Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

9E3M

Cryo-EM structure of the human P2X7 receptor in the apo closed state

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0001530	molecular_function	lipopolysaccharide binding
A	0001614	molecular_function	purinergic nucleotide receptor activity
A	0002028	biological_process	regulation of sodium ion transport
A	0002931	biological_process	response to ischemia
A	0004931	molecular_function	extracellularly ATP-gated monoatomic cation channel activity
A	0005102	molecular_function	signaling receptor binding
A	0005267	molecular_function	potassium channel activity
A	0005272	molecular_function	sodium channel activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005525	molecular_function	GTP binding
A	0005737	cellular_component	cytoplasm
A	0005886	cellular_component	plasma membrane
A	0005911	cellular_component	cell-cell junction
A	0006811	biological_process	monoatomic ion transport
A	0007166	biological_process	cell surface receptor signaling pathway
A	0009897	cellular_component	external side of plasma membrane
A	0010524	biological_process	positive regulation of calcium ion transport into cytosol
A	0010628	biological_process	positive regulation of gene expression
A	0015267	molecular_function	channel activity
A	0015748	biological_process	organophosphate ester transport
A	0016020	cellular_component	membrane
A	0017121	biological_process	plasma membrane phospholipid scrambling
A	0019233	biological_process	sensory perception of pain
A	0019722	biological_process	calcium-mediated signaling
A	0030501	biological_process	positive regulation of bone mineralization
A	0031594	cellular_component	neuromuscular junction
A	0032059	cellular_component	bleb
A	0032060	biological_process	bleb assembly
A	0032731	biological_process	positive regulation of interleukin-1 beta production
A	0033198	biological_process	response to ATP
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0034767	biological_process	positive regulation of monoatomic ion transmembrane transport
A	0035590	biological_process	purinergic nucleotide receptor signaling pathway
A	0035725	biological_process	sodium ion transmembrane transport
A	0038023	molecular_function	signaling receptor activity
A	0042802	molecular_function	identical protein binding
A	0043025	cellular_component	neuronal cell body
A	0043409	biological_process	negative regulation of MAPK cascade
A	0045202	cellular_component	synapse
A	0045779	biological_process	negative regulation of bone resorption
A	0045794	biological_process	negative regulation of cell volume
A	0045821	biological_process	positive regulation of glycolytic process
A	0046872	molecular_function	metal ion binding
A	0046931	biological_process	pore complex assembly
A	0050877	biological_process	nervous system process
A	0051049	biological_process	regulation of transport
A	0051130	biological_process	positive regulation of cellular component organization
A	0051495	biological_process	positive regulation of cytoskeleton organization
A	0051899	biological_process	membrane depolarization
A	0060079	biological_process	excitatory postsynaptic potential
A	0070207	biological_process	protein homotrimerization
A	0070588	biological_process	calcium ion transmembrane transport
A	0071318	biological_process	cellular response to ATP
A	0071805	biological_process	potassium ion transmembrane transport
A	0097190	biological_process	apoptotic signaling pathway
A	0097191	biological_process	extrinsic apoptotic signaling pathway
A	0098794	cellular_component	postsynapse
A	1900227	biological_process	positive regulation of NLRP3 inflammasome complex assembly
A	1904172	biological_process	positive regulation of bleb assembly
B	0000166	molecular_function	nucleotide binding
B	0001530	molecular_function	lipopolysaccharide binding
B	0001614	molecular_function	purinergic nucleotide receptor activity
B	0002028	biological_process	regulation of sodium ion transport
B	0002931	biological_process	response to ischemia
B	0004931	molecular_function	extracellularly ATP-gated monoatomic cation channel activity
B	0005102	molecular_function	signaling receptor binding
B	0005267	molecular_function	potassium channel activity
B	0005272	molecular_function	sodium channel activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005525	molecular_function	GTP binding
B	0005737	cellular_component	cytoplasm
B	0005886	cellular_component	plasma membrane
B	0005911	cellular_component	cell-cell junction
B	0006811	biological_process	monoatomic ion transport
B	0007166	biological_process	cell surface receptor signaling pathway
B	0009897	cellular_component	external side of plasma membrane
B	0010524	biological_process	positive regulation of calcium ion transport into cytosol
B	0010628	biological_process	positive regulation of gene expression
B	0015267	molecular_function	channel activity
B	0015748	biological_process	organophosphate ester transport
B	0016020	cellular_component	membrane
B	0017121	biological_process	plasma membrane phospholipid scrambling
B	0019233	biological_process	sensory perception of pain
B	0019722	biological_process	calcium-mediated signaling
B	0030501	biological_process	positive regulation of bone mineralization
B	0031594	cellular_component	neuromuscular junction
B	0032059	cellular_component	bleb
B	0032060	biological_process	bleb assembly
B	0032731	biological_process	positive regulation of interleukin-1 beta production
B	0033198	biological_process	response to ATP
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0034767	biological_process	positive regulation of monoatomic ion transmembrane transport
B	0035590	biological_process	purinergic nucleotide receptor signaling pathway
B	0035725	biological_process	sodium ion transmembrane transport
B	0038023	molecular_function	signaling receptor activity
B	0042802	molecular_function	identical protein binding
B	0043025	cellular_component	neuronal cell body
B	0043409	biological_process	negative regulation of MAPK cascade
B	0045202	cellular_component	synapse
B	0045779	biological_process	negative regulation of bone resorption
B	0045794	biological_process	negative regulation of cell volume
B	0045821	biological_process	positive regulation of glycolytic process
B	0046872	molecular_function	metal ion binding
B	0046931	biological_process	pore complex assembly
