9E8P

Crystal Structure of GABARAP-ATG3 conjugate

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0000045	biological_process	autophagosome assembly
C	0000139	cellular_component	Golgi membrane
C	0000421	cellular_component	autophagosome membrane
C	0000423	biological_process	mitophagy
C	0005515	molecular_function	protein binding
C	0005543	molecular_function	phospholipid binding
C	0005764	cellular_component	lysosome
C	0005776	cellular_component	autophagosome
C	0005790	cellular_component	smooth endoplasmic reticulum
C	0005794	cellular_component	Golgi apparatus
C	0005829	cellular_component	cytosol
C	0005856	cellular_component	cytoskeleton
C	0005874	cellular_component	microtubule
C	0005875	cellular_component	microtubule associated complex
C	0005886	cellular_component	plasma membrane
C	0005930	cellular_component	axoneme
C	0006605	biological_process	protein targeting
C	0006914	biological_process	autophagy
C	0006915	biological_process	apoptotic process
C	0006995	biological_process	cellular response to nitrogen starvation
C	0007268	biological_process	chemical synaptic transmission
C	0008017	molecular_function	microtubule binding
C	0008429	molecular_function	phosphatidylethanolamine binding
C	0008625	biological_process	extrinsic apoptotic signaling pathway via death domain receptors
C	0012505	cellular_component	endomembrane system
C	0015031	biological_process	protein transport
C	0015629	cellular_component	actin cytoskeleton
C	0031410	cellular_component	cytoplasmic vesicle
C	0031625	molecular_function	ubiquitin protein ligase binding
C	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
C	0035020	biological_process	regulation of Rac protein signal transduction
C	0048487	molecular_function	beta-tubulin binding
C	0050811	molecular_function	GABA receptor binding
C	0097225	cellular_component	sperm midpiece
C	0097352	biological_process	autophagosome maturation
C	0098696	biological_process	regulation of neurotransmitter receptor localization to postsynaptic specialization membrane
C	0098982	cellular_component	GABA-ergic synapse
C	1902524	biological_process	positive regulation of protein K48-linked ubiquitination
D	0000045	biological_process	autophagosome assembly
D	0000139	cellular_component	Golgi membrane
D	0000421	cellular_component	autophagosome membrane
D	0000423	biological_process	mitophagy
D	0005515	molecular_function	protein binding
D	0005543	molecular_function	phospholipid binding
D	0005764	cellular_component	lysosome
D	0005776	cellular_component	autophagosome
D	0005790	cellular_component	smooth endoplasmic reticulum
D	0005794	cellular_component	Golgi apparatus
D	0005829	cellular_component	cytosol
D	0005856	cellular_component	cytoskeleton
D	0005874	cellular_component	microtubule
D	0005875	cellular_component	microtubule associated complex
D	0005886	cellular_component	plasma membrane
D	0005930	cellular_component	axoneme
D	0006605	biological_process	protein targeting
D	0006914	biological_process	autophagy
D	0006915	biological_process	apoptotic process
D	0006995	biological_process	cellular response to nitrogen starvation
D	0007268	biological_process	chemical synaptic transmission
D	0008017	molecular_function	microtubule binding
D	0008429	molecular_function	phosphatidylethanolamine binding
D	0008625	biological_process	extrinsic apoptotic signaling pathway via death domain receptors
D	0012505	cellular_component	endomembrane system
D	0015031	biological_process	protein transport
D	0015629	cellular_component	actin cytoskeleton
D	0031410	cellular_component	cytoplasmic vesicle
D	0031625	molecular_function	ubiquitin protein ligase binding
D	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
D	0035020	biological_process	regulation of Rac protein signal transduction
D	0048487	molecular_function	beta-tubulin binding
D	0050811	molecular_function	GABA receptor binding
D	0097225	cellular_component	sperm midpiece
D	0097352	biological_process	autophagosome maturation
D	0098696	biological_process	regulation of neurotransmitter receptor localization to postsynaptic specialization membrane
D	0098982	cellular_component	GABA-ergic synapse
D	1902524	biological_process	positive regulation of protein K48-linked ubiquitination

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Glycyl thioester intermediate","evidences":[{"source":"PubMed","id":"11825910","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ATG12)","evidences":[{"source":"UniProtKB","id":"Q9CPX6","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	64
Details	Region: {"description":"Interaction with GABRG2","evidences":[{"source":"PubMed","id":"9892355","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	4
Details	Region: {"description":"Interaction with LIR (LC3 nteracting Region) motif of ATG3","evidences":[{"source":"PubMed","id":"37252361","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8AFI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	4
Details	Site: {"description":"Interaction with LIR (LC3 nteracting Region) motif of ATG3","evidences":[{"source":"PubMed","id":"37252361","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8AFI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI6
Number of Residues	2
Details	Lipidation: {"description":"Phosphatidylserine amidated glycine; alternate","evidences":[{"source":"PubMed","id":"33909989","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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