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9CFC

Cryo-EM structure of human kidney V-ATPase state 2

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
00000139cellular_componentGolgi membrane
00000220cellular_componentvacuolar proton-transporting V-type ATPase, V0 domain
00005515molecular_functionprotein binding
00005765cellular_componentlysosomal membrane
00005768cellular_componentendosome
00005886cellular_componentplasma membrane
00006811biological_processmonoatomic ion transport
00007035biological_processvacuolar acidification
00007042biological_processlysosomal lumen acidification
00010008cellular_componentendosome membrane
00016020cellular_componentmembrane
00016241biological_processregulation of macroautophagy
00030665cellular_componentclathrin-coated vesicle membrane
00030670cellular_componentphagocytic vesicle membrane
00031410cellular_componentcytoplasmic vesicle
00033176cellular_componentproton-transporting V-type ATPase complex
00046961molecular_functionproton-transporting ATPase activity, rotational mechanism
00048388biological_processendosomal lumen acidification
00051452biological_processintracellular pH reduction
00061795biological_processGolgi lumen acidification
01902600biological_processproton transmembrane transport
10000139cellular_componentGolgi membrane
10000220cellular_componentvacuolar proton-transporting V-type ATPase, V0 domain
10005515molecular_functionprotein binding
10005765cellular_componentlysosomal membrane
10005886cellular_componentplasma membrane
10005925cellular_componentfocal adhesion
10006811biological_processmonoatomic ion transport
10007035biological_processvacuolar acidification
10007042biological_processlysosomal lumen acidification
10010008cellular_componentendosome membrane
10015986biological_processproton motive force-driven ATP synthesis
10016020cellular_componentmembrane
10016241biological_processregulation of macroautophagy
10030177biological_processpositive regulation of Wnt signaling pathway
10030665cellular_componentclathrin-coated vesicle membrane
10030670cellular_componentphagocytic vesicle membrane
10030672cellular_componentsynaptic vesicle membrane
10031410cellular_componentcytoplasmic vesicle
10031625molecular_functionubiquitin protein ligase binding
10033176cellular_componentproton-transporting V-type ATPase complex
10035577cellular_componentazurophil granule membrane
10046933molecular_functionproton-transporting ATP synthase activity, rotational mechanism
10046961molecular_functionproton-transporting ATPase activity, rotational mechanism
10048388biological_processendosomal lumen acidification
10051452biological_processintracellular pH reduction
10061795biological_processGolgi lumen acidification
10070062cellular_componentextracellular exosome
10070821cellular_componenttertiary granule membrane
10097401biological_processsynaptic vesicle lumen acidification
10098588cellular_componentbounding membrane of organelle
10101003cellular_componentficolin-1-rich granule membrane
11902600biological_processproton transmembrane transport
20000139cellular_componentGolgi membrane
20000220cellular_componentvacuolar proton-transporting V-type ATPase, V0 domain
20005515molecular_functionprotein binding
20005765cellular_componentlysosomal membrane
20005886cellular_componentplasma membrane
20005925cellular_componentfocal adhesion
20006811biological_processmonoatomic ion transport
20007035biological_processvacuolar acidification
20007042biological_processlysosomal lumen acidification
20010008cellular_componentendosome membrane
20015986biological_processproton motive force-driven ATP synthesis
20016020cellular_componentmembrane
20016241biological_processregulation of macroautophagy
20030177biological_processpositive regulation of Wnt signaling pathway
20030665cellular_componentclathrin-coated vesicle membrane
20030670cellular_componentphagocytic vesicle membrane
20030672cellular_componentsynaptic vesicle membrane
20031410cellular_componentcytoplasmic vesicle
20031625molecular_functionubiquitin protein ligase binding
20033176cellular_componentproton-transporting V-type ATPase complex
20035577cellular_componentazurophil granule membrane
20046933molecular_functionproton-transporting ATP synthase activity, rotational mechanism
20046961molecular_functionproton-transporting ATPase activity, rotational mechanism
20048388biological_processendosomal lumen acidification
20051452biological_processintracellular pH reduction
20061795biological_processGolgi lumen acidification
20070062cellular_componentextracellular exosome
20070821cellular_componenttertiary granule membrane
20097401biological_processsynaptic vesicle lumen acidification
20098588cellular_componentbounding membrane of organelle
20101003cellular_componentficolin-1-rich granule membrane
21902600biological_processproton transmembrane transport
30000139cellular_componentGolgi membrane
30000220cellular_componentvacuolar proton-transporting V-type ATPase, V0 domain
30005515molecular_functionprotein binding
30005765cellular_componentlysosomal membrane
30005886cellular_componentplasma membrane
30005925cellular_componentfocal adhesion
30006811biological_processmonoatomic ion transport
30007035biological_processvacuolar acidification
30007042biological_processlysosomal lumen acidification
30010008cellular_componentendosome membrane
30015986biological_processproton motive force-driven ATP synthesis
30016020cellular_componentmembrane
30016241biological_processregulation of macroautophagy
30030177biological_processpositive regulation of Wnt signaling pathway
30030665cellular_componentclathrin-coated vesicle membrane
30030670cellular_componentphagocytic vesicle membrane
