9E14

Full-length human dynein-1 in phi-like comformation bound to a Lis1 dimer under Nde1-Lis1 condition

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0001673	cellular_component	male germ cell nucleus
A	0003723	molecular_function	RNA binding
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005576	cellular_component	extracellular region
A	0005737	cellular_component	cytoplasm
A	0005813	cellular_component	centrosome
A	0005829	cellular_component	cytosol
A	0005856	cellular_component	cytoskeleton
A	0005868	cellular_component	cytoplasmic dynein complex
A	0005874	cellular_component	microtubule
A	0005881	cellular_component	cytoplasmic microtubule
A	0005938	cellular_component	cell cortex
A	0007052	biological_process	mitotic spindle organization
A	0007097	biological_process	nuclear migration
A	0008090	biological_process	retrograde axonal transport
A	0008569	molecular_function	minus-end-directed microtubule motor activity
A	0016020	cellular_component	membrane
A	0030175	cellular_component	filopodium
A	0030286	cellular_component	dynein complex
A	0031122	biological_process	cytoplasmic microtubule organization
A	0032388	biological_process	positive regulation of intracellular transport
A	0033962	biological_process	P-body assembly
A	0034063	biological_process	stress granule assembly
A	0035578	cellular_component	azurophil granule lumen
A	0042802	molecular_function	identical protein binding
A	0045505	molecular_function	dynein intermediate chain binding
A	0051293	biological_process	establishment of spindle localization
A	0051301	biological_process	cell division
A	0051959	molecular_function	dynein light intermediate chain binding
A	0060236	biological_process	regulation of mitotic spindle organization
A	0070062	cellular_component	extracellular exosome
A	0090235	biological_process	regulation of metaphase plate congression
A	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
A	0120162	biological_process	positive regulation of cold-induced thermogenesis
A	1904115	cellular_component	axon cytoplasm
A	1905832	biological_process	positive regulation of spindle assembly
B	0000166	molecular_function	nucleotide binding
B	0001673	cellular_component	male germ cell nucleus
B	0003723	molecular_function	RNA binding
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005576	cellular_component	extracellular region
B	0005737	cellular_component	cytoplasm
B	0005813	cellular_component	centrosome
B	0005829	cellular_component	cytosol
B	0005856	cellular_component	cytoskeleton
B	0005868	cellular_component	cytoplasmic dynein complex
B	0005874	cellular_component	microtubule
B	0005881	cellular_component	cytoplasmic microtubule
B	0005938	cellular_component	cell cortex
B	0007052	biological_process	mitotic spindle organization
B	0007097	biological_process	nuclear migration
B	0008090	biological_process	retrograde axonal transport
B	0008569	molecular_function	minus-end-directed microtubule motor activity
B	0016020	cellular_component	membrane
B	0030175	cellular_component	filopodium
B	0030286	cellular_component	dynein complex
B	0031122	biological_process	cytoplasmic microtubule organization
B	0032388	biological_process	positive regulation of intracellular transport
B	0033962	biological_process	P-body assembly
B	0034063	biological_process	stress granule assembly
B	0035578	cellular_component	azurophil granule lumen
B	0042802	molecular_function	identical protein binding
B	0045505	molecular_function	dynein intermediate chain binding
B	0051293	biological_process	establishment of spindle localization
B	0051301	biological_process	cell division
B	0051959	molecular_function	dynein light intermediate chain binding
B	0060236	biological_process	regulation of mitotic spindle organization
B	0070062	cellular_component	extracellular exosome
B	0090235	biological_process	regulation of metaphase plate congression
B	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
B	0120162	biological_process	positive regulation of cold-induced thermogenesis
B	1904115	cellular_component	axon cytoplasm
B	1905832	biological_process	positive regulation of spindle assembly
C	0001673	cellular_component	male germ cell nucleus
C	0003777	molecular_function	microtubule motor activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005813	cellular_component	centrosome
C	0005829	cellular_component	cytosol
C	0005856	cellular_component	cytoskeleton
C	0005868	cellular_component	cytoplasmic dynein complex
C	0005874	cellular_component	microtubule