B	0050877	biological_process	nervous system process
B	0051049	biological_process	regulation of transport
B	0051130	biological_process	positive regulation of cellular component organization
B	0051495	biological_process	positive regulation of cytoskeleton organization
B	0051899	biological_process	membrane depolarization
B	0060079	biological_process	excitatory postsynaptic potential
B	0070207	biological_process	protein homotrimerization
B	0070588	biological_process	calcium ion transmembrane transport
B	0071318	biological_process	cellular response to ATP
B	0071805	biological_process	potassium ion transmembrane transport
B	0097190	biological_process	apoptotic signaling pathway
B	0097191	biological_process	extrinsic apoptotic signaling pathway
B	0098794	cellular_component	postsynapse
B	1900227	biological_process	positive regulation of NLRP3 inflammasome complex assembly
B	1904172	biological_process	positive regulation of bleb assembly
C	0000166	molecular_function	nucleotide binding
C	0001530	molecular_function	lipopolysaccharide binding
C	0001614	molecular_function	purinergic nucleotide receptor activity
C	0002028	biological_process	regulation of sodium ion transport
C	0002931	biological_process	response to ischemia
C	0004931	molecular_function	extracellularly ATP-gated monoatomic cation channel activity
C	0005102	molecular_function	signaling receptor binding
C	0005267	molecular_function	potassium channel activity
C	0005272	molecular_function	sodium channel activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005525	molecular_function	GTP binding
C	0005737	cellular_component	cytoplasm
C	0005886	cellular_component	plasma membrane
C	0005911	cellular_component	cell-cell junction
C	0006811	biological_process	monoatomic ion transport
C	0007166	biological_process	cell surface receptor signaling pathway
C	0009897	cellular_component	external side of plasma membrane
C	0010524	biological_process	positive regulation of calcium ion transport into cytosol
C	0010628	biological_process	positive regulation of gene expression
C	0015267	molecular_function	channel activity
C	0015748	biological_process	organophosphate ester transport
C	0016020	cellular_component	membrane
C	0017121	biological_process	plasma membrane phospholipid scrambling
C	0019233	biological_process	sensory perception of pain
C	0019722	biological_process	calcium-mediated signaling
C	0030501	biological_process	positive regulation of bone mineralization
C	0031594	cellular_component	neuromuscular junction
C	0032059	cellular_component	bleb
C	0032060	biological_process	bleb assembly
C	0032731	biological_process	positive regulation of interleukin-1 beta production
C	0033198	biological_process	response to ATP
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0034767	biological_process	positive regulation of monoatomic ion transmembrane transport
C	0035590	biological_process	purinergic nucleotide receptor signaling pathway
C	0035725	biological_process	sodium ion transmembrane transport
C	0038023	molecular_function	signaling receptor activity
C	0042802	molecular_function	identical protein binding
C	0043025	cellular_component	neuronal cell body
C	0043409	biological_process	negative regulation of MAPK cascade
C	0045202	cellular_component	synapse
C	0045779	biological_process	negative regulation of bone resorption
C	0045794	biological_process	negative regulation of cell volume
C	0045821	biological_process	positive regulation of glycolytic process
C	0046872	molecular_function	metal ion binding
C	0046931	biological_process	pore complex assembly
C	0050877	biological_process	nervous system process
C	0051049	biological_process	regulation of transport
C	0051130	biological_process	positive regulation of cellular component organization
C	0051495	biological_process	positive regulation of cytoskeleton organization
C	0051899	biological_process	membrane depolarization
C	0060079	biological_process	excitatory postsynaptic potential
C	0070207	biological_process	protein homotrimerization
C	0070588	biological_process	calcium ion transmembrane transport
C	0071318	biological_process	cellular response to ATP
C	0071805	biological_process	potassium ion transmembrane transport
C	0097190	biological_process	apoptotic signaling pathway
C	0097191	biological_process	extrinsic apoptotic signaling pathway
C	0098794	cellular_component	postsynapse
C	1900227	biological_process	positive regulation of NLRP3 inflammasome complex assembly
C	1904172	biological_process	positive regulation of bleb assembly

Functional Information from PROSITE/UniProt

site_id	PS01212
Number of Residues	27
Details	P2X_RECEPTOR ATP P2X receptors signature. GGiMGIeIyWdCNLDrwfhhCrPkYsF

Chain	Residue	Details
A	GLY249-PHE275

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	69
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"UniProtKB","id":"Q64663","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	72
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"UniProtKB","id":"Q64663","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	51
Details	Region: {"description":"C-cys anchor","evidences":[{"source":"UniProtKB","id":"Q64663","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	45
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q64663","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	9
Details	Site: {"description":"Selectivity filter 2","evidences":[{"source":"PubMed","id":"39262850","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	3
Details	Site: {"description":"Selectivity filter 1","evidences":[{"source":"PubMed","id":"28235784","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39262850","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	6
Details	Modified residue: {"description":"ADP-ribosylarginine","evidences":[{"source":"UniProtKB","id":"Q9Z1M0","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	3
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"11707406","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	3
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	12
Details	Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"UniProtKB","id":"Q64663","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	15
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"20450227","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)