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9CDA

Structure of type I-2 alpha-synuclein filament from multiple system atrophy

Functional Information from GO Data
ChainGOidnamespacecontents
K0000122biological_processnegative regulation of transcription by RNA polymerase II
K0000149molecular_functionSNARE binding
K0000287molecular_functionmagnesium ion binding
K0000976molecular_functiontranscription cis-regulatory region binding
K0001774biological_processmicroglial cell activation
K0001921biological_processpositive regulation of receptor recycling
K0001956biological_processpositive regulation of neurotransmitter secretion
K0001963biological_processsynaptic transmission, dopaminergic
K0003779molecular_functionactin binding
K0004857molecular_functionenzyme inhibitor activity
K0004860molecular_functionprotein kinase inhibitor activity
K0004869molecular_functioncysteine-type endopeptidase inhibitor activity
K0005504molecular_functionfatty acid binding
K0005507molecular_functioncopper ion binding
K0005509molecular_functioncalcium ion binding
K0005515molecular_functionprotein binding
K0005543molecular_functionphospholipid binding
K0005576cellular_componentextracellular region
K0005615cellular_componentextracellular space
K0005634cellular_componentnucleus
K0005640cellular_componentnuclear outer membrane
K0005737cellular_componentcytoplasm
K0005739cellular_componentmitochondrion
K0005741cellular_componentmitochondrial outer membrane
K0005743cellular_componentmitochondrial inner membrane
K0005759cellular_componentmitochondrial matrix
K0005764cellular_componentlysosome
K0005829cellular_componentcytosol
K0005840cellular_componentribosome
K0005856cellular_componentcytoskeleton
K0005886cellular_componentplasma membrane
K0005938cellular_componentcell cortex
K0006631biological_processfatty acid metabolic process
K0006638biological_processneutral lipid metabolic process
K0006644biological_processphospholipid metabolic process
K0006749biological_processglutathione metabolic process
K0007006biological_processmitochondrial membrane organization
K0007268biological_processchemical synaptic transmission
K0007269biological_processneurotransmitter secretion
K0008017molecular_functionmicrotubule binding
K0008021cellular_componentsynaptic vesicle
K0008047molecular_functionenzyme activator activity
K0008198molecular_functionferrous iron binding
K0008270molecular_functionzinc ion binding
K0008289molecular_functionlipid binding
K0008344biological_processadult locomotory behavior
K0009410biological_processresponse to xenobiotic stimulus
K0010040biological_processresponse to iron(II) ion
K0010642biological_processnegative regulation of platelet-derived growth factor receptor signaling pathway
K0014048biological_processregulation of glutamate secretion
K0014059biological_processregulation of dopamine secretion
K0015629cellular_componentactin cytoskeleton
K0016020cellular_componentmembrane
K0016079biological_processsynaptic vesicle exocytosis
K0016082biological_processsynaptic vesicle priming
K0016234cellular_componentinclusion body
K0016491molecular_functionoxidoreductase activity
K0019894molecular_functionkinesin binding
K0019899molecular_functionenzyme binding
K0019904molecular_functionprotein domain specific binding
K0030424cellular_componentaxon
K0030426cellular_componentgrowth cone
K0030544molecular_functionHsp70 protein binding
K0030659cellular_componentcytoplasmic vesicle membrane
K0030672cellular_componentsynaptic vesicle membrane
K0031092cellular_componentplatelet alpha granule membrane
K0031115biological_processnegative regulation of microtubule polymerization
K0031623biological_processreceptor internalization
K0031648biological_processprotein destabilization
K0032026biological_processresponse to magnesium ion
K0032496biological_processresponse to lipopolysaccharide
K0032991cellular_componentprotein-containing complex
K0034341biological_processresponse to type II interferon
K0034599biological_processcellular response to oxidative stress
K0035493biological_processSNARE complex assembly
K0035543biological_processpositive regulation of SNARE complex assembly
K0040012biological_processregulation of locomotion
K0042220biological_processresponse to cocaine
K0042393molecular_functionhistone binding
K0042416biological_processdopamine biosynthetic process
K0042417biological_processdopamine metabolic process
K0042775biological_processmitochondrial ATP synthesis coupled electron transport
K0042802molecular_functionidentical protein binding
K0042995cellular_componentcell projection
K0043014molecular_functionalpha-tubulin binding
K0043025cellular_componentneuronal cell body
K0043030biological_processregulation of macrophage activation
K0043065biological_processpositive regulation of apoptotic process
K0043066biological_processnegative regulation of apoptotic process
K0043195cellular_componentterminal bouton
K0043274molecular_functionphospholipase binding
K0043524biological_processnegative regulation of neuron apoptotic process
K0043679cellular_componentaxon terminus
K0044344biological_processcellular response to fibroblast growth factor stimulus
K0045202cellular_componentsynapse
K0045807biological_processpositive regulation of endocytosis
K0045920biological_processnegative regulation of exocytosis
K0045921biological_processpositive regulation of exocytosis
K0045963biological_processnegative regulation of dopamine metabolic process
K0046872molecular_functionmetal ion binding
K0046928biological_processregulation of neurotransmitter secretion
K0048148biological_processbehavioral response to cocaine
K0048156molecular_functiontau protein binding
K0048168biological_processregulation of neuronal synaptic plasticity
K0048169biological_processregulation of long-term neuronal synaptic plasticity
K0048471cellular_componentperinuclear region of cytoplasm
K0048487molecular_functionbeta-tubulin binding
K0048488biological_processsynaptic vesicle endocytosis
K0048489biological_processsynaptic vesicle transport
K0050729biological_processpositive regulation of inflammatory response
K0050806biological_processpositive regulation of synaptic transmission
K0050808biological_processsynapse organization
K0050812biological_processregulation of acyl-CoA biosynthetic process
K0051219molecular_functionphosphoprotein binding
K0051259biological_processprotein complex oligomerization
K0051262biological_processprotein tetramerization
K0051281biological_processpositive regulation of release of sequestered calcium ion into cytosol
K0051402biological_processneuron apoptotic process
K0051583biological_processdopamine uptake involved in synaptic transmission
K0051585biological_processnegative regulation of dopamine uptake involved in synaptic transmission
K0051612biological_processnegative regulation of serotonin uptake
K0051621biological_processregulation of norepinephrine uptake
K0051622biological_processnegative regulation of norepinephrine uptake
K0055074biological_processcalcium ion homeostasis
K0060079biological_processexcitatory postsynaptic potential
K0060090molecular_functionmolecular adaptor activity
K0060291biological_processlong-term synaptic potentiation
K0060732biological_processpositive regulation of inositol phosphate biosynthetic process
K0060961molecular_functionphospholipase D inhibitor activity
K0061024biological_processmembrane organization
K0070495biological_processnegative regulation of thrombin-activated receptor signaling pathway
K0070507biological_processregulation of microtubule cytoskeleton organization
K0070555biological_processresponse to interleukin-1
K0070840molecular_functiondynein complex binding
K0071280biological_processcellular response to copper ion
K0071872biological_processcellular response to epinephrine stimulus
K0097435biological_processsupramolecular fiber organization
K0098793cellular_componentpresynapse
K0098794cellular_componentpostsynapse
K0099512cellular_componentsupramolecular fiber
K0140311molecular_functionprotein sequestering activity
K0141108molecular_functiontransporter regulator activity
K1902957biological_processnegative regulation of mitochondrial electron transport, NADH to ubiquinone
K1903136molecular_functioncuprous ion binding
K1903285biological_processpositive regulation of hydrogen peroxide catabolic process
K1903421biological_processregulation of synaptic vesicle recycling
K1903426biological_processregulation of reactive oxygen species biosynthetic process
K1904307biological_processresponse to desipramine
K1904377biological_processpositive regulation of protein localization to cell periphery
K1904715biological_processnegative regulation of chaperone-mediated autophagy
K1905606biological_processregulation of presynapse assembly
K1990000biological_processamyloid fibril formation
K2000377biological_processregulation of reactive oxygen species metabolic process
L0000122biological_processnegative regulation of transcription by RNA polymerase II
L0000149molecular_functionSNARE binding
L0000287molecular_functionmagnesium ion binding
L0000976molecular_functiontranscription cis-regulatory region binding
L0001774biological_processmicroglial cell activation
L0001921biological_processpositive regulation of receptor recycling
L0001956biological_processpositive regulation of neurotransmitter secretion
L0001963biological_processsynaptic transmission, dopaminergic
L0003779molecular_functionactin binding
L0004857molecular_functionenzyme inhibitor activity
L0004860molecular_functionprotein kinase inhibitor activity
L0004869molecular_functioncysteine-type endopeptidase inhibitor activity
L0005504molecular_functionfatty acid binding
L0005507molecular_functioncopper ion binding
L0005509molecular_functioncalcium ion binding
L0005515molecular_functionprotein binding
L0005543molecular_functionphospholipid binding
L0005576cellular_componentextracellular region
L0005615cellular_componentextracellular space
L0005634cellular_componentnucleus
L0005640cellular_componentnuclear outer membrane
L0005737cellular_componentcytoplasm
L0005739cellular_componentmitochondrion
L0005741cellular_componentmitochondrial outer membrane
L0005743cellular_componentmitochondrial inner membrane
L0005759cellular_componentmitochondrial matrix
L0005764cellular_componentlysosome
L0005829cellular_componentcytosol
L0005840cellular_componentribosome