C	0007018	biological_process	microtubule-based movement
C	0010970	biological_process	transport along microtubule
C	0030286	cellular_component	dynein complex
C	0031982	cellular_component	vesicle
C	0032388	biological_process	positive regulation of intracellular transport
C	0045503	molecular_function	dynein light chain binding
C	0045504	molecular_function	dynein heavy chain binding
C	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
D	0001673	cellular_component	male germ cell nucleus
D	0003777	molecular_function	microtubule motor activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005813	cellular_component	centrosome
D	0005829	cellular_component	cytosol
D	0005856	cellular_component	cytoskeleton
D	0005868	cellular_component	cytoplasmic dynein complex
D	0005874	cellular_component	microtubule
D	0007018	biological_process	microtubule-based movement
D	0010970	biological_process	transport along microtubule
D	0030286	cellular_component	dynein complex
D	0031982	cellular_component	vesicle
D	0032388	biological_process	positive regulation of intracellular transport
D	0045503	molecular_function	dynein light chain binding
D	0045504	molecular_function	dynein heavy chain binding
D	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
E	0000166	molecular_function	nucleotide binding
E	0000226	biological_process	microtubule cytoskeleton organization
E	0000776	cellular_component	kinetochore
E	0001673	cellular_component	male germ cell nucleus
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005770	cellular_component	late endosome
E	0005813	cellular_component	centrosome
E	0005829	cellular_component	cytosol
E	0005856	cellular_component	cytoskeleton
E	0005868	cellular_component	cytoplasmic dynein complex
E	0005874	cellular_component	microtubule
E	0007018	biological_process	microtubule-based movement
E	0016020	cellular_component	membrane
E	0030286	cellular_component	dynein complex
E	0032388	biological_process	positive regulation of intracellular transport
E	0042802	molecular_function	identical protein binding
E	0045504	molecular_function	dynein heavy chain binding
E	1990090	biological_process	cellular response to nerve growth factor stimulus
F	0000166	molecular_function	nucleotide binding
F	0000226	biological_process	microtubule cytoskeleton organization
F	0000776	cellular_component	kinetochore
F	0001673	cellular_component	male germ cell nucleus
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005770	cellular_component	late endosome
F	0005813	cellular_component	centrosome
F	0005829	cellular_component	cytosol
F	0005856	cellular_component	cytoskeleton
F	0005868	cellular_component	cytoplasmic dynein complex
F	0005874	cellular_component	microtubule
F	0007018	biological_process	microtubule-based movement
F	0016020	cellular_component	membrane
F	0030286	cellular_component	dynein complex
F	0032388	biological_process	positive regulation of intracellular transport
F	0042802	molecular_function	identical protein binding
F	0045504	molecular_function	dynein heavy chain binding
F	1990090	biological_process	cellular response to nerve growth factor stimulus
G	0003777	molecular_function	microtubule motor activity
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0005813	cellular_component	centrosome
G	0005856	cellular_component	cytoskeleton
G	0005868	cellular_component	cytoplasmic dynein complex
G	0005874	cellular_component	microtubule
G	0005929	cellular_component	cilium
G	0007018	biological_process	microtubule-based movement
G	0007632	biological_process	visual behavior
G	0016020	cellular_component	membrane
G	0030286	cellular_component	dynein complex
G	0032388	biological_process	positive regulation of intracellular transport
G	0035721	biological_process	intraciliary retrograde transport
G	0042802	molecular_function	identical protein binding
G	0045505	molecular_function	dynein intermediate chain binding
G	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
G	0097542	cellular_component	ciliary tip
H	0003777	molecular_function	microtubule motor activity
H	0005515	molecular_function	protein binding
H	0005737	cellular_component	cytoplasm
H	0005813	cellular_component	centrosome
H	0005856	cellular_component	cytoskeleton
H	0005868	cellular_component	cytoplasmic dynein complex
H	0005874	cellular_component	microtubule
H	0005929	cellular_component	cilium
H	0007018	biological_process	microtubule-based movement
H	0007632	biological_process	visual behavior
H	0016020	cellular_component	membrane
H	0030286	cellular_component	dynein complex
