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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9CI3

Structure of the LRRK2/14-3-3 complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0000139cellular_componentGolgi membrane
A0000149molecular_functionSNARE binding
A0000165biological_processMAPK cascade
A0000166molecular_functionnucleotide binding
A0000287molecular_functionmagnesium ion binding
A0003779molecular_functionactin binding
A0003924molecular_functionGTPase activity
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0004706molecular_functionJUN kinase kinase kinase activity
A0004709molecular_functionMAP kinase kinase kinase activity
A0005096molecular_functionGTPase activator activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005525molecular_functionGTP binding
A0005615cellular_componentextracellular space
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005741cellular_componentmitochondrial outer membrane
A0005743cellular_componentmitochondrial inner membrane
A0005759cellular_componentmitochondrial matrix
A0005764cellular_componentlysosome
A0005768cellular_componentendosome
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0005794cellular_componentGolgi apparatus
A0005798cellular_componentGolgi-associated vesicle
A0005802cellular_componenttrans-Golgi network
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0005886cellular_componentplasma membrane
A0005902cellular_componentmicrovillus
A0006468biological_processprotein phosphorylation
A0006606biological_processprotein import into nucleus
A0006897biological_processendocytosis
A0006914biological_processautophagy
A0006979biological_processresponse to oxidative stress
A0007005biological_processmitochondrion organization
A0007029biological_processendoplasmic reticulum organization
A0007030biological_processGolgi organization
A0007040biological_processlysosome organization
A0007166biological_processcell surface receptor signaling pathway
A0007254biological_processJNK cascade
A0007266biological_processRho protein signal transduction
A0007283biological_processspermatogenesis
A0007528biological_processneuromuscular junction development
A0008017molecular_functionmicrotubule binding
A0008021cellular_componentsynaptic vesicle
A0008104biological_processintracellular protein localization
A0008340biological_processdetermination of adult lifespan
A0009267biological_processcellular response to starvation
A0009653biological_processanatomical structure morphogenesis
A0009968biological_processnegative regulation of signal transduction
A0010468biological_processregulation of gene expression
A0010506biological_processregulation of autophagy
A0010508biological_processpositive regulation of autophagy
A0010955biological_processnegative regulation of protein processing
A0010977biological_processnegative regulation of neuron projection development
A0014041biological_processregulation of neuron maturation
A0015631molecular_functiontubulin binding
A0016192biological_processvesicle-mediated transport
A0016242biological_processnegative regulation of macroautophagy
A0016301molecular_functionkinase activity
A0016740molecular_functiontransferase activity
A0016787molecular_functionhydrolase activity
A0017075molecular_functionsyntaxin-1 binding
A0019722biological_processcalcium-mediated signaling
A0021756biological_processstriatum development
A0021772biological_processolfactory bulb development
A0022028biological_processtangential migration from the subventricular zone to the olfactory bulb
A0030154biological_processcell differentiation
A0030159molecular_functionsignaling receptor complex adaptor activity
A0030162biological_processregulation of proteolysis
A0030182biological_processneuron differentiation
A0030276molecular_functionclathrin binding
A0030424cellular_componentaxon
A0030425cellular_componentdendrite
A0030426cellular_componentgrowth cone
A0030672cellular_componentsynaptic vesicle membrane
A0031267molecular_functionsmall GTPase binding
A0031344biological_processregulation of cell projection organization
A0031398biological_processpositive regulation of protein ubiquitination
A0031410cellular_componentcytoplasmic vesicle
A0031647biological_processregulation of protein stability
A0031965cellular_componentnuclear membrane
A0031966cellular_componentmitochondrial membrane
A0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
A0032473cellular_componentcytoplasmic side of mitochondrial outer membrane
A0032760biological_processpositive regulation of tumor necrosis factor production
A0032839cellular_componentdendrite cytoplasm
A0034211molecular_functionGTP-dependent protein kinase activity
A0034260biological_processnegative regulation of GTPase activity
A0034599biological_processcellular response to oxidative stress
A0034614biological_processcellular response to reactive oxygen species
A0035542biological_processregulation of SNARE complex assembly
A0035556biological_processintracellular signal transduction
A0035564biological_processregulation of kidney size
A0035640biological_processexploration behavior
A0035641biological_processlocomotory exploration behavior
A0035751biological_processregulation of lysosomal lumen pH
A0036064cellular_componentciliary basal body
A0036479molecular_functionperoxidase inhibitor activity
A0039706molecular_functionco-receptor binding
A0040012biological_processregulation of locomotion
A0042391biological_processregulation of membrane potential
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0043005cellular_componentneuron projection
A0043025cellular_componentneuronal cell body
A0043068biological_processpositive regulation of programmed cell death
A0043195cellular_componentterminal bouton
A0043204cellular_componentperikaryon
A0043410biological_processpositive regulation of MAPK cascade
A0044325molecular_functiontransmembrane transporter binding
A0044753cellular_componentamphisome
A0044754cellular_componentautolysosome
A0045121cellular_componentmembrane raft
A0045202cellular_componentsynapse
A0045335cellular_componentphagocytic vesicle
A0045746biological_processnegative regulation of Notch signaling pathway
