9BI4

cryo EM structure of dsDNA bound Mre11-Rad50 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000014	molecular_function	single-stranded DNA endodeoxyribonuclease activity
A	0000723	biological_process	telomere maintenance
A	0000724	biological_process	double-strand break repair via homologous recombination
A	0000727	biological_process	double-strand break repair via break-induced replication
A	0000729	biological_process	DNA double-strand break processing
A	0000781	cellular_component	chromosome, telomeric region
A	0003691	molecular_function	double-stranded telomeric DNA binding
A	0004017	molecular_function	AMP kinase activity
A	0004518	molecular_function	nuclease activity
A	0004519	molecular_function	endonuclease activity
A	0004520	molecular_function	DNA endonuclease activity
A	0004527	molecular_function	exonuclease activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005694	cellular_component	chromosome
A	0005739	cellular_component	mitochondrion
A	0006281	biological_process	DNA repair
A	0006284	biological_process	base-excision repair
A	0006302	biological_process	double-strand break repair
A	0006303	biological_process	double-strand break repair via nonhomologous end joining
A	0006357	biological_process	regulation of transcription by RNA polymerase II
A	0006974	biological_process	DNA damage response
A	0007095	biological_process	mitotic G2 DNA damage checkpoint signaling
A	0007131	biological_process	reciprocal meiotic recombination
A	0008296	molecular_function	3'-5'-DNA exonuclease activity
A	0008408	molecular_function	3'-5' exonuclease activity
A	0010780	biological_process	meiotic DNA double-strand break formation involved in reciprocal meiotic recombination
A	0010791	biological_process	DNA double-strand break processing involved in repair via synthesis-dependent strand annealing
A	0016787	molecular_function	hydrolase activity
A	0030145	molecular_function	manganese ion binding
A	0030437	biological_process	ascospore formation
A	0030870	cellular_component	Mre11 complex
A	0031573	biological_process	mitotic intra-S DNA damage checkpoint signaling
A	0035753	biological_process	maintenance of DNA trinucleotide repeats
A	0035861	cellular_component	site of double-strand break
A	0042138	biological_process	meiotic DNA double-strand break formation
A	0042162	molecular_function	telomeric DNA binding
A	0043047	molecular_function	single-stranded telomeric DNA binding
A	0046872	molecular_function	metal ion binding
A	0046940	biological_process	nucleoside monophosphate phosphorylation
A	0051321	biological_process	meiotic cell cycle
A	0051880	molecular_function	G-quadruplex DNA binding
A	0060090	molecular_function	molecular adaptor activity
A	0062176	biological_process	R-loop processing
A	0097552	biological_process	mitochondrial double-strand break repair via homologous recombination
B	0000014	molecular_function	single-stranded DNA endodeoxyribonuclease activity
B	0000723	biological_process	telomere maintenance
B	0000724	biological_process	double-strand break repair via homologous recombination
B	0000727	biological_process	double-strand break repair via break-induced replication
B	0000729	biological_process	DNA double-strand break processing
B	0000781	cellular_component	chromosome, telomeric region
B	0003691	molecular_function	double-stranded telomeric DNA binding
B	0004017	molecular_function	AMP kinase activity
B	0004518	molecular_function	nuclease activity
B	0004519	molecular_function	endonuclease activity
B	0004520	molecular_function	DNA endonuclease activity
B	0004527	molecular_function	exonuclease activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005694	cellular_component	chromosome
B	0005739	cellular_component	mitochondrion
B	0006281	biological_process	DNA repair
B	0006284	biological_process	base-excision repair
B	0006302	biological_process	double-strand break repair
B	0006303	biological_process	double-strand break repair via nonhomologous end joining
B	0006357	biological_process	regulation of transcription by RNA polymerase II
B	0006974	biological_process	DNA damage response
B	0007095	biological_process	mitotic G2 DNA damage checkpoint signaling
B	0007131	biological_process	reciprocal meiotic recombination
B	0008296	molecular_function	3'-5'-DNA exonuclease activity
B	0008408	molecular_function	3'-5' exonuclease activity
B	0010780	biological_process	meiotic DNA double-strand break formation involved in reciprocal meiotic recombination
B	0010791	biological_process	DNA double-strand break processing involved in repair via synthesis-dependent strand annealing
B	0016787	molecular_function	hydrolase activity
B	0030145	molecular_function	manganese ion binding
B	0030437	biological_process	ascospore formation
B	0030870	cellular_component	Mre11 complex
B	0031573	biological_process	mitotic intra-S DNA damage checkpoint signaling
B	0035753	biological_process	maintenance of DNA trinucleotide repeats
B	0035861	cellular_component	site of double-strand break