30030672cellular_componentsynaptic vesicle membrane
30031410cellular_componentcytoplasmic vesicle
30031625molecular_functionubiquitin protein ligase binding
30033176cellular_componentproton-transporting V-type ATPase complex
30035577cellular_componentazurophil granule membrane
30046933molecular_functionproton-transporting ATP synthase activity, rotational mechanism
30046961molecular_functionproton-transporting ATPase activity, rotational mechanism
30048388biological_processendosomal lumen acidification
30051452biological_processintracellular pH reduction
30061795biological_processGolgi lumen acidification
30070062cellular_componentextracellular exosome
30070821cellular_componenttertiary granule membrane
30097401biological_processsynaptic vesicle lumen acidification
30098588cellular_componentbounding membrane of organelle
30101003cellular_componentficolin-1-rich granule membrane
31902600biological_processproton transmembrane transport
40000139cellular_componentGolgi membrane
40000220cellular_componentvacuolar proton-transporting V-type ATPase, V0 domain
40005515molecular_functionprotein binding
40005765cellular_componentlysosomal membrane
40005886cellular_componentplasma membrane
40005925cellular_componentfocal adhesion
40006811biological_processmonoatomic ion transport
40007035biological_processvacuolar acidification
40007042biological_processlysosomal lumen acidification
40010008cellular_componentendosome membrane
40015986biological_processproton motive force-driven ATP synthesis
40016020cellular_componentmembrane
40016241biological_processregulation of macroautophagy
40030177biological_processpositive regulation of Wnt signaling pathway
40030665cellular_componentclathrin-coated vesicle membrane
40030670cellular_componentphagocytic vesicle membrane
40030672cellular_componentsynaptic vesicle membrane
40031410cellular_componentcytoplasmic vesicle
40031625molecular_functionubiquitin protein ligase binding
40033176cellular_componentproton-transporting V-type ATPase complex
40035577cellular_componentazurophil granule membrane
40046933molecular_functionproton-transporting ATP synthase activity, rotational mechanism
40046961molecular_functionproton-transporting ATPase activity, rotational mechanism
40048388biological_processendosomal lumen acidification
40051452biological_processintracellular pH reduction
40061795biological_processGolgi lumen acidification
40070062cellular_componentextracellular exosome
40070821cellular_componenttertiary granule membrane
40097401biological_processsynaptic vesicle lumen acidification
40098588cellular_componentbounding membrane of organelle
40101003cellular_componentficolin-1-rich granule membrane
41902600biological_processproton transmembrane transport
50000139cellular_componentGolgi membrane
50000220cellular_componentvacuolar proton-transporting V-type ATPase, V0 domain
50005515molecular_functionprotein binding
50005765cellular_componentlysosomal membrane
50005886cellular_componentplasma membrane
50005925cellular_componentfocal adhesion
50006811biological_processmonoatomic ion transport
50007035biological_processvacuolar acidification
50007042biological_processlysosomal lumen acidification
50010008cellular_componentendosome membrane
50015986biological_processproton motive force-driven ATP synthesis
50016020cellular_componentmembrane
50016241biological_processregulation of macroautophagy
50030177biological_processpositive regulation of Wnt signaling pathway
50030665cellular_componentclathrin-coated vesicle membrane
50030670cellular_componentphagocytic vesicle membrane
50030672cellular_componentsynaptic vesicle membrane
50031410cellular_componentcytoplasmic vesicle
50031625molecular_functionubiquitin protein ligase binding
50033176cellular_componentproton-transporting V-type ATPase complex
50035577cellular_componentazurophil granule membrane
50046933molecular_functionproton-transporting ATP synthase activity, rotational mechanism
50046961molecular_functionproton-transporting ATPase activity, rotational mechanism
50048388biological_processendosomal lumen acidification
50051452biological_processintracellular pH reduction
50061795biological_processGolgi lumen acidification
50070062cellular_componentextracellular exosome
50070821cellular_componenttertiary granule membrane
50097401biological_processsynaptic vesicle lumen acidification
50098588cellular_componentbounding membrane of organelle
50101003cellular_componentficolin-1-rich granule membrane
51902600biological_processproton transmembrane transport
60000139cellular_componentGolgi membrane
60000220cellular_componentvacuolar proton-transporting V-type ATPase, V0 domain
60005515molecular_functionprotein binding
60005765cellular_componentlysosomal membrane
60005886cellular_componentplasma membrane
60005925cellular_componentfocal adhesion
60006811biological_processmonoatomic ion transport
60007035biological_processvacuolar acidification
60007042biological_processlysosomal lumen acidification
60010008cellular_componentendosome membrane
60015986biological_processproton motive force-driven ATP synthesis
60016020cellular_componentmembrane
60016241biological_processregulation of macroautophagy
60030177biological_processpositive regulation of Wnt signaling pathway
60030665cellular_componentclathrin-coated vesicle membrane
60030670cellular_componentphagocytic vesicle membrane
60030672cellular_componentsynaptic vesicle membrane
60031410cellular_componentcytoplasmic vesicle
60031625molecular_functionubiquitin protein ligase binding
60033176cellular_componentproton-transporting V-type ATPase complex
60035577cellular_componentazurophil granule membrane
60046933molecular_functionproton-transporting ATP synthase activity, rotational mechanism
