9CSN

Crystal structure of human ribonuclease 7 (RNase 7) in complex with 5'-adenosine monophosphate (5'-AMP)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001530	molecular_function	lipopolysaccharide binding
A	0004518	molecular_function	nuclease activity
A	0004519	molecular_function	endonuclease activity
A	0004540	molecular_function	RNA nuclease activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005737	cellular_component	cytoplasm
A	0016787	molecular_function	hydrolase activity
A	0019731	biological_process	antibacterial humoral response
A	0042742	biological_process	defense response to bacterium
A	0042834	molecular_function	peptidoglycan binding
A	0045087	biological_process	innate immune response
A	0050829	biological_process	defense response to Gram-negative bacterium
A	0050830	biological_process	defense response to Gram-positive bacterium
A	0050832	biological_process	defense response to fungus
A	0051715	biological_process	cytolysis in another organism
A	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
B	0001530	molecular_function	lipopolysaccharide binding
B	0004518	molecular_function	nuclease activity
B	0004519	molecular_function	endonuclease activity
B	0004540	molecular_function	RNA nuclease activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005737	cellular_component	cytoplasm
B	0016787	molecular_function	hydrolase activity
B	0019731	biological_process	antibacterial humoral response
B	0042742	biological_process	defense response to bacterium
B	0042834	molecular_function	peptidoglycan binding
B	0045087	biological_process	innate immune response
B	0050829	biological_process	defense response to Gram-negative bacterium
B	0050830	biological_process	defense response to Gram-positive bacterium
B	0050832	biological_process	defense response to fungus
B	0051715	biological_process	cytolysis in another organism
B	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide

Functional Information from PROSITE/UniProt

site_id	PS00127
Number of Residues	7
Details	RNASE_PANCREATIC Pancreatic ribonuclease family signature. CKdlNTF

Chain	Residue	Details
A	CYS37-PHE43

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Region: {"description":"Important for antibacterial activity","evidences":[{"source":"PubMed","id":"17150966","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"17150966","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	2
Details	Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"17150966","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P15468","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	2
Details	Site: {"description":"Critical for catalytic activity","evidences":[{"source":"PubMed","id":"17150966","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI6
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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