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9B62

Human RANBP2/RAN(GTP)/RANGAP1-SUMO1/UBC9/CRM1/RAN(GTP) - composite map and model

Functional Information from GO Data
ChainGOidnamespacecontents
A0000054biological_processribosomal subunit export from nucleus
A0000055biological_processribosomal large subunit export from nucleus
A0000056biological_processribosomal small subunit export from nucleus
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0000776cellular_componentkinetochore
A0003723molecular_functionRNA binding
A0005049molecular_functionnuclear export signal receptor activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005635cellular_componentnuclear envelope
A0005642cellular_componentannulate lamellae
A0005654cellular_componentnucleoplasm
A0005730cellular_componentnucleolus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006406biological_processmRNA export from nucleus
A0006611biological_processprotein export from nucleus
A0006886biological_processintracellular protein transport
A0006913biological_processnucleocytoplasmic transport
A0009410biological_processresponse to xenobiotic stimulus
A0010824biological_processregulation of centrosome duplication
A0015030cellular_componentCajal body
A0015031biological_processprotein transport
A0016020cellular_componentmembrane
A0019904molecular_functionprotein domain specific binding
A0031267molecular_functionsmall GTPase binding
A0031965cellular_componentnuclear membrane
A0032434biological_processregulation of proteasomal ubiquitin-dependent protein catabolic process
A0032991cellular_componentprotein-containing complex
A0034504biological_processprotein localization to nucleus
A0042176biological_processregulation of protein catabolic process
A0042254biological_processribosome biogenesis
A0046825biological_processregulation of protein export from nucleus
A0051028biological_processmRNA transport
A0071401biological_processcellular response to triglyceride
A0140297molecular_functionDNA-binding transcription factor binding
A1902075biological_processcellular response to salt
A1990904cellular_componentribonucleoprotein complex
B0000054biological_processribosomal subunit export from nucleus
B0000055biological_processribosomal large subunit export from nucleus
B0000056biological_processribosomal small subunit export from nucleus
B0000070biological_processmitotic sister chromatid segregation
B0000166molecular_functionnucleotide binding
B0000278biological_processmitotic cell cycle
B0000287molecular_functionmagnesium ion binding
B0000785cellular_componentchromatin
B0001673cellular_componentmale germ cell nucleus
B0002177cellular_componentmanchette
B0003682molecular_functionchromatin binding
B0003723molecular_functionRNA binding
B0003924molecular_functionGTPase activity
B0003925molecular_functionG protein activity
B0005049molecular_functionnuclear export signal receptor activity
B0005515molecular_functionprotein binding
B0005525molecular_functionGTP binding
B0005634cellular_componentnucleus
B0005635cellular_componentnuclear envelope
B0005643cellular_componentnuclear pore
B0005654cellular_componentnucleoplasm
B0005730cellular_componentnucleolus
B0005737cellular_componentcytoplasm
B0005814cellular_componentcentriole
B0005829cellular_componentcytosol
B0006096biological_processglycolytic process
B0006259biological_processDNA metabolic process
B0006606biological_processprotein import into nucleus
B0006611biological_processprotein export from nucleus
B0006913biological_processnucleocytoplasmic transport
B0007052biological_processmitotic spindle organization
B0007286biological_processspermatid development
B0008104biological_processprotein localization
B0015031biological_processprotein transport
B0016020cellular_componentmembrane
B0016032biological_processviral process
B0016787molecular_functionhydrolase activity
B0019003molecular_functionGDP binding
B0019904molecular_functionprotein domain specific binding
B0021766biological_processhippocampus development
B0030036biological_processactin cytoskeleton organization
B0030496cellular_componentmidbody
B0031503biological_processprotein-containing complex localization
B0032991cellular_componentprotein-containing complex
B0035281biological_processpre-miRNA export from nucleus
B0036126cellular_componentsperm flagellum
B0042307biological_processpositive regulation of protein import into nucleus
B0042470cellular_componentmelanosome
B0042565cellular_componentRNA nuclear export complex
B0044877molecular_functionprotein-containing complex binding
B0045296molecular_functioncadherin binding
B0045505molecular_functiondynein intermediate chain binding
B0046039biological_processGTP metabolic process
B0046872molecular_functionmetal ion binding
B0046982molecular_functionprotein heterodimerization activity
B0051301biological_processcell division
B0055037cellular_componentrecycling endosome
B0061015biological_processsnRNA import into nucleus
B0061676molecular_functionimportin-alpha family protein binding