H	0032388	biological_process	positive regulation of intracellular transport
H	0035721	biological_process	intraciliary retrograde transport
H	0042802	molecular_function	identical protein binding
H	0045505	molecular_function	dynein intermediate chain binding
H	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
H	0097542	cellular_component	ciliary tip
I	0000776	cellular_component	kinetochore
I	0001673	cellular_component	male germ cell nucleus
I	0004857	molecular_function	enzyme inhibitor activity
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005694	cellular_component	chromosome
I	0005737	cellular_component	cytoplasm
I	0005739	cellular_component	mitochondrion
I	0005813	cellular_component	centrosome
I	0005829	cellular_component	cytosol
I	0005856	cellular_component	cytoskeleton
I	0005868	cellular_component	cytoplasmic dynein complex
I	0005874	cellular_component	microtubule
I	0005886	cellular_component	plasma membrane
I	0005929	cellular_component	cilium
I	0006351	biological_process	DNA-templated transcription
I	0006915	biological_process	apoptotic process
I	0006974	biological_process	DNA damage response
I	0007286	biological_process	spermatid development
I	0008180	cellular_component	COP9 signalosome
I	0015630	cellular_component	microtubule cytoskeleton
I	0016020	cellular_component	membrane
I	0019899	molecular_function	enzyme binding
I	0021762	biological_process	substantia nigra development
I	0030141	cellular_component	secretory granule
I	0030235	molecular_function	nitric-oxide synthase regulator activity
I	0030286	cellular_component	dynein complex
I	0032388	biological_process	positive regulation of intracellular transport
I	0035721	biological_process	intraciliary retrograde transport
I	0035774	biological_process	positive regulation of insulin secretion involved in cellular response to glucose stimulus
I	0035861	cellular_component	site of double-strand break
I	0036487	molecular_function	nitric-oxide synthase inhibitor activity
I	0042326	biological_process	negative regulation of phosphorylation
I	0042802	molecular_function	identical protein binding
I	0044458	biological_process	motile cilium assembly
I	0044877	molecular_function	protein-containing complex binding
I	0045505	molecular_function	dynein intermediate chain binding
I	0070821	cellular_component	tertiary granule membrane
I	0072686	cellular_component	mitotic spindle
I	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
I	0097110	molecular_function	scaffold protein binding
I	0097542	cellular_component	ciliary tip
I	0101003	cellular_component	ficolin-1-rich granule membrane
I	0110027	biological_process	negative regulation of DNA strand resection involved in replication fork processing
I	1904115	cellular_component	axon cytoplasm
J	0000776	cellular_component	kinetochore
J	0001673	cellular_component	male germ cell nucleus
J	0004857	molecular_function	enzyme inhibitor activity
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005694	cellular_component	chromosome
J	0005737	cellular_component	cytoplasm
J	0005739	cellular_component	mitochondrion
J	0005813	cellular_component	centrosome
J	0005829	cellular_component	cytosol
J	0005856	cellular_component	cytoskeleton
J	0005868	cellular_component	cytoplasmic dynein complex
J	0005874	cellular_component	microtubule
J	0005886	cellular_component	plasma membrane
J	0005929	cellular_component	cilium
J	0006351	biological_process	DNA-templated transcription
J	0006915	biological_process	apoptotic process
J	0006974	biological_process	DNA damage response
J	0007286	biological_process	spermatid development
J	0008180	cellular_component	COP9 signalosome
J	0015630	cellular_component	microtubule cytoskeleton
J	0016020	cellular_component	membrane
J	0019899	molecular_function	enzyme binding
J	0021762	biological_process	substantia nigra development
J	0030141	cellular_component	secretory granule
J	0030235	molecular_function	nitric-oxide synthase regulator activity
J	0030286	cellular_component	dynein complex
J	0032388	biological_process	positive regulation of intracellular transport
J	0035721	biological_process	intraciliary retrograde transport
J	0035774	biological_process	positive regulation of insulin secretion involved in cellular response to glucose stimulus
J	0035861	cellular_component	site of double-strand break
J	0036487	molecular_function	nitric-oxide synthase inhibitor activity
J	0042326	biological_process	negative regulation of phosphorylation