60046961molecular_functionproton-transporting ATPase activity, rotational mechanism
60048388biological_processendosomal lumen acidification
60051452biological_processintracellular pH reduction
60061795biological_processGolgi lumen acidification
60070062cellular_componentextracellular exosome
60070821cellular_componenttertiary granule membrane
60097401biological_processsynaptic vesicle lumen acidification
60098588cellular_componentbounding membrane of organelle
60101003cellular_componentficolin-1-rich granule membrane
61902600biological_processproton transmembrane transport
70000139cellular_componentGolgi membrane
70000220cellular_componentvacuolar proton-transporting V-type ATPase, V0 domain
70005515molecular_functionprotein binding
70005765cellular_componentlysosomal membrane
70005886cellular_componentplasma membrane
70005925cellular_componentfocal adhesion
70006811biological_processmonoatomic ion transport
70007035biological_processvacuolar acidification
70007042biological_processlysosomal lumen acidification
70010008cellular_componentendosome membrane
70015986biological_processproton motive force-driven ATP synthesis
70016020cellular_componentmembrane
70016241biological_processregulation of macroautophagy
70030177biological_processpositive regulation of Wnt signaling pathway
70030665cellular_componentclathrin-coated vesicle membrane
70030670cellular_componentphagocytic vesicle membrane
70030672cellular_componentsynaptic vesicle membrane
70031410cellular_componentcytoplasmic vesicle
70031625molecular_functionubiquitin protein ligase binding
70033176cellular_componentproton-transporting V-type ATPase complex
70035577cellular_componentazurophil granule membrane
70046933molecular_functionproton-transporting ATP synthase activity, rotational mechanism
70046961molecular_functionproton-transporting ATPase activity, rotational mechanism
70048388biological_processendosomal lumen acidification
70051452biological_processintracellular pH reduction
70061795biological_processGolgi lumen acidification
70070062cellular_componentextracellular exosome
70070821cellular_componenttertiary granule membrane
70097401biological_processsynaptic vesicle lumen acidification
70098588cellular_componentbounding membrane of organelle
70101003cellular_componentficolin-1-rich granule membrane
71902600biological_processproton transmembrane transport
80000139cellular_componentGolgi membrane
80000220cellular_componentvacuolar proton-transporting V-type ATPase, V0 domain
80005515molecular_functionprotein binding
80005765cellular_componentlysosomal membrane
80005886cellular_componentplasma membrane
80005925cellular_componentfocal adhesion
80006811biological_processmonoatomic ion transport
80007035biological_processvacuolar acidification
80007042biological_processlysosomal lumen acidification
80010008cellular_componentendosome membrane
80015986biological_processproton motive force-driven ATP synthesis
80016020cellular_componentmembrane
80016241biological_processregulation of macroautophagy
80030177biological_processpositive regulation of Wnt signaling pathway
80030665cellular_componentclathrin-coated vesicle membrane
80030670cellular_componentphagocytic vesicle membrane
80030672cellular_componentsynaptic vesicle membrane
80031410cellular_componentcytoplasmic vesicle
80031625molecular_functionubiquitin protein ligase binding
80033176cellular_componentproton-transporting V-type ATPase complex
80035577cellular_componentazurophil granule membrane
80046933molecular_functionproton-transporting ATP synthase activity, rotational mechanism
80046961molecular_functionproton-transporting ATPase activity, rotational mechanism
80048388biological_processendosomal lumen acidification
80051452biological_processintracellular pH reduction
80061795biological_processGolgi lumen acidification
80070062cellular_componentextracellular exosome
80070821cellular_componenttertiary granule membrane
80097401biological_processsynaptic vesicle lumen acidification
80098588cellular_componentbounding membrane of organelle
80101003cellular_componentficolin-1-rich granule membrane
81902600biological_processproton transmembrane transport
90000139cellular_componentGolgi membrane
90000220cellular_componentvacuolar proton-transporting V-type ATPase, V0 domain
90005515molecular_functionprotein binding
90005765cellular_componentlysosomal membrane
90005886cellular_componentplasma membrane
90005925cellular_componentfocal adhesion
90006811biological_processmonoatomic ion transport
90007035biological_processvacuolar acidification
90007042biological_processlysosomal lumen acidification
90010008cellular_componentendosome membrane
90015986biological_processproton motive force-driven ATP synthesis
90016020cellular_componentmembrane
90016241biological_processregulation of macroautophagy
90030177biological_processpositive regulation of Wnt signaling pathway
90030665cellular_componentclathrin-coated vesicle membrane
90030670cellular_componentphagocytic vesicle membrane
90030672cellular_componentsynaptic vesicle membrane
90031410cellular_componentcytoplasmic vesicle
90031625molecular_functionubiquitin protein ligase binding
90033176cellular_componentproton-transporting V-type ATPase complex
90035577cellular_componentazurophil granule membrane
90046933molecular_functionproton-transporting ATP synthase activity, rotational mechanism
90046961molecular_functionproton-transporting ATPase activity, rotational mechanism
90048388biological_processendosomal lumen acidification
90051452biological_processintracellular pH reduction
90061795biological_processGolgi lumen acidification
90070062cellular_componentextracellular exosome