B0070062cellular_componentextracellular exosome
B0070883molecular_functionpre-miRNA binding
B0071389biological_processcellular response to mineralocorticoid stimulus
B0090543cellular_componentFlemming body
B1902570biological_processprotein localization to nucleolus
C0000122biological_processnegative regulation of transcription by RNA polymerase II
C0000166molecular_functionnucleotide binding
C0000795cellular_componentsynaptonemal complex
C0001221molecular_functiontranscription coregulator binding
C0003723molecular_functionRNA binding
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005634cellular_componentnucleus
C0005635cellular_componentnuclear envelope
C0005643cellular_componentnuclear pore
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006511biological_processubiquitin-dependent protein catabolic process
C0007059biological_processchromosome segregation
C0007084biological_processmitotic nuclear membrane reassembly
C0008134molecular_functiontranscription factor binding
C0016604cellular_componentnuclear body
C0016605cellular_componentPML body
C0016740molecular_functiontransferase activity
C0016925biological_processprotein sumoylation
C0019789molecular_functionSUMO transferase activity
C0019899molecular_functionenzyme binding
C0030335biological_processpositive regulation of cell migration
C0036211biological_processprotein modification process
C0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
C0043398molecular_functionHLH domain binding
C0044388molecular_functionsmall protein activating enzyme binding
C0045892biological_processnegative regulation of DNA-templated transcription
C0048471cellular_componentperinuclear region of cytoplasm
C0050804biological_processmodulation of chemical synaptic transmission
C0051168biological_processnuclear export
C0051301biological_processcell division
C0061656molecular_functionSUMO conjugating enzyme activity
C0071535molecular_functionRING-like zinc finger domain binding
C0098685cellular_componentSchaffer collateral - CA1 synapse
C0098978cellular_componentglutamatergic synapse
C0099523cellular_componentpresynaptic cytosol
C0099524cellular_componentpostsynaptic cytosol
C0106068cellular_componentSUMO ligase complex
C1990234cellular_componenttransferase complex
D0001741cellular_componentXY body
D0003723molecular_functionRNA binding
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005643cellular_componentnuclear pore
D0005654cellular_componentnucleoplasm
D0005730cellular_componentnucleolus
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0006281biological_processDNA repair
D0006355biological_processregulation of DNA-templated transcription
D0008076cellular_componentvoltage-gated potassium channel complex
D0008134molecular_functiontranscription factor binding
D0010621biological_processnegative regulation of transcription by transcription factor localization
D0015459molecular_functionpotassium channel regulator activity
D0016020cellular_componentmembrane
D0016604cellular_componentnuclear body
D0016605cellular_componentPML body
D0016607cellular_componentnuclear speck
D0016925biological_processprotein sumoylation
D0019899molecular_functionenzyme binding
D0030578biological_processPML body organization
D0031334biological_processpositive regulation of protein-containing complex assembly
D0031386molecular_functionprotein tag activity
D0031625molecular_functionubiquitin protein ligase binding
D0031647biological_processregulation of protein stability
D0031965cellular_componentnuclear membrane
D0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
D0032880biological_processregulation of protein localization
D0034605biological_processcellular response to heat
D0042308biological_processnegative regulation of protein import into nucleus
D0043392biological_processnegative regulation of DNA binding
D0043433biological_processnegative regulation of DNA-binding transcription factor activity
D0044388molecular_functionsmall protein activating enzyme binding
D0044389molecular_functionubiquitin-like protein ligase binding
D0045759biological_processnegative regulation of action potential
D0045892biological_processnegative regulation of DNA-templated transcription
D0050821biological_processprotein stabilization
D0060021biological_processroof of mouth development
D0071276biological_processcellular response to cadmium ion
D0086004biological_processregulation of cardiac muscle cell contraction
D0090204biological_processprotein localization to nuclear pore
D0097165cellular_componentnuclear stress granule
D0098978cellular_componentglutamatergic synapse
D0099523cellular_componentpresynaptic cytosol
D0099524cellular_componentpostsynaptic cytosol
D0141109molecular_functiontransporter activator activity
D1901017biological_processnegative regulation of potassium ion transmembrane transporter activity
D1902260biological_processnegative regulation of delayed rectifier potassium channel activity
D1903169biological_processregulation of calcium ion transmembrane transport