L0005856cellular_componentcytoskeleton
L0005886cellular_componentplasma membrane
L0005938cellular_componentcell cortex
L0006631biological_processfatty acid metabolic process
L0006638biological_processneutral lipid metabolic process
L0006644biological_processphospholipid metabolic process
L0006749biological_processglutathione metabolic process
L0007006biological_processmitochondrial membrane organization
L0007268biological_processchemical synaptic transmission
L0007269biological_processneurotransmitter secretion
L0008017molecular_functionmicrotubule binding
L0008021cellular_componentsynaptic vesicle
L0008047molecular_functionenzyme activator activity
L0008198molecular_functionferrous iron binding
L0008270molecular_functionzinc ion binding
L0008289molecular_functionlipid binding
L0008344biological_processadult locomotory behavior
L0009410biological_processresponse to xenobiotic stimulus
L0010040biological_processresponse to iron(II) ion
L0010642biological_processnegative regulation of platelet-derived growth factor receptor signaling pathway
L0014048biological_processregulation of glutamate secretion
L0014059biological_processregulation of dopamine secretion
L0015629cellular_componentactin cytoskeleton
L0016020cellular_componentmembrane
L0016079biological_processsynaptic vesicle exocytosis
L0016082biological_processsynaptic vesicle priming
L0016234cellular_componentinclusion body
L0016491molecular_functionoxidoreductase activity
L0019894molecular_functionkinesin binding
L0019899molecular_functionenzyme binding
L0019904molecular_functionprotein domain specific binding
L0030424cellular_componentaxon
L0030426cellular_componentgrowth cone
L0030544molecular_functionHsp70 protein binding
L0030659cellular_componentcytoplasmic vesicle membrane
L0030672cellular_componentsynaptic vesicle membrane
L0031092cellular_componentplatelet alpha granule membrane
L0031115biological_processnegative regulation of microtubule polymerization
L0031623biological_processreceptor internalization
L0031648biological_processprotein destabilization
L0032026biological_processresponse to magnesium ion
L0032496biological_processresponse to lipopolysaccharide
L0032991cellular_componentprotein-containing complex
L0034341biological_processresponse to type II interferon
L0034599biological_processcellular response to oxidative stress
L0035493biological_processSNARE complex assembly
L0035543biological_processpositive regulation of SNARE complex assembly
L0040012biological_processregulation of locomotion
L0042220biological_processresponse to cocaine
L0042393molecular_functionhistone binding
L0042416biological_processdopamine biosynthetic process
L0042417biological_processdopamine metabolic process
L0042775biological_processmitochondrial ATP synthesis coupled electron transport
L0042802molecular_functionidentical protein binding
L0042995cellular_componentcell projection
L0043014molecular_functionalpha-tubulin binding
L0043025cellular_componentneuronal cell body
L0043030biological_processregulation of macrophage activation
L0043065biological_processpositive regulation of apoptotic process
L0043066biological_processnegative regulation of apoptotic process
L0043195cellular_componentterminal bouton
L0043274molecular_functionphospholipase binding
L0043524biological_processnegative regulation of neuron apoptotic process
L0043679cellular_componentaxon terminus
L0044344biological_processcellular response to fibroblast growth factor stimulus
L0045202cellular_componentsynapse
L0045807biological_processpositive regulation of endocytosis
L0045920biological_processnegative regulation of exocytosis
L0045921biological_processpositive regulation of exocytosis
L0045963biological_processnegative regulation of dopamine metabolic process
L0046872molecular_functionmetal ion binding
L0046928biological_processregulation of neurotransmitter secretion
L0048148biological_processbehavioral response to cocaine
L0048156molecular_functiontau protein binding
L0048168biological_processregulation of neuronal synaptic plasticity
L0048169biological_processregulation of long-term neuronal synaptic plasticity
L0048471cellular_componentperinuclear region of cytoplasm
L0048487molecular_functionbeta-tubulin binding
L0048488biological_processsynaptic vesicle endocytosis
L0048489biological_processsynaptic vesicle transport
L0050729biological_processpositive regulation of inflammatory response
L0050806biological_processpositive regulation of synaptic transmission
L0050808biological_processsynapse organization
L0050812biological_processregulation of acyl-CoA biosynthetic process
L0051219molecular_functionphosphoprotein binding
L0051259biological_processprotein complex oligomerization
L0051262biological_processprotein tetramerization
L0051281biological_processpositive regulation of release of sequestered calcium ion into cytosol
L0051402biological_processneuron apoptotic process
L0051583biological_processdopamine uptake involved in synaptic transmission
L0051585biological_processnegative regulation of dopamine uptake involved in synaptic transmission
L0051612biological_processnegative regulation of serotonin uptake
L0051621biological_processregulation of norepinephrine uptake
L0051622biological_processnegative regulation of norepinephrine uptake
L0055074biological_processcalcium ion homeostasis
L0060079biological_processexcitatory postsynaptic potential
L0060090molecular_functionmolecular adaptor activity
L0060291biological_processlong-term synaptic potentiation
L0060732biological_processpositive regulation of inositol phosphate biosynthetic process
L0060961molecular_functionphospholipase D inhibitor activity
L0061024biological_processmembrane organization
L0070495biological_processnegative regulation of thrombin-activated receptor signaling pathway
L0070507biological_processregulation of microtubule cytoskeleton organization
L0070555biological_processresponse to interleukin-1
L0070840molecular_functiondynein complex binding
L0071280biological_processcellular response to copper ion
L0071872biological_processcellular response to epinephrine stimulus
L0097435biological_processsupramolecular fiber organization
L0098793cellular_componentpresynapse
L0098794cellular_componentpostsynapse
L0099512cellular_componentsupramolecular fiber
L0140311molecular_functionprotein sequestering activity
L0141108molecular_functiontransporter regulator activity
L1902957biological_processnegative regulation of mitochondrial electron transport, NADH to ubiquinone
L1903136molecular_functioncuprous ion binding
L1903285biological_processpositive regulation of hydrogen peroxide catabolic process
L1903421biological_processregulation of synaptic vesicle recycling
L1903426biological_processregulation of reactive oxygen species biosynthetic process
L1904307biological_processresponse to desipramine
L1904377biological_processpositive regulation of protein localization to cell periphery
L1904715biological_processnegative regulation of chaperone-mediated autophagy
L1905606biological_processregulation of presynapse assembly
L1990000biological_processamyloid fibril formation
L2000377biological_processregulation of reactive oxygen species metabolic process
M0000122biological_processnegative regulation of transcription by RNA polymerase II
M0000149molecular_functionSNARE binding
M0000287molecular_functionmagnesium ion binding
M0000976molecular_functiontranscription cis-regulatory region binding
M0001774biological_processmicroglial cell activation
M0001921biological_processpositive regulation of receptor recycling
M0001956biological_processpositive regulation of neurotransmitter secretion
M0001963biological_processsynaptic transmission, dopaminergic
M0003779molecular_functionactin binding
M0004857molecular_functionenzyme inhibitor activity
M0004860molecular_functionprotein kinase inhibitor activity
M0004869molecular_functioncysteine-type endopeptidase inhibitor activity
M0005504molecular_functionfatty acid binding
M0005507molecular_functioncopper ion binding
M0005509molecular_functioncalcium ion binding
M0005515molecular_functionprotein binding
M0005543molecular_functionphospholipid binding
M0005576cellular_componentextracellular region
M0005615cellular_componentextracellular space
M0005634cellular_componentnucleus
M0005640cellular_componentnuclear outer membrane
M0005737cellular_componentcytoplasm
M0005739cellular_componentmitochondrion
M0005741cellular_componentmitochondrial outer membrane
M0005743cellular_componentmitochondrial inner membrane
M0005759cellular_componentmitochondrial matrix
M0005764cellular_componentlysosome
M0005829cellular_componentcytosol
M0005840cellular_componentribosome
M0005856cellular_componentcytoskeleton
M0005886cellular_componentplasma membrane
M0005938cellular_componentcell cortex
M0006631biological_processfatty acid metabolic process
M0006638biological_processneutral lipid metabolic process
M0006644biological_processphospholipid metabolic process
M0006749biological_processglutathione metabolic process
M0007006biological_processmitochondrial membrane organization
M0007268biological_processchemical synaptic transmission
M0007269biological_processneurotransmitter secretion
M0008017molecular_functionmicrotubule binding
M0008021cellular_componentsynaptic vesicle
M0008047molecular_functionenzyme activator activity
M0008198molecular_functionferrous iron binding
M0008270molecular_functionzinc ion binding
M0008289molecular_functionlipid binding
M0008344biological_processadult locomotory behavior
M0009410biological_processresponse to xenobiotic stimulus
M0010040biological_processresponse to iron(II) ion
M0010642biological_processnegative regulation of platelet-derived growth factor receptor signaling pathway
M0014048biological_processregulation of glutamate secretion
M0014059biological_processregulation of dopamine secretion
M0015629cellular_componentactin cytoskeleton
M0016020cellular_componentmembrane
M0016079biological_processsynaptic vesicle exocytosis
M0016082biological_processsynaptic vesicle priming
M0016234cellular_componentinclusion body
M0016491molecular_functionoxidoreductase activity
M0019894molecular_functionkinesin binding
M0019899molecular_functionenzyme binding
M0019904molecular_functionprotein domain specific binding
M0030424cellular_componentaxon
