Loading
PDBj
English日本語简体中文繁體中文한국어
✖
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help
SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9BCX

Cryo-EM structure of the S. cerevisiae ORC-Cdc6-Mcm2-7-DNA complex with a fully closed Mcm2-Mcm5 DNA entry gate

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
20000166molecular_functionnucleotide binding
20000727biological_processdouble-strand break repair via break-induced replication
20003677molecular_functionDNA binding
20003682molecular_functionchromatin binding
20003688molecular_functionDNA replication origin binding
20003697molecular_functionsingle-stranded DNA binding
20004386molecular_functionhelicase activity
20005515molecular_functionprotein binding
20005524molecular_functionATP binding
20005634cellular_componentnucleus
20005654cellular_componentnucleoplasm
20005656cellular_componentnuclear pre-replicative complex
20005737cellular_componentcytoplasm
20006260biological_processDNA replication
20006267biological_processpre-replicative complex assembly involved in nuclear cell cycle DNA replication
20006270biological_processDNA replication initiation
20006271biological_processDNA strand elongation involved in DNA replication
20006279biological_processpremeiotic DNA replication
20006974biological_processDNA damage response
20008270molecular_functionzinc ion binding
20016787molecular_functionhydrolase activity
20016887molecular_functionATP hydrolysis activity
20017116molecular_functionsingle-stranded DNA helicase activity
20031261cellular_componentDNA replication preinitiation complex
20031298cellular_componentreplication fork protection complex
20042555cellular_componentMCM complex
20043138molecular_function3'-5' DNA helicase activity
20043596cellular_componentnuclear replication fork
20046872molecular_functionmetal ion binding
20071162cellular_componentCMG complex
21902975biological_processmitotic DNA replication initiation
30000166molecular_functionnucleotide binding
30000727biological_processdouble-strand break repair via break-induced replication
30000781cellular_componentchromosome, telomeric region
30003677molecular_functionDNA binding
30003682molecular_functionchromatin binding
30003688molecular_functionDNA replication origin binding
30003697molecular_functionsingle-stranded DNA binding
30004386molecular_functionhelicase activity
30005515molecular_functionprotein binding
30005524molecular_functionATP binding
30005634cellular_componentnucleus
30005654cellular_componentnucleoplasm
30005656cellular_componentnuclear pre-replicative complex
30005737cellular_componentcytoplasm
30006260biological_processDNA replication
30006267biological_processpre-replicative complex assembly involved in nuclear cell cycle DNA replication
30006270biological_processDNA replication initiation
30006271biological_processDNA strand elongation involved in DNA replication
30006279biological_processpremeiotic DNA replication
30016787molecular_functionhydrolase activity
30016887molecular_functionATP hydrolysis activity
30017116molecular_functionsingle-stranded DNA helicase activity
30030466biological_processsilent mating-type cassette heterochromatin formation
30031261cellular_componentDNA replication preinitiation complex
30031298cellular_componentreplication fork protection complex
30031509biological_processsubtelomeric heterochromatin formation
30042555cellular_componentMCM complex
30043596cellular_componentnuclear replication fork
30071162cellular_componentCMG complex
31902975biological_processmitotic DNA replication initiation
31904931molecular_functionMCM complex binding
40000166molecular_functionnucleotide binding
40000727biological_processdouble-strand break repair via break-induced replication
40003677molecular_functionDNA binding
40003678molecular_functionDNA helicase activity
40003688molecular_functionDNA replication origin binding
40003697molecular_functionsingle-stranded DNA binding
40004386molecular_functionhelicase activity
40005515molecular_functionprotein binding
40005524molecular_functionATP binding
40005634cellular_componentnucleus
40005654cellular_componentnucleoplasm
40005656cellular_componentnuclear pre-replicative complex
40005737cellular_componentcytoplasm
40006260biological_processDNA replication
40006267biological_processpre-replicative complex assembly involved in nuclear cell cycle DNA replication
40006270biological_processDNA replication initiation
40006271biological_processDNA strand elongation involved in DNA replication
40006279biological_processpremeiotic DNA replication
40008270molecular_functionzinc ion binding
40009378molecular_functionfour-way junction helicase activity
