Loading
PDBj
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help

9B4L

Filament of Tau in complex with D-TLKIVWI, a D-peptide that disaggregates Alzheimer's Paired Helical Filaments, determined by Cryo-EM

Functional Information from GO Data
ChainGOidnamespacecontents
00000226biological_processmicrotubule cytoskeleton organization
00001774biological_processmicroglial cell activation
00003677molecular_functionDNA binding
00003680molecular_functionminor groove of adenine-thymine-rich DNA binding
00003690molecular_functiondouble-stranded DNA binding
00003697molecular_functionsingle-stranded DNA binding
00003723molecular_functionRNA binding
00003779molecular_functionactin binding
00005515molecular_functionprotein binding
00005576cellular_componentextracellular region
00005634cellular_componentnucleus
00005737cellular_componentcytoplasm
00005739cellular_componentmitochondrion
00005829cellular_componentcytosol
00005856cellular_componentcytoskeleton
00005874cellular_componentmicrotubule
00005886cellular_componentplasma membrane
00006974biological_processDNA damage response
00007267biological_processcell-cell signaling
00007613biological_processmemory
00008017molecular_functionmicrotubule binding
00010288biological_processresponse to lead ion
00010506biological_processregulation of autophagy
00010629biological_processnegative regulation of gene expression
00010917biological_processnegative regulation of mitochondrial membrane potential
00015630cellular_componentmicrotubule cytoskeleton
00016020cellular_componentmembrane
00016072biological_processrRNA metabolic process
00017124molecular_functionSH3 domain binding
00019896biological_processaxonal transport of mitochondrion
00019899molecular_functionenzyme binding
00019901molecular_functionprotein kinase binding
00021954biological_processcentral nervous system neuron development
00030424cellular_componentaxon
00030425cellular_componentdendrite
00030426cellular_componentgrowth cone
00030673cellular_componentaxolemma
00030674molecular_functionprotein-macromolecule adaptor activity
00031110biological_processregulation of microtubule polymerization or depolymerization
00031113biological_processregulation of microtubule polymerization
00031116biological_processpositive regulation of microtubule polymerization
00031122biological_processcytoplasmic microtubule organization
00031175biological_processneuron projection development
00032930biological_processpositive regulation of superoxide anion generation
00033044biological_processregulation of chromosome organization
00034063biological_processstress granule assembly
00034185molecular_functionapolipoprotein binding
00034399cellular_componentnuclear periphery
00034452molecular_functiondynactin binding
00034605biological_processcellular response to heat
00034614biological_processcellular response to reactive oxygen species
00035091molecular_functionphosphatidylinositol binding
00036464cellular_componentcytoplasmic ribonucleoprotein granule
00036477cellular_componentsomatodendritic compartment
00042802molecular_functionidentical protein binding
00042995cellular_componentcell projection
00043005cellular_componentneuron projection
00043025cellular_componentneuronal cell body
00043197cellular_componentdendritic spine
00043565molecular_functionsequence-specific DNA binding
00044297cellular_componentcell body
00044304cellular_componentmain axon
00045121cellular_componentmembrane raft
00045298cellular_componenttubulin complex
00045773biological_processpositive regulation of axon extension
00046785biological_processmicrotubule polymerization
00048143biological_processastrocyte activation
00048167biological_processregulation of synaptic plasticity
00048312biological_processintracellular distribution of mitochondria
00048699biological_processgeneration of neurons
00050808biological_processsynapse organization
00050848biological_processregulation of calcium-mediated signaling
00051087molecular_functionprotein-folding chaperone binding
00051258biological_processprotein polymerization
00051721molecular_functionprotein phosphatase 2A binding
00051879molecular_functionHsp90 protein binding
00061564biological_processaxon development
00070507biological_processregulation of microtubule cytoskeleton organization
00071813molecular_functionlipoprotein particle binding
00072386biological_processplus-end-directed organelle transport along microtubule
00090140biological_processregulation of mitochondrial fission
00090258biological_processnegative regulation of mitochondrial fission
00097386cellular_componentglial cell projection
00097418cellular_componentneurofibrillary tangle
00097435biological_processsupramolecular fiber organization
00098930biological_processaxonal transport
00099077molecular_functionhistone-dependent DNA binding
00099609molecular_functionmicrotubule lateral binding
01900034biological_processregulation of cellular response to heat
01900452biological_processregulation of long-term synaptic depression
01902474biological_processpositive regulation of protein localization to synapse
01902936molecular_functionphosphatidylinositol bisphosphate binding
01902988biological_processneurofibrillary tangle assembly
01903748biological_processnegative regulation of establishment of protein localization to mitochondrion
01903829biological_processpositive regulation of protein localization
01904115cellular_componentaxon cytoplasm
01904428biological_processnegative regulation of tubulin deacetylation
01990000biological_processamyloid fibril formation
01990090biological_processcellular response to nerve growth factor stimulus
01990416biological_processcellular response to brain-derived neurotrophic factor stimulus
10000226biological_processmicrotubule cytoskeleton organization
10001774biological_processmicroglial cell activation
10003677molecular_functionDNA binding
10003680molecular_functionminor groove of adenine-thymine-rich DNA binding
10003690molecular_functiondouble-stranded DNA binding
10003697molecular_functionsingle-stranded DNA binding
10003723molecular_functionRNA binding
10003779molecular_functionactin binding
10005515molecular_functionprotein binding
10005576cellular_componentextracellular region
10005634cellular_componentnucleus
10005737cellular_componentcytoplasm
10005739cellular_componentmitochondrion
10005829cellular_componentcytosol
10005856cellular_componentcytoskeleton
10005874cellular_componentmicrotubule
10005886cellular_componentplasma membrane
10006974biological_processDNA damage response
10007267biological_processcell-cell signaling
10007613biological_processmemory
10008017molecular_functionmicrotubule binding
10010288biological_processresponse to lead ion
10010506biological_processregulation of autophagy
10010629biological_processnegative regulation of gene expression
10010917biological_processnegative regulation of mitochondrial membrane potential
10015630cellular_componentmicrotubule cytoskeleton
10016020cellular_componentmembrane
10016072biological_processrRNA metabolic process
10017124molecular_functionSH3 domain binding
10019896biological_processaxonal transport of mitochondrion
10019899molecular_functionenzyme binding
10019901molecular_functionprotein kinase binding
10021954biological_processcentral nervous system neuron development
10030424cellular_componentaxon
10030425cellular_componentdendrite
10030426cellular_componentgrowth cone
10030673cellular_componentaxolemma
10030674molecular_functionprotein-macromolecule adaptor activity