M0030426cellular_componentgrowth cone
M0030544molecular_functionHsp70 protein binding
M0030659cellular_componentcytoplasmic vesicle membrane
M0030672cellular_componentsynaptic vesicle membrane
M0031092cellular_componentplatelet alpha granule membrane
M0031115biological_processnegative regulation of microtubule polymerization
M0031623biological_processreceptor internalization
M0031648biological_processprotein destabilization
M0032026biological_processresponse to magnesium ion
M0032496biological_processresponse to lipopolysaccharide
M0032991cellular_componentprotein-containing complex
M0034341biological_processresponse to type II interferon
M0034599biological_processcellular response to oxidative stress
M0035493biological_processSNARE complex assembly
M0035543biological_processpositive regulation of SNARE complex assembly
M0040012biological_processregulation of locomotion
M0042220biological_processresponse to cocaine
M0042393molecular_functionhistone binding
M0042416biological_processdopamine biosynthetic process
M0042417biological_processdopamine metabolic process
M0042775biological_processmitochondrial ATP synthesis coupled electron transport
M0042802molecular_functionidentical protein binding
M0042995cellular_componentcell projection
M0043014molecular_functionalpha-tubulin binding
M0043025cellular_componentneuronal cell body
M0043030biological_processregulation of macrophage activation
M0043065biological_processpositive regulation of apoptotic process
M0043066biological_processnegative regulation of apoptotic process
M0043195cellular_componentterminal bouton
M0043274molecular_functionphospholipase binding
M0043524biological_processnegative regulation of neuron apoptotic process
M0043679cellular_componentaxon terminus
M0044344biological_processcellular response to fibroblast growth factor stimulus
M0045202cellular_componentsynapse
M0045807biological_processpositive regulation of endocytosis
M0045920biological_processnegative regulation of exocytosis
M0045921biological_processpositive regulation of exocytosis
M0045963biological_processnegative regulation of dopamine metabolic process
M0046872molecular_functionmetal ion binding
M0046928biological_processregulation of neurotransmitter secretion
M0048148biological_processbehavioral response to cocaine
M0048156molecular_functiontau protein binding
M0048168biological_processregulation of neuronal synaptic plasticity
M0048169biological_processregulation of long-term neuronal synaptic plasticity
M0048471cellular_componentperinuclear region of cytoplasm
M0048487molecular_functionbeta-tubulin binding
M0048488biological_processsynaptic vesicle endocytosis
M0048489biological_processsynaptic vesicle transport
M0050729biological_processpositive regulation of inflammatory response
M0050806biological_processpositive regulation of synaptic transmission
M0050808biological_processsynapse organization
M0050812biological_processregulation of acyl-CoA biosynthetic process
M0051219molecular_functionphosphoprotein binding
M0051259biological_processprotein complex oligomerization
M0051262biological_processprotein tetramerization
M0051281biological_processpositive regulation of release of sequestered calcium ion into cytosol
M0051402biological_processneuron apoptotic process
M0051583biological_processdopamine uptake involved in synaptic transmission
M0051585biological_processnegative regulation of dopamine uptake involved in synaptic transmission
M0051612biological_processnegative regulation of serotonin uptake
M0051621biological_processregulation of norepinephrine uptake
M0051622biological_processnegative regulation of norepinephrine uptake
M0055074biological_processcalcium ion homeostasis
M0060079biological_processexcitatory postsynaptic potential
M0060090molecular_functionmolecular adaptor activity
M0060291biological_processlong-term synaptic potentiation
M0060732biological_processpositive regulation of inositol phosphate biosynthetic process
M0060961molecular_functionphospholipase D inhibitor activity
M0061024biological_processmembrane organization
M0070495biological_processnegative regulation of thrombin-activated receptor signaling pathway
M0070507biological_processregulation of microtubule cytoskeleton organization
M0070555biological_processresponse to interleukin-1
M0070840molecular_functiondynein complex binding
M0071280biological_processcellular response to copper ion
M0071872biological_processcellular response to epinephrine stimulus
M0097435biological_processsupramolecular fiber organization
M0098793cellular_componentpresynapse
M0098794cellular_componentpostsynapse
M0099512cellular_componentsupramolecular fiber
M0140311molecular_functionprotein sequestering activity
M0141108molecular_functiontransporter regulator activity
M1902957biological_processnegative regulation of mitochondrial electron transport, NADH to ubiquinone
M1903136molecular_functioncuprous ion binding
M1903285biological_processpositive regulation of hydrogen peroxide catabolic process
M1903421biological_processregulation of synaptic vesicle recycling
M1903426biological_processregulation of reactive oxygen species biosynthetic process
M1904307biological_processresponse to desipramine
M1904377biological_processpositive regulation of protein localization to cell periphery
M1904715biological_processnegative regulation of chaperone-mediated autophagy
M1905606biological_processregulation of presynapse assembly
M1990000biological_processamyloid fibril formation
M2000377biological_processregulation of reactive oxygen species metabolic process
N0000122biological_processnegative regulation of transcription by RNA polymerase II
N0000149molecular_functionSNARE binding
N0000287molecular_functionmagnesium ion binding
N0000976molecular_functiontranscription cis-regulatory region binding
N0001774biological_processmicroglial cell activation
N0001921biological_processpositive regulation of receptor recycling
N0001956biological_processpositive regulation of neurotransmitter secretion
N0001963biological_processsynaptic transmission, dopaminergic
N0003779molecular_functionactin binding
N0004857molecular_functionenzyme inhibitor activity
N0004860molecular_functionprotein kinase inhibitor activity
N0004869molecular_functioncysteine-type endopeptidase inhibitor activity
N0005504molecular_functionfatty acid binding
N0005507molecular_functioncopper ion binding
N0005509molecular_functioncalcium ion binding
N0005515molecular_functionprotein binding
N0005543molecular_functionphospholipid binding
N0005576cellular_componentextracellular region
N0005615cellular_componentextracellular space
N0005634cellular_componentnucleus
N0005640cellular_componentnuclear outer membrane
N0005737cellular_componentcytoplasm
N0005739cellular_componentmitochondrion
N0005741cellular_componentmitochondrial outer membrane
N0005743cellular_componentmitochondrial inner membrane
N0005759cellular_componentmitochondrial matrix
N0005764cellular_componentlysosome
N0005829cellular_componentcytosol
N0005840cellular_componentribosome
N0005856cellular_componentcytoskeleton
N0005886cellular_componentplasma membrane
N0005938cellular_componentcell cortex
N0006631biological_processfatty acid metabolic process
N0006638biological_processneutral lipid metabolic process
N0006644biological_processphospholipid metabolic process
N0006749biological_processglutathione metabolic process
N0007006biological_processmitochondrial membrane organization
N0007268biological_processchemical synaptic transmission
N0007269biological_processneurotransmitter secretion
N0008017molecular_functionmicrotubule binding
N0008021cellular_componentsynaptic vesicle
N0008047molecular_functionenzyme activator activity
N0008198molecular_functionferrous iron binding
N0008270molecular_functionzinc ion binding
N0008289molecular_functionlipid binding
N0008344biological_processadult locomotory behavior
N0009410biological_processresponse to xenobiotic stimulus
N0010040biological_processresponse to iron(II) ion
N0010642biological_processnegative regulation of platelet-derived growth factor receptor signaling pathway
N0014048biological_processregulation of glutamate secretion
N0014059biological_processregulation of dopamine secretion
N0015629cellular_componentactin cytoskeleton
N0016020cellular_componentmembrane
N0016079biological_processsynaptic vesicle exocytosis
N0016082biological_processsynaptic vesicle priming
N0016234cellular_componentinclusion body
N0016491molecular_functionoxidoreductase activity
N0019894molecular_functionkinesin binding
N0019899molecular_functionenzyme binding
N0019904molecular_functionprotein domain specific binding
N0030424cellular_componentaxon
N0030426cellular_componentgrowth cone
N0030544molecular_functionHsp70 protein binding
N0030659cellular_componentcytoplasmic vesicle membrane
N0030672cellular_componentsynaptic vesicle membrane
N0031092cellular_componentplatelet alpha granule membrane
N0031115biological_processnegative regulation of microtubule polymerization
N0031623biological_processreceptor internalization
N0031648biological_processprotein destabilization
N0032026biological_processresponse to magnesium ion
N0032496biological_processresponse to lipopolysaccharide
N0032991cellular_componentprotein-containing complex
N0034341biological_processresponse to type II interferon
N0034599biological_processcellular response to oxidative stress
N0035493biological_processSNARE complex assembly
N0035543biological_processpositive regulation of SNARE complex assembly
N0040012biological_processregulation of locomotion
N0042220biological_processresponse to cocaine
N0042393molecular_functionhistone binding
N0042416biological_processdopamine biosynthetic process
N0042417biological_processdopamine metabolic process
N0042775biological_processmitochondrial ATP synthesis coupled electron transport
N0042802molecular_functionidentical protein binding
N0042995cellular_componentcell projection
N0043014molecular_functionalpha-tubulin binding
N0043025cellular_componentneuronal cell body
N0043030biological_processregulation of macrophage activation
N0043065biological_processpositive regulation of apoptotic process
N0043066biological_processnegative regulation of apoptotic process
N0043195cellular_componentterminal bouton
N0043274molecular_functionphospholipase binding