40016787molecular_functionhydrolase activity
40016887molecular_functionATP hydrolysis activity
40017116molecular_functionsingle-stranded DNA helicase activity
40031261cellular_componentDNA replication preinitiation complex
40031298cellular_componentreplication fork protection complex
40033260biological_processnuclear DNA replication
40042555cellular_componentMCM complex
40043138molecular_function3'-5' DNA helicase activity
40043596cellular_componentnuclear replication fork
40071162cellular_componentCMG complex
40097373cellular_componentMCM core complex
41902975biological_processmitotic DNA replication initiation
50000166molecular_functionnucleotide binding
50000727biological_processdouble-strand break repair via break-induced replication
50000781cellular_componentchromosome, telomeric region
50003677molecular_functionDNA binding
50003682molecular_functionchromatin binding
50003688molecular_functionDNA replication origin binding
50003697molecular_functionsingle-stranded DNA binding
50004386molecular_functionhelicase activity
50005515molecular_functionprotein binding
50005524molecular_functionATP binding
50005634cellular_componentnucleus
50005654cellular_componentnucleoplasm
50005656cellular_componentnuclear pre-replicative complex
50005737cellular_componentcytoplasm
50006260biological_processDNA replication
50006267biological_processpre-replicative complex assembly involved in nuclear cell cycle DNA replication
50006270biological_processDNA replication initiation
50006279biological_processpremeiotic DNA replication
50006368biological_processtranscription elongation by RNA polymerase II
50008270molecular_functionzinc ion binding
50016787molecular_functionhydrolase activity
50016887molecular_functionATP hydrolysis activity
50017116molecular_functionsingle-stranded DNA helicase activity
50030174biological_processregulation of DNA-templated DNA replication initiation
50031261cellular_componentDNA replication preinitiation complex
50031298cellular_componentreplication fork protection complex
50031507biological_processheterochromatin formation
50031509biological_processsubtelomeric heterochromatin formation
50033260biological_processnuclear DNA replication
50042555cellular_componentMCM complex
50043138molecular_function3'-5' DNA helicase activity
50043596cellular_componentnuclear replication fork
50071162cellular_componentCMG complex
60000166molecular_functionnucleotide binding
60000727biological_processdouble-strand break repair via break-induced replication
60003677molecular_functionDNA binding
60003678molecular_functionDNA helicase activity
60003688molecular_functionDNA replication origin binding
60003697molecular_functionsingle-stranded DNA binding
60004386molecular_functionhelicase activity
60005515molecular_functionprotein binding
60005524molecular_functionATP binding
60005634cellular_componentnucleus
60005654cellular_componentnucleoplasm
60005656cellular_componentnuclear pre-replicative complex
60005737cellular_componentcytoplasm
60006260biological_processDNA replication
60006267biological_processpre-replicative complex assembly involved in nuclear cell cycle DNA replication
60006270biological_processDNA replication initiation
60006271biological_processDNA strand elongation involved in DNA replication
60006279biological_processpremeiotic DNA replication
60008270molecular_functionzinc ion binding
60009378molecular_functionfour-way junction helicase activity
60016787molecular_functionhydrolase activity
60016887molecular_functionATP hydrolysis activity
60017116molecular_functionsingle-stranded DNA helicase activity
60031261cellular_componentDNA replication preinitiation complex
60031298cellular_componentreplication fork protection complex
60042555cellular_componentMCM complex
60043138molecular_function3'-5' DNA helicase activity
60043596cellular_componentnuclear replication fork
60071162cellular_componentCMG complex
60097373cellular_componentMCM core complex
61902969biological_processmitotic DNA replication
61990518molecular_functionsingle-stranded 3'-5' DNA helicase activity
70000166molecular_functionnucleotide binding
70000727biological_processdouble-strand break repair via break-induced replication
70000781cellular_componentchromosome, telomeric region
70003677molecular_functionDNA binding
70003678molecular_functionDNA helicase activity
70003682molecular_functionchromatin binding
70003688molecular_functionDNA replication origin binding
70003697molecular_functionsingle-stranded DNA binding
70004386molecular_functionhelicase activity
70005515molecular_functionprotein binding
70005524molecular_functionATP binding
