Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

9D0A

CryoEM structure of PAR2 with endogenous tethered ligand.

Functional Information from PROSITE/UniProt

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS

Chain	Residue	Details
B	LEU70-SER84
B	ILE157-ILE171
B	LEU285-ALA299

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	48
Details	Repeat: {"description":"WD 1","evidences":[{"source":"PubMed","id":"38600377","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38776963","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VY7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YKY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	45
Details	Repeat: {"description":"WD 2","evidences":[{"source":"PubMed","id":"38600377","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38776963","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VY7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YKY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	40
Details	Repeat: {"description":"WD 3","evidences":[{"source":"PubMed","id":"38600377","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38776963","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VY7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YKY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	41
Details	Repeat: {"description":"WD 4","evidences":[{"source":"PubMed","id":"38600377","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38776963","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VY7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YKY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	43
Details	Repeat: {"description":"WD 5","evidences":[{"source":"PubMed","id":"38600377","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38776963","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VY7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YKY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	41
Details	Repeat: {"description":"WD 6","evidences":[{"source":"PubMed","id":"38600377","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38776963","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VY7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YKY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	30
Details	Repeat: {"description":"WD 7","evidences":[{"source":"PubMed","id":"38600377","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38776963","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8VY7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8VY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8XQT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8YKY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	1
Details	Modified residue: {"description":"Phosphohistidine","evidences":[{"source":"UniProtKB","id":"P62871","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	29
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"28445455","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	18
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"28445455","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	28
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"28445455","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	39
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"28445455","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	27
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"28445455","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	27
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"28445455","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	33
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"28445455","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	39
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"28445455","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	23
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"28445455","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"12171601","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	13
Details	Region: {"description":"G1 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	7
Details	Region: {"description":"G4 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI21
Number of Residues	5
Details	Region: {"description":"G5 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI22
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P21279","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI23
Number of Residues	13
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P04896","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI24
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI25
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)"}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)