N0043524biological_processnegative regulation of neuron apoptotic process
N0043679cellular_componentaxon terminus
N0044344biological_processcellular response to fibroblast growth factor stimulus
N0045202cellular_componentsynapse
N0045807biological_processpositive regulation of endocytosis
N0045920biological_processnegative regulation of exocytosis
N0045921biological_processpositive regulation of exocytosis
N0045963biological_processnegative regulation of dopamine metabolic process
N0046872molecular_functionmetal ion binding
N0046928biological_processregulation of neurotransmitter secretion
N0048148biological_processbehavioral response to cocaine
N0048156molecular_functiontau protein binding
N0048168biological_processregulation of neuronal synaptic plasticity
N0048169biological_processregulation of long-term neuronal synaptic plasticity
N0048471cellular_componentperinuclear region of cytoplasm
N0048487molecular_functionbeta-tubulin binding
N0048488biological_processsynaptic vesicle endocytosis
N0048489biological_processsynaptic vesicle transport
N0050729biological_processpositive regulation of inflammatory response
N0050806biological_processpositive regulation of synaptic transmission
N0050808biological_processsynapse organization
N0050812biological_processregulation of acyl-CoA biosynthetic process
N0051219molecular_functionphosphoprotein binding
N0051259biological_processprotein complex oligomerization
N0051262biological_processprotein tetramerization
N0051281biological_processpositive regulation of release of sequestered calcium ion into cytosol
N0051402biological_processneuron apoptotic process
N0051583biological_processdopamine uptake involved in synaptic transmission
N0051585biological_processnegative regulation of dopamine uptake involved in synaptic transmission
N0051612biological_processnegative regulation of serotonin uptake
N0051621biological_processregulation of norepinephrine uptake
N0051622biological_processnegative regulation of norepinephrine uptake
N0055074biological_processcalcium ion homeostasis
N0060079biological_processexcitatory postsynaptic potential
N0060090molecular_functionmolecular adaptor activity
N0060291biological_processlong-term synaptic potentiation
N0060732biological_processpositive regulation of inositol phosphate biosynthetic process
N0060961molecular_functionphospholipase D inhibitor activity
N0061024biological_processmembrane organization
N0070495biological_processnegative regulation of thrombin-activated receptor signaling pathway
N0070507biological_processregulation of microtubule cytoskeleton organization
N0070555biological_processresponse to interleukin-1
N0070840molecular_functiondynein complex binding
N0071280biological_processcellular response to copper ion
N0071872biological_processcellular response to epinephrine stimulus
N0097435biological_processsupramolecular fiber organization
N0098793cellular_componentpresynapse
N0098794cellular_componentpostsynapse
N0099512cellular_componentsupramolecular fiber
N0140311molecular_functionprotein sequestering activity
N0141108molecular_functiontransporter regulator activity
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N1903136molecular_functioncuprous ion binding
N1903285biological_processpositive regulation of hydrogen peroxide catabolic process
N1903421biological_processregulation of synaptic vesicle recycling
N1903426biological_processregulation of reactive oxygen species biosynthetic process
N1904307biological_processresponse to desipramine
N1904377biological_processpositive regulation of protein localization to cell periphery
N1904715biological_processnegative regulation of chaperone-mediated autophagy
N1905606biological_processregulation of presynapse assembly
N1990000biological_processamyloid fibril formation
N2000377biological_processregulation of reactive oxygen species metabolic process
O0000122biological_processnegative regulation of transcription by RNA polymerase II
O0000149molecular_functionSNARE binding
O0000287molecular_functionmagnesium ion binding
O0000976molecular_functiontranscription cis-regulatory region binding
O0001774biological_processmicroglial cell activation
O0001921biological_processpositive regulation of receptor recycling
O0001956biological_processpositive regulation of neurotransmitter secretion
O0001963biological_processsynaptic transmission, dopaminergic
O0003779molecular_functionactin binding
O0004857molecular_functionenzyme inhibitor activity
O0004860molecular_functionprotein kinase inhibitor activity
O0004869molecular_functioncysteine-type endopeptidase inhibitor activity
O0005504molecular_functionfatty acid binding
O0005507molecular_functioncopper ion binding
O0005509molecular_functioncalcium ion binding
O0005515molecular_functionprotein binding
O0005543molecular_functionphospholipid binding
O0005576cellular_componentextracellular region
O0005615cellular_componentextracellular space
O0005634cellular_componentnucleus
O0005640cellular_componentnuclear outer membrane
O0005737cellular_componentcytoplasm
O0005739cellular_componentmitochondrion
O0005741cellular_componentmitochondrial outer membrane
O0005743cellular_componentmitochondrial inner membrane
O0005759cellular_componentmitochondrial matrix
O0005764cellular_componentlysosome
O0005829cellular_componentcytosol
O0005840cellular_componentribosome
O0005856cellular_componentcytoskeleton
O0005886cellular_componentplasma membrane
O0005938cellular_componentcell cortex
O0006631biological_processfatty acid metabolic process
O0006638biological_processneutral lipid metabolic process
O0006644biological_processphospholipid metabolic process
O0006749biological_processglutathione metabolic process
O0007006biological_processmitochondrial membrane organization
O0007268biological_processchemical synaptic transmission
O0007269biological_processneurotransmitter secretion
O0008017molecular_functionmicrotubule binding
O0008021cellular_componentsynaptic vesicle
O0008047molecular_functionenzyme activator activity
O0008198molecular_functionferrous iron binding
O0008270molecular_functionzinc ion binding
O0008289molecular_functionlipid binding
O0008344biological_processadult locomotory behavior
O0009410biological_processresponse to xenobiotic stimulus
O0010040biological_processresponse to iron(II) ion
O0010642biological_processnegative regulation of platelet-derived growth factor receptor signaling pathway
O0014048biological_processregulation of glutamate secretion
O0014059biological_processregulation of dopamine secretion
O0015629cellular_componentactin cytoskeleton
O0016020cellular_componentmembrane
O0016079biological_processsynaptic vesicle exocytosis
O0016082biological_processsynaptic vesicle priming
O0016234cellular_componentinclusion body
O0016491molecular_functionoxidoreductase activity
O0019894molecular_functionkinesin binding
O0019899molecular_functionenzyme binding
O0019904molecular_functionprotein domain specific binding
O0030424cellular_componentaxon
O0030426cellular_componentgrowth cone
O0030544molecular_functionHsp70 protein binding
O0030659cellular_componentcytoplasmic vesicle membrane
O0030672cellular_componentsynaptic vesicle membrane
O0031092cellular_componentplatelet alpha granule membrane
O0031115biological_processnegative regulation of microtubule polymerization
O0031623biological_processreceptor internalization
O0031648biological_processprotein destabilization
O0032026biological_processresponse to magnesium ion
O0032496biological_processresponse to lipopolysaccharide
O0032991cellular_componentprotein-containing complex
O0034341biological_processresponse to type II interferon
O0034599biological_processcellular response to oxidative stress
O0035493biological_processSNARE complex assembly
O0035543biological_processpositive regulation of SNARE complex assembly
O0040012biological_processregulation of locomotion
O0042220biological_processresponse to cocaine
O0042393molecular_functionhistone binding
O0042416biological_processdopamine biosynthetic process
O0042417biological_processdopamine metabolic process
O0042775biological_processmitochondrial ATP synthesis coupled electron transport
O0042802molecular_functionidentical protein binding
O0042995cellular_componentcell projection
O0043014molecular_functionalpha-tubulin binding
O0043025cellular_componentneuronal cell body
O0043030biological_processregulation of macrophage activation
O0043065biological_processpositive regulation of apoptotic process
O0043066biological_processnegative regulation of apoptotic process
O0043195cellular_componentterminal bouton
O0043274molecular_functionphospholipase binding
O0043524biological_processnegative regulation of neuron apoptotic process
O0043679cellular_componentaxon terminus
O0044344biological_processcellular response to fibroblast growth factor stimulus
O0045202cellular_componentsynapse
O0045807biological_processpositive regulation of endocytosis
O0045920biological_processnegative regulation of exocytosis
O0045921biological_processpositive regulation of exocytosis
O0045963biological_processnegative regulation of dopamine metabolic process
O0046872molecular_functionmetal ion binding
O0046928biological_processregulation of neurotransmitter secretion
O0048148biological_processbehavioral response to cocaine
O0048156molecular_functiontau protein binding
O0048168biological_processregulation of neuronal synaptic plasticity
O0048169biological_processregulation of long-term neuronal synaptic plasticity
O0048471cellular_componentperinuclear region of cytoplasm
O0048487molecular_functionbeta-tubulin binding
O0048488biological_processsynaptic vesicle endocytosis
O0048489biological_processsynaptic vesicle transport
O0050729biological_processpositive regulation of inflammatory response
O0050806biological_processpositive regulation of synaptic transmission
O0050808biological_processsynapse organization
O0050812biological_processregulation of acyl-CoA biosynthetic process
O0051219molecular_functionphosphoprotein binding
O0051259biological_processprotein complex oligomerization
O0051262biological_processprotein tetramerization
O0051281biological_processpositive regulation of release of sequestered calcium ion into cytosol
O0051402biological_processneuron apoptotic process
O0051583biological_processdopamine uptake involved in synaptic transmission
