9DC9

Mtb GuaB dCBS in complex with inhibitor compound 5

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0003938	molecular_function	IMP dehydrogenase activity
A	0006164	biological_process	purine nucleotide biosynthetic process
A	0016491	molecular_function	oxidoreductase activity

Functional Information from PROSITE/UniProt

site_id	PS00487
Number of Residues	13
Details	IMP_DH_GMP_RED IMP dehydrogenase / GMP reductase signature. VKVGVGpGSICtT

Chain	Residue	Details
A	VAL331-THR343

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Thioimidate intermediate => ECO:0000255|HAMAP-Rule:MF_01964, ECO:0000305|PubMed:26440283

Chain	Residue	Details
A	CYS341

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000255|HAMAP-Rule:MF_01964, ECO:0000305|PubMed:26440283

Chain	Residue	Details
A	ARG443

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01964, ECO:0000269|PubMed:26440283

Chain	Residue	Details
A	ASP283
A	SER339
A	ASP374
A	GLY397
A	TYR421
A	GLU511
A	SER512
A	HIS513

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:26440283

Chain	Residue	Details
A	ASN289
A	THR343
A	GLU458

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01964

Chain	Residue	Details
A	GLY334

---

site_id	SWS_FT_FI6
Number of Residues	3
Details	BINDING: in other chain => ECO:0000255|HAMAP-Rule:MF_01964, ECO:0000269|PubMed:26440283

Chain	Residue	Details
A	GLY336
A	GLY338
A	CYS341

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