9CMI

Cryo-EM structure of human claudin-4 complex with Clostridium perfringens enterotoxin, sFab COP-1, and Nanobody

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004888	molecular_function	transmembrane signaling receptor activity
A	0005198	molecular_function	structural molecule activity
A	0005254	molecular_function	chloride channel activity
A	0005515	molecular_function	protein binding
A	0005886	cellular_component	plasma membrane
A	0005911	cellular_component	cell-cell junction
A	0005923	cellular_component	bicellular tight junction
A	0006811	biological_process	monoatomic ion transport
A	0006821	biological_process	chloride transport
A	0007155	biological_process	cell adhesion
A	0007565	biological_process	female pregnancy
A	0007623	biological_process	circadian rhythm
A	0009925	cellular_component	basal plasma membrane
A	0016020	cellular_component	membrane
A	0016324	cellular_component	apical plasma membrane
A	0016327	cellular_component	apicolateral plasma membrane
A	0016328	cellular_component	lateral plasma membrane
A	0016338	biological_process	calcium-independent cell-cell adhesion
A	0022604	biological_process	regulation of cell morphogenesis
A	0030335	biological_process	positive regulation of cell migration
A	0032570	biological_process	response to progesterone
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0034707	cellular_component	chloride channel complex
A	0042802	molecular_function	identical protein binding
A	0061436	biological_process	establishment of skin barrier
A	0070160	cellular_component	tight junction
A	0070293	biological_process	renal absorption
A	0070830	biological_process	bicellular tight junction assembly
A	0090303	biological_process	positive regulation of wound healing
A	0160184	biological_process	paracellular transport
A	1902476	biological_process	chloride transmembrane transport
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0035821	biological_process	modulation of process of another organism
B	0090729	molecular_function	toxin activity

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH

Chain	Residue	Details
L	TYR217-HIS223
H	TYR234-HIS240

---

site_id	PS01346
Number of Residues	16
Details	CLAUDIN Claudin family signature. GLWmnCvvqstgqm.QC

Chain	Residue	Details
A	GLY49-CYS64

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	80
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	73
Details	Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	14
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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