70005634cellular_componentnucleus
70005654cellular_componentnucleoplasm
70005656cellular_componentnuclear pre-replicative complex
70005737cellular_componentcytoplasm
70006260biological_processDNA replication
70006267biological_processpre-replicative complex assembly involved in nuclear cell cycle DNA replication
70006270biological_processDNA replication initiation
70006271biological_processDNA strand elongation involved in DNA replication
70006279biological_processpremeiotic DNA replication
70008270molecular_functionzinc ion binding
70009378molecular_functionfour-way junction helicase activity
70016787molecular_functionhydrolase activity
70016887molecular_functionATP hydrolysis activity
70017116molecular_functionsingle-stranded DNA helicase activity
70030466biological_processsilent mating-type cassette heterochromatin formation
70031261cellular_componentDNA replication preinitiation complex
70031298cellular_componentreplication fork protection complex
70031509biological_processsubtelomeric heterochromatin formation
70033260biological_processnuclear DNA replication
70042555cellular_componentMCM complex
70043138molecular_function3'-5' DNA helicase activity
70043596cellular_componentnuclear replication fork
70071162cellular_componentCMG complex
70097373cellular_componentMCM core complex
71904931molecular_functionMCM complex binding
80000727biological_processdouble-strand break repair via break-induced replication
80003677molecular_functionDNA binding
80003688molecular_functionDNA replication origin binding
80005515molecular_functionprotein binding
80005634cellular_componentnucleus
80005654cellular_componentnucleoplasm
80005656cellular_componentnuclear pre-replicative complex
80005737cellular_componentcytoplasm
80006267biological_processpre-replicative complex assembly involved in nuclear cell cycle DNA replication
80030174biological_processregulation of DNA-templated DNA replication initiation
80051301biological_processcell division
B0000166molecular_functionnucleotide binding
B0003677molecular_functionDNA binding
B0003682molecular_functionchromatin binding
B0003688molecular_functionDNA replication origin binding
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005656cellular_componentnuclear pre-replicative complex
B0005664cellular_componentnuclear origin of replication recognition complex
B0006260biological_processDNA replication
B0006267biological_processpre-replicative complex assembly involved in nuclear cell cycle DNA replication
B0006270biological_processDNA replication initiation
B0016887molecular_functionATP hydrolysis activity
B0030466biological_processsilent mating-type cassette heterochromatin formation
B0031261cellular_componentDNA replication preinitiation complex
B0031491molecular_functionnucleosome binding
B0033314biological_processmitotic DNA replication checkpoint signaling
B0034728biological_processnucleosome organization
B0043007biological_processmaintenance of rDNA
B0046872molecular_functionmetal ion binding
C0000781cellular_componentchromosome, telomeric region
C0000808cellular_componentorigin recognition complex
C0003682molecular_functionchromatin binding
C0003688molecular_functionDNA replication origin binding
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005656cellular_componentnuclear pre-replicative complex
C0005664cellular_componentnuclear origin of replication recognition complex
C0006260biological_processDNA replication
C0006267biological_processpre-replicative complex assembly involved in nuclear cell cycle DNA replication
C0006270biological_processDNA replication initiation
C0030466biological_processsilent mating-type cassette heterochromatin formation
C0031261cellular_componentDNA replication preinitiation complex
C0031509biological_processsubtelomeric heterochromatin formation
D0003677molecular_functionDNA binding
D0003682molecular_functionchromatin binding
D0003688molecular_functionDNA replication origin binding
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005656cellular_componentnuclear pre-replicative complex
D0005664cellular_componentnuclear origin of replication recognition complex
D0006260biological_processDNA replication
D0006267biological_processpre-replicative complex assembly involved in nuclear cell cycle DNA replication
D0006270biological_processDNA replication initiation
D0030466biological_processsilent mating-type cassette heterochromatin formation
D0031261cellular_componentDNA replication preinitiation complex
E0000808cellular_componentorigin recognition complex
E0003677molecular_functionDNA binding
E0003688molecular_functionDNA replication origin binding
