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9BC2

Transglutaminase 2 - Open State

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
A0000785cellular_componentchromatin
A0000786cellular_componentnucleosome
A0003810molecular_functionprotein-glutamine gamma-glutamyltransferase activity
A0005509molecular_functioncalcium ion binding
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005576cellular_componentextracellular region
A0005634cellular_componentnucleus
A0005694cellular_componentchromosome
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005783cellular_componentendoplasmic reticulum
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0005925cellular_componentfocal adhesion
A0006338biological_processchromatin remodeling
A0006508biological_processproteolysis
A0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
A0008233molecular_functionpeptidase activity
A0010467biological_processgene expression
A0014046biological_processdopamine secretion
A0016746molecular_functionacyltransferase activity
A0018149biological_processpeptide cross-linking
A0018277biological_processprotein deamination
A0031012cellular_componentextracellular matrix
A0032471biological_processnegative regulation of endoplasmic reticulum calcium ion concentration
A0042981biological_processregulation of apoptotic process
A0043065biological_processpositive regulation of apoptotic process
A0043277biological_processapoptotic cell clearance
A0043547biological_processpositive regulation of GTPase activity
A0045785biological_processpositive regulation of cell adhesion
A0046872molecular_functionmetal ion binding
A0048471cellular_componentperinuclear region of cytoplasm
A0050568molecular_functionprotein-glutamine glutaminase activity
A0050769biological_processpositive regulation of neurogenesis
A0051057biological_processpositive regulation of small GTPase mediated signal transduction
A0051561biological_processpositive regulation of mitochondrial calcium ion concentration
A0060348biological_processbone development
A0060445biological_processbranching involved in salivary gland morphogenesis
A0060662biological_processsalivary gland cavitation
A0062023cellular_componentcollagen-containing extracellular matrix
A0070062cellular_componentextracellular exosome
A0071314biological_processcellular response to cocaine
A0120294molecular_functionpeptide serotonyltransferase activity
A0120295molecular_functionhistone serotonyltransferase activity
A0120296molecular_functionpeptide dopaminyltransferase activity
A0120297molecular_functionhistone dopaminyltransferase activity
A0120298molecular_functionpeptide noradrenalinyltransferase activity
A0120299molecular_functionpeptide histaminyltransferase activity
A1903351biological_processcellular response to dopamine
A1903672biological_processpositive regulation of sprouting angiogenesis
A1904015biological_processcellular response to serotonin
A2000425biological_processregulation of apoptotic cell clearance
Functional Information from PROSITE/UniProt
site_idPS00547
Number of Residues18
DetailsTRANSGLUTAMINASES Transglutaminases active site. GQCWVfAAVacTvLRCLG
ChainResidueDetails
AGLY275-GLY292

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10024, ECO:0000305|PubMed:7649299, ECO:0000305|PubMed:8943303
ChainResidueDetails
ACYS277

site_idSWS_FT_FI2
Number of Residues2
DetailsACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10024
ChainResidueDetails
AHIS335
AASP358

site_idSWS_FT_FI3
Number of Residues4
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P00488
ChainResidueDetails
AASN398
AASP400
AGLU447
AGLU452

site_idSWS_FT_FI4
Number of Residues2
DetailsBINDING: BINDING => ECO:0000305|PubMed:31991788
ChainResidueDetails
AGLU437
AGLU539

site_idSWS_FT_FI5
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:25192068, ECO:0000269|PubMed:30321187, ECO:0000269|PubMed:31991788, ECO:0000305|PubMed:11867708, ECO:0000305|PubMed:20450932, ECO:0007744|PDB:1KV3, ECO:0007744|PDB:3LY6, ECO:0007744|PDB:4PYG, ECO:0007744|PDB:6A8P, ECO:0007744|PDB:6KZB
ChainResidueDetails
AARG476
AARG580

site_idSWS_FT_FI6
Number of Residues1
DetailsSITE: Important for catalytic activity => ECO:0000250|UniProtKB:P52181
ChainResidueDetails
ATYR516

site_idSWS_FT_FI7
Number of Residues1
DetailsMOD_RES: N-acetylalanine => ECO:0000269|Ref.10, ECO:0007744|PubMed:22814378
ChainResidueDetails
AALA2

site_idSWS_FT_FI8
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569
ChainResidueDetails
ASER60

site_idSWS_FT_FI9
Number of Residues1
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P21981
ChainResidueDetails
ALYS468

site_idSWS_FT_FI10
Number of Residues2
DetailsCROSSLNK: Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-?) => ECO:0000250|UniProtKB:P08587
ChainResidueDetails
AGLN633

226707

PDB entries from 2024-10-30

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