10031110biological_processregulation of microtubule polymerization or depolymerization
10031113biological_processregulation of microtubule polymerization
10031116biological_processpositive regulation of microtubule polymerization
10031122biological_processcytoplasmic microtubule organization
10031175biological_processneuron projection development
10032930biological_processpositive regulation of superoxide anion generation
10033044biological_processregulation of chromosome organization
10034063biological_processstress granule assembly
10034185molecular_functionapolipoprotein binding
10034399cellular_componentnuclear periphery
10034452molecular_functiondynactin binding
10034605biological_processcellular response to heat
10034614biological_processcellular response to reactive oxygen species
10035091molecular_functionphosphatidylinositol binding
10036464cellular_componentcytoplasmic ribonucleoprotein granule
10036477cellular_componentsomatodendritic compartment
10042802molecular_functionidentical protein binding
10042995cellular_componentcell projection
10043005cellular_componentneuron projection
10043025cellular_componentneuronal cell body
10043197cellular_componentdendritic spine
10043565molecular_functionsequence-specific DNA binding
10044297cellular_componentcell body
10044304cellular_componentmain axon
10045121cellular_componentmembrane raft
10045298cellular_componenttubulin complex
10045773biological_processpositive regulation of axon extension
10046785biological_processmicrotubule polymerization
10048143biological_processastrocyte activation
10048167biological_processregulation of synaptic plasticity
10048312biological_processintracellular distribution of mitochondria
10048699biological_processgeneration of neurons
10050808biological_processsynapse organization
10050848biological_processregulation of calcium-mediated signaling
10051087molecular_functionprotein-folding chaperone binding
10051258biological_processprotein polymerization
10051721molecular_functionprotein phosphatase 2A binding
10051879molecular_functionHsp90 protein binding
10061564biological_processaxon development
10070507biological_processregulation of microtubule cytoskeleton organization
10071813molecular_functionlipoprotein particle binding
10072386biological_processplus-end-directed organelle transport along microtubule
10090140biological_processregulation of mitochondrial fission
10090258biological_processnegative regulation of mitochondrial fission
10097386cellular_componentglial cell projection
10097418cellular_componentneurofibrillary tangle
10097435biological_processsupramolecular fiber organization
10098930biological_processaxonal transport
10099077molecular_functionhistone-dependent DNA binding
10099609molecular_functionmicrotubule lateral binding
11900034biological_processregulation of cellular response to heat
11900452biological_processregulation of long-term synaptic depression
11902474biological_processpositive regulation of protein localization to synapse
11902936molecular_functionphosphatidylinositol bisphosphate binding
11902988biological_processneurofibrillary tangle assembly
11903748biological_processnegative regulation of establishment of protein localization to mitochondrion
11903829biological_processpositive regulation of protein localization
11904115cellular_componentaxon cytoplasm
11904428biological_processnegative regulation of tubulin deacetylation
11990000biological_processamyloid fibril formation
11990090biological_processcellular response to nerve growth factor stimulus
11990416biological_processcellular response to brain-derived neurotrophic factor stimulus
A0000226biological_processmicrotubule cytoskeleton organization
A0001774biological_processmicroglial cell activation
A0003677molecular_functionDNA binding
A0003680molecular_functionminor groove of adenine-thymine-rich DNA binding
A0003690molecular_functiondouble-stranded DNA binding
A0003697molecular_functionsingle-stranded DNA binding
A0003723molecular_functionRNA binding
A0003779molecular_functionactin binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0005874cellular_componentmicrotubule
A0005886cellular_componentplasma membrane
A0006974biological_processDNA damage response
A0007267biological_processcell-cell signaling
A0007613biological_processmemory
A0008017molecular_functionmicrotubule binding
A0010288biological_processresponse to lead ion
A0010506biological_processregulation of autophagy
A0010629biological_processnegative regulation of gene expression
A0010917biological_processnegative regulation of mitochondrial membrane potential
A0015630cellular_componentmicrotubule cytoskeleton
A0016020cellular_componentmembrane
A0016072biological_processrRNA metabolic process
A0017124molecular_functionSH3 domain binding
A0019896biological_processaxonal transport of mitochondrion
A0019899molecular_functionenzyme binding
A0019901molecular_functionprotein kinase binding
A0021954biological_processcentral nervous system neuron development
A0030424cellular_componentaxon
A0030425cellular_componentdendrite
A0030426cellular_componentgrowth cone
A0030673cellular_componentaxolemma
A0030674molecular_functionprotein-macromolecule adaptor activity
A0031110biological_processregulation of microtubule polymerization or depolymerization
A0031113biological_processregulation of microtubule polymerization
A0031116biological_processpositive regulation of microtubule polymerization
A0031122biological_processcytoplasmic microtubule organization
A0031175biological_processneuron projection development
A0032930biological_processpositive regulation of superoxide anion generation
A0033044biological_processregulation of chromosome organization
A0034063biological_processstress granule assembly
A0034185molecular_functionapolipoprotein binding
A0034399cellular_componentnuclear periphery
A0034452molecular_functiondynactin binding
A0034605biological_processcellular response to heat
A0034614biological_processcellular response to reactive oxygen species
A0035091molecular_functionphosphatidylinositol binding
A0036464cellular_componentcytoplasmic ribonucleoprotein granule
A0036477cellular_componentsomatodendritic compartment
A0042802molecular_functionidentical protein binding
A0042995cellular_componentcell projection
A0043005cellular_componentneuron projection
A0043025cellular_componentneuronal cell body
A0043197cellular_componentdendritic spine
A0043565molecular_functionsequence-specific DNA binding
A0044297cellular_componentcell body
A0044304cellular_componentmain axon
A0045121cellular_componentmembrane raft
A0045298cellular_componenttubulin complex
A0045773biological_processpositive regulation of axon extension
A0046785biological_processmicrotubule polymerization
A0048143biological_processastrocyte activation
A0048167biological_processregulation of synaptic plasticity
A0048312biological_processintracellular distribution of mitochondria
A0048699biological_processgeneration of neurons
A0050808biological_processsynapse organization
A0050848biological_processregulation of calcium-mediated signaling
A0051087molecular_functionprotein-folding chaperone binding
A0051258biological_processprotein polymerization
A0051721molecular_functionprotein phosphatase 2A binding
A0051879molecular_functionHsp90 protein binding
A0061564biological_processaxon development
A0070507biological_processregulation of microtubule cytoskeleton organization
A0071813molecular_functionlipoprotein particle binding
A0072386biological_processplus-end-directed organelle transport along microtubule
