9C3C

Cryo-EM structure of native dystrophin-glycoprotein complex (DGC)

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005509	molecular_function	calcium ion binding
A	0016010	cellular_component	dystrophin-associated glycoprotein complex
A	0016020	cellular_component	membrane
B	0016010	cellular_component	dystrophin-associated glycoprotein complex
D	0005737	cellular_component	cytoplasm
D	0005886	cellular_component	plasma membrane
D	0007519	biological_process	skeletal muscle tissue development
D	0008270	molecular_function	zinc ion binding
D	0042383	cellular_component	sarcolemma
D	0046872	molecular_function	metal ion binding
D	0048666	biological_process	neuron development
D	0055001	biological_process	muscle cell development
D	0090257	biological_process	regulation of muscle system process
D	0098794	cellular_component	postsynapse
D	0099536	biological_process	synaptic signaling
V	0008270	molecular_function	zinc ion binding
a	0005509	molecular_function	calcium ion binding
a	0005856	cellular_component	cytoskeleton
a	0016010	cellular_component	dystrophin-associated glycoprotein complex
a	0016012	cellular_component	sarcoglycan complex
a	0016020	cellular_component	membrane
a	0042383	cellular_component	sarcolemma
b	0005856	cellular_component	cytoskeleton
b	0005886	cellular_component	plasma membrane
b	0007517	biological_process	muscle organ development
b	0016012	cellular_component	sarcoglycan complex
b	0016020	cellular_component	membrane
b	0042383	cellular_component	sarcolemma
d	0016012	cellular_component	sarcoglycan complex
d	0016020	cellular_component	membrane
g	0005856	cellular_component	cytoskeleton
g	0005886	cellular_component	plasma membrane
g	0016012	cellular_component	sarcoglycan complex
g	0016020	cellular_component	membrane
g	0042383	cellular_component	sarcolemma
g	0048738	biological_process	cardiac muscle tissue development
g	0060047	biological_process	heart contraction
n	0005886	cellular_component	plasma membrane
n	0016010	cellular_component	dystrophin-associated glycoprotein complex
n	0016020	cellular_component	membrane
n	0042383	cellular_component	sarcolemma
n	0045211	cellular_component	postsynaptic membrane

Functional Information from PROSITE/UniProt

site_id	PS00019
Number of Residues	10
Details	ACTININ_1 Actinin-type actin-binding domain signature 1. QKkTFTKWIN

Chain	Residue	Details
D	GLN17-ASN26

---

site_id	PS00020
Number of Residues	25
Details	ACTININ_2 Actinin-type actin-binding domain signature 2. LvNIGStDIvDgnhkLtLGLIWnII

Chain	Residue	Details
D	LEU91-ILE115

---

site_id	PS01159
Number of Residues	26
Details	WW_DOMAIN_1 WW/rsp5/WWP domain signature. Weraispnkvp.YYinhetqtTCWDHP

Chain	Residue	Details
D	TRP3054-PRO3079

---

site_id	PS01357
Number of Residues	28
Details	ZF_ZZ_1 Zinc finger ZZ-type signature. CsyChsesmmgfRYrCqq...ChNYqLCqdC

Chain	Residue	Details
V	CYS243-CYS270
D	CYS3306-CYS3333

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	9
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	95
Details	Topological domain: {"description":"Extracellular"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	125
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	23
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	Motif: {"description":"Nuclear localization signal","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	11
Details	Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Site: {"description":"Cleavage; by MMP9","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q14118","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Signal-anchor for type II membrane protein","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	280
Details	Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	25
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---