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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9DVU

CryoEM structure of RpaA bound to PkaiBC DNA and Syn7942 RNAP-SigA holoenzyme

Functional Information from GO Data
ChainGOidnamespacecontents
A0000428cellular_componentDNA-directed RNA polymerase complex
A0003677molecular_functionDNA binding
A0003899molecular_functionDNA-directed RNA polymerase activity
A0005737cellular_componentcytoplasm
A0006351biological_processDNA-templated transcription
A0016740molecular_functiontransferase activity
A0016779molecular_functionnucleotidyltransferase activity
A0034062molecular_function5'-3' RNA polymerase activity
B0000428cellular_componentDNA-directed RNA polymerase complex
B0003677molecular_functionDNA binding
B0003899molecular_functionDNA-directed RNA polymerase activity
B0005737cellular_componentcytoplasm
B0006351biological_processDNA-templated transcription
B0016740molecular_functiontransferase activity
B0016779molecular_functionnucleotidyltransferase activity
B0034062molecular_function5'-3' RNA polymerase activity
C0000428cellular_componentDNA-directed RNA polymerase complex
C0003677molecular_functionDNA binding
C0003899molecular_functionDNA-directed RNA polymerase activity
C0006351biological_processDNA-templated transcription
C0016740molecular_functiontransferase activity
C0016779molecular_functionnucleotidyltransferase activity
C0034062molecular_function5'-3' RNA polymerase activity
D0000287molecular_functionmagnesium ion binding
D0000428cellular_componentDNA-directed RNA polymerase complex
D0003677molecular_functionDNA binding
D0003899molecular_functionDNA-directed RNA polymerase activity
D0006351biological_processDNA-templated transcription
D0008270molecular_functionzinc ion binding
D0016740molecular_functiontransferase activity
D0016779molecular_functionnucleotidyltransferase activity
D0034062molecular_function5'-3' RNA polymerase activity
D0046872molecular_functionmetal ion binding
E0000428cellular_componentDNA-directed RNA polymerase complex
E0003677molecular_functionDNA binding
E0003899molecular_functionDNA-directed RNA polymerase activity
E0006351biological_processDNA-templated transcription
E0016740molecular_functiontransferase activity
E0016779molecular_functionnucleotidyltransferase activity
E0034062molecular_function5'-3' RNA polymerase activity
F0000428cellular_componentDNA-directed RNA polymerase complex
F0003677molecular_functionDNA binding
F0003899molecular_functionDNA-directed RNA polymerase activity
F0006351biological_processDNA-templated transcription
F0008270molecular_functionzinc ion binding
F0016740molecular_functiontransferase activity
F0016779molecular_functionnucleotidyltransferase activity
F0034062molecular_function5'-3' RNA polymerase activity
F0046872molecular_functionmetal ion binding
G0003677molecular_functionDNA binding
G0005737cellular_componentcytoplasm
G0006351biological_processDNA-templated transcription
G0006352biological_processDNA-templated transcription initiation
G0006355biological_processregulation of DNA-templated transcription
G0010468biological_processregulation of gene expression
G0016987molecular_functionsigma factor activity
G2000142biological_processregulation of DNA-templated transcription initiation
R0000156molecular_functionphosphorelay response regulator activity
R0000160biological_processphosphorelay signal transduction system
R0000976molecular_functiontranscription cis-regulatory region binding
R0003677molecular_functionDNA binding
R0005737cellular_componentcytoplasm
R0005829cellular_componentcytosol
R0006351biological_processDNA-templated transcription
R0006355biological_processregulation of DNA-templated transcription
R0007623biological_processcircadian rhythm
R0032993cellular_componentprotein-DNA complex
R0048511biological_processrhythmic process
R0051301biological_processcell division
R0097167biological_processcircadian regulation of translation
S0000156molecular_functionphosphorelay response regulator activity
S0000160biological_processphosphorelay signal transduction system
S0000976molecular_functiontranscription cis-regulatory region binding
S0003677molecular_functionDNA binding
S0005737cellular_componentcytoplasm
S0005829cellular_componentcytosol
S0006351biological_processDNA-templated transcription
S0006355biological_processregulation of DNA-templated transcription
S0007623biological_processcircadian rhythm
S0032993cellular_componentprotein-DNA complex
S0048511biological_processrhythmic process
S0051301biological_processcell division
S0097167biological_processcircadian regulation of translation
Functional Information from PROSITE/UniProt
site_idPS00217
Number of Residues26
DetailsSUGAR_TRANSPORT_2 Sugar transport proteins signature 2. VeGFNaGAddyltkpFevEemlarvR
ChainResidueDetails
RVAL92-ARG117
site_idPS00715
Number of Residues14
DetailsSIGMA70_1 Sigma-70 factors family signature 1. DLIQeGsLGLIrAA
ChainResidueDetails
GASP191-ALA204
site_idPS00716
Number of Residues27
DetailsSIGMA70_2 Sigma-70 factors family signature 2. TleEIGqlfnVTrerIrQIEakaLrkL
ChainResidueDetails
GTHR359-LEU385
site_idPS01166
Number of Residues13
DetailsRNA_POL_BETA RNA polymerases beta chain signature. GdKMAGrHGNKGI
ChainResidueDetails
CGLY819-ILE831
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues7
DetailsBinding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01323","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01324","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues19
DetailsDNA binding: {"description":"H-T-H motif","evidences":[{"source":"HAMAP-Rule","id":"MF_00963","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues70
DetailsRegion: {"description":"Sigma-70 factor domain-2","evidences":[{"source":"HAMAP-Rule","id":"MF_00963","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues53
DetailsRegion: {"description":"Sigma-70 factor domain-4","evidences":[{"source":"HAMAP-Rule","id":"MF_00963","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues3
DetailsMotif: {"description":"Interaction with polymerase core subunit RpoC"}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues198
DetailsDNA binding: {"description":"OmpR/PhoB-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU01091","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues2
DetailsModified residue: {"description":"4-aspartylphosphate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00169","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"24315105","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

247536

PDB entries from 2026-01-14

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