9E93

Structural Insights into HIV-1 Vif-Mediated Ubiquitination and Degradation of APOBEC3H

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004126	molecular_function	cytidine deaminase activity
A	0005737	cellular_component	cytoplasm
A	0010526	biological_process	transposable element silencing
A	0044355	biological_process	clearance of foreign intracellular DNA
A	0045071	biological_process	negative regulation of viral genome replication
A	0051607	biological_process	defense response to virus
E	0004126	molecular_function	cytidine deaminase activity
E	0005737	cellular_component	cytoplasm
E	0010526	biological_process	transposable element silencing
E	0044355	biological_process	clearance of foreign intracellular DNA
E	0045071	biological_process	negative regulation of viral genome replication
E	0051607	biological_process	defense response to virus
o	0000122	biological_process	negative regulation of transcription by RNA polymerase II
o	0000209	biological_process	protein polyubiquitination
o	0003677	molecular_function	DNA binding
o	0003713	molecular_function	transcription coactivator activity
o	0005515	molecular_function	protein binding
o	0005634	cellular_component	nucleus
o	0005654	cellular_component	nucleoplasm
o	0006357	biological_process	regulation of transcription by RNA polymerase II
o	0006366	biological_process	transcription by RNA polymerase II
o	0016020	cellular_component	membrane
o	0016513	cellular_component	core-binding factor complex
o	0043371	biological_process	negative regulation of CD4-positive, alpha-beta T cell differentiation
o	0043378	biological_process	positive regulation of CD8-positive, alpha-beta T cell differentiation
o	0043565	molecular_function	sequence-specific DNA binding
o	0045893	biological_process	positive regulation of DNA-templated transcription
p	0003723	molecular_function	RNA binding
p	0005515	molecular_function	protein binding
p	0016020	cellular_component	membrane
p	0020002	cellular_component	host cell plasma membrane
p	0030430	cellular_component	host cell cytoplasm
p	0044423	cellular_component	virion component
s	0000122	biological_process	negative regulation of transcription by RNA polymerase II
s	0000209	biological_process	protein polyubiquitination
s	0003677	molecular_function	DNA binding
s	0003713	molecular_function	transcription coactivator activity
s	0005515	molecular_function	protein binding
s	0005634	cellular_component	nucleus
s	0005654	cellular_component	nucleoplasm
s	0006357	biological_process	regulation of transcription by RNA polymerase II
s	0006366	biological_process	transcription by RNA polymerase II
s	0016020	cellular_component	membrane
s	0016513	cellular_component	core-binding factor complex
s	0043371	biological_process	negative regulation of CD4-positive, alpha-beta T cell differentiation
s	0043378	biological_process	positive regulation of CD8-positive, alpha-beta T cell differentiation
s	0043565	molecular_function	sequence-specific DNA binding
s	0045893	biological_process	positive regulation of DNA-templated transcription
t	0003723	molecular_function	RNA binding
t	0005515	molecular_function	protein binding
t	0016020	cellular_component	membrane
t	0020002	cellular_component	host cell plasma membrane
t	0030430	cellular_component	host cell cytoplasm
t	0044423	cellular_component	virion component

Functional Information from PROSITE/UniProt

site_id	PS00903
Number of Residues	39
Details	CYT_DCMP_DEAMINASES_1 Cytidine and deoxycytidylate deaminases zinc-binding region signature. HAEicFIneiksmgldetqcyqvtcyltws..........PCss......CawkL

Chain	Residue	Details
A	HIS54-LEU92

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI3
Number of Residues	6
Details	Region: {"description":"Interaction with host APOBEC3F; F1-box","evidences":[{"source":"HAMAP-Rule","id":"MF_04081","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	8
Details	Region: {"description":"Interaction with host APOBEC3G; G-box","evidences":[{"source":"HAMAP-Rule","id":"MF_04081","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	36
Details	Region: {"description":"Interaction with host APOBEC3F and APOBEC3G; FG-box","evidences":[{"source":"HAMAP-Rule","id":"MF_04081","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	26
Details	Region: {"description":"Multimerization","evidences":[{"source":"HAMAP-Rule","id":"MF_04081","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	62
Details	Motif: {"description":"HCCH motif","evidences":[{"source":"HAMAP-Rule","id":"MF_04081","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	18
Details	Motif: {"description":"BC-box-like motif","evidences":[{"source":"HAMAP-Rule","id":"MF_04081","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24402281","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37640699","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4N9F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FVI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	Site: {"description":"Cleavage in virion (by viral protease)","evidences":[{"source":"HAMAP-Rule","id":"MF_04081","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"12186895","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine; by host MAP4K1","evidences":[{"source":"HAMAP-Rule","id":"MF_04081","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by host","evidences":[{"source":"HAMAP-Rule","id":"MF_04081","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by host MAP4K1","evidences":[{"source":"HAMAP-Rule","id":"MF_04081","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---