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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9E9V

Structural Insights into HIV-1 Vif-Mediated Ubiquitination and Degradation of APOBEC3H

Functional Information from GO Data
ChainGOidnamespacecontents
A0004126molecular_functioncytidine deaminase activity
A0005737cellular_componentcytoplasm
A0010526biological_processtransposable element silencing
A0044355biological_processclearance of foreign intracellular DNA
A0045071biological_processnegative regulation of viral genome replication
A0051607biological_processdefense response to virus
B0004126molecular_functioncytidine deaminase activity
B0005737cellular_componentcytoplasm
B0010526biological_processtransposable element silencing
B0044355biological_processclearance of foreign intracellular DNA
B0045071biological_processnegative regulation of viral genome replication
B0051607biological_processdefense response to virus
E0004126molecular_functioncytidine deaminase activity
E0005737cellular_componentcytoplasm
E0010526biological_processtransposable element silencing
E0044355biological_processclearance of foreign intracellular DNA
E0045071biological_processnegative regulation of viral genome replication
E0051607biological_processdefense response to virus
o0000122biological_processnegative regulation of transcription by RNA polymerase II
o0000209biological_processprotein polyubiquitination
o0003677molecular_functionDNA binding
o0003713molecular_functiontranscription coactivator activity
o0005515molecular_functionprotein binding
o0005634cellular_componentnucleus
o0005654cellular_componentnucleoplasm
o0006357biological_processregulation of transcription by RNA polymerase II
o0006366biological_processtranscription by RNA polymerase II
o0016020cellular_componentmembrane
o0016513cellular_componentcore-binding factor complex
o0043371biological_processnegative regulation of CD4-positive, alpha-beta T cell differentiation
o0043378biological_processpositive regulation of CD8-positive, alpha-beta T cell differentiation
o0043565molecular_functionsequence-specific DNA binding
o0045893biological_processpositive regulation of DNA-templated transcription
p0003723molecular_functionRNA binding
p0005515molecular_functionprotein binding
p0016020cellular_componentmembrane
p0020002cellular_componenthost cell plasma membrane
p0030430cellular_componenthost cell cytoplasm
p0044423cellular_componentvirion component
s0000122biological_processnegative regulation of transcription by RNA polymerase II
s0000209biological_processprotein polyubiquitination
s0003677molecular_functionDNA binding
s0003713molecular_functiontranscription coactivator activity
s0005515molecular_functionprotein binding
s0005634cellular_componentnucleus
s0005654cellular_componentnucleoplasm
s0006357biological_processregulation of transcription by RNA polymerase II
s0006366biological_processtranscription by RNA polymerase II
s0016020cellular_componentmembrane
s0016513cellular_componentcore-binding factor complex
s0043371biological_processnegative regulation of CD4-positive, alpha-beta T cell differentiation
s0043378biological_processpositive regulation of CD8-positive, alpha-beta T cell differentiation
s0043565molecular_functionsequence-specific DNA binding
s0045893biological_processpositive regulation of DNA-templated transcription
t0003723molecular_functionRNA binding
t0005515molecular_functionprotein binding
t0016020cellular_componentmembrane
t0020002cellular_componenthost cell plasma membrane
t0030430cellular_componenthost cell cytoplasm
t0044423cellular_componentvirion component
Functional Information from PROSITE/UniProt
site_idPS00903
Number of Residues39
DetailsCYT_DCMP_DEAMINASES_1 Cytidine and deoxycytidylate deaminases zinc-binding region signature. HAEicFIneiksmgldetqcyqvtcyltws..........PCss......CawkL
ChainResidueDetails
AHIS54-LEU92
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI3
Number of Residues6
DetailsRegion: {"description":"Interaction with host APOBEC3F; F1-box","evidences":[{"source":"HAMAP-Rule","id":"MF_04081","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues8
DetailsRegion: {"description":"Interaction with host APOBEC3G; G-box","evidences":[{"source":"HAMAP-Rule","id":"MF_04081","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues36
DetailsRegion: {"description":"Interaction with host APOBEC3F and APOBEC3G; FG-box","evidences":[{"source":"HAMAP-Rule","id":"MF_04081","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues13
DetailsRegion: {"description":"Multimerization","evidences":[{"source":"HAMAP-Rule","id":"MF_04081","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues31
DetailsMotif: {"description":"HCCH motif","evidences":[{"source":"HAMAP-Rule","id":"MF_04081","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues9
DetailsMotif: {"description":"BC-box-like motif","evidences":[{"source":"HAMAP-Rule","id":"MF_04081","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues5
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"24402281","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37640699","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4N9F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FVI","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues1
DetailsSite: {"description":"Cleavage in virion (by viral protease)","evidences":[{"source":"HAMAP-Rule","id":"MF_04081","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"12186895","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine; by host MAP4K1","evidences":[{"source":"HAMAP-Rule","id":"MF_04081","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine; by host","evidences":[{"source":"HAMAP-Rule","id":"MF_04081","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine; by host MAP4K1","evidences":[{"source":"HAMAP-Rule","id":"MF_04081","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

253795

PDB entries from 2026-05-20

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