J	0042802	molecular_function	identical protein binding
J	0044458	biological_process	motile cilium assembly
J	0044877	molecular_function	protein-containing complex binding
J	0045505	molecular_function	dynein intermediate chain binding
J	0070821	cellular_component	tertiary granule membrane
J	0072686	cellular_component	mitotic spindle
J	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
J	0097110	molecular_function	scaffold protein binding
J	0097542	cellular_component	ciliary tip
J	0101003	cellular_component	ficolin-1-rich granule membrane
J	0110027	biological_process	negative regulation of DNA strand resection involved in replication fork processing
J	1904115	cellular_component	axon cytoplasm
K	0000132	biological_process	establishment of mitotic spindle orientation
K	0001673	cellular_component	male germ cell nucleus
K	0005515	molecular_function	protein binding
K	0005576	cellular_component	extracellular region
K	0005737	cellular_component	cytoplasm
K	0005794	cellular_component	Golgi apparatus
K	0005819	cellular_component	spindle
K	0005868	cellular_component	cytoplasmic dynein complex
K	0005874	cellular_component	microtubule
K	0005881	cellular_component	cytoplasmic microtubule
K	0005929	cellular_component	cilium
K	0007018	biological_process	microtubule-based movement
K	0007399	biological_process	nervous system development
K	0008277	biological_process	regulation of G protein-coupled receptor signaling pathway
K	0019060	biological_process	intracellular transport of viral protein in host cell
K	0030286	cellular_component	dynein complex
K	0032388	biological_process	positive regulation of intracellular transport
K	0034774	cellular_component	secretory granule lumen
K	0035721	biological_process	intraciliary retrograde transport
K	0042802	molecular_function	identical protein binding
K	0043657	cellular_component	host cell
K	0045505	molecular_function	dynein intermediate chain binding
K	0046718	biological_process	symbiont entry into host cell
K	0050768	biological_process	negative regulation of neurogenesis
K	0051301	biological_process	cell division
K	0075521	biological_process	microtubule-dependent intracellular transport of viral material towards nucleus
K	0075606	biological_process	transport of viral material towards nucleus
K	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
K	0099503	cellular_component	secretory vesicle
K	1904813	cellular_component	ficolin-1-rich granule lumen
L	0000132	biological_process	establishment of mitotic spindle orientation
L	0001673	cellular_component	male germ cell nucleus
L	0005515	molecular_function	protein binding
L	0005576	cellular_component	extracellular region
L	0005737	cellular_component	cytoplasm
L	0005794	cellular_component	Golgi apparatus
L	0005819	cellular_component	spindle
L	0005868	cellular_component	cytoplasmic dynein complex
L	0005874	cellular_component	microtubule
L	0005881	cellular_component	cytoplasmic microtubule
L	0005929	cellular_component	cilium
L	0007018	biological_process	microtubule-based movement
L	0007399	biological_process	nervous system development
L	0008277	biological_process	regulation of G protein-coupled receptor signaling pathway
L	0019060	biological_process	intracellular transport of viral protein in host cell
L	0030286	cellular_component	dynein complex
L	0032388	biological_process	positive regulation of intracellular transport
L	0034774	cellular_component	secretory granule lumen
L	0035721	biological_process	intraciliary retrograde transport
L	0042802	molecular_function	identical protein binding
L	0043657	cellular_component	host cell
L	0045505	molecular_function	dynein intermediate chain binding
L	0046718	biological_process	symbiont entry into host cell
L	0050768	biological_process	negative regulation of neurogenesis
L	0051301	biological_process	cell division
L	0075521	biological_process	microtubule-dependent intracellular transport of viral material towards nucleus
L	0075606	biological_process	transport of viral material towards nucleus
L	0090267	biological_process	positive regulation of mitotic cell cycle spindle assembly checkpoint
L	0099503	cellular_component	secretory vesicle
L	1904813	cellular_component	ficolin-1-rich granule lumen
O	0000132	biological_process	establishment of mitotic spindle orientation
O	0000226	biological_process	microtubule cytoskeleton organization
O	0000235	cellular_component	astral microtubule
O	0000776	cellular_component	kinetochore
O	0001675	biological_process	acrosome assembly
O	0001764	biological_process	neuron migration