A0046039biological_processGTP metabolic process
A0046777biological_processprotein autophosphorylation
A0048312biological_processintracellular distribution of mitochondria
A0048513biological_processanimal organ development
A0048812biological_processneuron projection morphogenesis
A0050804biological_processmodulation of chemical synaptic transmission
A0051018molecular_functionprotein kinase A binding
A0051239biological_processregulation of multicellular organismal process
A0051247biological_processpositive regulation of protein metabolic process
A0051646biological_processmitochondrion localization
A0051900biological_processregulation of mitochondrial depolarization
A0051966biological_processregulation of synaptic transmission, glutamatergic
A0060070biological_processcanonical Wnt signaling pathway
A0060079biological_processexcitatory postsynaptic potential
A0060159biological_processregulation of dopamine receptor signaling pathway
A0060161biological_processpositive regulation of dopamine receptor signaling pathway
A0060627biological_processregulation of vesicle-mediated transport
A0060628biological_processregulation of ER to Golgi vesicle-mediated transport
A0060828biological_processregulation of canonical Wnt signaling pathway
A0061001biological_processregulation of dendritic spine morphogenesis
A0070013cellular_componentintracellular organelle lumen
A0070062cellular_componentextracellular exosome
A0070585biological_processprotein localization to mitochondrion
A0070971cellular_componentendoplasmic reticulum exit site
A0070973biological_processprotein localization to endoplasmic reticulum exit site
A0071287biological_processcellular response to manganese ion
A0090140biological_processregulation of mitochondrial fission
A0090263biological_processpositive regulation of canonical Wnt signaling pathway
A0090394biological_processnegative regulation of excitatory postsynaptic potential
A0097413cellular_componentLewy body
A0097487cellular_componentmultivesicular body, internal vesicle
A0098794cellular_componentpostsynapse
A0098978cellular_componentglutamatergic synapse
A0099400cellular_componentcaveola neck
A0099523cellular_componentpresynaptic cytosol
A0106310molecular_functionprotein serine kinase activity
A0140058biological_processneuron projection arborization
A0141161biological_processregulation of cAMP/PKA signal transduction
A1900242biological_processregulation of synaptic vesicle endocytosis
A1900244biological_processpositive regulation of synaptic vesicle endocytosis
A1901030biological_processpositive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
A1902236biological_processnegative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
A1902499biological_processpositive regulation of protein autoubiquitination
A1902531biological_processregulation of intracellular signal transduction
A1902692biological_processregulation of neuroblast proliferation
A1902803biological_processregulation of synaptic vesicle transport
A1902823biological_processnegative regulation of late endosome to lysosome transport
A1902902biological_processnegative regulation of autophagosome assembly
A1903215biological_processnegative regulation of protein targeting to mitochondrion
A1903217biological_processnegative regulation of protein processing involved in protein targeting to mitochondrion
A1903351biological_processcellular response to dopamine
A1903980biological_processpositive regulation of microglial cell activation
A1904644biological_processcellular response to curcumin
A1904713molecular_functionbeta-catenin destruction complex binding
A1904887biological_processWnt signalosome assembly
A1905279biological_processregulation of retrograde transport, endosome to Golgi
A1905289biological_processregulation of CAMKK-AMPK signaling cascade
A1905504biological_processnegative regulation of motile cilium assembly
A1990904cellular_componentribonucleoprotein complex
A1990909cellular_componentWnt signalosome
A2000172biological_processregulation of branching morphogenesis of a nerve
A2000300biological_processregulation of synaptic vesicle exocytosis
A2000377biological_processregulation of reactive oxygen species metabolic process
B0002842biological_processpositive regulation of T cell mediated immune response to tumor cell
B0003723molecular_functionRNA binding
B0005080molecular_functionprotein kinase C binding
B0005159molecular_functioninsulin-like growth factor receptor binding
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005759cellular_componentmitochondrial matrix
B0005829cellular_componentcytosol
B0005925cellular_componentfocal adhesion
B0006469biological_processnegative regulation of protein kinase activity
B0006605biological_processprotein targeting
B0007165biological_processsignal transduction
B0008104biological_processintracellular protein localization
B0008426molecular_functionprotein kinase C inhibitor activity
B0009966biological_processregulation of signal transduction
B0016020cellular_componentmembrane
B0019904molecular_functionprotein domain specific binding
B0022409biological_processpositive regulation of cell-cell adhesion
B0030971molecular_functionreceptor tyrosine kinase binding
B0031982cellular_componentvesicle
B0032869biological_processcellular response to insulin stimulus
B0032880biological_processregulation of protein localization
B0042149biological_processcellular response to glucose starvation
B0042802molecular_functionidentical protein binding
B0045202cellular_componentsynapse
B0045664biological_processregulation of neuron differentiation
B0048167biological_processregulation of synaptic plasticity
B0050870biological_processpositive regulation of T cell activation
B0070062cellular_componentextracellular exosome
B0098793cellular_componentpresynapse
B0140031molecular_functionphosphorylation-dependent protein binding
B0140311molecular_functionprotein sequestering activity
B1904262biological_processnegative regulation of TORC1 signaling
C0002842biological_processpositive regulation of T cell mediated immune response to tumor cell