90070821cellular_componenttertiary granule membrane
90097401biological_processsynaptic vesicle lumen acidification
90098588cellular_componentbounding membrane of organelle
90101003cellular_componentficolin-1-rich granule membrane
91902600biological_processproton transmembrane transport
A0000139cellular_componentGolgi membrane
A0000166molecular_functionnucleotide binding
A0000221cellular_componentvacuolar proton-transporting V-type ATPase, V1 domain
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005764cellular_componentlysosome
A0005765cellular_componentlysosomal membrane
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0005902cellular_componentmicrovillus
A0006811biological_processmonoatomic ion transport
A0006879biological_processintracellular iron ion homeostasis
A0007035biological_processvacuolar acidification
A0007042biological_processlysosomal lumen acidification
A0010008cellular_componentendosome membrane
A0016020cellular_componentmembrane
A0016241biological_processregulation of macroautophagy
A0016324cellular_componentapical plasma membrane
A0016469cellular_componentproton-transporting two-sector ATPase complex
A0030133cellular_componenttransport vesicle
A0030141cellular_componentsecretory granule
A0030665cellular_componentclathrin-coated vesicle membrane
A0031410cellular_componentcytoplasmic vesicle
A0033176cellular_componentproton-transporting V-type ATPase complex
A0033180cellular_componentproton-transporting V-type ATPase, V1 domain
A0036295biological_processcellular response to increased oxygen levels
A0042592biological_processhomeostatic process
A0046961molecular_functionproton-transporting ATPase activity, rotational mechanism
A0048388biological_processendosomal lumen acidification
A0051452biological_processintracellular pH reduction
A0061795biological_processGolgi lumen acidification
A0070062cellular_componentextracellular exosome
A0097401biological_processsynaptic vesicle lumen acidification
A0098850cellular_componentextrinsic component of synaptic vesicle membrane
A1902600biological_processproton transmembrane transport
A1904949cellular_componentATPase complex
B0000139cellular_componentGolgi membrane
B0000166molecular_functionnucleotide binding
B0000221cellular_componentvacuolar proton-transporting V-type ATPase, V1 domain
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005764cellular_componentlysosome
B0005765cellular_componentlysosomal membrane
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0005902cellular_componentmicrovillus
B0006811biological_processmonoatomic ion transport
B0006879biological_processintracellular iron ion homeostasis
B0007035biological_processvacuolar acidification
B0007042biological_processlysosomal lumen acidification
B0010008cellular_componentendosome membrane
B0016020cellular_componentmembrane
B0016241biological_processregulation of macroautophagy
B0016324cellular_componentapical plasma membrane
B0016469cellular_componentproton-transporting two-sector ATPase complex
B0030133cellular_componenttransport vesicle
B0030141cellular_componentsecretory granule
B0030665cellular_componentclathrin-coated vesicle membrane
B0031410cellular_componentcytoplasmic vesicle
B0033176cellular_componentproton-transporting V-type ATPase complex
B0033180cellular_componentproton-transporting V-type ATPase, V1 domain
B0036295biological_processcellular response to increased oxygen levels
B0042592biological_processhomeostatic process
B0046961molecular_functionproton-transporting ATPase activity, rotational mechanism
B0048388biological_processendosomal lumen acidification
B0051452biological_processintracellular pH reduction
B0061795biological_processGolgi lumen acidification
B0070062cellular_componentextracellular exosome
B0097401biological_processsynaptic vesicle lumen acidification
B0098850cellular_componentextrinsic component of synaptic vesicle membrane
B1902600biological_processproton transmembrane transport
B1904949cellular_componentATPase complex
C0000139cellular_componentGolgi membrane
C0000166molecular_functionnucleotide binding
C0000221cellular_componentvacuolar proton-transporting V-type ATPase, V1 domain
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005764cellular_componentlysosome
C0005765cellular_componentlysosomal membrane
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0005902cellular_componentmicrovillus
C0006811biological_processmonoatomic ion transport
C0006879biological_processintracellular iron ion homeostasis
C0007035biological_processvacuolar acidification
C0007042biological_processlysosomal lumen acidification
C0010008cellular_componentendosome membrane
C0016020cellular_componentmembrane
C0016241biological_processregulation of macroautophagy
C0016324cellular_componentapical plasma membrane
C0016469cellular_componentproton-transporting two-sector ATPase complex
C0030133cellular_componenttransport vesicle
C0030141cellular_componentsecretory granule
C0030665cellular_componentclathrin-coated vesicle membrane
C0031410cellular_componentcytoplasmic vesicle
C0033176cellular_componentproton-transporting V-type ATPase complex
C0033180cellular_componentproton-transporting V-type ATPase, V1 domain
C0036295biological_processcellular response to increased oxygen levels
C0042592biological_processhomeostatic process
C0046961molecular_functionproton-transporting ATPase activity, rotational mechanism
C0048388biological_processendosomal lumen acidification
C0051452biological_processintracellular pH reduction
C0061795biological_processGolgi lumen acidification
C0070062cellular_componentextracellular exosome
C0097401biological_processsynaptic vesicle lumen acidification
C0098850cellular_componentextrinsic component of synaptic vesicle membrane
