Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

9C18

Human biliverdin IX beta reductase in complex with NADP in space group P1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004074	molecular_function	biliverdin reductase [NAD(P)H] activity
A	0005515	molecular_function	protein binding
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0008286	biological_process	insulin receptor signaling pathway
A	0016491	molecular_function	oxidoreductase activity
A	0016740	molecular_function	transferase activity
A	0030219	biological_process	megakaryocyte differentiation
A	0035605	molecular_function	peptidyl-cysteine S-nitrosylase activity
A	0042167	biological_process	heme catabolic process
A	0042602	molecular_function	riboflavin reductase (NADPH) activity
A	0046627	biological_process	negative regulation of insulin receptor signaling pathway
A	0052873	molecular_function	FMN reductase (NADPH) activity
A	0052874	molecular_function	FMN reductase (NADH) activity
A	0070062	cellular_component	extracellular exosome
B	0004074	molecular_function	biliverdin reductase [NAD(P)H] activity
B	0005515	molecular_function	protein binding
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0008286	biological_process	insulin receptor signaling pathway
B	0016491	molecular_function	oxidoreductase activity
B	0016740	molecular_function	transferase activity
B	0030219	biological_process	megakaryocyte differentiation
B	0035605	molecular_function	peptidyl-cysteine S-nitrosylase activity
B	0042167	biological_process	heme catabolic process
B	0042602	molecular_function	riboflavin reductase (NADPH) activity
B	0046627	biological_process	negative regulation of insulin receptor signaling pathway
B	0052873	molecular_function	FMN reductase (NADPH) activity
B	0052874	molecular_function	FMN reductase (NADH) activity
B	0070062	cellular_component	extracellular exosome

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"S-nitroso-cysteine intermediate; for S-nitroso-CoA-dependent nitrosyltransferase activity","evidences":[{"source":"PubMed","id":"38056462","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11224564","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29487133","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34957824","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1HDO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5OOG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5OOH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ER7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11224564","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29487133","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32246827","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34957824","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1HDO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HE2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HE3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HE4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HE5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5OOG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5OOH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OPL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ER6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ER7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ER8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ER9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ERA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ERB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ERC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ERD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ERE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11224564","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32246827","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34957824","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1HDO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HE2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HE3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HE4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HE5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5OOG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5OOH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OPL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ER6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ER7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ER8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ER9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ERA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ERB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ERC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ERD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ERE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11224564","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29487133","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34957824","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1HDO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HE2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HE3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HE4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HE5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5OOG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5OOH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ER6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ER7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ER8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ER9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ERA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ERB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ERC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ERD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ERE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"34957824","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7ER6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ER9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ERA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ERB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ERD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ERE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"29487133","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32246827","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34957824","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5OOH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OPL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ER6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ER7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ER8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ER9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ERA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ERB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ERC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ERE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11224564","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32246827","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34957824","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1HDO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HE2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HE3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HE4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HE5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OPL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ER6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ER7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ER8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ER9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ERA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ERB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ERC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ERD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ERE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11224564","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29487133","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32246827","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34957824","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1HDO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HE2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HE3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HE4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HE5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5OOH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OPL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ER6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ER7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ER8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ER9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ERA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ERB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ERC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ERD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ERE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11224564","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29487133","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32246827","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34957824","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1HE3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5OOG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5OOH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6OPL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ER8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ER9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ERB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ERC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"32246827","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34957824","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6OPL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ERB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ERD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)