D1990381molecular_functionubiquitin-specific protease binding
E0046907biological_processintracellular transport
F0000054biological_processribosomal subunit export from nucleus
F0000055biological_processribosomal large subunit export from nucleus
F0000056biological_processribosomal small subunit export from nucleus
F0000070biological_processmitotic sister chromatid segregation
F0000166molecular_functionnucleotide binding
F0000278biological_processmitotic cell cycle
F0000287molecular_functionmagnesium ion binding
F0000785cellular_componentchromatin
F0001673cellular_componentmale germ cell nucleus
F0002177cellular_componentmanchette
F0003682molecular_functionchromatin binding
F0003723molecular_functionRNA binding
F0003924molecular_functionGTPase activity
F0003925molecular_functionG protein activity
F0005049molecular_functionnuclear export signal receptor activity
F0005515molecular_functionprotein binding
F0005525molecular_functionGTP binding
F0005634cellular_componentnucleus
F0005635cellular_componentnuclear envelope
F0005643cellular_componentnuclear pore
F0005654cellular_componentnucleoplasm
F0005730cellular_componentnucleolus
F0005737cellular_componentcytoplasm
F0005814cellular_componentcentriole
F0005829cellular_componentcytosol
F0006096biological_processglycolytic process
F0006259biological_processDNA metabolic process
F0006606biological_processprotein import into nucleus
F0006611biological_processprotein export from nucleus
F0006913biological_processnucleocytoplasmic transport
F0007052biological_processmitotic spindle organization
F0007286biological_processspermatid development
F0008104biological_processprotein localization
F0015031biological_processprotein transport
F0016020cellular_componentmembrane
F0016032biological_processviral process
F0016787molecular_functionhydrolase activity
F0019003molecular_functionGDP binding
F0019904molecular_functionprotein domain specific binding
F0021766biological_processhippocampus development
F0030036biological_processactin cytoskeleton organization
F0030496cellular_componentmidbody
F0031503biological_processprotein-containing complex localization
F0032991cellular_componentprotein-containing complex
F0035281biological_processpre-miRNA export from nucleus
F0036126cellular_componentsperm flagellum
F0042307biological_processpositive regulation of protein import into nucleus
F0042470cellular_componentmelanosome
F0042565cellular_componentRNA nuclear export complex
F0044877molecular_functionprotein-containing complex binding
F0045296molecular_functioncadherin binding
F0045505molecular_functiondynein intermediate chain binding
F0046039biological_processGTP metabolic process
F0046872molecular_functionmetal ion binding
F0046982molecular_functionprotein heterodimerization activity
F0051301biological_processcell division
F0055037cellular_componentrecycling endosome
F0061015biological_processsnRNA import into nucleus
F0061676molecular_functionimportin-alpha family protein binding
F0070062cellular_componentextracellular exosome
F0070883molecular_functionpre-miRNA binding
F0071389biological_processcellular response to mineralocorticoid stimulus
F0090543cellular_componentFlemming body
F1902570biological_processprotein localization to nucleolus
G0000775cellular_componentchromosome, centromeric region
G0000776cellular_componentkinetochore
G0003723molecular_functionRNA binding
G0005096molecular_functionGTPase activator activity
G0005515molecular_functionprotein binding
G0005634cellular_componentnucleus
G0005635cellular_componentnuclear envelope
G0005643cellular_componentnuclear pore
G0005654cellular_componentnucleoplasm
G0005694cellular_componentchromosome
G0005737cellular_componentcytoplasm
G0005819cellular_componentspindle
G0005829cellular_componentcytosol
G0005856cellular_componentcytoskeleton
G0007165biological_processsignal transduction
G0016235cellular_componentaggresome
G0016925biological_processprotein sumoylation
G0030425cellular_componentdendrite
G0031267molecular_functionsmall GTPase binding
G0031625molecular_functionubiquitin protein ligase binding
G0031965cellular_componentnuclear membrane
G0044614cellular_componentnuclear pore cytoplasmic filaments
G0045296molecular_functioncadherin binding
G0046826biological_processnegative regulation of protein export from nucleus
G0048471cellular_componentperinuclear region of cytoplasm
G0048678biological_processresponse to axon injury
G0051168biological_processnuclear export
G0071375biological_processcellular response to peptide hormone stimulus
G0072686cellular_componentmitotic spindle
G0090630biological_processactivation of GTPase activity
G0106068cellular_componentSUMO ligase complex
G1904115cellular_componentaxon cytoplasm
G1904117biological_processcellular response to vasopressin
G1990723cellular_componentcytoplasmic periphery of the nuclear pore complex
Functional Information from PROSITE/UniProt
site_idPS00183
Number of Residues16
DetailsUBC_1 Ubiquitin-conjugating (UBC) active site signature. FHPNVyps.GtVCLsiL
ChainResidueDetails
CPHE82-LEU97

