Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

9BZS

Cryo-EM structure of cardiac amyloid fibril from a variant ATTR V30M amyloidosis patient

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001523	biological_process	retinoid metabolic process
A	0003105	biological_process	negative regulation of glomerular filtration
A	0005179	molecular_function	hormone activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005737	cellular_component	cytoplasm
A	0006144	biological_process	purine nucleobase metabolic process
A	0007603	biological_process	phototransduction, visible light
A	0032991	cellular_component	protein-containing complex
A	0035578	cellular_component	azurophil granule lumen
A	0042562	molecular_function	hormone binding
A	0042802	molecular_function	identical protein binding
A	0044877	molecular_function	protein-containing complex binding
A	0070062	cellular_component	extracellular exosome
A	0140313	molecular_function	molecular sequestering activity
B	0001523	biological_process	retinoid metabolic process
B	0003105	biological_process	negative regulation of glomerular filtration
B	0005179	molecular_function	hormone activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005737	cellular_component	cytoplasm
B	0006144	biological_process	purine nucleobase metabolic process
B	0007603	biological_process	phototransduction, visible light
B	0032991	cellular_component	protein-containing complex
B	0035578	cellular_component	azurophil granule lumen
B	0042562	molecular_function	hormone binding
B	0042802	molecular_function	identical protein binding
B	0044877	molecular_function	protein-containing complex binding
B	0070062	cellular_component	extracellular exosome
B	0140313	molecular_function	molecular sequestering activity
C	0001523	biological_process	retinoid metabolic process
C	0003105	biological_process	negative regulation of glomerular filtration
C	0005179	molecular_function	hormone activity
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005737	cellular_component	cytoplasm
C	0006144	biological_process	purine nucleobase metabolic process
C	0007603	biological_process	phototransduction, visible light
C	0032991	cellular_component	protein-containing complex
C	0035578	cellular_component	azurophil granule lumen
C	0042562	molecular_function	hormone binding
C	0042802	molecular_function	identical protein binding
C	0044877	molecular_function	protein-containing complex binding
C	0070062	cellular_component	extracellular exosome
C	0140313	molecular_function	molecular sequestering activity
D	0001523	biological_process	retinoid metabolic process
D	0003105	biological_process	negative regulation of glomerular filtration
D	0005179	molecular_function	hormone activity
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005737	cellular_component	cytoplasm
D	0006144	biological_process	purine nucleobase metabolic process
D	0007603	biological_process	phototransduction, visible light
D	0032991	cellular_component	protein-containing complex
D	0035578	cellular_component	azurophil granule lumen
D	0042562	molecular_function	hormone binding
D	0042802	molecular_function	identical protein binding
D	0044877	molecular_function	protein-containing complex binding
D	0070062	cellular_component	extracellular exosome
D	0140313	molecular_function	molecular sequestering activity
E	0001523	biological_process	retinoid metabolic process
E	0003105	biological_process	negative regulation of glomerular filtration
E	0005179	molecular_function	hormone activity
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0005737	cellular_component	cytoplasm
E	0006144	biological_process	purine nucleobase metabolic process
E	0007603	biological_process	phototransduction, visible light
E	0032991	cellular_component	protein-containing complex
E	0035578	cellular_component	azurophil granule lumen
E	0042562	molecular_function	hormone binding
E	0042802	molecular_function	identical protein binding
E	0044877	molecular_function	protein-containing complex binding
E	0070062	cellular_component	extracellular exosome
E	0140313	molecular_function	molecular sequestering activity

Functional Information from PROSITE/UniProt

site_id	PS00769
Number of Residues	13
Details	TRANSTHYRETIN_2 Transthyretin signature 2. YTIAalLSPYSYS

Chain	Residue	Details
A	TYR105-SER117

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	15
Details	BINDING: BINDING => ECO:0000269\|PubMed:11418763, ECO:0007744\|PDB:1ICT

Chain	Residue	Details
A	LYS15
D	LYS15
D	GLU54
D	SER117
E	LYS15
E	GLU54
E	SER117
A	GLU54
A	SER117
B	LYS15
B	GLU54
B	SER117
C	LYS15
C	GLU54
C	SER117

site_id	SWS_FT_FI2
Number of Residues	5
Details	MOD_RES: Sulfocysteine => ECO:0000269\|PubMed:17175208, ECO:0007744\|PDB:2H4E

Chain	Residue	Details
A	CYS10
B	CYS10
C	CYS10
D	CYS10
E	CYS10

site_id	SWS_FT_FI3
Number of Residues	5
Details	MOD_RES: 4-carboxyglutamate; in a patient with Moyamoya disease => ECO:0000269\|PubMed:18221012

Chain	Residue	Details
A	GLU42
B	GLU42
C	GLU42
D	GLU42
E	GLU42

site_id	SWS_FT_FI4
Number of Residues	5
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P02767

Chain	Residue	Details
A	SER52
B	SER52
C	SER52
D	SER52
E	SER52

site_id	SWS_FT_FI5
Number of Residues	5
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:16335952, ECO:0000269\|PubMed:19167329

Chain	Residue	Details
A	ASN98
B	ASN98
C	ASN98
D	ASN98
E	ASN98

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)