9BZ4

Crystal structure of the C2 and GAP domains of human p120RasGAP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0043087	biological_process	regulation of GTPase activity
B	0043087	biological_process	regulation of GTPase activity
C	0043087	biological_process	regulation of GTPase activity
D	0043087	biological_process	regulation of GTPase activity

Functional Information from PROSITE/UniProt

site_id	PS00509
Number of Residues	15
Details	RAS_GTPASE_ACTIV_1 Ras GTPase-activating proteins (rasGAP) domain signature. GfVFLRLICPAILNP

Chain	Residue	Details
A	GLY898-PRO912

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	Site: {"description":"Arginine finger; crucial for GTP hydrolysis by stabilizing the transition state","evidences":[{"source":"PROSITE-ProRule","id":"PRU00167","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	4
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"15592455","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	3
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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