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9DCH

Single-stranded RNA-mediated PRC2 dimer

Functional Information from GO Data
ChainGOidnamespacecontents
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0000978molecular_functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
B0001222molecular_functiontranscription corepressor binding
B0001739cellular_componentsex chromatin
B0003682molecular_functionchromatin binding
B0003723molecular_functionRNA binding
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005677cellular_componentchromatin silencing complex
B0005730cellular_componentnucleolus
B0006325biological_processchromatin organization
B0008047molecular_functionenzyme activator activity
B0008270molecular_functionzinc ion binding
B0008283biological_processcell population proliferation
B0008284biological_processpositive regulation of cell population proliferation
B0016586cellular_componentRSC-type complex
B0016604cellular_componentnuclear body
B0031490molecular_functionchromatin DNA binding
B0032993cellular_componentprotein-DNA complex
B0035098cellular_componentESC/E(Z) complex
B0043565molecular_functionsequence-specific DNA binding
B0045596biological_processnegative regulation of cell differentiation
B0046872molecular_functionmetal ion binding
B0048709biological_processoligodendrocyte differentiation
B0060816biological_processrandom inactivation of X chromosome
B0062072molecular_functionhistone H3K9me2/3 reader activity
B0106222molecular_functionlncRNA binding
B0140718biological_processfacultative heterochromatin formation
B1990841molecular_functionpromoter-specific chromatin binding
B1990904cellular_componentribonucleoprotein complex
C0000122biological_processnegative regulation of transcription by RNA polymerase II
C0001222molecular_functiontranscription corepressor binding
C0001739cellular_componentsex chromatin
C0003682molecular_functionchromatin binding
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005677cellular_componentchromatin silencing complex
C0005694cellular_componentchromosome
C0005829cellular_componentcytosol
C0006325biological_processchromatin organization
C0008047molecular_functionenzyme activator activity
C0021510biological_processspinal cord development
C0031491molecular_functionnucleosome binding
C0031507biological_processheterochromatin formation
C0035064molecular_functionmethylated histone binding
C0035098cellular_componentESC/E(Z) complex
C0042802molecular_functionidentical protein binding
C0045120cellular_componentpronucleus
C0045892biological_processnegative regulation of DNA-templated transcription
C0048709biological_processoligodendrocyte differentiation
C0071514biological_processgenomic imprinting
C0140718biological_processfacultative heterochromatin formation
C1990830biological_processcellular response to leukemia inhibitory factor
C2000011biological_processregulation of adaxial/abaxial pattern formation
D0000118cellular_componenthistone deacetylase complex
D0000122biological_processnegative regulation of transcription by RNA polymerase II
D0000781cellular_componentchromosome, telomeric region
D0000785cellular_componentchromatin
D0000978molecular_functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005694cellular_componentchromosome
D0005829cellular_componentcytosol
D0006260biological_processDNA replication
D0006281biological_processDNA repair
D0006325biological_processchromatin organization
D0006334biological_processnucleosome assembly
D0006335biological_processDNA replication-dependent chromatin assembly
D0006338biological_processchromatin remodeling
D0006355biological_processregulation of DNA-templated transcription
D0006974biological_processDNA damage response
D0007420biological_processbrain development
D0008094molecular_functionATP-dependent activity, acting on DNA
D0008285biological_processnegative regulation of cell population proliferation
D0016581cellular_componentNuRD complex
D0016589cellular_componentNURF complex
D0030336biological_processnegative regulation of cell migration
D0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
D0031492molecular_functionnucleosomal DNA binding
D0032991cellular_componentprotein-containing complex
D0033186cellular_componentCAF-1 complex
D0035098cellular_componentESC/E(Z) complex
D0042393molecular_functionhistone binding
D0042659biological_processregulation of cell fate specification
D0042826molecular_functionhistone deacetylase binding
D0045892biological_processnegative regulation of DNA-templated transcription
D0045893biological_processpositive regulation of DNA-templated transcription
D0070822cellular_componentSin3-type complex
D1902455biological_processnegative regulation of stem cell population maintenance
D1902459biological_processpositive regulation of stem cell population maintenance
D1904949cellular_componentATPase complex
D2000736biological_processregulation of stem cell differentiation
I0000122biological_processnegative regulation of transcription by RNA polymerase II
I0000978molecular_functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
I0001222molecular_functiontranscription corepressor binding
I0001739cellular_componentsex chromatin
I0003682molecular_functionchromatin binding
I0003723molecular_functionRNA binding
I0005515molecular_functionprotein binding
I0005634cellular_componentnucleus
I0005654cellular_componentnucleoplasm
I0005677cellular_componentchromatin silencing complex
I0005730cellular_componentnucleolus
I0006325biological_processchromatin organization
I0008047molecular_functionenzyme activator activity
I0008270molecular_functionzinc ion binding
I0008283biological_processcell population proliferation
I0008284biological_processpositive regulation of cell population proliferation