O0051585biological_processnegative regulation of dopamine uptake involved in synaptic transmission
O0051612biological_processnegative regulation of serotonin uptake
O0051621biological_processregulation of norepinephrine uptake
O0051622biological_processnegative regulation of norepinephrine uptake
O0055074biological_processcalcium ion homeostasis
O0060079biological_processexcitatory postsynaptic potential
O0060090molecular_functionmolecular adaptor activity
O0060291biological_processlong-term synaptic potentiation
O0060732biological_processpositive regulation of inositol phosphate biosynthetic process
O0060961molecular_functionphospholipase D inhibitor activity
O0061024biological_processmembrane organization
O0070495biological_processnegative regulation of thrombin-activated receptor signaling pathway
O0070507biological_processregulation of microtubule cytoskeleton organization
O0070555biological_processresponse to interleukin-1
O0070840molecular_functiondynein complex binding
O0071280biological_processcellular response to copper ion
O0071872biological_processcellular response to epinephrine stimulus
O0097435biological_processsupramolecular fiber organization
O0098793cellular_componentpresynapse
O0098794cellular_componentpostsynapse
O0099512cellular_componentsupramolecular fiber
O0140311molecular_functionprotein sequestering activity
O0141108molecular_functiontransporter regulator activity
O1902957biological_processnegative regulation of mitochondrial electron transport, NADH to ubiquinone
O1903136molecular_functioncuprous ion binding
O1903285biological_processpositive regulation of hydrogen peroxide catabolic process
O1903421biological_processregulation of synaptic vesicle recycling
O1903426biological_processregulation of reactive oxygen species biosynthetic process
O1904307biological_processresponse to desipramine
O1904377biological_processpositive regulation of protein localization to cell periphery
O1904715biological_processnegative regulation of chaperone-mediated autophagy
O1905606biological_processregulation of presynapse assembly
O1990000biological_processamyloid fibril formation
O2000377biological_processregulation of reactive oxygen species metabolic process
P0000122biological_processnegative regulation of transcription by RNA polymerase II
P0000149molecular_functionSNARE binding
P0000287molecular_functionmagnesium ion binding
P0000976molecular_functiontranscription cis-regulatory region binding
P0001774biological_processmicroglial cell activation
P0001921biological_processpositive regulation of receptor recycling
P0001956biological_processpositive regulation of neurotransmitter secretion
P0001963biological_processsynaptic transmission, dopaminergic
P0003779molecular_functionactin binding
P0004857molecular_functionenzyme inhibitor activity
P0004860molecular_functionprotein kinase inhibitor activity
P0004869molecular_functioncysteine-type endopeptidase inhibitor activity
P0005504molecular_functionfatty acid binding
P0005507molecular_functioncopper ion binding
P0005509molecular_functioncalcium ion binding
P0005515molecular_functionprotein binding
P0005543molecular_functionphospholipid binding
P0005576cellular_componentextracellular region
P0005615cellular_componentextracellular space
P0005634cellular_componentnucleus
P0005640cellular_componentnuclear outer membrane
P0005737cellular_componentcytoplasm
P0005739cellular_componentmitochondrion
P0005741cellular_componentmitochondrial outer membrane
P0005743cellular_componentmitochondrial inner membrane
P0005759cellular_componentmitochondrial matrix
P0005764cellular_componentlysosome
P0005829cellular_componentcytosol
P0005840cellular_componentribosome
P0005856cellular_componentcytoskeleton
P0005886cellular_componentplasma membrane
P0005938cellular_componentcell cortex
P0006631biological_processfatty acid metabolic process
P0006638biological_processneutral lipid metabolic process
P0006644biological_processphospholipid metabolic process
P0006749biological_processglutathione metabolic process
P0007006biological_processmitochondrial membrane organization
P0007268biological_processchemical synaptic transmission
P0007269biological_processneurotransmitter secretion
P0008017molecular_functionmicrotubule binding
P0008021cellular_componentsynaptic vesicle
P0008047molecular_functionenzyme activator activity
P0008198molecular_functionferrous iron binding
P0008270molecular_functionzinc ion binding
P0008289molecular_functionlipid binding
P0008344biological_processadult locomotory behavior
P0009410biological_processresponse to xenobiotic stimulus
P0010040biological_processresponse to iron(II) ion
P0010642biological_processnegative regulation of platelet-derived growth factor receptor signaling pathway
P0014048biological_processregulation of glutamate secretion
P0014059biological_processregulation of dopamine secretion
P0015629cellular_componentactin cytoskeleton
P0016020cellular_componentmembrane
P0016079biological_processsynaptic vesicle exocytosis
P0016082biological_processsynaptic vesicle priming
P0016234cellular_componentinclusion body
P0016491molecular_functionoxidoreductase activity
P0019894molecular_functionkinesin binding
P0019899molecular_functionenzyme binding
P0019904molecular_functionprotein domain specific binding
P0030424cellular_componentaxon
P0030426cellular_componentgrowth cone
P0030544molecular_functionHsp70 protein binding
P0030659cellular_componentcytoplasmic vesicle membrane
P0030672cellular_componentsynaptic vesicle membrane
P0031092cellular_componentplatelet alpha granule membrane
P0031115biological_processnegative regulation of microtubule polymerization
P0031623biological_processreceptor internalization
P0031648biological_processprotein destabilization
P0032026biological_processresponse to magnesium ion
P0032496biological_processresponse to lipopolysaccharide
P0032991cellular_componentprotein-containing complex
P0034341biological_processresponse to type II interferon
P0034599biological_processcellular response to oxidative stress
P0035493biological_processSNARE complex assembly
P0035543biological_processpositive regulation of SNARE complex assembly
P0040012biological_processregulation of locomotion
P0042220biological_processresponse to cocaine
P0042393molecular_functionhistone binding
P0042416biological_processdopamine biosynthetic process
P0042417biological_processdopamine metabolic process
P0042775biological_processmitochondrial ATP synthesis coupled electron transport
P0042802molecular_functionidentical protein binding
P0042995cellular_componentcell projection
P0043014molecular_functionalpha-tubulin binding
P0043025cellular_componentneuronal cell body
P0043030biological_processregulation of macrophage activation
P0043065biological_processpositive regulation of apoptotic process
P0043066biological_processnegative regulation of apoptotic process
P0043195cellular_componentterminal bouton
P0043274molecular_functionphospholipase binding
P0043524biological_processnegative regulation of neuron apoptotic process
P0043679cellular_componentaxon terminus
P0044344biological_processcellular response to fibroblast growth factor stimulus
P0045202cellular_componentsynapse
P0045807biological_processpositive regulation of endocytosis
P0045920biological_processnegative regulation of exocytosis
P0045921biological_processpositive regulation of exocytosis
P0045963biological_processnegative regulation of dopamine metabolic process
P0046872molecular_functionmetal ion binding
P0046928biological_processregulation of neurotransmitter secretion
P0048148biological_processbehavioral response to cocaine
P0048156molecular_functiontau protein binding
P0048168biological_processregulation of neuronal synaptic plasticity
P0048169biological_processregulation of long-term neuronal synaptic plasticity
P0048471cellular_componentperinuclear region of cytoplasm
P0048487molecular_functionbeta-tubulin binding
P0048488biological_processsynaptic vesicle endocytosis
P0048489biological_processsynaptic vesicle transport
P0050729biological_processpositive regulation of inflammatory response
P0050806biological_processpositive regulation of synaptic transmission
P0050808biological_processsynapse organization
P0050812biological_processregulation of acyl-CoA biosynthetic process
P0051219molecular_functionphosphoprotein binding
P0051259biological_processprotein complex oligomerization
P0051262biological_processprotein tetramerization
P0051281biological_processpositive regulation of release of sequestered calcium ion into cytosol
P0051402biological_processneuron apoptotic process
P0051583biological_processdopamine uptake involved in synaptic transmission
P0051585biological_processnegative regulation of dopamine uptake involved in synaptic transmission
P0051612biological_processnegative regulation of serotonin uptake
P0051621biological_processregulation of norepinephrine uptake
P0051622biological_processnegative regulation of norepinephrine uptake
P0055074biological_processcalcium ion homeostasis
P0060079biological_processexcitatory postsynaptic potential
P0060090molecular_functionmolecular adaptor activity
P0060291biological_processlong-term synaptic potentiation
P0060732biological_processpositive regulation of inositol phosphate biosynthetic process
P0060961molecular_functionphospholipase D inhibitor activity
P0061024biological_processmembrane organization
P0070495biological_processnegative regulation of thrombin-activated receptor signaling pathway
P0070507biological_processregulation of microtubule cytoskeleton organization
P0070555biological_processresponse to interleukin-1
P0070840molecular_functiondynein complex binding
P0071280biological_processcellular response to copper ion
P0071872biological_processcellular response to epinephrine stimulus
P0097435biological_processsupramolecular fiber organization
P0098793cellular_componentpresynapse
P0098794cellular_componentpostsynapse
P0099512cellular_componentsupramolecular fiber
P0140311molecular_functionprotein sequestering activity
P0141108molecular_functiontransporter regulator activity
P1902957biological_processnegative regulation of mitochondrial electron transport, NADH to ubiquinone
P1903136molecular_functioncuprous ion binding
P1903285biological_processpositive regulation of hydrogen peroxide catabolic process
P1903421biological_processregulation of synaptic vesicle recycling