O	0005515	molecular_function	protein binding
O	0005635	cellular_component	nuclear envelope
O	0005737	cellular_component	cytoplasm
O	0005813	cellular_component	centrosome
O	0005819	cellular_component	spindle
O	0005829	cellular_component	cytosol
O	0005856	cellular_component	cytoskeleton
O	0005871	cellular_component	kinesin complex
O	0005874	cellular_component	microtubule
O	0005875	cellular_component	microtubule associated complex
O	0005881	cellular_component	cytoplasmic microtubule
O	0005938	cellular_component	cell cortex
O	0006629	biological_process	lipid metabolic process
O	0007017	biological_process	microtubule-based process
O	0007097	biological_process	nuclear migration
O	0007268	biological_process	chemical synaptic transmission
O	0007281	biological_process	germ cell development
O	0007399	biological_process	nervous system development
O	0007405	biological_process	neuroblast proliferation
O	0007611	biological_process	learning or memory
O	0008017	molecular_function	microtubule binding
O	0008090	biological_process	retrograde axonal transport
O	0008201	molecular_function	heparin binding
O	0008247	cellular_component	1-alkyl-2-acetylglycerophosphocholine esterase complex
O	0008344	biological_process	adult locomotory behavior
O	0010977	biological_process	negative regulation of neuron projection development
O	0015630	cellular_component	microtubule cytoskeleton
O	0016042	biological_process	lipid catabolic process
O	0017145	biological_process	stem cell division
O	0019226	biological_process	transmission of nerve impulse
O	0021540	biological_process	corpus callosum morphogenesis
O	0021766	biological_process	hippocampus development
O	0021819	biological_process	layer formation in cerebral cortex
O	0021895	biological_process	cerebral cortex neuron differentiation
O	0021987	biological_process	cerebral cortex development
O	0030036	biological_process	actin cytoskeleton organization
O	0030154	biological_process	cell differentiation
O	0030424	cellular_component	axon
O	0030426	cellular_component	growth cone
O	0030900	biological_process	forebrain development
O	0031023	biological_process	microtubule organizing center organization
O	0031252	cellular_component	cell leading edge
O	0031514	cellular_component	motile cilium
O	0031965	cellular_component	nuclear membrane
O	0031982	cellular_component	vesicle
O	0032420	cellular_component	stereocilium
O	0034452	molecular_function	dynactin binding
O	0038026	biological_process	reelin-mediated signaling pathway
O	0040019	biological_process	positive regulation of embryonic development
O	0042249	biological_process	establishment of planar polarity of embryonic epithelium
O	0042802	molecular_function	identical protein binding
O	0043005	cellular_component	neuron projection
O	0043025	cellular_component	neuronal cell body
O	0043274	molecular_function	phospholipase binding
O	0043622	biological_process	cortical microtubule organization
O	0044877	molecular_function	protein-containing complex binding
O	0045505	molecular_function	dynein intermediate chain binding
O	0045773	biological_process	positive regulation of axon extension
O	0045931	biological_process	positive regulation of mitotic cell cycle
O	0046469	biological_process	platelet activating factor metabolic process
O	0046982	molecular_function	protein heterodimerization activity
O	0047496	biological_process	vesicle transport along microtubule
O	0048471	cellular_component	perinuclear region of cytoplasm
O	0048854	biological_process	brain morphogenesis
O	0050804	biological_process	modulation of chemical synaptic transmission
O	0050885	biological_process	neuromuscular process controlling balance
O	0051010	molecular_function	microtubule plus-end binding
O	0051012	biological_process	microtubule sliding
O	0051130	biological_process	positive regulation of cellular component organization
O	0051219	molecular_function	phosphoprotein binding
O	0051301	biological_process	cell division
O	0051656	biological_process	establishment of organelle localization
O	0051660	biological_process	establishment of centrosome localization
O	0060117	biological_process	auditory receptor cell development
O	0061003	biological_process	positive regulation of dendritic spine morphogenesis
O	0062234	biological_process	platelet activating factor catabolic process
O	0070062	cellular_component	extracellular exosome
O	0070507	biological_process	regulation of microtubule cytoskeleton organization
O	0070840	molecular_function	dynein complex binding