A0090140biological_processregulation of mitochondrial fission
A0090258biological_processnegative regulation of mitochondrial fission
A0097386cellular_componentglial cell projection
A0097418cellular_componentneurofibrillary tangle
A0097435biological_processsupramolecular fiber organization
A0098930biological_processaxonal transport
A0099077molecular_functionhistone-dependent DNA binding
A0099609molecular_functionmicrotubule lateral binding
A1900034biological_processregulation of cellular response to heat
A1900452biological_processregulation of long-term synaptic depression
A1902474biological_processpositive regulation of protein localization to synapse
A1902936molecular_functionphosphatidylinositol bisphosphate binding
A1902988biological_processneurofibrillary tangle assembly
A1903748biological_processnegative regulation of establishment of protein localization to mitochondrion
A1903829biological_processpositive regulation of protein localization
A1904115cellular_componentaxon cytoplasm
A1904428biological_processnegative regulation of tubulin deacetylation
A1990000biological_processamyloid fibril formation
A1990090biological_processcellular response to nerve growth factor stimulus
A1990416biological_processcellular response to brain-derived neurotrophic factor stimulus
B0000226biological_processmicrotubule cytoskeleton organization
B0001774biological_processmicroglial cell activation
B0003677molecular_functionDNA binding
B0003680molecular_functionminor groove of adenine-thymine-rich DNA binding
B0003690molecular_functiondouble-stranded DNA binding
B0003697molecular_functionsingle-stranded DNA binding
B0003723molecular_functionRNA binding
B0003779molecular_functionactin binding
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0005874cellular_componentmicrotubule
B0005886cellular_componentplasma membrane
B0006974biological_processDNA damage response
B0007267biological_processcell-cell signaling
B0007613biological_processmemory
B0008017molecular_functionmicrotubule binding
B0010288biological_processresponse to lead ion
B0010506biological_processregulation of autophagy
B0010629biological_processnegative regulation of gene expression
B0010917biological_processnegative regulation of mitochondrial membrane potential
B0015630cellular_componentmicrotubule cytoskeleton
B0016020cellular_componentmembrane
B0016072biological_processrRNA metabolic process
B0017124molecular_functionSH3 domain binding
B0019896biological_processaxonal transport of mitochondrion
B0019899molecular_functionenzyme binding
B0019901molecular_functionprotein kinase binding
B0021954biological_processcentral nervous system neuron development
B0030424cellular_componentaxon
B0030425cellular_componentdendrite
B0030426cellular_componentgrowth cone
B0030673cellular_componentaxolemma
B0030674molecular_functionprotein-macromolecule adaptor activity
B0031110biological_processregulation of microtubule polymerization or depolymerization
B0031113biological_processregulation of microtubule polymerization
B0031116biological_processpositive regulation of microtubule polymerization
B0031122biological_processcytoplasmic microtubule organization
B0031175biological_processneuron projection development
B0032930biological_processpositive regulation of superoxide anion generation
B0033044biological_processregulation of chromosome organization
B0034063biological_processstress granule assembly
B0034185molecular_functionapolipoprotein binding
B0034399cellular_componentnuclear periphery
B0034452molecular_functiondynactin binding
B0034605biological_processcellular response to heat
B0034614biological_processcellular response to reactive oxygen species
B0035091molecular_functionphosphatidylinositol binding
B0036464cellular_componentcytoplasmic ribonucleoprotein granule
B0036477cellular_componentsomatodendritic compartment
B0042802molecular_functionidentical protein binding
B0042995cellular_componentcell projection
B0043005cellular_componentneuron projection
B0043025cellular_componentneuronal cell body
B0043197cellular_componentdendritic spine
B0043565molecular_functionsequence-specific DNA binding
B0044297cellular_componentcell body
B0044304cellular_componentmain axon
B0045121cellular_componentmembrane raft
B0045298cellular_componenttubulin complex
B0045773biological_processpositive regulation of axon extension
B0046785biological_processmicrotubule polymerization
B0048143biological_processastrocyte activation
B0048167biological_processregulation of synaptic plasticity
B0048312biological_processintracellular distribution of mitochondria
B0048699biological_processgeneration of neurons
B0050808biological_processsynapse organization
B0050848biological_processregulation of calcium-mediated signaling
B0051087molecular_functionprotein-folding chaperone binding
B0051258biological_processprotein polymerization
B0051721molecular_functionprotein phosphatase 2A binding
B0051879molecular_functionHsp90 protein binding
B0061564biological_processaxon development
B0070507biological_processregulation of microtubule cytoskeleton organization
B0071813molecular_functionlipoprotein particle binding
B0072386biological_processplus-end-directed organelle transport along microtubule
B0090140biological_processregulation of mitochondrial fission
B0090258biological_processnegative regulation of mitochondrial fission
B0097386cellular_componentglial cell projection
B0097418cellular_componentneurofibrillary tangle
B0097435biological_processsupramolecular fiber organization
B0098930biological_processaxonal transport
B0099077molecular_functionhistone-dependent DNA binding
B0099609molecular_functionmicrotubule lateral binding
B1900034biological_processregulation of cellular response to heat
B1900452biological_processregulation of long-term synaptic depression
B1902474biological_processpositive regulation of protein localization to synapse
B1902936molecular_functionphosphatidylinositol bisphosphate binding
B1902988biological_processneurofibrillary tangle assembly
B1903748biological_processnegative regulation of establishment of protein localization to mitochondrion
B1903829biological_processpositive regulation of protein localization
B1904115cellular_componentaxon cytoplasm
B1904428biological_processnegative regulation of tubulin deacetylation
B1990000biological_processamyloid fibril formation
B1990090biological_processcellular response to nerve growth factor stimulus
B1990416biological_processcellular response to brain-derived neurotrophic factor stimulus
C0000226biological_processmicrotubule cytoskeleton organization
C0001774biological_processmicroglial cell activation
C0003677molecular_functionDNA binding
C0003680molecular_functionminor groove of adenine-thymine-rich DNA binding
C0003690molecular_functiondouble-stranded DNA binding
C0003697molecular_functionsingle-stranded DNA binding
C0003723molecular_functionRNA binding
C0003779molecular_functionactin binding
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005829cellular_componentcytosol
C0005856cellular_componentcytoskeleton
C0005874cellular_componentmicrotubule
C0005886cellular_componentplasma membrane
C0006974biological_processDNA damage response
C0007267biological_processcell-cell signaling
C0007613biological_processmemory
C0008017molecular_functionmicrotubule binding
C0010288biological_processresponse to lead ion
C0010506biological_processregulation of autophagy
C0010629biological_processnegative regulation of gene expression
C0010917biological_processnegative regulation of mitochondrial membrane potential
