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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9CHT

Human E3 ligase E6AP in complex with HPV16-E6 and p53

Functional Information from GO Data
ChainGOidnamespacecontents
A0000209biological_processprotein polyubiquitination
A0000502cellular_componentproteasome complex
A0003713molecular_functiontranscription coactivator activity
A0004842molecular_functionubiquitin-protein transferase activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006508biological_processproteolysis
A0006511biological_processubiquitin-dependent protein catabolic process
A0007420biological_processbrain development
A0008021cellular_componentsynaptic vesicle
A0008270molecular_functionzinc ion binding
A0010604biological_processpositive regulation of macromolecule metabolic process
A0016567biological_processprotein ubiquitination
A0016740molecular_functiontransferase activity
A0030518biological_processnuclear receptor-mediated steroid hormone signaling pathway
A0031398biological_processpositive regulation of protein ubiquitination
A0032570biological_processresponse to progesterone
A0042752biological_processregulation of circadian rhythm
A0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
A0045893biological_processpositive regulation of DNA-templated transcription
A0046872molecular_functionmetal ion binding
A0048167biological_processregulation of synaptic plasticity
A0048511biological_processrhythmic process
A0048513biological_processanimal organ development
A0048731biological_processsystem development
A0050804biological_processmodulation of chemical synaptic transmission
A0050847biological_processprogesterone receptor signaling pathway
A0051865biological_processprotein autoubiquitination
A0061630molecular_functionubiquitin protein ligase activity
A0070936biological_processprotein K48-linked ubiquitination
A0080090biological_processregulation of primary metabolic process
A0098978cellular_componentglutamatergic synapse
A0099524cellular_componentpostsynaptic cytosol
A1904262biological_processnegative regulation of TORC1 signaling
A1905528biological_processpositive regulation of Golgi lumen acidification
A2000058biological_processregulation of ubiquitin-dependent protein catabolic process
B0000976molecular_functiontranscription cis-regulatory region binding
B0003677molecular_functionDNA binding
B0003700molecular_functionDNA-binding transcription factor activity
B0005618cellular_componentcell wall
B0005634cellular_componentnucleus
B0006355biological_processregulation of DNA-templated transcription
B0006915biological_processapoptotic process
C0003677molecular_functionDNA binding
C0005515molecular_functionprotein binding
C0006351biological_processDNA-templated transcription
C0006355biological_processregulation of DNA-templated transcription
C0008270molecular_functionzinc ion binding
C0030162biological_processregulation of proteolysis
C0030165molecular_functionPDZ domain binding
C0030430cellular_componenthost cell cytoplasm
C0032489biological_processregulation of Cdc42 protein signal transduction
C0033668biological_processsymbiont-mediated suppression of host apoptosis
C0039502biological_processsymbiont-mediated suppression of host type I interferon-mediated signaling pathway
C0039548biological_processsymbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity
C0039648biological_processsymbiont-mediated perturbation of host ubiquitin-like protein modification
C0039653biological_processsymbiont-mediated suppression of host transcription
C0042025cellular_componenthost cell nucleus
C0042802molecular_functionidentical protein binding
C0045944biological_processpositive regulation of transcription by RNA polymerase II
C0046872molecular_functionmetal ion binding
C0052031biological_processsymbiont-mediated perturbation of host defense response
C0052150biological_processsymbiont-mediated perturbation of host apoptosis
C0052170biological_processsymbiont-mediated suppression of host innate immune response
C0060255biological_processregulation of macromolecule metabolic process
C0080090biological_processregulation of primary metabolic process
C0140537molecular_functiontranscription regulator activator activity
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues99
DetailsDomain: {"description":"HECT","evidences":[{"source":"PROSITE-ProRule","id":"PRU00104","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues17
DetailsRegion: {"description":"E6-binding"}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues99
DetailsRegion: {"description":"Interaction with HCV core protein"}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues1
DetailsActive site: {"description":"Glycyl thioester intermediate"}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues1
DetailsModified residue: {"description":"Phosphotyrosine; by ABL1","evidences":[{"source":"PubMed","id":"23581475","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues190
DetailsDNA binding: {"evidences":[{"source":"PubMed","id":"16793544","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18996393","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20364130","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues123
DetailsRegion: {"description":"Required for interaction with FBXO42","evidences":[{"source":"PubMed","id":"19509332","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues176
DetailsRegion: {"description":"Interaction with AXIN1","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues7
DetailsRegion: {"description":"Interaction with the 53BP2 SH3 domain"}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues7
DetailsRegion: {"description":"Interaction with DNA"}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"14534297","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16793544","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17015838","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18650397","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19515728","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20142040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20364130","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues1
DetailsSite: {"description":"Interaction with DNA","evidences":[{"source":"PubMed","id":"16793544","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18996393","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20364130","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues2
DetailsModified residue: {"description":"N6-lactoyllysine","evidences":[{"source":"PubMed","id":"38653238","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine; by AURKB","evidences":[{"source":"PubMed","id":"20959462","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine; by AURKB","evidences":[{"source":"PubMed","id":"20959462","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues3
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"19536131","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues72
DetailsZinc finger: {"evidences":[{"source":"HAMAP-Rule","id":"MF_04006","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
Catalytic Information from CSA
site_idMCSA1
Number of Residues6
DetailsM-CSA 438
ChainResidueDetails
AARG529unknown
AGLU562unknown
AGLU573unknown
AASP630electrostatic stabiliser
AHIS841
ACYS843covalent catalysis

246905

PDB entries from 2025-12-31

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