O	0090102	biological_process	cochlea development
O	0090176	biological_process	microtubule cytoskeleton organization involved in establishment of planar polarity
O	0090724	cellular_component	central region of growth cone
O	0098685	cellular_component	Schaffer collateral - CA1 synapse
O	0098978	cellular_component	glutamatergic synapse
O	0099175	biological_process	regulation of postsynapse organization
O	1904115	cellular_component	axon cytoplasm
P	0000132	biological_process	establishment of mitotic spindle orientation
P	0000226	biological_process	microtubule cytoskeleton organization
P	0000235	cellular_component	astral microtubule
P	0000776	cellular_component	kinetochore
P	0001675	biological_process	acrosome assembly
P	0001764	biological_process	neuron migration
P	0005515	molecular_function	protein binding
P	0005635	cellular_component	nuclear envelope
P	0005737	cellular_component	cytoplasm
P	0005813	cellular_component	centrosome
P	0005819	cellular_component	spindle
P	0005829	cellular_component	cytosol
P	0005856	cellular_component	cytoskeleton
P	0005871	cellular_component	kinesin complex
P	0005874	cellular_component	microtubule
P	0005875	cellular_component	microtubule associated complex
P	0005881	cellular_component	cytoplasmic microtubule
P	0005938	cellular_component	cell cortex
P	0006629	biological_process	lipid metabolic process
P	0007017	biological_process	microtubule-based process
P	0007097	biological_process	nuclear migration
P	0007268	biological_process	chemical synaptic transmission
P	0007281	biological_process	germ cell development
P	0007399	biological_process	nervous system development
P	0007405	biological_process	neuroblast proliferation
P	0007611	biological_process	learning or memory
P	0008017	molecular_function	microtubule binding
P	0008090	biological_process	retrograde axonal transport
P	0008201	molecular_function	heparin binding
P	0008247	cellular_component	1-alkyl-2-acetylglycerophosphocholine esterase complex
P	0008344	biological_process	adult locomotory behavior
P	0010977	biological_process	negative regulation of neuron projection development
P	0015630	cellular_component	microtubule cytoskeleton
P	0016042	biological_process	lipid catabolic process
P	0017145	biological_process	stem cell division
P	0019226	biological_process	transmission of nerve impulse
P	0021540	biological_process	corpus callosum morphogenesis
P	0021766	biological_process	hippocampus development
P	0021819	biological_process	layer formation in cerebral cortex
P	0021895	biological_process	cerebral cortex neuron differentiation
P	0021987	biological_process	cerebral cortex development
P	0030036	biological_process	actin cytoskeleton organization
P	0030154	biological_process	cell differentiation
P	0030424	cellular_component	axon
P	0030426	cellular_component	growth cone
P	0030900	biological_process	forebrain development
P	0031023	biological_process	microtubule organizing center organization
P	0031252	cellular_component	cell leading edge
P	0031514	cellular_component	motile cilium
P	0031965	cellular_component	nuclear membrane
P	0031982	cellular_component	vesicle
P	0032420	cellular_component	stereocilium
P	0034452	molecular_function	dynactin binding
P	0038026	biological_process	reelin-mediated signaling pathway
P	0040019	biological_process	positive regulation of embryonic development
P	0042249	biological_process	establishment of planar polarity of embryonic epithelium
P	0042802	molecular_function	identical protein binding
P	0043005	cellular_component	neuron projection
P	0043025	cellular_component	neuronal cell body
P	0043274	molecular_function	phospholipase binding
P	0043622	biological_process	cortical microtubule organization
P	0044877	molecular_function	protein-containing complex binding
P	0045505	molecular_function	dynein intermediate chain binding
P	0045773	biological_process	positive regulation of axon extension
P	0045931	biological_process	positive regulation of mitotic cell cycle
P	0046469	biological_process	platelet activating factor metabolic process
P	0046982	molecular_function	protein heterodimerization activity
P	0047496	biological_process	vesicle transport along microtubule
P	0048471	cellular_component	perinuclear region of cytoplasm
P	0048854	biological_process	brain morphogenesis
P	0050804	biological_process	modulation of chemical synaptic transmission
P	0050885	biological_process	neuromuscular process controlling balance
P	0051010	molecular_function	microtubule plus-end binding