C1902600biological_processproton transmembrane transport
C1904949cellular_componentATPase complex
D0000166molecular_functionnucleotide binding
D0000221cellular_componentvacuolar proton-transporting V-type ATPase, V1 domain
D0001726cellular_componentruffle
D0005515molecular_functionprotein binding
D0005524molecular_functionATP binding
D0005737cellular_componentcytoplasm
D0005765cellular_componentlysosomal membrane
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0005902cellular_componentmicrovillus
D0006811biological_processmonoatomic ion transport
D0007035biological_processvacuolar acidification
D0015078molecular_functionproton transmembrane transporter activity
D0016241biological_processregulation of macroautophagy
D0016324cellular_componentapical plasma membrane
D0030665cellular_componentclathrin-coated vesicle membrane
D0030672cellular_componentsynaptic vesicle membrane
D0031410cellular_componentcytoplasmic vesicle
D0042470cellular_componentmelanosome
D0046961molecular_functionproton-transporting ATPase activity, rotational mechanism
D0070062cellular_componentextracellular exosome
D0097401biological_processsynaptic vesicle lumen acidification
D0098850cellular_componentextrinsic component of synaptic vesicle membrane
D1902600biological_processproton transmembrane transport
E0000166molecular_functionnucleotide binding
E0000221cellular_componentvacuolar proton-transporting V-type ATPase, V1 domain
E0001726cellular_componentruffle
E0005515molecular_functionprotein binding
E0005524molecular_functionATP binding
E0005737cellular_componentcytoplasm
E0005765cellular_componentlysosomal membrane
E0005829cellular_componentcytosol
E0005886cellular_componentplasma membrane
E0005902cellular_componentmicrovillus
E0006811biological_processmonoatomic ion transport
E0007035biological_processvacuolar acidification
E0015078molecular_functionproton transmembrane transporter activity
E0016241biological_processregulation of macroautophagy
E0016324cellular_componentapical plasma membrane
E0030665cellular_componentclathrin-coated vesicle membrane
E0030672cellular_componentsynaptic vesicle membrane
E0031410cellular_componentcytoplasmic vesicle
E0042470cellular_componentmelanosome
E0046961molecular_functionproton-transporting ATPase activity, rotational mechanism
E0070062cellular_componentextracellular exosome
E0097401biological_processsynaptic vesicle lumen acidification
E0098850cellular_componentextrinsic component of synaptic vesicle membrane
E1902600biological_processproton transmembrane transport
F0000166molecular_functionnucleotide binding
F0000221cellular_componentvacuolar proton-transporting V-type ATPase, V1 domain
F0001726cellular_componentruffle
F0005515molecular_functionprotein binding
F0005524molecular_functionATP binding
F0005737cellular_componentcytoplasm
F0005765cellular_componentlysosomal membrane
F0005829cellular_componentcytosol
F0005886cellular_componentplasma membrane
F0005902cellular_componentmicrovillus
F0006811biological_processmonoatomic ion transport
F0007035biological_processvacuolar acidification
F0015078molecular_functionproton transmembrane transporter activity
F0016241biological_processregulation of macroautophagy
F0016324cellular_componentapical plasma membrane
F0030665cellular_componentclathrin-coated vesicle membrane
F0030672cellular_componentsynaptic vesicle membrane
F0031410cellular_componentcytoplasmic vesicle
F0042470cellular_componentmelanosome
F0046961molecular_functionproton-transporting ATPase activity, rotational mechanism
F0070062cellular_componentextracellular exosome
F0097401biological_processsynaptic vesicle lumen acidification
F0098850cellular_componentextrinsic component of synaptic vesicle membrane
F1902600biological_processproton transmembrane transport
G0000139cellular_componentGolgi membrane
G0000221cellular_componentvacuolar proton-transporting V-type ATPase, V1 domain
G0005515molecular_functionprotein binding
G0005654cellular_componentnucleoplasm
G0005765cellular_componentlysosomal membrane
G0005813cellular_componentcentrosome
G0005829cellular_componentcytosol
G0005886cellular_componentplasma membrane
G0005929cellular_componentcilium
G0006811biological_processmonoatomic ion transport
G0007035biological_processvacuolar acidification
G0007042biological_processlysosomal lumen acidification
G0010008cellular_componentendosome membrane
G0016020cellular_componentmembrane
G0016241biological_processregulation of macroautophagy
G0030030biological_processcell projection organization
G0030665cellular_componentclathrin-coated vesicle membrane
G0031410cellular_componentcytoplasmic vesicle
G0033176cellular_componentproton-transporting V-type ATPase complex
G0035579cellular_componentspecific granule membrane
G0048388biological_processendosomal lumen acidification
G0051452biological_processintracellular pH reduction
G0060271biological_processcilium assembly
G0061512biological_processprotein localization to cilium
G0061795biological_processGolgi lumen acidification
G0070062cellular_componentextracellular exosome
G0097401biological_processsynaptic vesicle lumen acidification
G0098850cellular_componentextrinsic component of synaptic vesicle membrane
G1902600biological_processproton transmembrane transport
H0000221cellular_componentvacuolar proton-transporting V-type ATPase, V1 domain
H0005515molecular_functionprotein binding
H0005737cellular_componentcytoplasm
H0005765cellular_componentlysosomal membrane
H0005768cellular_componentendosome
H0005829cellular_componentcytosol
H0005902cellular_componentmicrovillus
H0006811biological_processmonoatomic ion transport
H0016241biological_processregulation of macroautophagy
