9BLR

Human SCNN1D-SCNN1B-SCNN1G ENaC trimer

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005272	molecular_function	sodium channel activity
A	0006814	biological_process	sodium ion transport
A	0015280	molecular_function	ligand-gated sodium channel activity
A	0016020	cellular_component	membrane
B	0002269	biological_process	leukocyte activation involved in inflammatory response
B	0002283	biological_process	neutrophil activation involved in immune response
B	0003014	biological_process	renal system process
B	0005272	molecular_function	sodium channel activity
B	0005515	molecular_function	protein binding
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0006814	biological_process	sodium ion transport
B	0006883	biological_process	intracellular sodium ion homeostasis
B	0008217	biological_process	regulation of blood pressure
B	0009410	biological_process	response to xenobiotic stimulus
B	0009897	cellular_component	external side of plasma membrane
B	0010467	biological_process	gene expression
B	0014824	biological_process	artery smooth muscle contraction
B	0015280	molecular_function	ligand-gated sodium channel activity
B	0016020	cellular_component	membrane
B	0016324	cellular_component	apical plasma membrane
B	0030659	cellular_component	cytoplasmic vesicle membrane
B	0031410	cellular_component	cytoplasmic vesicle
B	0032094	biological_process	response to food
B	0032341	biological_process	aldosterone metabolic process
B	0034101	biological_process	erythrocyte homeostasis
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0034706	cellular_component	sodium channel complex
B	0035264	biological_process	multicellular organism growth
B	0035725	biological_process	sodium ion transmembrane transport
B	0042045	biological_process	epithelial fluid transport
B	0050699	molecular_function	WW domain binding
B	0050891	biological_process	multicellular organismal-level water homeostasis
B	0050914	biological_process	sensory perception of salty taste
B	0050915	biological_process	sensory perception of sour taste
B	0055075	biological_process	potassium ion homeostasis
B	0055078	biological_process	sodium ion homeostasis
B	0070062	cellular_component	extracellular exosome
B	0070254	biological_process	mucus secretion
B	0070944	biological_process	neutrophil-mediated killing of bacterium
B	0071468	biological_process	cellular response to acidic pH
B	0098719	biological_process	sodium ion import across plasma membrane
B	1904045	biological_process	cellular response to aldosterone
B	1904117	biological_process	cellular response to vasopressin
C	0005216	molecular_function	monoatomic ion channel activity
C	0005272	molecular_function	sodium channel activity
C	0005515	molecular_function	protein binding
C	0005654	cellular_component	nucleoplasm
C	0005886	cellular_component	plasma membrane
C	0006811	biological_process	monoatomic ion transport
C	0006814	biological_process	sodium ion transport
C	0006883	biological_process	intracellular sodium ion homeostasis
C	0008217	biological_process	regulation of blood pressure
C	0009897	cellular_component	external side of plasma membrane
C	0015280	molecular_function	ligand-gated sodium channel activity
C	0016020	cellular_component	membrane
C	0016324	cellular_component	apical plasma membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0034706	cellular_component	sodium channel complex
C	0035725	biological_process	sodium ion transmembrane transport
C	0050699	molecular_function	WW domain binding
C	0050891	biological_process	multicellular organismal-level water homeostasis
C	0050914	biological_process	sensory perception of salty taste
C	0050915	biological_process	sensory perception of sour taste
C	0055078	biological_process	sodium ion homeostasis
C	0070062	cellular_component	extracellular exosome
C	0071468	biological_process	cellular response to acidic pH
C	0098719	biological_process	sodium ion import across plasma membrane
C	1904045	biological_process	cellular response to aldosterone
C	1904117	biological_process	cellular response to vasopressin

Functional Information from PROSITE/UniProt

site_id	PS01206
Number of Residues	21
Details	ASC Amiloride-sensitive sodium channels signature. YslQiClhsCfQtkMVekCgC

Chain	Residue	Details
C	TYR389-CYS409
A	TYR387-CYS407
B	TYR381-CYS401

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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