C0015630cellular_componentmicrotubule cytoskeleton
C0016020cellular_componentmembrane
C0016072biological_processrRNA metabolic process
C0017124molecular_functionSH3 domain binding
C0019896biological_processaxonal transport of mitochondrion
C0019899molecular_functionenzyme binding
C0019901molecular_functionprotein kinase binding
C0021954biological_processcentral nervous system neuron development
C0030424cellular_componentaxon
C0030425cellular_componentdendrite
C0030426cellular_componentgrowth cone
C0030673cellular_componentaxolemma
C0030674molecular_functionprotein-macromolecule adaptor activity
C0031110biological_processregulation of microtubule polymerization or depolymerization
C0031113biological_processregulation of microtubule polymerization
C0031116biological_processpositive regulation of microtubule polymerization
C0031122biological_processcytoplasmic microtubule organization
C0031175biological_processneuron projection development
C0032930biological_processpositive regulation of superoxide anion generation
C0033044biological_processregulation of chromosome organization
C0034063biological_processstress granule assembly
C0034185molecular_functionapolipoprotein binding
C0034399cellular_componentnuclear periphery
C0034452molecular_functiondynactin binding
C0034605biological_processcellular response to heat
C0034614biological_processcellular response to reactive oxygen species
C0035091molecular_functionphosphatidylinositol binding
C0036464cellular_componentcytoplasmic ribonucleoprotein granule
C0036477cellular_componentsomatodendritic compartment
C0042802molecular_functionidentical protein binding
C0042995cellular_componentcell projection
C0043005cellular_componentneuron projection
C0043025cellular_componentneuronal cell body
C0043197cellular_componentdendritic spine
C0043565molecular_functionsequence-specific DNA binding
C0044297cellular_componentcell body
C0044304cellular_componentmain axon
C0045121cellular_componentmembrane raft
C0045298cellular_componenttubulin complex
C0045773biological_processpositive regulation of axon extension
C0046785biological_processmicrotubule polymerization
C0048143biological_processastrocyte activation
C0048167biological_processregulation of synaptic plasticity
C0048312biological_processintracellular distribution of mitochondria
C0048699biological_processgeneration of neurons
C0050808biological_processsynapse organization
C0050848biological_processregulation of calcium-mediated signaling
C0051087molecular_functionprotein-folding chaperone binding
C0051258biological_processprotein polymerization
C0051721molecular_functionprotein phosphatase 2A binding
C0051879molecular_functionHsp90 protein binding
C0061564biological_processaxon development
C0070507biological_processregulation of microtubule cytoskeleton organization
C0071813molecular_functionlipoprotein particle binding
C0072386biological_processplus-end-directed organelle transport along microtubule
C0090140biological_processregulation of mitochondrial fission
C0090258biological_processnegative regulation of mitochondrial fission
C0097386cellular_componentglial cell projection
C0097418cellular_componentneurofibrillary tangle
C0097435biological_processsupramolecular fiber organization
C0098930biological_processaxonal transport
C0099077molecular_functionhistone-dependent DNA binding
C0099609molecular_functionmicrotubule lateral binding
C1900034biological_processregulation of cellular response to heat
C1900452biological_processregulation of long-term synaptic depression
C1902474biological_processpositive regulation of protein localization to synapse
C1902936molecular_functionphosphatidylinositol bisphosphate binding
C1902988biological_processneurofibrillary tangle assembly
C1903748biological_processnegative regulation of establishment of protein localization to mitochondrion
C1903829biological_processpositive regulation of protein localization
C1904115cellular_componentaxon cytoplasm
C1904428biological_processnegative regulation of tubulin deacetylation
C1990000biological_processamyloid fibril formation
C1990090biological_processcellular response to nerve growth factor stimulus
C1990416biological_processcellular response to brain-derived neurotrophic factor stimulus
D0000226biological_processmicrotubule cytoskeleton organization
D0001774biological_processmicroglial cell activation
D0003677molecular_functionDNA binding
D0003680molecular_functionminor groove of adenine-thymine-rich DNA binding
D0003690molecular_functiondouble-stranded DNA binding
D0003697molecular_functionsingle-stranded DNA binding
D0003723molecular_functionRNA binding
D0003779molecular_functionactin binding
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005739cellular_componentmitochondrion
D0005829cellular_componentcytosol
D0005856cellular_componentcytoskeleton
D0005874cellular_componentmicrotubule
D0005886cellular_componentplasma membrane
D0006974biological_processDNA damage response
D0007267biological_processcell-cell signaling
D0007613biological_processmemory
D0008017molecular_functionmicrotubule binding
D0010288biological_processresponse to lead ion
D0010506biological_processregulation of autophagy
D0010629biological_processnegative regulation of gene expression
D0010917biological_processnegative regulation of mitochondrial membrane potential
D0015630cellular_componentmicrotubule cytoskeleton
D0016020cellular_componentmembrane
D0016072biological_processrRNA metabolic process
D0017124molecular_functionSH3 domain binding
D0019896biological_processaxonal transport of mitochondrion
D0019899molecular_functionenzyme binding
D0019901molecular_functionprotein kinase binding
D0021954biological_processcentral nervous system neuron development
D0030424cellular_componentaxon
D0030425cellular_componentdendrite
D0030426cellular_componentgrowth cone
D0030673cellular_componentaxolemma
D0030674molecular_functionprotein-macromolecule adaptor activity
D0031110biological_processregulation of microtubule polymerization or depolymerization
D0031113biological_processregulation of microtubule polymerization
D0031116biological_processpositive regulation of microtubule polymerization
D0031122biological_processcytoplasmic microtubule organization
D0031175biological_processneuron projection development
D0032930biological_processpositive regulation of superoxide anion generation
D0033044biological_processregulation of chromosome organization
D0034063biological_processstress granule assembly
D0034185molecular_functionapolipoprotein binding
D0034399cellular_componentnuclear periphery
D0034452molecular_functiondynactin binding
D0034605biological_processcellular response to heat
D0034614biological_processcellular response to reactive oxygen species
D0035091molecular_functionphosphatidylinositol binding
D0036464cellular_componentcytoplasmic ribonucleoprotein granule
D0036477cellular_componentsomatodendritic compartment
D0042802molecular_functionidentical protein binding
D0042995cellular_componentcell projection
D0043005cellular_componentneuron projection
D0043025cellular_componentneuronal cell body
D0043197cellular_componentdendritic spine
D0043565molecular_functionsequence-specific DNA binding
D0044297cellular_componentcell body
D0044304cellular_componentmain axon
D0045121cellular_componentmembrane raft
D0045298cellular_componenttubulin complex
D0045773biological_processpositive regulation of axon extension
D0046785biological_processmicrotubule polymerization
D0048143biological_processastrocyte activation