H0016324cellular_componentapical plasma membrane
H0016469cellular_componentproton-transporting two-sector ATPase complex
H0030665cellular_componentclathrin-coated vesicle membrane
H0030672cellular_componentsynaptic vesicle membrane
H0031410cellular_componentcytoplasmic vesicle
H0046961molecular_functionproton-transporting ATPase activity, rotational mechanism
H0051117molecular_functionATPase binding
H0070062cellular_componentextracellular exosome
H0097401biological_processsynaptic vesicle lumen acidification
H1902600biological_processproton transmembrane transport
I0000221cellular_componentvacuolar proton-transporting V-type ATPase, V1 domain
I0005515molecular_functionprotein binding
I0005737cellular_componentcytoplasm
I0005765cellular_componentlysosomal membrane
I0005768cellular_componentendosome
I0005829cellular_componentcytosol
I0005902cellular_componentmicrovillus
I0006811biological_processmonoatomic ion transport
I0016241biological_processregulation of macroautophagy
I0016324cellular_componentapical plasma membrane
I0016469cellular_componentproton-transporting two-sector ATPase complex
I0030665cellular_componentclathrin-coated vesicle membrane
I0030672cellular_componentsynaptic vesicle membrane
I0031410cellular_componentcytoplasmic vesicle
I0046961molecular_functionproton-transporting ATPase activity, rotational mechanism
I0051117molecular_functionATPase binding
I0070062cellular_componentextracellular exosome
I0097401biological_processsynaptic vesicle lumen acidification
I1902600biological_processproton transmembrane transport
J0000221cellular_componentvacuolar proton-transporting V-type ATPase, V1 domain
J0005515molecular_functionprotein binding
J0005737cellular_componentcytoplasm
J0005765cellular_componentlysosomal membrane
J0005768cellular_componentendosome
J0005829cellular_componentcytosol
J0005902cellular_componentmicrovillus
J0006811biological_processmonoatomic ion transport
J0016241biological_processregulation of macroautophagy
J0016324cellular_componentapical plasma membrane
J0016469cellular_componentproton-transporting two-sector ATPase complex
J0030665cellular_componentclathrin-coated vesicle membrane
J0030672cellular_componentsynaptic vesicle membrane
J0031410cellular_componentcytoplasmic vesicle
J0046961molecular_functionproton-transporting ATPase activity, rotational mechanism
J0051117molecular_functionATPase binding
J0070062cellular_componentextracellular exosome
J0097401biological_processsynaptic vesicle lumen acidification
J1902600biological_processproton transmembrane transport
K0000221cellular_componentvacuolar proton-transporting V-type ATPase, V1 domain
K0005515molecular_functionprotein binding
K0005765cellular_componentlysosomal membrane
K0005829cellular_componentcytosol
K0005886cellular_componentplasma membrane
K0006811biological_processmonoatomic ion transport
K0006879biological_processintracellular iron ion homeostasis
K0016241biological_processregulation of macroautophagy
K0016324cellular_componentapical plasma membrane
K0016471cellular_componentvacuolar proton-transporting V-type ATPase complex
K0016887molecular_functionATP hydrolysis activity
K0030672cellular_componentsynaptic vesicle membrane
K0033176cellular_componentproton-transporting V-type ATPase complex
K0033180cellular_componentproton-transporting V-type ATPase, V1 domain
K0036295biological_processcellular response to increased oxygen levels
K0046961molecular_functionproton-transporting ATPase activity, rotational mechanism
K0051117molecular_functionATPase binding
K0070062cellular_componentextracellular exosome
K0097401biological_processsynaptic vesicle lumen acidification
K0098850cellular_componentextrinsic component of synaptic vesicle membrane
K1902600biological_processproton transmembrane transport
K1904949cellular_componentATPase complex
L0000221cellular_componentvacuolar proton-transporting V-type ATPase, V1 domain
L0005515molecular_functionprotein binding
L0005765cellular_componentlysosomal membrane
L0005829cellular_componentcytosol
L0005886cellular_componentplasma membrane
L0006811biological_processmonoatomic ion transport
L0006879biological_processintracellular iron ion homeostasis
L0016241biological_processregulation of macroautophagy
L0016324cellular_componentapical plasma membrane
L0016471cellular_componentvacuolar proton-transporting V-type ATPase complex
L0016887molecular_functionATP hydrolysis activity
L0030672cellular_componentsynaptic vesicle membrane
L0033176cellular_componentproton-transporting V-type ATPase complex
L0033180cellular_componentproton-transporting V-type ATPase, V1 domain
L0036295biological_processcellular response to increased oxygen levels
L0046961molecular_functionproton-transporting ATPase activity, rotational mechanism
L0051117molecular_functionATPase binding
L0070062cellular_componentextracellular exosome
L0097401biological_processsynaptic vesicle lumen acidification
L0098850cellular_componentextrinsic component of synaptic vesicle membrane
L1902600biological_processproton transmembrane transport
L1904949cellular_componentATPase complex
M0000221cellular_componentvacuolar proton-transporting V-type ATPase, V1 domain
M0005515molecular_functionprotein binding
M0005765cellular_componentlysosomal membrane
M0005829cellular_componentcytosol
M0005886cellular_componentplasma membrane
M0006811biological_processmonoatomic ion transport
M0006879biological_processintracellular iron ion homeostasis
M0016241biological_processregulation of macroautophagy
M0016324cellular_componentapical plasma membrane
M0016471cellular_componentvacuolar proton-transporting V-type ATPase complex
M0016887molecular_functionATP hydrolysis activity
M0030672cellular_componentsynaptic vesicle membrane