P1903426biological_processregulation of reactive oxygen species biosynthetic process
P1904307biological_processresponse to desipramine
P1904377biological_processpositive regulation of protein localization to cell periphery
P1904715biological_processnegative regulation of chaperone-mediated autophagy
P1905606biological_processregulation of presynapse assembly
P1990000biological_processamyloid fibril formation
P2000377biological_processregulation of reactive oxygen species metabolic process
Q0000122biological_processnegative regulation of transcription by RNA polymerase II
Q0000149molecular_functionSNARE binding
Q0000287molecular_functionmagnesium ion binding
Q0000976molecular_functiontranscription cis-regulatory region binding
Q0001774biological_processmicroglial cell activation
Q0001921biological_processpositive regulation of receptor recycling
Q0001956biological_processpositive regulation of neurotransmitter secretion
Q0001963biological_processsynaptic transmission, dopaminergic
Q0003779molecular_functionactin binding
Q0004857molecular_functionenzyme inhibitor activity
Q0004860molecular_functionprotein kinase inhibitor activity
Q0004869molecular_functioncysteine-type endopeptidase inhibitor activity
Q0005504molecular_functionfatty acid binding
Q0005507molecular_functioncopper ion binding
Q0005509molecular_functioncalcium ion binding
Q0005515molecular_functionprotein binding
Q0005543molecular_functionphospholipid binding
Q0005576cellular_componentextracellular region
Q0005615cellular_componentextracellular space
Q0005634cellular_componentnucleus
Q0005640cellular_componentnuclear outer membrane
Q0005737cellular_componentcytoplasm
Q0005739cellular_componentmitochondrion
Q0005741cellular_componentmitochondrial outer membrane
Q0005743cellular_componentmitochondrial inner membrane
Q0005759cellular_componentmitochondrial matrix
Q0005764cellular_componentlysosome
Q0005829cellular_componentcytosol
Q0005840cellular_componentribosome
Q0005856cellular_componentcytoskeleton
Q0005886cellular_componentplasma membrane
Q0005938cellular_componentcell cortex
Q0006631biological_processfatty acid metabolic process
Q0006638biological_processneutral lipid metabolic process
Q0006644biological_processphospholipid metabolic process
Q0006749biological_processglutathione metabolic process
Q0007006biological_processmitochondrial membrane organization
Q0007268biological_processchemical synaptic transmission
Q0007269biological_processneurotransmitter secretion
Q0008017molecular_functionmicrotubule binding
Q0008021cellular_componentsynaptic vesicle
Q0008047molecular_functionenzyme activator activity
Q0008198molecular_functionferrous iron binding
Q0008270molecular_functionzinc ion binding
Q0008289molecular_functionlipid binding
Q0008344biological_processadult locomotory behavior
Q0009410biological_processresponse to xenobiotic stimulus
Q0010040biological_processresponse to iron(II) ion
Q0010642biological_processnegative regulation of platelet-derived growth factor receptor signaling pathway
Q0014048biological_processregulation of glutamate secretion
Q0014059biological_processregulation of dopamine secretion
Q0015629cellular_componentactin cytoskeleton
Q0016020cellular_componentmembrane
Q0016079biological_processsynaptic vesicle exocytosis
Q0016082biological_processsynaptic vesicle priming
Q0016234cellular_componentinclusion body
Q0016491molecular_functionoxidoreductase activity
Q0019894molecular_functionkinesin binding
Q0019899molecular_functionenzyme binding
Q0019904molecular_functionprotein domain specific binding
Q0030424cellular_componentaxon
Q0030426cellular_componentgrowth cone
Q0030544molecular_functionHsp70 protein binding
Q0030659cellular_componentcytoplasmic vesicle membrane
Q0030672cellular_componentsynaptic vesicle membrane
Q0031092cellular_componentplatelet alpha granule membrane
Q0031115biological_processnegative regulation of microtubule polymerization
Q0031623biological_processreceptor internalization
Q0031648biological_processprotein destabilization
Q0032026biological_processresponse to magnesium ion
Q0032496biological_processresponse to lipopolysaccharide
Q0032991cellular_componentprotein-containing complex
Q0034341biological_processresponse to type II interferon
Q0034599biological_processcellular response to oxidative stress
Q0035493biological_processSNARE complex assembly
Q0035543biological_processpositive regulation of SNARE complex assembly
Q0040012biological_processregulation of locomotion
Q0042220biological_processresponse to cocaine
Q0042393molecular_functionhistone binding
Q0042416biological_processdopamine biosynthetic process
Q0042417biological_processdopamine metabolic process
Q0042775biological_processmitochondrial ATP synthesis coupled electron transport
Q0042802molecular_functionidentical protein binding
Q0042995cellular_componentcell projection
Q0043014molecular_functionalpha-tubulin binding
Q0043025cellular_componentneuronal cell body
Q0043030biological_processregulation of macrophage activation
Q0043065biological_processpositive regulation of apoptotic process
Q0043066biological_processnegative regulation of apoptotic process
Q0043195cellular_componentterminal bouton
Q0043274molecular_functionphospholipase binding
Q0043524biological_processnegative regulation of neuron apoptotic process
Q0043679cellular_componentaxon terminus
Q0044344biological_processcellular response to fibroblast growth factor stimulus
Q0045202cellular_componentsynapse
Q0045807biological_processpositive regulation of endocytosis
Q0045920biological_processnegative regulation of exocytosis
Q0045921biological_processpositive regulation of exocytosis
Q0045963biological_processnegative regulation of dopamine metabolic process
Q0046872molecular_functionmetal ion binding
Q0046928biological_processregulation of neurotransmitter secretion
Q0048148biological_processbehavioral response to cocaine
Q0048156molecular_functiontau protein binding
Q0048168biological_processregulation of neuronal synaptic plasticity
Q0048169biological_processregulation of long-term neuronal synaptic plasticity
Q0048471cellular_componentperinuclear region of cytoplasm
Q0048487molecular_functionbeta-tubulin binding
Q0048488biological_processsynaptic vesicle endocytosis
Q0048489biological_processsynaptic vesicle transport
Q0050729biological_processpositive regulation of inflammatory response
Q0050806biological_processpositive regulation of synaptic transmission
Q0050808biological_processsynapse organization
Q0050812biological_processregulation of acyl-CoA biosynthetic process
Q0051219molecular_functionphosphoprotein binding
Q0051259biological_processprotein complex oligomerization
Q0051262biological_processprotein tetramerization
Q0051281biological_processpositive regulation of release of sequestered calcium ion into cytosol
Q0051402biological_processneuron apoptotic process
Q0051583biological_processdopamine uptake involved in synaptic transmission
Q0051585biological_processnegative regulation of dopamine uptake involved in synaptic transmission
Q0051612biological_processnegative regulation of serotonin uptake
Q0051621biological_processregulation of norepinephrine uptake
Q0051622biological_processnegative regulation of norepinephrine uptake
Q0055074biological_processcalcium ion homeostasis
Q0060079biological_processexcitatory postsynaptic potential
Q0060090molecular_functionmolecular adaptor activity
Q0060291biological_processlong-term synaptic potentiation
Q0060732biological_processpositive regulation of inositol phosphate biosynthetic process
Q0060961molecular_functionphospholipase D inhibitor activity
Q0061024biological_processmembrane organization
Q0070495biological_processnegative regulation of thrombin-activated receptor signaling pathway
Q0070507biological_processregulation of microtubule cytoskeleton organization
Q0070555biological_processresponse to interleukin-1
Q0070840molecular_functiondynein complex binding
Q0071280biological_processcellular response to copper ion
Q0071872biological_processcellular response to epinephrine stimulus
Q0097435biological_processsupramolecular fiber organization
Q0098793cellular_componentpresynapse
Q0098794cellular_componentpostsynapse
Q0099512cellular_componentsupramolecular fiber
Q0140311molecular_functionprotein sequestering activity
Q0141108molecular_functiontransporter regulator activity
Q1902957biological_processnegative regulation of mitochondrial electron transport, NADH to ubiquinone
Q1903136molecular_functioncuprous ion binding
Q1903285biological_processpositive regulation of hydrogen peroxide catabolic process
Q1903421biological_processregulation of synaptic vesicle recycling
Q1903426biological_processregulation of reactive oxygen species biosynthetic process
Q1904307biological_processresponse to desipramine
Q1904377biological_processpositive regulation of protein localization to cell periphery
Q1904715biological_processnegative regulation of chaperone-mediated autophagy
Q1905606biological_processregulation of presynapse assembly
Q1990000biological_processamyloid fibril formation
Q2000377biological_processregulation of reactive oxygen species metabolic process
R0000122biological_processnegative regulation of transcription by RNA polymerase II
R0000149molecular_functionSNARE binding
R0000287molecular_functionmagnesium ion binding
R0000976molecular_functiontranscription cis-regulatory region binding
R0001774biological_processmicroglial cell activation
R0001921biological_processpositive regulation of receptor recycling
R0001956biological_processpositive regulation of neurotransmitter secretion
R0001963biological_processsynaptic transmission, dopaminergic
R0003779molecular_functionactin binding
R0004857molecular_functionenzyme inhibitor activity
R0004860molecular_functionprotein kinase inhibitor activity
R0004869molecular_functioncysteine-type endopeptidase inhibitor activity
R0005504molecular_functionfatty acid binding
R0005507molecular_functioncopper ion binding
R0005509molecular_functioncalcium ion binding
R0005515molecular_functionprotein binding
R0005543molecular_functionphospholipid binding
R0005576cellular_componentextracellular region
R0005615cellular_componentextracellular space
R0005634cellular_componentnucleus
R0005640cellular_componentnuclear outer membrane