B	0042138	biological_process	meiotic DNA double-strand break formation
B	0042162	molecular_function	telomeric DNA binding
B	0043047	molecular_function	single-stranded telomeric DNA binding
B	0046872	molecular_function	metal ion binding
B	0046940	biological_process	nucleoside monophosphate phosphorylation
B	0051321	biological_process	meiotic cell cycle
B	0051880	molecular_function	G-quadruplex DNA binding
B	0060090	molecular_function	molecular adaptor activity
B	0062176	biological_process	R-loop processing
B	0097552	biological_process	mitochondrial double-strand break repair via homologous recombination
C	0000166	molecular_function	nucleotide binding
C	0000722	biological_process	telomere maintenance via recombination
C	0000723	biological_process	telomere maintenance
C	0000725	biological_process	recombinational repair
C	0000794	cellular_component	condensed nuclear chromosome
C	0003677	molecular_function	DNA binding
C	0003690	molecular_function	double-stranded DNA binding
C	0003691	molecular_function	double-stranded telomeric DNA binding
C	0004017	molecular_function	AMP kinase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005694	cellular_component	chromosome
C	0005739	cellular_component	mitochondrion
C	0006281	biological_process	DNA repair
C	0006284	biological_process	base-excision repair
C	0006302	biological_process	double-strand break repair
C	0006303	biological_process	double-strand break repair via nonhomologous end joining
C	0006974	biological_process	DNA damage response
C	0007004	biological_process	telomere maintenance via telomerase
C	0007127	biological_process	meiosis I
C	0007129	biological_process	homologous chromosome pairing at meiosis
C	0008270	molecular_function	zinc ion binding
C	0016787	molecular_function	hydrolase activity
C	0016887	molecular_function	ATP hydrolysis activity
C	0030870	cellular_component	Mre11 complex
C	0035753	biological_process	maintenance of DNA trinucleotide repeats
C	0042138	biological_process	meiotic DNA double-strand break formation
C	0042162	molecular_function	telomeric DNA binding
C	0043047	molecular_function	single-stranded telomeric DNA binding
C	0046872	molecular_function	metal ion binding
C	0046940	biological_process	nucleoside monophosphate phosphorylation
C	0051321	biological_process	meiotic cell cycle
C	0051880	molecular_function	G-quadruplex DNA binding
C	0062176	biological_process	R-loop processing
C	0070192	biological_process	chromosome organization involved in meiotic cell cycle
C	0097552	biological_process	mitochondrial double-strand break repair via homologous recombination
D	0000166	molecular_function	nucleotide binding
D	0000722	biological_process	telomere maintenance via recombination
D	0000723	biological_process	telomere maintenance
D	0000725	biological_process	recombinational repair
D	0000794	cellular_component	condensed nuclear chromosome
D	0003677	molecular_function	DNA binding
D	0003690	molecular_function	double-stranded DNA binding
D	0003691	molecular_function	double-stranded telomeric DNA binding
D	0004017	molecular_function	AMP kinase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005694	cellular_component	chromosome
D	0005739	cellular_component	mitochondrion
D	0006281	biological_process	DNA repair
D	0006284	biological_process	base-excision repair
D	0006302	biological_process	double-strand break repair
D	0006303	biological_process	double-strand break repair via nonhomologous end joining
D	0006974	biological_process	DNA damage response
D	0007004	biological_process	telomere maintenance via telomerase
D	0007127	biological_process	meiosis I
D	0007129	biological_process	homologous chromosome pairing at meiosis
D	0008270	molecular_function	zinc ion binding
D	0016787	molecular_function	hydrolase activity
D	0016887	molecular_function	ATP hydrolysis activity
D	0030870	cellular_component	Mre11 complex
D	0035753	biological_process	maintenance of DNA trinucleotide repeats
D	0042138	biological_process	meiotic DNA double-strand break formation
D	0042162	molecular_function	telomeric DNA binding
D	0043047	molecular_function	single-stranded telomeric DNA binding
D	0046872	molecular_function	metal ion binding
D	0046940	biological_process	nucleoside monophosphate phosphorylation
D	0051321	biological_process	meiotic cell cycle
D	0051880	molecular_function	G-quadruplex DNA binding
D	0062176	biological_process	R-loop processing
D	0070192	biological_process	chromosome organization involved in meiotic cell cycle
D	0097552	biological_process	mitochondrial double-strand break repair via homologous recombination

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"G0SHW7","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {"description":"Proton donor","evidences":[{"source":"PIRSR","id":"PIRSR000882-1","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"G0RYR3","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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