M0033176cellular_componentproton-transporting V-type ATPase complex
M0033180cellular_componentproton-transporting V-type ATPase, V1 domain
M0036295biological_processcellular response to increased oxygen levels
M0046961molecular_functionproton-transporting ATPase activity, rotational mechanism
M0051117molecular_functionATPase binding
M0070062cellular_componentextracellular exosome
M0097401biological_processsynaptic vesicle lumen acidification
M0098850cellular_componentextrinsic component of synaptic vesicle membrane
M1902600biological_processproton transmembrane transport
M1904949cellular_componentATPase complex
N0000139cellular_componentGolgi membrane
N0000221cellular_componentvacuolar proton-transporting V-type ATPase, V1 domain
N0005515molecular_functionprotein binding
N0005765cellular_componentlysosomal membrane
N0005829cellular_componentcytosol
N0005886cellular_componentplasma membrane
N0006811biological_processmonoatomic ion transport
N0007035biological_processvacuolar acidification
N0007042biological_processlysosomal lumen acidification
N0010008cellular_componentendosome membrane
N0015078molecular_functionproton transmembrane transporter activity
N0016020cellular_componentmembrane
N0016471cellular_componentvacuolar proton-transporting V-type ATPase complex
N0030665cellular_componentclathrin-coated vesicle membrane
N0030672cellular_componentsynaptic vesicle membrane
N0031410cellular_componentcytoplasmic vesicle
N0033176cellular_componentproton-transporting V-type ATPase complex
N0042625molecular_functionATPase-coupled ion transmembrane transporter activity
N0048388biological_processendosomal lumen acidification
N0051452biological_processintracellular pH reduction
N0061795biological_processGolgi lumen acidification
N0070062cellular_componentextracellular exosome
N0097401biological_processsynaptic vesicle lumen acidification
N1902600biological_processproton transmembrane transport
Q0000220cellular_componentvacuolar proton-transporting V-type ATPase, V0 domain
Q0005515molecular_functionprotein binding
Q0005765cellular_componentlysosomal membrane
Q0005769cellular_componentearly endosome
Q0005813cellular_componentcentrosome
Q0006811biological_processmonoatomic ion transport
Q0006879biological_processintracellular iron ion homeostasis
Q0007034biological_processvacuolar transport
Q0007035biological_processvacuolar acidification
Q0008021cellular_componentsynaptic vesicle
Q0010008cellular_componentendosome membrane
Q0016020cellular_componentmembrane
Q0016241biological_processregulation of macroautophagy
Q0016324cellular_componentapical plasma membrane
Q0016471cellular_componentvacuolar proton-transporting V-type ATPase complex
Q0030030biological_processcell projection organization
Q0030665cellular_componentclathrin-coated vesicle membrane
Q0030670cellular_componentphagocytic vesicle membrane
Q0030672cellular_componentsynaptic vesicle membrane
Q0031410cellular_componentcytoplasmic vesicle
Q0032991cellular_componentprotein-containing complex
Q0033176cellular_componentproton-transporting V-type ATPase complex
Q0033179cellular_componentproton-transporting V-type ATPase, V0 domain
Q0033181cellular_componentplasma membrane proton-transporting V-type ATPase complex
Q0036295biological_processcellular response to increased oxygen levels
Q0042592biological_processhomeostatic process
Q0043679cellular_componentaxon terminus
Q0044877molecular_functionprotein-containing complex binding
Q0046961molecular_functionproton-transporting ATPase activity, rotational mechanism
Q0060271biological_processcilium assembly
Q0070062cellular_componentextracellular exosome
Q0097401biological_processsynaptic vesicle lumen acidification
Q1902600biological_processproton transmembrane transport
R0000220cellular_componentvacuolar proton-transporting V-type ATPase, V0 domain
R0005515molecular_functionprotein binding
R0005737cellular_componentcytoplasm
R0005765cellular_componentlysosomal membrane
R0005794cellular_componentGolgi apparatus
R0005829cellular_componentcytosol
R0005886cellular_componentplasma membrane
R0006811biological_processmonoatomic ion transport
R0007035biological_processvacuolar acidification
R0007042biological_processlysosomal lumen acidification
R0010008cellular_componentendosome membrane
R0016020cellular_componentmembrane
R0016241biological_processregulation of macroautophagy
R0016471cellular_componentvacuolar proton-transporting V-type ATPase complex
R0016607cellular_componentnuclear speck
R0030665cellular_componentclathrin-coated vesicle membrane
R0030667cellular_componentsecretory granule membrane
R0030670cellular_componentphagocytic vesicle membrane
R0030672cellular_componentsynaptic vesicle membrane
R0031410cellular_componentcytoplasmic vesicle
R0033176cellular_componentproton-transporting V-type ATPase complex
R0042470cellular_componentmelanosome
R0048388biological_processendosomal lumen acidification
R0048471cellular_componentperinuclear region of cytoplasm
R0051117molecular_functionATPase binding
R0070062cellular_componentextracellular exosome
R0097401biological_processsynaptic vesicle lumen acidification
R0101003cellular_componentficolin-1-rich granule membrane
R1902600biological_processproton transmembrane transport
S0005515molecular_functionprotein binding
S0005765cellular_componentlysosomal membrane
S0006811biological_processmonoatomic ion transport
S0007035biological_processvacuolar acidification
S0010008cellular_componentendosome membrane
S0016020cellular_componentmembrane
S0016241biological_processregulation of macroautophagy
S0030670cellular_componentphagocytic vesicle membrane
S0033176cellular_componentproton-transporting V-type ATPase complex
