9D18
Ca2+ bound open-inactivated hSlo1 + beta2N-beta4 channel in detergent-conformation 2 of inactivating domain
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| E | 0001508 | biological_process | action potential |
| E | 0005513 | biological_process | detection of calcium ion |
| E | 0005515 | molecular_function | protein binding |
| E | 0005886 | cellular_component | plasma membrane |
| E | 0006811 | biological_process | monoatomic ion transport |
| E | 0006813 | biological_process | potassium ion transport |
| E | 0007268 | biological_process | chemical synaptic transmission |
| E | 0008076 | cellular_component | voltage-gated potassium channel complex |
| E | 0015269 | molecular_function | calcium-activated potassium channel activity |
| E | 0015459 | molecular_function | potassium channel regulator activity |
| E | 0016020 | cellular_component | membrane |
| E | 0019228 | biological_process | neuronal action potential |
| E | 0019229 | biological_process | regulation of vasoconstriction |
| E | 0034220 | biological_process | monoatomic ion transmembrane transport |
| E | 0045202 | cellular_component | synapse |
| E | 0046928 | biological_process | regulation of neurotransmitter secretion |
| E | 0071805 | biological_process | potassium ion transmembrane transport |
| E | 0099505 | biological_process | regulation of presynaptic membrane potential |
| E | 0099508 | molecular_function | voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential |
| F | 0001508 | biological_process | action potential |
| F | 0005513 | biological_process | detection of calcium ion |
| F | 0005515 | molecular_function | protein binding |
| F | 0005886 | cellular_component | plasma membrane |
| F | 0006811 | biological_process | monoatomic ion transport |
| F | 0006813 | biological_process | potassium ion transport |
| F | 0007268 | biological_process | chemical synaptic transmission |
| F | 0008076 | cellular_component | voltage-gated potassium channel complex |
| F | 0015269 | molecular_function | calcium-activated potassium channel activity |
| F | 0015459 | molecular_function | potassium channel regulator activity |
| F | 0016020 | cellular_component | membrane |
| F | 0019228 | biological_process | neuronal action potential |
| F | 0019229 | biological_process | regulation of vasoconstriction |
| F | 0034220 | biological_process | monoatomic ion transmembrane transport |
| F | 0045202 | cellular_component | synapse |
| F | 0046928 | biological_process | regulation of neurotransmitter secretion |
| F | 0071805 | biological_process | potassium ion transmembrane transport |
| F | 0099505 | biological_process | regulation of presynaptic membrane potential |
| F | 0099508 | molecular_function | voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential |
| G | 0001508 | biological_process | action potential |
| G | 0005513 | biological_process | detection of calcium ion |
| G | 0005515 | molecular_function | protein binding |
| G | 0005886 | cellular_component | plasma membrane |
| G | 0006811 | biological_process | monoatomic ion transport |
| G | 0006813 | biological_process | potassium ion transport |
| G | 0007268 | biological_process | chemical synaptic transmission |
| G | 0008076 | cellular_component | voltage-gated potassium channel complex |
| G | 0015269 | molecular_function | calcium-activated potassium channel activity |
| G | 0015459 | molecular_function | potassium channel regulator activity |
| G | 0016020 | cellular_component | membrane |
| G | 0019228 | biological_process | neuronal action potential |
| G | 0019229 | biological_process | regulation of vasoconstriction |
| G | 0034220 | biological_process | monoatomic ion transmembrane transport |
| G | 0045202 | cellular_component | synapse |
| G | 0046928 | biological_process | regulation of neurotransmitter secretion |
| G | 0071805 | biological_process | potassium ion transmembrane transport |
| G | 0099505 | biological_process | regulation of presynaptic membrane potential |
| G | 0099508 | molecular_function | voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential |
| H | 0001508 | biological_process | action potential |
| H | 0005513 | biological_process | detection of calcium ion |
| H | 0005515 | molecular_function | protein binding |
| H | 0005886 | cellular_component | plasma membrane |
| H | 0006811 | biological_process | monoatomic ion transport |
| H | 0006813 | biological_process | potassium ion transport |
| H | 0007268 | biological_process | chemical synaptic transmission |
| H | 0008076 | cellular_component | voltage-gated potassium channel complex |
| H | 0015269 | molecular_function | calcium-activated potassium channel activity |
| H | 0015459 | molecular_function | potassium channel regulator activity |
| H | 0016020 | cellular_component | membrane |
| H | 0019228 | biological_process | neuronal action potential |
| H | 0019229 | biological_process | regulation of vasoconstriction |
| H | 0034220 | biological_process | monoatomic ion transmembrane transport |
| H | 0045202 | cellular_component | synapse |
| H | 0046928 | biological_process | regulation of neurotransmitter secretion |
| H | 0071805 | biological_process | potassium ion transmembrane transport |
| H | 0099505 | biological_process | regulation of presynaptic membrane potential |
| H | 0099508 | molecular_function | voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential |
Functional Information from PROSITE/UniProt
| site_id | PS00092 |
| Number of Residues | 7 |
| Details | N6_MTASE N-6 Adenine-specific DNA methylases signature. VITNPPY |
| Chain | Residue | Details |
| A | VAL1033-TYR1039 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 80 |
| Details | Transmembrane: {"description":"Helical; Name=Segment S0","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 80 |
| Details | Transmembrane: {"description":"Helical; Name=Segment S1","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 656 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 80 |
| Details | Transmembrane: {"description":"Helical; Name=Segment S2","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 68 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 80 |
| Details | Transmembrane: {"description":"Helical; Name=Segment S3","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 80 |
| Details | Transmembrane: {"description":"Helical; Name=Segment S4","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 80 |
| Details | Transmembrane: {"description":"Helical; Name=Segment S5","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 88 |
| Details | Intramembrane: {"description":"Pore-forming; Name=P region","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 80 |
| Details | Transmembrane: {"description":"Helical; Name=Segment S6","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 568 |
| Details | Domain: {"description":"RCK N-terminal 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00543","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 80 |
| Details | Region: {"description":"Segment S7"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 80 |
| Details | Region: {"description":"Segment S8"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 80 |
| Details | Region: {"description":"Segment S9"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 80 |
| Details | Region: {"description":"Segment S10"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 12 |
| Details | Motif: {"description":"Selectivity for potassium"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI17 |
| Number of Residues | 88 |
| Details | Motif: {"description":"Calcium bowl","evidences":[{"source":"UniProtKB","id":"B7ZC96","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI18 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI19 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"B7ZC96","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI20 |
| Number of Residues | 8 |
| Details | Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"PubMed","id":"20693285","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22399288","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI21 |
| Number of Residues | 80 |
| Details | Transmembrane: {"description":"Helical; Name=1","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI22 |
| Number of Residues | 80 |
| Details | Transmembrane: {"description":"Helical; Name=2","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI23 |
| Number of Residues | 8 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine"} |
| Chain | Residue | Details |