P	0051012	biological_process	microtubule sliding
P	0051130	biological_process	positive regulation of cellular component organization
P	0051219	molecular_function	phosphoprotein binding
P	0051301	biological_process	cell division
P	0051656	biological_process	establishment of organelle localization
P	0051660	biological_process	establishment of centrosome localization
P	0060117	biological_process	auditory receptor cell development
P	0061003	biological_process	positive regulation of dendritic spine morphogenesis
P	0062234	biological_process	platelet activating factor catabolic process
P	0070062	cellular_component	extracellular exosome
P	0070507	biological_process	regulation of microtubule cytoskeleton organization
P	0070840	molecular_function	dynein complex binding
P	0090102	biological_process	cochlea development
P	0090176	biological_process	microtubule cytoskeleton organization involved in establishment of planar polarity
P	0090724	cellular_component	central region of growth cone
P	0098685	cellular_component	Schaffer collateral - CA1 synapse
P	0098978	cellular_component	glutamatergic synapse
P	0099175	biological_process	regulation of postsynapse organization
P	1904115	cellular_component	axon cytoplasm

Functional Information from PROSITE/UniProt

site_id	PS00639
Number of Residues	11
Details	THIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. INHGLMMVGPS

Chain	Residue	Details
A	ILE2216-SER2226

---

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. LASCsaDmTIKLWDF

Chain	Residue	Details
O	LEU165-PHE179
O	ILE207-VAL221
O	LEU311-VAL325
O	VAL395-CYS409

---

site_id	PS01239
Number of Residues	15
Details	DYNEIN_LIGHT_1 Dynein light chain type 1 signature. HcIvGRnFGSyVTHE

Chain	Residue	Details
I	HIS55-GLU69

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	302
Details	Region: {"description":"Interaction with DYNC1LI2","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	462
Details	Region: {"description":"AAA 1","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	498
Details	Region: {"description":"AAA 3","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	538
Details	Region: {"description":"AAA 4","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	622
Details	Region: {"description":"Stalk","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	458
Details	Region: {"description":"AAA 5","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	432
Details	Region: {"description":"AAA 6","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	834
Details	Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	70
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	6
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	8
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q9JHU4","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	180
Details	Repeat: {"description":"WD 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	158
Details	Repeat: {"description":"WD 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	160
Details	Repeat: {"description":"WD 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	158
Details	Repeat: {"description":"WD 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	208
Details	Repeat: {"description":"WD 5"}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	162
Details	Repeat: {"description":"WD 6"}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	142
Details	Repeat: {"description":"WD 7"}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	44
Details	Region: {"description":"Interaction with ESR1","evidences":[{"source":"PubMed","id":"15891768","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"15193260","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30464262","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37696958","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	144
Details	Region: {"description":"Interaction with GNB1","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI24
Number of Residues	2
Details	Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"25944712","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI25
Number of Residues	84
Details	Region: {"description":"Interaction with DCX","evidences":[{"source":"PubMed","id":"11001923","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI26
Number of Residues	44
Details	Region: {"description":"Interaction with NDEL1","evidences":[{"source":"HAMAP-Rule","id":"MF_03141","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---