C0003723molecular_functionRNA binding
C0005080molecular_functionprotein kinase C binding
C0005159molecular_functioninsulin-like growth factor receptor binding
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005759cellular_componentmitochondrial matrix
C0005829cellular_componentcytosol
C0005925cellular_componentfocal adhesion
C0006469biological_processnegative regulation of protein kinase activity
C0006605biological_processprotein targeting
C0007165biological_processsignal transduction
C0008104biological_processintracellular protein localization
C0008426molecular_functionprotein kinase C inhibitor activity
C0009966biological_processregulation of signal transduction
C0016020cellular_componentmembrane
C0019904molecular_functionprotein domain specific binding
C0022409biological_processpositive regulation of cell-cell adhesion
C0030971molecular_functionreceptor tyrosine kinase binding
C0031982cellular_componentvesicle
C0032869biological_processcellular response to insulin stimulus
C0032880biological_processregulation of protein localization
C0042149biological_processcellular response to glucose starvation
C0042802molecular_functionidentical protein binding
C0045202cellular_componentsynapse
C0045664biological_processregulation of neuron differentiation
C0048167biological_processregulation of synaptic plasticity
C0050870biological_processpositive regulation of T cell activation
C0070062cellular_componentextracellular exosome
C0098793cellular_componentpresynapse
C0140031molecular_functionphosphorylation-dependent protein binding
C0140311molecular_functionprotein sequestering activity
C1904262biological_processnegative regulation of TORC1 signaling
Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues22
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGDGSFGSVYrAayegee............VAVK
ChainResidueDetails
ALEU1885-LYS1906
site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiYrDLKphNVLL
ChainResidueDetails
AILE1990-LEU2002
site_idPS00626
Number of Residues11
DetailsRCC1_2 Regulator of chromosome condensation (RCC1) signature 2. IGTGgGHILLL
ChainResidueDetails
AILE2427-LEU2437
site_idPS00796
Number of Residues11
Details1433_1 14-3-3 proteins signature 1. RNLLSVAYKNV
ChainResidueDetails
CARG42-VAL52
site_idPS00797
Number of Residues20
Details1433_2 14-3-3 proteins signature 2. YKDSTLIMQLLRDNLTLWTS
ChainResidueDetails
CTYR216-SER235
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues328
DetailsRegion: {"description":"Required for interaction with SPATA18/MIEAP (isoform 2) but dispensable for binding to SPATA18/MIEAP (isoform 1)","evidences":[{"source":"PubMed","id":"22532927","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues4
DetailsSite: {"description":"Interaction with phosphoserine on interacting protein","evidences":[{"source":"PubMed","id":"17085597","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues2
DetailsModified residue: {"description":"N-acetylmethionine; in 14-3-3 protein gamma; alternate; partial","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"DEC-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Boldt K.","von Kriegsheim A.F.","Zebisch A.","Kolch W."]}}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues2
DetailsModified residue: {"description":"N-acetylvaline; partial","evidences":[{"source":"PubMed","id":"14534293","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"DEC-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Boldt K.","von Kriegsheim A.F.","Zebisch A.","Kolch W."]}},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"NOV-2005","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Claeys D."]}},{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues2
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P61983","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"DEC-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Boldt K.","von Kriegsheim A.F.","Zebisch A.","Kolch W."]}}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P61983","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues21
DetailsRepeat: {"description":"LRR 1","evidences":[{"source":"PubMed","id":"38127736","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8FO2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FO8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FO9","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues21
DetailsRepeat: {"description":"LRR 2","evidences":[{"source":"PubMed","id":"38127736","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8FO2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FO8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FO9","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues21
DetailsRepeat: {"description":"LRR 3","evidences":[{"source":"PubMed","id":"38127736","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8FO2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FO8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FO9","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues21
DetailsRepeat: {"description":"LRR 4","evidences":[{"source":"PubMed","id":"38127736","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8FO2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FO8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FO9","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues21
DetailsRepeat: {"description":"LRR 5","evidences":[{"source":"PubMed","id":"38127736","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8FO2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FO8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FO9","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues21
DetailsRepeat: {"description":"LRR 6","evidences":[{"source":"PubMed","id":"38127736","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8FO2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FO8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FO9","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues20