E0005515molecular_functionprotein binding
E0005634cellular_componentnucleus
E0005654cellular_componentnucleoplasm
E0005656cellular_componentnuclear pre-replicative complex
E0005664cellular_componentnuclear origin of replication recognition complex
E0006260biological_processDNA replication
E0006267biological_processpre-replicative complex assembly involved in nuclear cell cycle DNA replication
E0006270biological_processDNA replication initiation
E0030466biological_processsilent mating-type cassette heterochromatin formation
E0031261cellular_componentDNA replication preinitiation complex
F0000166molecular_functionnucleotide binding
F0000808cellular_componentorigin recognition complex
F0003688molecular_functionDNA replication origin binding
F0005515molecular_functionprotein binding
F0005524molecular_functionATP binding
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0005656cellular_componentnuclear pre-replicative complex
F0005664cellular_componentnuclear origin of replication recognition complex
F0006260biological_processDNA replication
F0006267biological_processpre-replicative complex assembly involved in nuclear cell cycle DNA replication
F0006270biological_processDNA replication initiation
F0006275biological_processregulation of DNA replication
F0030466biological_processsilent mating-type cassette heterochromatin formation
F0031261cellular_componentDNA replication preinitiation complex
F0035361cellular_componentCul8-RING ubiquitin ligase complex
G0003677molecular_functionDNA binding
G0003688molecular_functionDNA replication origin binding
G0005515molecular_functionprotein binding
G0005634cellular_componentnucleus
G0005654cellular_componentnucleoplasm
G0005656cellular_componentnuclear pre-replicative complex
G0005664cellular_componentnuclear origin of replication recognition complex
G0006260biological_processDNA replication
G0006267biological_processpre-replicative complex assembly involved in nuclear cell cycle DNA replication
G0006270biological_processDNA replication initiation
G0030466biological_processsilent mating-type cassette heterochromatin formation
G0031261cellular_componentDNA replication preinitiation complex
I0000082biological_processG1/S transition of mitotic cell cycle
I0000166molecular_functionnucleotide binding
I0003682molecular_functionchromatin binding
I0003688molecular_functionDNA replication origin binding
I0003924molecular_functionGTPase activity
I0004861molecular_functioncyclin-dependent protein serine/threonine kinase inhibitor activity
I0005515molecular_functionprotein binding
I0005524molecular_functionATP binding
I0005525molecular_functionGTP binding
I0005634cellular_componentnucleus
I0005654cellular_componentnucleoplasm
I0005656cellular_componentnuclear pre-replicative complex
I0005694cellular_componentchromosome
I0005737cellular_componentcytoplasm
I0006260biological_processDNA replication
I0006267biological_processpre-replicative complex assembly involved in nuclear cell cycle DNA replication
I0006270biological_processDNA replication initiation
I0016887molecular_functionATP hydrolysis activity
I0030174biological_processregulation of DNA-templated DNA replication initiation
I0031261cellular_componentDNA replication preinitiation complex
I0033314biological_processmitotic DNA replication checkpoint signaling
I0051301biological_processcell division
I0140530biological_processMCM complex loading
Functional Information from PROSITE/UniProt
site_idPS00018
Number of Residues13
DetailsEF_HAND_1 EF-hand calcium-binding domain. DLNQSKKMNvsEF
ChainResidueDetails
DASP3-PHE15
site_idPS00847
Number of Residues9
DetailsMCM_1 MCM family signature. GICCIDEFD
ChainResidueDetails
6GLY634-ASP642
2GLY602-ASP610
3GLY468-ASP476
5GLY475-ASP483
4GLY627-ASP635
7GLY519-ASP527
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues26
DetailsZinc finger: {"description":"C4-type","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues18
DetailsMotif: {"description":"Arginine finger"}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues49
DetailsBinding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues10
DetailsCompositional bias: {"description":"Acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues621
DetailsDomain: {"description":"MCM"}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"17330950","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P33993","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues12
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"Q13415","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

239492

PDB entries from 2025-07-30

PDB statisticsPDBj update infoContact PDBjnumon