R0005737cellular_componentcytoplasm
R0005739cellular_componentmitochondrion
R0005741cellular_componentmitochondrial outer membrane
R0005743cellular_componentmitochondrial inner membrane
R0005759cellular_componentmitochondrial matrix
R0005764cellular_componentlysosome
R0005829cellular_componentcytosol
R0005840cellular_componentribosome
R0005856cellular_componentcytoskeleton
R0005886cellular_componentplasma membrane
R0005938cellular_componentcell cortex
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R0006638biological_processneutral lipid metabolic process
R0006644biological_processphospholipid metabolic process
R0006749biological_processglutathione metabolic process
R0007006biological_processmitochondrial membrane organization
R0007268biological_processchemical synaptic transmission
R0007269biological_processneurotransmitter secretion
R0008017molecular_functionmicrotubule binding
R0008021cellular_componentsynaptic vesicle
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R0008198molecular_functionferrous iron binding
R0008270molecular_functionzinc ion binding
R0008289molecular_functionlipid binding
R0008344biological_processadult locomotory behavior
R0009410biological_processresponse to xenobiotic stimulus
R0010040biological_processresponse to iron(II) ion
R0010642biological_processnegative regulation of platelet-derived growth factor receptor signaling pathway
R0014048biological_processregulation of glutamate secretion
R0014059biological_processregulation of dopamine secretion
R0015629cellular_componentactin cytoskeleton
R0016020cellular_componentmembrane
R0016079biological_processsynaptic vesicle exocytosis
R0016082biological_processsynaptic vesicle priming
R0016234cellular_componentinclusion body
R0016491molecular_functionoxidoreductase activity
R0019894molecular_functionkinesin binding
R0019899molecular_functionenzyme binding
R0019904molecular_functionprotein domain specific binding
R0030424cellular_componentaxon
R0030426cellular_componentgrowth cone
R0030544molecular_functionHsp70 protein binding
R0030659cellular_componentcytoplasmic vesicle membrane
R0030672cellular_componentsynaptic vesicle membrane
R0031092cellular_componentplatelet alpha granule membrane
R0031115biological_processnegative regulation of microtubule polymerization
R0031623biological_processreceptor internalization
R0031648biological_processprotein destabilization
R0032026biological_processresponse to magnesium ion
R0032496biological_processresponse to lipopolysaccharide
R0032991cellular_componentprotein-containing complex
R0034341biological_processresponse to type II interferon
R0034599biological_processcellular response to oxidative stress
R0035493biological_processSNARE complex assembly
R0035543biological_processpositive regulation of SNARE complex assembly
R0040012biological_processregulation of locomotion
R0042220biological_processresponse to cocaine
R0042393molecular_functionhistone binding
R0042416biological_processdopamine biosynthetic process
R0042417biological_processdopamine metabolic process
R0042775biological_processmitochondrial ATP synthesis coupled electron transport
R0042802molecular_functionidentical protein binding
R0042995cellular_componentcell projection
R0043014molecular_functionalpha-tubulin binding
R0043025cellular_componentneuronal cell body
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Z0005739cellular_componentmitochondrion
Z0005741cellular_componentmitochondrial outer membrane
Z0005743cellular_componentmitochondrial inner membrane
Z0005759cellular_componentmitochondrial matrix
Z0005764cellular_componentlysosome
Z0005829cellular_componentcytosol
Z0005840cellular_componentribosome
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Z0005886cellular_componentplasma membrane
Z0005938cellular_componentcell cortex
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Z0006638biological_processneutral lipid metabolic process
Z0006644biological_processphospholipid metabolic process
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Z0007268biological_processchemical synaptic transmission
Z0007269biological_processneurotransmitter secretion
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Z0008021cellular_componentsynaptic vesicle
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Z0008270molecular_functionzinc ion binding
Z0008289molecular_functionlipid binding
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Z0009410biological_processresponse to xenobiotic stimulus
Z0010040biological_processresponse to iron(II) ion
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Z0014048biological_processregulation of glutamate secretion
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Z0030426cellular_componentgrowth cone
Z0030544molecular_functionHsp70 protein binding
Z0030659cellular_componentcytoplasmic vesicle membrane
Z0030672cellular_componentsynaptic vesicle membrane
Z0031092cellular_componentplatelet alpha granule membrane
Z0031115biological_processnegative regulation of microtubule polymerization
Z0031623biological_processreceptor internalization
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Z0043195cellular_componentterminal bouton
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Z0048156molecular_functiontau protein binding
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Z0051612biological_processnegative regulation of serotonin uptake
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Z0097435biological_processsupramolecular fiber organization
Z0098793cellular_componentpresynapse
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Z0099512cellular_componentsupramolecular fiber
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Z1990000biological_processamyloid fibril formation
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a0000122biological_processnegative regulation of transcription by RNA polymerase II
a0000149molecular_functionSNARE binding
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a0000976molecular_functiontranscription cis-regulatory region binding
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a0001956biological_processpositive regulation of neurotransmitter secretion
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a0004857molecular_functionenzyme inhibitor activity
a0004860molecular_functionprotein kinase inhibitor activity
a0004869molecular_functioncysteine-type endopeptidase inhibitor activity
a0005504molecular_functionfatty acid binding
a0005507molecular_functioncopper ion binding
a0005509molecular_functioncalcium ion binding
a0005515molecular_functionprotein binding
a0005543molecular_functionphospholipid binding
a0005576cellular_componentextracellular region
a0005615cellular_componentextracellular space
a0005634cellular_componentnucleus
a0005640cellular_componentnuclear outer membrane
a0005737cellular_componentcytoplasm
a0005739cellular_componentmitochondrion
a0005741cellular_componentmitochondrial outer membrane
a0005743cellular_componentmitochondrial inner membrane
a0005759cellular_componentmitochondrial matrix
a0005764cellular_componentlysosome
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a0007269biological_processneurotransmitter secretion
a0008017molecular_functionmicrotubule binding
a0008021cellular_componentsynaptic vesicle
a0008047molecular_functionenzyme activator activity
a0008198molecular_functionferrous iron binding
a0008270molecular_functionzinc ion binding
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a0008344biological_processadult locomotory behavior
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a0010642biological_processnegative regulation of platelet-derived growth factor receptor signaling pathway
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a0031623biological_processreceptor internalization
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a0032496biological_processresponse to lipopolysaccharide
a0032991cellular_componentprotein-containing complex
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a0042393molecular_functionhistone binding
a0042416biological_processdopamine biosynthetic process
a0042417biological_processdopamine metabolic process
a0042775biological_processmitochondrial ATP synthesis coupled electron transport
a0042802molecular_functionidentical protein binding
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a0043195cellular_componentterminal bouton
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a0044344biological_processcellular response to fibroblast growth factor stimulus
a0045202cellular_componentsynapse
a0045807biological_processpositive regulation of endocytosis
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a0045921biological_processpositive regulation of exocytosis
a0045963biological_processnegative regulation of dopamine metabolic process
a0046872molecular_functionmetal ion binding
a0046928biological_processregulation of neurotransmitter secretion
a0048148biological_processbehavioral response to cocaine
a0048156molecular_functiontau protein binding
a0048168biological_processregulation of neuronal synaptic plasticity
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a0048471cellular_componentperinuclear region of cytoplasm
a0048487molecular_functionbeta-tubulin binding
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a0050808biological_processsynapse organization
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a0051219molecular_functionphosphoprotein binding
a0051259biological_processprotein complex oligomerization
a0051262biological_processprotein tetramerization
a0051281biological_processpositive regulation of release of sequestered calcium ion into cytosol
a0051402biological_processneuron apoptotic process
a0051583biological_processdopamine uptake involved in synaptic transmission
a0051585biological_processnegative regulation of dopamine uptake involved in synaptic transmission
a0051612biological_processnegative regulation of serotonin uptake
a0051621biological_processregulation of norepinephrine uptake
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a0055074biological_processcalcium ion homeostasis
a0060079biological_processexcitatory postsynaptic potential
a0060090molecular_functionmolecular adaptor activity
a0060291biological_processlong-term synaptic potentiation