D0048167biological_processregulation of synaptic plasticity
D0048312biological_processintracellular distribution of mitochondria
D0048699biological_processgeneration of neurons
D0050808biological_processsynapse organization
D0050848biological_processregulation of calcium-mediated signaling
D0051087molecular_functionprotein-folding chaperone binding
D0051258biological_processprotein polymerization
D0051721molecular_functionprotein phosphatase 2A binding
D0051879molecular_functionHsp90 protein binding
D0061564biological_processaxon development
D0070507biological_processregulation of microtubule cytoskeleton organization
D0071813molecular_functionlipoprotein particle binding
D0072386biological_processplus-end-directed organelle transport along microtubule
D0090140biological_processregulation of mitochondrial fission
D0090258biological_processnegative regulation of mitochondrial fission
D0097386cellular_componentglial cell projection
D0097418cellular_componentneurofibrillary tangle
D0097435biological_processsupramolecular fiber organization
D0098930biological_processaxonal transport
D0099077molecular_functionhistone-dependent DNA binding
D0099609molecular_functionmicrotubule lateral binding
D1900034biological_processregulation of cellular response to heat
D1900452biological_processregulation of long-term synaptic depression
D1902474biological_processpositive regulation of protein localization to synapse
D1902936molecular_functionphosphatidylinositol bisphosphate binding
D1902988biological_processneurofibrillary tangle assembly
D1903748biological_processnegative regulation of establishment of protein localization to mitochondrion
D1903829biological_processpositive regulation of protein localization
D1904115cellular_componentaxon cytoplasm
D1904428biological_processnegative regulation of tubulin deacetylation
D1990000biological_processamyloid fibril formation
D1990090biological_processcellular response to nerve growth factor stimulus
D1990416biological_processcellular response to brain-derived neurotrophic factor stimulus
M0000226biological_processmicrotubule cytoskeleton organization
M0001774biological_processmicroglial cell activation
M0003677molecular_functionDNA binding
M0003680molecular_functionminor groove of adenine-thymine-rich DNA binding
M0003690molecular_functiondouble-stranded DNA binding
M0003697molecular_functionsingle-stranded DNA binding
M0003723molecular_functionRNA binding
M0003779molecular_functionactin binding
M0005515molecular_functionprotein binding
M0005576cellular_componentextracellular region
M0005634cellular_componentnucleus
M0005737cellular_componentcytoplasm
M0005739cellular_componentmitochondrion
M0005829cellular_componentcytosol
M0005856cellular_componentcytoskeleton
M0005874cellular_componentmicrotubule
M0005886cellular_componentplasma membrane
M0006974biological_processDNA damage response
M0007267biological_processcell-cell signaling
M0007613biological_processmemory
M0008017molecular_functionmicrotubule binding
M0010288biological_processresponse to lead ion
M0010506biological_processregulation of autophagy
M0010629biological_processnegative regulation of gene expression
M0010917biological_processnegative regulation of mitochondrial membrane potential
M0015630cellular_componentmicrotubule cytoskeleton
M0016020cellular_componentmembrane
M0016072biological_processrRNA metabolic process
M0017124molecular_functionSH3 domain binding
M0019896biological_processaxonal transport of mitochondrion
M0019899molecular_functionenzyme binding
M0019901molecular_functionprotein kinase binding
M0021954biological_processcentral nervous system neuron development
M0030424cellular_componentaxon
M0030425cellular_componentdendrite
M0030426cellular_componentgrowth cone
M0030673cellular_componentaxolemma
M0030674molecular_functionprotein-macromolecule adaptor activity
M0031110biological_processregulation of microtubule polymerization or depolymerization
M0031113biological_processregulation of microtubule polymerization
M0031116biological_processpositive regulation of microtubule polymerization
M0031122biological_processcytoplasmic microtubule organization
M0031175biological_processneuron projection development
M0032930biological_processpositive regulation of superoxide anion generation
M0033044biological_processregulation of chromosome organization
M0034063biological_processstress granule assembly
M0034185molecular_functionapolipoprotein binding
M0034399cellular_componentnuclear periphery
M0034452molecular_functiondynactin binding
M0034605biological_processcellular response to heat
M0034614biological_processcellular response to reactive oxygen species
M0035091molecular_functionphosphatidylinositol binding
M0036464cellular_componentcytoplasmic ribonucleoprotein granule
M0036477cellular_componentsomatodendritic compartment
M0042802molecular_functionidentical protein binding
M0042995cellular_componentcell projection
M0043005cellular_componentneuron projection
M0043025cellular_componentneuronal cell body
M0043197cellular_componentdendritic spine
M0043565molecular_functionsequence-specific DNA binding
M0044297cellular_componentcell body
M0044304cellular_componentmain axon
M0045121cellular_componentmembrane raft
M0045298cellular_componenttubulin complex
M0045773biological_processpositive regulation of axon extension
M0046785biological_processmicrotubule polymerization
M0048143biological_processastrocyte activation
M0048167biological_processregulation of synaptic plasticity
M0048312biological_processintracellular distribution of mitochondria
M0048699biological_processgeneration of neurons
M0050808biological_processsynapse organization
M0050848biological_processregulation of calcium-mediated signaling
M0051087molecular_functionprotein-folding chaperone binding
M0051258biological_processprotein polymerization
M0051721molecular_functionprotein phosphatase 2A binding
M0051879molecular_functionHsp90 protein binding
M0061564biological_processaxon development
M0070507biological_processregulation of microtubule cytoskeleton organization
M0071813molecular_functionlipoprotein particle binding
M0072386biological_processplus-end-directed organelle transport along microtubule
M0090140biological_processregulation of mitochondrial fission
M0090258biological_processnegative regulation of mitochondrial fission
M0097386cellular_componentglial cell projection
M0097418cellular_componentneurofibrillary tangle
M0097435biological_processsupramolecular fiber organization
M0098930biological_processaxonal transport
M0099077molecular_functionhistone-dependent DNA binding
M0099609molecular_functionmicrotubule lateral binding
M1900034biological_processregulation of cellular response to heat
M1900452biological_processregulation of long-term synaptic depression
M1902474biological_processpositive regulation of protein localization to synapse
M1902936molecular_functionphosphatidylinositol bisphosphate binding
M1902988biological_processneurofibrillary tangle assembly
M1903748biological_processnegative regulation of establishment of protein localization to mitochondrion
M1903829biological_processpositive regulation of protein localization
M1904115cellular_componentaxon cytoplasm
M1904428biological_processnegative regulation of tubulin deacetylation
M1990000biological_processamyloid fibril formation
M1990090biological_processcellular response to nerve growth factor stimulus
M1990416biological_processcellular response to brain-derived neurotrophic factor stimulus
N0000226biological_processmicrotubule cytoskeleton organization
