Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

9E2U

Crystal structure of DDB1-CRBN-ALV1 complex bound to triple ZnF of Helios (IKZF2 ZF1-3)

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0016020	cellular_component	membrane
B	0016567	biological_process	protein ubiquitination
B	0030177	biological_process	positive regulation of Wnt signaling pathway
B	0031333	biological_process	negative regulation of protein-containing complex assembly
B	0031334	biological_process	positive regulation of protein-containing complex assembly
B	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
B	0034766	biological_process	negative regulation of monoatomic ion transmembrane transport
B	0035641	biological_process	locomotory exploration behavior
B	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
B	0044325	molecular_function	transmembrane transporter binding
B	0046872	molecular_function	metal ion binding
B	0048471	cellular_component	perinuclear region of cytoplasm
B	0060173	biological_process	limb development
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0016020	cellular_component	membrane
D	0016567	biological_process	protein ubiquitination
D	0030177	biological_process	positive regulation of Wnt signaling pathway
D	0031333	biological_process	negative regulation of protein-containing complex assembly
D	0031334	biological_process	positive regulation of protein-containing complex assembly
D	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
D	0034766	biological_process	negative regulation of monoatomic ion transmembrane transport
D	0035641	biological_process	locomotory exploration behavior
D	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
D	0044325	molecular_function	transmembrane transporter binding
D	0046872	molecular_function	metal ion binding
D	0048471	cellular_component	perinuclear region of cytoplasm
D	0060173	biological_process	limb development
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0016020	cellular_component	membrane
F	0016567	biological_process	protein ubiquitination
F	0030177	biological_process	positive regulation of Wnt signaling pathway
F	0031333	biological_process	negative regulation of protein-containing complex assembly
F	0031334	biological_process	positive regulation of protein-containing complex assembly
F	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
F	0034766	biological_process	negative regulation of monoatomic ion transmembrane transport
F	0035641	biological_process	locomotory exploration behavior
F	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
F	0044325	molecular_function	transmembrane transporter binding
F	0046872	molecular_function	metal ion binding
F	0048471	cellular_component	perinuclear region of cytoplasm
F	0060173	biological_process	limb development
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0016020	cellular_component	membrane
H	0016567	biological_process	protein ubiquitination
H	0030177	biological_process	positive regulation of Wnt signaling pathway
H	0031333	biological_process	negative regulation of protein-containing complex assembly
H	0031334	biological_process	positive regulation of protein-containing complex assembly
H	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
H	0034766	biological_process	negative regulation of monoatomic ion transmembrane transport
H	0035641	biological_process	locomotory exploration behavior
H	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
H	0044325	molecular_function	transmembrane transporter binding
H	0046872	molecular_function	metal ion binding
H	0048471	cellular_component	perinuclear region of cytoplasm
H	0060173	biological_process	limb development
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0016020	cellular_component	membrane
J	0016567	biological_process	protein ubiquitination
J	0030177	biological_process	positive regulation of Wnt signaling pathway
J	0031333	biological_process	negative regulation of protein-containing complex assembly
J	0031334	biological_process	positive regulation of protein-containing complex assembly
J	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
J	0034766	biological_process	negative regulation of monoatomic ion transmembrane transport
J	0035641	biological_process	locomotory exploration behavior
J	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
J	0044325	molecular_function	transmembrane transporter binding
J	0046872	molecular_function	metal ion binding
J	0048471	cellular_component	perinuclear region of cytoplasm
J	0060173	biological_process	limb development
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0016020	cellular_component	membrane
L	0016567	biological_process	protein ubiquitination
L	0030177	biological_process	positive regulation of Wnt signaling pathway
L	0031333	biological_process	negative regulation of protein-containing complex assembly
L	0031334	biological_process	positive regulation of protein-containing complex assembly
L	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
L	0034766	biological_process	negative regulation of monoatomic ion transmembrane transport
L	0035641	biological_process	locomotory exploration behavior
L	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
L	0044325	molecular_function	transmembrane transporter binding
L	0046872	molecular_function	metal ion binding
L	0048471	cellular_component	perinuclear region of cytoplasm
L	0060173	biological_process	limb development
N	0005515	molecular_function	protein binding
N	0005634	cellular_component	nucleus
N	0005737	cellular_component	cytoplasm
N	0005829	cellular_component	cytosol
N	0016020	cellular_component	membrane
N	0016567	biological_process	protein ubiquitination
N	0030177	biological_process	positive regulation of Wnt signaling pathway
N	0031333	biological_process	negative regulation of protein-containing complex assembly
N	0031334	biological_process	positive regulation of protein-containing complex assembly
N	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
N	0034766	biological_process	negative regulation of monoatomic ion transmembrane transport
N	0035641	biological_process	locomotory exploration behavior
N	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
N	0044325	molecular_function	transmembrane transporter binding
N	0046872	molecular_function	metal ion binding
N	0048471	cellular_component	perinuclear region of cytoplasm
N	0060173	biological_process	limb development
P	0005515	molecular_function	protein binding
P	0005634	cellular_component	nucleus
P	0005737	cellular_component	cytoplasm
P	0005829	cellular_component	cytosol
P	0016020	cellular_component	membrane
P	0016567	biological_process	protein ubiquitination
P	0030177	biological_process	positive regulation of Wnt signaling pathway
P	0031333	biological_process	negative regulation of protein-containing complex assembly
P	0031334	biological_process	positive regulation of protein-containing complex assembly
P	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
P	0034766	biological_process	negative regulation of monoatomic ion transmembrane transport
P	0035641	biological_process	locomotory exploration behavior
P	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
P	0044325	molecular_function	transmembrane transporter binding
P	0046872	molecular_function	metal ion binding
P	0048471	cellular_component	perinuclear region of cytoplasm
P	0060173	biological_process	limb development

Functional Information from PROSITE/UniProt

site_id	PS00028
Number of Residues	21
Details	ZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. Cdv..CgmvCigpnvlmvHkrs..H

Chain	Residue	Details
R	CYS114-HIS134
R	CYS142-HIS162
R	CYS170-HIS190

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2744
Details	Region: {"description":"WD repeat beta-propeller A"}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	2952
Details	Region: {"description":"Interaction with CDT1 and CUL4A","evidences":[{"source":"PubMed","id":"15448697","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	8
Details	Modified residue: {"description":"N-acetylserine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	8
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	8
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q9ESW0","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	16
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	1904
Details	Domain: {"description":"Lon N-terminal","evidences":[{"source":"PROSITE-ProRule","id":"PRU01123","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	864
Details	Domain: {"description":"CULT","evidences":[{"source":"PROSITE-ProRule","id":"PRU01124","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	56
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25108355","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4TZ4","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)