor activity
C	0042276	biological_process	error-prone translesion synthesis
C	0043625	cellular_component	delta DNA polymerase complex
C	0071897	biological_process	DNA biosynthetic process
C	1904161	biological_process	DNA synthesis involved in UV-damage excision repair
D	0000731	biological_process	DNA synthesis involved in DNA repair
D	0003887	molecular_function	DNA-directed DNA polymerase activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0006260	biological_process	DNA replication
D	0006261	biological_process	DNA-templated DNA replication
D	0006281	biological_process	DNA repair
D	0006974	biological_process	DNA damage response
D	0043625	cellular_component	delta DNA polymerase complex

Functional Information from PROSITE/UniProt

site_id	PS00116
Number of Residues	9
Details	DNA_POLYMERASE_B DNA polymerase family B signature. YGDTDSVMC

Chain	Residue	Details
A	TYR753-CYS761

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	17
Details	Zinc finger: {"description":"CysA-type"}

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Residue

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site_id	SWS_FT_FI2
Number of Residues	18
Details	Motif: {"description":"CysB motif"}

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site_id	SWS_FT_FI3
Number of Residues	8
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

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site_id	SWS_FT_FI4
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

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Residue

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site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

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Residue

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site_id	SWS_FT_FI6
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

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Residue

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