N0001774biological_processmicroglial cell activation
N0003677molecular_functionDNA binding
N0003680molecular_functionminor groove of adenine-thymine-rich DNA binding
N0003690molecular_functiondouble-stranded DNA binding
N0003697molecular_functionsingle-stranded DNA binding
N0003723molecular_functionRNA binding
N0003779molecular_functionactin binding
N0005515molecular_functionprotein binding
N0005576cellular_componentextracellular region
N0005634cellular_componentnucleus
N0005737cellular_componentcytoplasm
N0005739cellular_componentmitochondrion
N0005829cellular_componentcytosol
N0005856cellular_componentcytoskeleton
N0005874cellular_componentmicrotubule
N0005886cellular_componentplasma membrane
N0006974biological_processDNA damage response
N0007267biological_processcell-cell signaling
N0007613biological_processmemory
N0008017molecular_functionmicrotubule binding
N0010288biological_processresponse to lead ion
N0010506biological_processregulation of autophagy
N0010629biological_processnegative regulation of gene expression
N0010917biological_processnegative regulation of mitochondrial membrane potential
N0015630cellular_componentmicrotubule cytoskeleton
N0016020cellular_componentmembrane
N0016072biological_processrRNA metabolic process
N0017124molecular_functionSH3 domain binding
N0019896biological_processaxonal transport of mitochondrion
N0019899molecular_functionenzyme binding
N0019901molecular_functionprotein kinase binding
N0021954biological_processcentral nervous system neuron development
N0030424cellular_componentaxon
N0030425cellular_componentdendrite
N0030426cellular_componentgrowth cone
N0030673cellular_componentaxolemma
N0030674molecular_functionprotein-macromolecule adaptor activity
N0031110biological_processregulation of microtubule polymerization or depolymerization
N0031113biological_processregulation of microtubule polymerization
N0031116biological_processpositive regulation of microtubule polymerization
N0031122biological_processcytoplasmic microtubule organization
N0031175biological_processneuron projection development
N0032930biological_processpositive regulation of superoxide anion generation
N0033044biological_processregulation of chromosome organization
N0034063biological_processstress granule assembly
N0034185molecular_functionapolipoprotein binding
N0034399cellular_componentnuclear periphery
N0034452molecular_functiondynactin binding
N0034605biological_processcellular response to heat
N0034614biological_processcellular response to reactive oxygen species
N0035091molecular_functionphosphatidylinositol binding
N0036464cellular_componentcytoplasmic ribonucleoprotein granule
N0036477cellular_componentsomatodendritic compartment
N0042802molecular_functionidentical protein binding
N0042995cellular_componentcell projection
N0043005cellular_componentneuron projection
N0043025cellular_componentneuronal cell body
N0043197cellular_componentdendritic spine
N0043565molecular_functionsequence-specific DNA binding
N0044297cellular_componentcell body
N0044304cellular_componentmain axon
N0045121cellular_componentmembrane raft
N0045298cellular_componenttubulin complex
N0045773biological_processpositive regulation of axon extension
N0046785biological_processmicrotubule polymerization
N0048143biological_processastrocyte activation
N0048167biological_processregulation of synaptic plasticity
N0048312biological_processintracellular distribution of mitochondria
N0048699biological_processgeneration of neurons
N0050808biological_processsynapse organization
N0050848biological_processregulation of calcium-mediated signaling
N0051087molecular_functionprotein-folding chaperone binding
N0051258biological_processprotein polymerization
N0051721molecular_functionprotein phosphatase 2A binding
N0051879molecular_functionHsp90 protein binding
N0061564biological_processaxon development
N0070507biological_processregulation of microtubule cytoskeleton organization
N0071813molecular_functionlipoprotein particle binding
N0072386biological_processplus-end-directed organelle transport along microtubule
N0090140biological_processregulation of mitochondrial fission
N0090258biological_processnegative regulation of mitochondrial fission
N0097386cellular_componentglial cell projection
N0097418cellular_componentneurofibrillary tangle
N0097435biological_processsupramolecular fiber organization
N0098930biological_processaxonal transport
N0099077molecular_functionhistone-dependent DNA binding
N0099609molecular_functionmicrotubule lateral binding
N1900034biological_processregulation of cellular response to heat
N1900452biological_processregulation of long-term synaptic depression
N1902474biological_processpositive regulation of protein localization to synapse
N1902936molecular_functionphosphatidylinositol bisphosphate binding
N1902988biological_processneurofibrillary tangle assembly
N1903748biological_processnegative regulation of establishment of protein localization to mitochondrion
N1903829biological_processpositive regulation of protein localization
N1904115cellular_componentaxon cytoplasm
N1904428biological_processnegative regulation of tubulin deacetylation
N1990000biological_processamyloid fibril formation
N1990090biological_processcellular response to nerve growth factor stimulus
N1990416biological_processcellular response to brain-derived neurotrophic factor stimulus
O0000226biological_processmicrotubule cytoskeleton organization
O0001774biological_processmicroglial cell activation
O0003677molecular_functionDNA binding
O0003680molecular_functionminor groove of adenine-thymine-rich DNA binding
O0003690molecular_functiondouble-stranded DNA binding
O0003697molecular_functionsingle-stranded DNA binding
O0003723molecular_functionRNA binding
O0003779molecular_functionactin binding
O0005515molecular_functionprotein binding
O0005576cellular_componentextracellular region
O0005634cellular_componentnucleus
O0005737cellular_componentcytoplasm
O0005739cellular_componentmitochondrion
O0005829cellular_componentcytosol
O0005856cellular_componentcytoskeleton
O0005874cellular_componentmicrotubule
O0005886cellular_componentplasma membrane
O0006974biological_processDNA damage response
O0007267biological_processcell-cell signaling
O0007613biological_processmemory
O0008017molecular_functionmicrotubule binding
O0010288biological_processresponse to lead ion
O0010506biological_processregulation of autophagy
O0010629biological_processnegative regulation of gene expression
O0010917biological_processnegative regulation of mitochondrial membrane potential
O0015630cellular_componentmicrotubule cytoskeleton
O0016020cellular_componentmembrane
O0016072biological_processrRNA metabolic process
O0017124molecular_functionSH3 domain binding
O0019896biological_processaxonal transport of mitochondrion
O0019899molecular_functionenzyme binding
O0019901molecular_functionprotein kinase binding
O0021954biological_processcentral nervous system neuron development
O0030424cellular_componentaxon
O0030425cellular_componentdendrite
O0030426cellular_componentgrowth cone
O0030673cellular_componentaxolemma
O0030674molecular_functionprotein-macromolecule adaptor activity
O0031110biological_processregulation of microtubule polymerization or depolymerization
O0031113biological_processregulation of microtubule polymerization
O0031116biological_processpositive regulation of microtubule polymerization
O0031122biological_processcytoplasmic microtubule organization
O0031175biological_processneuron projection development