S0042625molecular_functionATPase-coupled ion transmembrane transporter activity
S0046961molecular_functionproton-transporting ATPase activity, rotational mechanism
S0055085biological_processtransmembrane transport
S1902600biological_processproton transmembrane transport
T0000139cellular_componentGolgi membrane
T0000220cellular_componentvacuolar proton-transporting V-type ATPase, V0 domain
T0004518molecular_functionnuclease activity
T0004519molecular_functionendonuclease activity
T0004521molecular_functionRNA endonuclease activity
T0005515molecular_functionprotein binding
T0005765cellular_componentlysosomal membrane
T0005886cellular_componentplasma membrane
T0006811biological_processmonoatomic ion transport
T0006897biological_processendocytosis
T0006898biological_processreceptor-mediated endocytosis
T0007035biological_processvacuolar acidification
T0007042biological_processlysosomal lumen acidification
T0010008cellular_componentendosome membrane
T0012505cellular_componentendomembrane system
T0016020cellular_componentmembrane
T0016787molecular_functionhydrolase activity
T0019065biological_processreceptor-mediated endocytosis of virus by host cell
T0030665cellular_componentclathrin-coated vesicle membrane
T0031410cellular_componentcytoplasmic vesicle
T0033176cellular_componentproton-transporting V-type ATPase complex
T0048388biological_processendosomal lumen acidification
T0051452biological_processintracellular pH reduction
T0061795biological_processGolgi lumen acidification
T1902600biological_processproton transmembrane transport
Functional Information from PROSITE/UniProt
site_idPS00152
Number of Residues10
DetailsATPASE_ALPHA_BETA ATP synthase alpha and beta subunits signature. PSVNWLISYS
ChainResidueDetails
APRO446-SER455
DPRO390-SER399

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues188
DetailsTopological domain: {"description":"Lumenal","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues1150
DetailsTransmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues415
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues1
DetailsSite: {"description":"Essential for proton translocation","evidences":[{"source":"UniProtKB","id":"Q2TA24","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues9
DetailsSite: {"description":"Essential for proton translocation","evidences":[{"source":"PubMed","id":"36074901","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues4
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues3
DetailsModified residue: {"description":"Phosphoserine; by AMPK","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI8
Number of Residues10
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"33065002","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6WLZ","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"6WM2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WM3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WM4","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI9
Number of Residues3
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P50518","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI10
Number of Residues1
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P51863","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI11
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P51863","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI12
Number of Residues83
DetailsTopological domain: {"description":"Vacuolar","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI13
Number of Residues1
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q9Z1G4","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI14
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GalNAc...) asparagine","evidences":[{"source":"PubMed","id":"33065002","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WM3","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"6WM4","evidenceCode":"ECO:0000312"}]}
ChainResidueDetails

site_idSWS_FT_FI15
Number of Residues6
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

site_idSWS_FT_FI16
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"33065002","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WLW","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"6WM2","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"6WM3","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"6WM4","evidenceCode":"ECO:0000312"}]}
ChainResidueDetails

site_idSWS_FT_FI17
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33065002","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WLW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WM2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WM3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WM4","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI18
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"33065002","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WM3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WM4","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI19
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"33065002","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WLW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WM2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WM3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WM4","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI20
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"33065002","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WM3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WM4","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

242199

PDB entries from 2025-09-24

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