a0060732biological_processpositive regulation of inositol phosphate biosynthetic process
a0060961molecular_functionphospholipase D inhibitor activity
a0061024biological_processmembrane organization
a0070495biological_processnegative regulation of thrombin-activated receptor signaling pathway
a0070507biological_processregulation of microtubule cytoskeleton organization
a0070555biological_processresponse to interleukin-1
a0070840molecular_functiondynein complex binding
a0071280biological_processcellular response to copper ion
a0071872biological_processcellular response to epinephrine stimulus
a0097435biological_processsupramolecular fiber organization
a0098793cellular_componentpresynapse
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a0099512cellular_componentsupramolecular fiber
a0140311molecular_functionprotein sequestering activity
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a1904307biological_processresponse to desipramine
a1904377biological_processpositive regulation of protein localization to cell periphery
a1904715biological_processnegative regulation of chaperone-mediated autophagy
a1905606biological_processregulation of presynapse assembly
a1990000biological_processamyloid fibril formation
a2000377biological_processregulation of reactive oxygen species metabolic process
b0000122biological_processnegative regulation of transcription by RNA polymerase II
b0000149molecular_functionSNARE binding
b0000287molecular_functionmagnesium ion binding
b0000976molecular_functiontranscription cis-regulatory region binding
b0001774biological_processmicroglial cell activation
b0001921biological_processpositive regulation of receptor recycling
b0001956biological_processpositive regulation of neurotransmitter secretion
b0001963biological_processsynaptic transmission, dopaminergic
b0003779molecular_functionactin binding
b0004857molecular_functionenzyme inhibitor activity
b0004860molecular_functionprotein kinase inhibitor activity
b0004869molecular_functioncysteine-type endopeptidase inhibitor activity
b0005504molecular_functionfatty acid binding
b0005507molecular_functioncopper ion binding
b0005509molecular_functioncalcium ion binding
b0005515molecular_functionprotein binding
b0005543molecular_functionphospholipid binding
b0005576cellular_componentextracellular region
b0005615cellular_componentextracellular space
b0005634cellular_componentnucleus
b0005640cellular_componentnuclear outer membrane
b0005737cellular_componentcytoplasm
b0005739cellular_componentmitochondrion
b0005741cellular_componentmitochondrial outer membrane
b0005743cellular_componentmitochondrial inner membrane
b0005759cellular_componentmitochondrial matrix
b0005764cellular_componentlysosome
b0005829cellular_componentcytosol
b0005840cellular_componentribosome
b0005856cellular_componentcytoskeleton
b0005886cellular_componentplasma membrane
b0005938cellular_componentcell cortex
b0006631biological_processfatty acid metabolic process
b0006638biological_processneutral lipid metabolic process
b0006644biological_processphospholipid metabolic process
b0006749biological_processglutathione metabolic process
b0007006biological_processmitochondrial membrane organization
b0007268biological_processchemical synaptic transmission
b0007269biological_processneurotransmitter secretion
b0008017molecular_functionmicrotubule binding
b0008021cellular_componentsynaptic vesicle
b0008047molecular_functionenzyme activator activity
b0008198molecular_functionferrous iron binding
b0008270molecular_functionzinc ion binding
b0008289molecular_functionlipid binding
b0008344biological_processadult locomotory behavior
b0009410biological_processresponse to xenobiotic stimulus
b0010040biological_processresponse to iron(II) ion
b0010642biological_processnegative regulation of platelet-derived growth factor receptor signaling pathway
b0014048biological_processregulation of glutamate secretion
b0014059biological_processregulation of dopamine secretion
b0015629cellular_componentactin cytoskeleton
b0016020cellular_componentmembrane
b0016079biological_processsynaptic vesicle exocytosis
b0016082biological_processsynaptic vesicle priming
b0016234cellular_componentinclusion body
b0016491molecular_functionoxidoreductase activity
b0019894molecular_functionkinesin binding
b0019899molecular_functionenzyme binding
b0019904molecular_functionprotein domain specific binding
b0030424cellular_componentaxon
b0030426cellular_componentgrowth cone
b0030544molecular_functionHsp70 protein binding
b0030659cellular_componentcytoplasmic vesicle membrane
b0030672cellular_componentsynaptic vesicle membrane
b0031092cellular_componentplatelet alpha granule membrane
b0031115biological_processnegative regulation of microtubule polymerization
b0031623biological_processreceptor internalization
b0031648biological_processprotein destabilization
b0032026biological_processresponse to magnesium ion
b0032496biological_processresponse to lipopolysaccharide
b0032991cellular_componentprotein-containing complex
b0034341biological_processresponse to type II interferon
b0034599biological_processcellular response to oxidative stress
b0035493biological_processSNARE complex assembly
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b0042393molecular_functionhistone binding
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b0042417biological_processdopamine metabolic process
b0042775biological_processmitochondrial ATP synthesis coupled electron transport
b0042802molecular_functionidentical protein binding
b0042995cellular_componentcell projection
b0043014molecular_functionalpha-tubulin binding
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b0043195cellular_componentterminal bouton
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b0043679cellular_componentaxon terminus
b0044344biological_processcellular response to fibroblast growth factor stimulus
b0045202cellular_componentsynapse
b0045807biological_processpositive regulation of endocytosis
b0045920biological_processnegative regulation of exocytosis
b0045921biological_processpositive regulation of exocytosis
b0045963biological_processnegative regulation of dopamine metabolic process
b0046872molecular_functionmetal ion binding
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b0048148biological_processbehavioral response to cocaine
b0048156molecular_functiontau protein binding
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b0048471cellular_componentperinuclear region of cytoplasm
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b0048488biological_processsynaptic vesicle endocytosis
b0048489biological_processsynaptic vesicle transport
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b0050806biological_processpositive regulation of synaptic transmission
b0050808biological_processsynapse organization
b0050812biological_processregulation of acyl-CoA biosynthetic process
b0051219molecular_functionphosphoprotein binding
b0051259biological_processprotein complex oligomerization
b0051262biological_processprotein tetramerization
b0051281biological_processpositive regulation of release of sequestered calcium ion into cytosol
b0051402biological_processneuron apoptotic process
b0051583biological_processdopamine uptake involved in synaptic transmission
b0051585biological_processnegative regulation of dopamine uptake involved in synaptic transmission
b0051612biological_processnegative regulation of serotonin uptake
b0051621biological_processregulation of norepinephrine uptake
b0051622biological_processnegative regulation of norepinephrine uptake
b0055074biological_processcalcium ion homeostasis
b0060079biological_processexcitatory postsynaptic potential
b0060090molecular_functionmolecular adaptor activity
b0060291biological_processlong-term synaptic potentiation
b0060732biological_processpositive regulation of inositol phosphate biosynthetic process
b0060961molecular_functionphospholipase D inhibitor activity
b0061024biological_processmembrane organization
b0070495biological_processnegative regulation of thrombin-activated receptor signaling pathway
b0070507biological_processregulation of microtubule cytoskeleton organization
b0070555biological_processresponse to interleukin-1
b0070840molecular_functiondynein complex binding
b0071280biological_processcellular response to copper ion
b0071872biological_processcellular response to epinephrine stimulus
b0097435biological_processsupramolecular fiber organization
b0098793cellular_componentpresynapse
b0098794cellular_componentpostsynapse
b0099512cellular_componentsupramolecular fiber
b0140311molecular_functionprotein sequestering activity
b0141108molecular_functiontransporter regulator activity
b1902957biological_processnegative regulation of mitochondrial electron transport, NADH to ubiquinone
b1903136molecular_functioncuprous ion binding
b1903285biological_processpositive regulation of hydrogen peroxide catabolic process
b1903421biological_processregulation of synaptic vesicle recycling
b1903426biological_processregulation of reactive oxygen species biosynthetic process
b1904307biological_processresponse to desipramine
b1904377biological_processpositive regulation of protein localization to cell periphery
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b1905606biological_processregulation of presynapse assembly
b1990000biological_processamyloid fibril formation
b2000377biological_processregulation of reactive oxygen species metabolic process
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues90
DetailsRepeat: {"description":"1"}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues180
DetailsRepeat: {"description":"2"}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues252
DetailsRepeat: {"description":"3; approximate"}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues180
DetailsRepeat: {"description":"4"}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues423
DetailsRegion: {"description":"4 X 11 AA tandem repeats of [EGS]-K-T-K-[EQ]-[GQ]-V-X(4)"}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues18
DetailsBinding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues18
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"10617630","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

238895

PDB entries from 2025-07-16

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