DetailsRepeat: {"description":"LRR 7","evidences":[{"source":"PubMed","id":"38127736","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8FO2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FO8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FO9","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues15
DetailsRepeat: {"description":"LRR 8","evidences":[{"source":"PubMed","id":"38127736","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8FO2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FO8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FO9","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues22
DetailsRepeat: {"description":"LRR 9","evidences":[{"source":"PubMed","id":"38127736","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8FO2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FO8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FO9","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues21
DetailsRepeat: {"description":"LRR 10","evidences":[{"source":"PubMed","id":"38127736","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8FO2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FO8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FO9","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues24
DetailsRepeat: {"description":"LRR 11","evidences":[{"source":"PubMed","id":"38127736","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8FO2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FO8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FO9","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues21
DetailsRepeat: {"description":"LRR 12","evidences":[{"source":"PubMed","id":"38127736","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8FO2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FO8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FO9","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues22
DetailsRepeat: {"description":"LRR 13","evidences":[{"source":"PubMed","id":"38127736","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8FO2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FO8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FO9","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI24
Number of Residues44
DetailsRepeat: {"description":"WD 1","evidences":[{"source":"PubMed","id":"38127736","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8FO2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FO8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FO9","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI25
Number of Residues40
DetailsRepeat: {"description":"WD 2","evidences":[{"source":"PubMed","id":"38127736","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8FO2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FO8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FO9","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI26
Number of Residues43
DetailsRepeat: {"description":"WD 3","evidences":[{"source":"PubMed","id":"38127736","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8FO2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FO8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FO9","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI27
Number of Residues46
DetailsRepeat: {"description":"WD 4","evidences":[{"source":"PubMed","id":"38127736","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8FO2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FO8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FO9","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI28
Number of Residues44
DetailsRepeat: {"description":"WD 5","evidences":[{"source":"PubMed","id":"38127736","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8FO2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FO8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FO9","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI29
Number of Residues1
DetailsActive site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI30
Number of Residues7
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00758","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"18230735","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI31
Number of Residues9
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"38127736","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8FO9","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI32
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"38127736","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8FO8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FO9","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI33
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"38127736","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8FO2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FO8","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI34
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI35
Number of Residues26
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00758","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI36
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"28202711","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28720718","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29212815","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI37
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"28202711","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28720718","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29127255","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29212815","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30635421","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI38
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine; by autocatalysis","evidences":[{"source":"PubMed","id":"29212815","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30635421","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38127736","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI39
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"28202711","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

243911

PDB entries from 2025-10-29

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