9B91
Cryo-EM structure of the human TRPM4 channel subunit in complex with calcium and ATP at 37 degrees Celsius
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0002250 | biological_process | adaptive immune response |
| A | 0002407 | biological_process | dendritic cell chemotaxis |
| A | 0002724 | biological_process | regulation of T cell cytokine production |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0005227 | molecular_function | calcium-activated cation channel activity |
| A | 0005262 | molecular_function | calcium channel activity |
| A | 0005272 | molecular_function | sodium channel activity |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005516 | molecular_function | calmodulin binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005794 | cellular_component | Golgi apparatus |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006816 | biological_process | calcium ion transport |
| A | 0007204 | biological_process | positive regulation of cytosolic calcium ion concentration |
| A | 0008284 | biological_process | positive regulation of cell population proliferation |
| A | 0010460 | biological_process | positive regulation of heart rate |
| A | 0016020 | cellular_component | membrane |
| A | 0016925 | biological_process | protein sumoylation |
| A | 0019722 | biological_process | calcium-mediated signaling |
| A | 0030001 | biological_process | metal ion transport |
| A | 0030502 | biological_process | negative regulation of bone mineralization |
| A | 0034220 | biological_process | monoatomic ion transmembrane transport |
| A | 0034706 | cellular_component | sodium channel complex |
| A | 0035774 | biological_process | positive regulation of insulin secretion involved in cellular response to glucose stimulus |
| A | 0043025 | cellular_component | neuronal cell body |
| A | 0045600 | biological_process | positive regulation of fat cell differentiation |
| A | 0045668 | biological_process | negative regulation of osteoblast differentiation |
| A | 0045907 | biological_process | positive regulation of vasoconstriction |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051289 | biological_process | protein homotetramerization |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0070588 | biological_process | calcium ion transmembrane transport |
| A | 0071318 | biological_process | cellular response to ATP |
| A | 0086045 | biological_process | membrane depolarization during AV node cell action potential |
| A | 0086047 | biological_process | membrane depolarization during Purkinje myocyte cell action potential |
| A | 0086048 | biological_process | membrane depolarization during bundle of His cell action potential |
| A | 0086091 | biological_process | regulation of heart rate by cardiac conduction |
| A | 0090263 | biological_process | positive regulation of canonical Wnt signaling pathway |
| A | 0098655 | biological_process | monoatomic cation transmembrane transport |
| A | 0098662 | biological_process | inorganic cation transmembrane transport |
| A | 0098719 | biological_process | sodium ion import across plasma membrane |
| A | 0098911 | biological_process | regulation of ventricular cardiac muscle cell action potential |
| A | 1903949 | biological_process | positive regulation of atrial cardiac muscle cell action potential |
| A | 1904179 | biological_process | positive regulation of adipose tissue development |
| A | 1904199 | biological_process | positive regulation of regulation of vascular associated smooth muscle cell membrane depolarization |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1000 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:29211723, ECO:0000269|PubMed:29217581 |
| Chain | Residue | Details |
| A | MET1-ILE782 | |
| A | GLY836-SER863 | |
| A | THR911-VAL930 | |
| A | ALA1041-ASP1214 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 123 |
| Details | TRANSMEM: Helical => ECO:0000269|PubMed:29211723, ECO:0000269|PubMed:29217581 |
| Chain | Residue | Details |
| A | PHE783-VAL803 | |
| A | LEU815-GLY835 | |
| A | TRP864-THR884 | |
| A | LEU887-PHE910 | |
| A | PHE931-LEU951 | |
| A | VAL1020-ILE1040 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 56 |
| Details | TOPO_DOM: Extracellular => ECO:0000269|PubMed:29211723, ECO:0000269|PubMed:29217581 |
| Chain | Residue | Details |
| A | ASP804-GLU814 | |
| A | PRO885-GLY886 | |
| A | LEU952-LEU963 | |
| A | VAL985-LEU1019 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 20 |
| Details | INTRAMEM: Pore-forming => ECO:0000269|PubMed:29211723, ECO:0000269|PubMed:29217581 |
| Chain | Residue | Details |
| A | ARG964-ASP984 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q7TN37 |
| Chain | Residue | Details |
| A | ARG171 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:38750366, ECO:0007744|PDB:9B90, ECO:0007744|PDB:9B91 |
| Chain | Residue | Details |
| A | ARG214 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:38750366, ECO:0007744|PDB:9B90 |
| Chain | Residue | Details |
| A | LEU225 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:38750366, ECO:0007744|PDB:9B8Y, ECO:0007744|PDB:9B91 |
| Chain | Residue | Details |
| A | ASP270 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:38750366, ECO:0007744|PDB:9B8W, ECO:0007744|PDB:9B8Y |
| Chain | Residue | Details |
| A | ALA392 | |
| A | ASP395 | |
| A | GLU396 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | BINDING: in other chain => ECO:0000250|UniProtKB:Q7TN37 |
| Chain | Residue | Details |
| A | ARG421 | |
| A | GLY448 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:29217581, ECO:0007744|PDB:6BQV |
| Chain | Residue | Details |
| A | GLU828 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:29217581, ECO:0000269|PubMed:38750366, ECO:0007744|PDB:6BQV, ECO:0007744|PDB:9B92 |
| Chain | Residue | Details |
| A | GLN831 | |
| A | ASN865 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:38750366, ECO:0000305|PubMed:29217581, ECO:0007744|PDB:6BQV, ECO:0007744|PDB:9B92 |
| Chain | Residue | Details |
| A | ASP868 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by PKC => ECO:0000305|PubMed:15590641 |
| Chain | Residue | Details |
| A | SER1145 | |
| A | SER1152 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:29217581 |
| Chain | Residue | Details |
| A | ASN992 |