O0032930biological_processpositive regulation of superoxide anion generation
O0033044biological_processregulation of chromosome organization
O0034063biological_processstress granule assembly
O0034185molecular_functionapolipoprotein binding
O0034399cellular_componentnuclear periphery
O0034452molecular_functiondynactin binding
O0034605biological_processcellular response to heat
O0034614biological_processcellular response to reactive oxygen species
O0035091molecular_functionphosphatidylinositol binding
O0036464cellular_componentcytoplasmic ribonucleoprotein granule
O0036477cellular_componentsomatodendritic compartment
O0042802molecular_functionidentical protein binding
O0042995cellular_componentcell projection
O0043005cellular_componentneuron projection
O0043025cellular_componentneuronal cell body
O0043197cellular_componentdendritic spine
O0043565molecular_functionsequence-specific DNA binding
O0044297cellular_componentcell body
O0044304cellular_componentmain axon
O0045121cellular_componentmembrane raft
O0045298cellular_componenttubulin complex
O0045773biological_processpositive regulation of axon extension
O0046785biological_processmicrotubule polymerization
O0048143biological_processastrocyte activation
O0048167biological_processregulation of synaptic plasticity
O0048312biological_processintracellular distribution of mitochondria
O0048699biological_processgeneration of neurons
O0050808biological_processsynapse organization
O0050848biological_processregulation of calcium-mediated signaling
O0051087molecular_functionprotein-folding chaperone binding
O0051258biological_processprotein polymerization
O0051721molecular_functionprotein phosphatase 2A binding
O0051879molecular_functionHsp90 protein binding
O0061564biological_processaxon development
O0070507biological_processregulation of microtubule cytoskeleton organization
O0071813molecular_functionlipoprotein particle binding
O0072386biological_processplus-end-directed organelle transport along microtubule
O0090140biological_processregulation of mitochondrial fission
O0090258biological_processnegative regulation of mitochondrial fission
O0097386cellular_componentglial cell projection
O0097418cellular_componentneurofibrillary tangle
O0097435biological_processsupramolecular fiber organization
O0098930biological_processaxonal transport
O0099077molecular_functionhistone-dependent DNA binding
O0099609molecular_functionmicrotubule lateral binding
O1900034biological_processregulation of cellular response to heat
O1900452biological_processregulation of long-term synaptic depression
O1902474biological_processpositive regulation of protein localization to synapse
O1902936molecular_functionphosphatidylinositol bisphosphate binding
O1902988biological_processneurofibrillary tangle assembly
O1903748biological_processnegative regulation of establishment of protein localization to mitochondrion
O1903829biological_processpositive regulation of protein localization
O1904115cellular_componentaxon cytoplasm
O1904428biological_processnegative regulation of tubulin deacetylation
O1990000biological_processamyloid fibril formation
O1990090biological_processcellular response to nerve growth factor stimulus
O1990416biological_processcellular response to brain-derived neurotrophic factor stimulus
P0000226biological_processmicrotubule cytoskeleton organization
P0001774biological_processmicroglial cell activation
P0003677molecular_functionDNA binding
P0003680molecular_functionminor groove of adenine-thymine-rich DNA binding
P0003690molecular_functiondouble-stranded DNA binding
P0003697molecular_functionsingle-stranded DNA binding
P0003723molecular_functionRNA binding
P0003779molecular_functionactin binding
P0005515molecular_functionprotein binding
P0005576cellular_componentextracellular region
P0005634cellular_componentnucleus
P0005737cellular_componentcytoplasm
P0005739cellular_componentmitochondrion
P0005829cellular_componentcytosol
P0005856cellular_componentcytoskeleton
P0005874cellular_componentmicrotubule
P0005886cellular_componentplasma membrane
P0006974biological_processDNA damage response
P0007267biological_processcell-cell signaling
P0007613biological_processmemory
P0008017molecular_functionmicrotubule binding
P0010288biological_processresponse to lead ion
P0010506biological_processregulation of autophagy
P0010629biological_processnegative regulation of gene expression
P0010917biological_processnegative regulation of mitochondrial membrane potential
P0015630cellular_componentmicrotubule cytoskeleton
P0016020cellular_componentmembrane
P0016072biological_processrRNA metabolic process
P0017124molecular_functionSH3 domain binding
P0019896biological_processaxonal transport of mitochondrion
P0019899molecular_functionenzyme binding
P0019901molecular_functionprotein kinase binding
P0021954biological_processcentral nervous system neuron development
P0030424cellular_componentaxon
P0030425cellular_componentdendrite
P0030426cellular_componentgrowth cone
P0030673cellular_componentaxolemma
P0030674molecular_functionprotein-macromolecule adaptor activity
P0031110biological_processregulation of microtubule polymerization or depolymerization
P0031113biological_processregulation of microtubule polymerization
P0031116biological_processpositive regulation of microtubule polymerization
P0031122biological_processcytoplasmic microtubule organization
P0031175biological_processneuron projection development
P0032930biological_processpositive regulation of superoxide anion generation
P0033044biological_processregulation of chromosome organization
P0034063biological_processstress granule assembly
P0034185molecular_functionapolipoprotein binding
P0034399cellular_componentnuclear periphery
P0034452molecular_functiondynactin binding
P0034605biological_processcellular response to heat
P0034614biological_processcellular response to reactive oxygen species
P0035091molecular_functionphosphatidylinositol binding
P0036464cellular_componentcytoplasmic ribonucleoprotein granule
P0036477cellular_componentsomatodendritic compartment
P0042802molecular_functionidentical protein binding
P0042995cellular_componentcell projection
P0043005cellular_componentneuron projection
P0043025cellular_componentneuronal cell body
P0043197cellular_componentdendritic spine
P0043565molecular_functionsequence-specific DNA binding
P0044297cellular_componentcell body
P0044304cellular_componentmain axon
P0045121cellular_componentmembrane raft
P0045298cellular_componenttubulin complex
P0045773biological_processpositive regulation of axon extension
P0046785biological_processmicrotubule polymerization
P0048143biological_processastrocyte activation
P0048167biological_processregulation of synaptic plasticity
P0048312biological_processintracellular distribution of mitochondria
P0048699biological_processgeneration of neurons
P0050808biological_processsynapse organization
P0050848biological_processregulation of calcium-mediated signaling
P0051087molecular_functionprotein-folding chaperone binding
P0051258biological_processprotein polymerization
P0051721molecular_functionprotein phosphatase 2A binding
P0051879molecular_functionHsp90 protein binding
P0061564biological_processaxon development
P0070507biological_processregulation of microtubule cytoskeleton organization
P0071813molecular_functionlipoprotein particle binding
P0072386biological_processplus-end-directed organelle transport along microtubule
P0090140biological_processregulation of mitochondrial fission