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsSITE: Hydrophobic interaction with UBE2I => ECO:0000250
ChainResidueDetails
GPHE562
GLYS565
ESER2510

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: N-acetylalanine => ECO:0000269|PubMed:20388717
ChainResidueDetails
GALA2
ESER2805
CLEU57

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
GSER24
GSER301

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:16428860, ECO:0007744|PubMed:18669648
ChainResidueDetails
GSER358
FASN122

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphothreonine; by CDK2 => ECO:0000269|PubMed:15037602
ChainResidueDetails
GTHR409
FSER150

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:15037602, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231
ChainResidueDetails
GSER428
DGLY97

site_idSWS_FT_FI7
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332
ChainResidueDetails
GSER435
FALA2

site_idSWS_FT_FI8
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:19690332
ChainResidueDetails
GTHR436
CLYS101

site_idSWS_FT_FI9
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:15037602, ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
ChainResidueDetails
GSER442
DLYS39
ELYS2612
ELYS2815

site_idSWS_FT_FI10
Number of Residues1
DetailsMOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861
ChainResidueDetails
GLYS524
BLYS99
FLYS60
FLYS99

site_idSWS_FT_FI11
Number of Residues1
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:28112733
ChainResidueDetails
GLYS8
FLYS71

site_idSWS_FT_FI12
Number of Residues5
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
ELYS2792
GLYS15
GLYS279
GLYS452
GLYS586

site_idSWS_FT_FI13
Number of Residues1
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:25114211, ECO:0007744|PubMed:25218447, ECO:0007744|PubMed:25755297, ECO:0007744|PubMed:25772364, ECO:0007744|PubMed:28112733
ChainResidueDetails
GLYS524
FLYS159

site_idSWS_FT_FI14
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate
ChainResidueDetails
BLYS71
FLYS71

site_idSWS_FT_FI15
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
BLYS152
FLYS152

237735

PDB entries from 2025-06-18

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