9BIT

Cryo-EM structure of the mammalian peptide transporter PepT2 bound to cloxacillin, pose 1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002376	biological_process	immune system process
A	0005886	cellular_component	plasma membrane
A	0006857	biological_process	oligopeptide transport
A	0015031	biological_process	protein transport
A	0015293	molecular_function	symporter activity
A	0015333	molecular_function	peptide:proton symporter activity
A	0015334	molecular_function	high-affinity oligopeptide transmembrane transporter activity
A	0015833	biological_process	peptide transport
A	0015835	biological_process	peptidoglycan transport
A	0016020	cellular_component	membrane
A	0016324	cellular_component	apical plasma membrane
A	0022857	molecular_function	transmembrane transporter activity
A	0030670	cellular_component	phagocytic vesicle membrane
A	0031410	cellular_component	cytoplasmic vesicle
A	0035673	molecular_function	oligopeptide transmembrane transporter activity
A	0042908	biological_process	xenobiotic transport
A	0042937	molecular_function	tripeptide transmembrane transporter activity
A	0042938	biological_process	dipeptide transport
A	0045087	biological_process	innate immune response
A	0055085	biological_process	transmembrane transport
A	0070293	biological_process	renal absorption
A	0070424	biological_process	regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
A	0071916	molecular_function	dipeptide transmembrane transporter activity
A	0072237	biological_process	metanephric proximal tubule development
A	0140206	biological_process	dipeptide import across plasma membrane
A	0140207	biological_process	tripeptide import across plasma membrane
A	0140367	biological_process	antibacterial innate immune response
A	1902600	biological_process	proton transmembrane transport

Functional Information from PROSITE/UniProt

site_id	PS01022
Number of Residues	25
Details	PTR2_1 PTR2 family proton/oligopeptide symporters signature 1. GAAIADsWLGkfkTIiylSlVyvlG

Chain	Residue	Details
A	GLY100-GLY124

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site_id	PS01023
Number of Residues	13
Details	PTR2_2 PTR2 family proton/oligopeptide symporters signature 2. FsvFYLaINAGSL

Chain	Residue	Details
A	PHE184-LEU196

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	240
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	59
Details	Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	107
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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