I0016586cellular_componentRSC-type complex
I0016604cellular_componentnuclear body
I0031490molecular_functionchromatin DNA binding
I0032993cellular_componentprotein-DNA complex
I0035098cellular_componentESC/E(Z) complex
I0043565molecular_functionsequence-specific DNA binding
I0045596biological_processnegative regulation of cell differentiation
I0046872molecular_functionmetal ion binding
I0048709biological_processoligodendrocyte differentiation
I0060816biological_processrandom inactivation of X chromosome
I0062072molecular_functionhistone H3K9me2/3 reader activity
I0106222molecular_functionlncRNA binding
I0140718biological_processfacultative heterochromatin formation
I1990841molecular_functionpromoter-specific chromatin binding
I1990904cellular_componentribonucleoprotein complex
J0000122biological_processnegative regulation of transcription by RNA polymerase II
J0001222molecular_functiontranscription corepressor binding
J0001739cellular_componentsex chromatin
J0003682molecular_functionchromatin binding
J0005515molecular_functionprotein binding
J0005634cellular_componentnucleus
J0005654cellular_componentnucleoplasm
J0005677cellular_componentchromatin silencing complex
J0005694cellular_componentchromosome
J0005829cellular_componentcytosol
J0006325biological_processchromatin organization
J0008047molecular_functionenzyme activator activity
J0021510biological_processspinal cord development
J0031491molecular_functionnucleosome binding
J0031507biological_processheterochromatin formation
J0035064molecular_functionmethylated histone binding
J0035098cellular_componentESC/E(Z) complex
J0042802molecular_functionidentical protein binding
J0045120cellular_componentpronucleus
J0045892biological_processnegative regulation of DNA-templated transcription
J0048709biological_processoligodendrocyte differentiation
J0071514biological_processgenomic imprinting
J0140718biological_processfacultative heterochromatin formation
J1990830biological_processcellular response to leukemia inhibitory factor
J2000011biological_processregulation of adaxial/abaxial pattern formation
K0000118cellular_componenthistone deacetylase complex
K0000122biological_processnegative regulation of transcription by RNA polymerase II
K0000781cellular_componentchromosome, telomeric region
K0000785cellular_componentchromatin
K0000978molecular_functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
K0005515molecular_functionprotein binding
K0005634cellular_componentnucleus
K0005654cellular_componentnucleoplasm
K0005694cellular_componentchromosome
K0005829cellular_componentcytosol
K0006260biological_processDNA replication
K0006281biological_processDNA repair
K0006325biological_processchromatin organization
K0006334biological_processnucleosome assembly
K0006335biological_processDNA replication-dependent chromatin assembly
K0006338biological_processchromatin remodeling
K0006355biological_processregulation of DNA-templated transcription
K0006974biological_processDNA damage response
K0007420biological_processbrain development
K0008094molecular_functionATP-dependent activity, acting on DNA
K0008285biological_processnegative regulation of cell population proliferation
K0016581cellular_componentNuRD complex
K0016589cellular_componentNURF complex
K0030336biological_processnegative regulation of cell migration
K0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
K0031492molecular_functionnucleosomal DNA binding
K0032991cellular_componentprotein-containing complex
K0033186cellular_componentCAF-1 complex
K0035098cellular_componentESC/E(Z) complex
K0042393molecular_functionhistone binding
K0042659biological_processregulation of cell fate specification
K0042826molecular_functionhistone deacetylase binding
K0045892biological_processnegative regulation of DNA-templated transcription
K0045893biological_processpositive regulation of DNA-templated transcription
K0070822cellular_componentSin3-type complex
K1902455biological_processnegative regulation of stem cell population maintenance
K1902459biological_processpositive regulation of stem cell population maintenance
K1904949cellular_componentATPase complex
K2000736biological_processregulation of stem cell differentiation
Functional Information from PROSITE/UniProt
site_idPS00028
Number of Residues22
DetailsZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. Cpw..CtlnCrklysllkHlklc.H
ChainResidueDetails
BCYS450-HIS471
FCYS55-HIS78
FCYS122-HIS144

site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LLSAsdDhTICLWDI
ChainResidueDetails
DLEU193-ILE207
DLEU289-LEU303
DLEU333-LEU347
CLEU206-ILE220

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
CSER2
JSER2

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q921E6
ChainResidueDetails
CSER34
JSER34
HSER76
HSER368

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648
ChainResidueDetails
CTHR55
JTHR55
BLYS738
IALA32
IGLN553
ILYS738

site_idSWS_FT_FI4
Number of Residues8
DetailsMOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:20974918
ChainResidueDetails
CLYS66
CLYS197
CLYS268
CLYS284
JLYS66
JLYS197
JLYS268
JLYS284

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692
ChainResidueDetails
FSER182
MSER182

site_idSWS_FT_FI6
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate
ChainResidueDetails
DLYS4
KLYS4
IGLU84
ILEU85

site_idSWS_FT_FI7
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:25755297, ECO:0007744|PubMed:28112733
ChainResidueDetails
ATHR492
DLYS160
BVAL402
KLYS160
IASN235
IVAL402

site_idSWS_FT_FI8
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:28112733
ChainResidueDetails
BLEU87
ILEU87

site_idSWS_FT_FI9
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
ALYS639
HLYS639

237423

PDB entries from 2025-06-11

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