P0090258biological_processnegative regulation of mitochondrial fission
P0097386cellular_componentglial cell projection
P0097418cellular_componentneurofibrillary tangle
P0097435biological_processsupramolecular fiber organization
P0098930biological_processaxonal transport
P0099077molecular_functionhistone-dependent DNA binding
P0099609molecular_functionmicrotubule lateral binding
P1900034biological_processregulation of cellular response to heat
P1900452biological_processregulation of long-term synaptic depression
P1902474biological_processpositive regulation of protein localization to synapse
P1902936molecular_functionphosphatidylinositol bisphosphate binding
P1902988biological_processneurofibrillary tangle assembly
P1903748biological_processnegative regulation of establishment of protein localization to mitochondrion
P1903829biological_processpositive regulation of protein localization
P1904115cellular_componentaxon cytoplasm
P1904428biological_processnegative regulation of tubulin deacetylation
P1990000biological_processamyloid fibril formation
P1990090biological_processcellular response to nerve growth factor stimulus
P1990416biological_processcellular response to brain-derived neurotrophic factor stimulus
Y0000226biological_processmicrotubule cytoskeleton organization
Y0001774biological_processmicroglial cell activation
Y0003677molecular_functionDNA binding
Y0003680molecular_functionminor groove of adenine-thymine-rich DNA binding
Y0003690molecular_functiondouble-stranded DNA binding
Y0003697molecular_functionsingle-stranded DNA binding
Y0003723molecular_functionRNA binding
Y0003779molecular_functionactin binding
Y0005515molecular_functionprotein binding
Y0005576cellular_componentextracellular region
Y0005634cellular_componentnucleus
Y0005737cellular_componentcytoplasm
Y0005739cellular_componentmitochondrion
Y0005829cellular_componentcytosol
Y0005856cellular_componentcytoskeleton
Y0005874cellular_componentmicrotubule
Y0005886cellular_componentplasma membrane
Y0006974biological_processDNA damage response
Y0007267biological_processcell-cell signaling
Y0007613biological_processmemory
Y0008017molecular_functionmicrotubule binding
Y0010288biological_processresponse to lead ion
Y0010506biological_processregulation of autophagy
Y0010629biological_processnegative regulation of gene expression
Y0010917biological_processnegative regulation of mitochondrial membrane potential
Y0015630cellular_componentmicrotubule cytoskeleton
Y0016020cellular_componentmembrane
Y0016072biological_processrRNA metabolic process
Y0017124molecular_functionSH3 domain binding
Y0019896biological_processaxonal transport of mitochondrion
Y0019899molecular_functionenzyme binding
Y0019901molecular_functionprotein kinase binding
Y0021954biological_processcentral nervous system neuron development
Y0030424cellular_componentaxon
Y0030425cellular_componentdendrite
Y0030426cellular_componentgrowth cone
Y0030673cellular_componentaxolemma
Y0030674molecular_functionprotein-macromolecule adaptor activity
Y0031110biological_processregulation of microtubule polymerization or depolymerization
Y0031113biological_processregulation of microtubule polymerization
Y0031116biological_processpositive regulation of microtubule polymerization
Y0031122biological_processcytoplasmic microtubule organization
Y0031175biological_processneuron projection development
Y0032930biological_processpositive regulation of superoxide anion generation
Y0033044biological_processregulation of chromosome organization
Y0034063biological_processstress granule assembly
Y0034185molecular_functionapolipoprotein binding
Y0034399cellular_componentnuclear periphery
Y0034452molecular_functiondynactin binding
Y0034605biological_processcellular response to heat
Y0034614biological_processcellular response to reactive oxygen species
Y0035091molecular_functionphosphatidylinositol binding
Y0036464cellular_componentcytoplasmic ribonucleoprotein granule
Y0036477cellular_componentsomatodendritic compartment
Y0042802molecular_functionidentical protein binding
Y0042995cellular_componentcell projection
Y0043005cellular_componentneuron projection
Y0043025cellular_componentneuronal cell body
Y0043197cellular_componentdendritic spine
Y0043565molecular_functionsequence-specific DNA binding
Y0044297cellular_componentcell body
Y0044304cellular_componentmain axon
Y0045121cellular_componentmembrane raft
Y0045298cellular_componenttubulin complex
Y0045773biological_processpositive regulation of axon extension
Y0046785biological_processmicrotubule polymerization
Y0048143biological_processastrocyte activation
Y0048167biological_processregulation of synaptic plasticity
Y0048312biological_processintracellular distribution of mitochondria
Y0048699biological_processgeneration of neurons
Y0050808biological_processsynapse organization
Y0050848biological_processregulation of calcium-mediated signaling
Y0051087molecular_functionprotein-folding chaperone binding
Y0051258biological_processprotein polymerization
Y0051721molecular_functionprotein phosphatase 2A binding
Y0051879molecular_functionHsp90 protein binding
Y0061564biological_processaxon development
Y0070507biological_processregulation of microtubule cytoskeleton organization
Y0071813molecular_functionlipoprotein particle binding
Y0072386biological_processplus-end-directed organelle transport along microtubule
Y0090140biological_processregulation of mitochondrial fission
Y0090258biological_processnegative regulation of mitochondrial fission
Y0097386cellular_componentglial cell projection
Y0097418cellular_componentneurofibrillary tangle
Y0097435biological_processsupramolecular fiber organization
Y0098930biological_processaxonal transport
Y0099077molecular_functionhistone-dependent DNA binding
Y0099609molecular_functionmicrotubule lateral binding
Y1900034biological_processregulation of cellular response to heat
Y1900452biological_processregulation of long-term synaptic depression
Y1902474biological_processpositive regulation of protein localization to synapse
Y1902936molecular_functionphosphatidylinositol bisphosphate binding
Y1902988biological_processneurofibrillary tangle assembly
Y1903748biological_processnegative regulation of establishment of protein localization to mitochondrion
Y1903829biological_processpositive regulation of protein localization
Y1904115cellular_componentaxon cytoplasm
Y1904428biological_processnegative regulation of tubulin deacetylation
Y1990000biological_processamyloid fibril formation
Y1990090biological_processcellular response to nerve growth factor stimulus
Y1990416biological_processcellular response to brain-derived neurotrophic factor stimulus
Z0000226biological_processmicrotubule cytoskeleton organization
Z0001774biological_processmicroglial cell activation
Z0003677molecular_functionDNA binding
Z0003680molecular_functionminor groove of adenine-thymine-rich DNA binding
Z0003690molecular_functiondouble-stranded DNA binding
Z0003697molecular_functionsingle-stranded DNA binding
Z0003723molecular_functionRNA binding
Z0003779molecular_functionactin binding
Z0005515molecular_functionprotein binding
Z0005576cellular_componentextracellular region
Z0005634cellular_componentnucleus
Z0005737cellular_componentcytoplasm
Z0005739cellular_componentmitochondrion
Z0005829cellular_componentcytosol
Z0005856cellular_componentcytoskeleton
Z0005874cellular_componentmicrotubule
Z0005886cellular_componentplasma membrane
Z0006974biological_processDNA damage response
Z0007267biological_processcell-cell signaling
Z0007613biological_processmemory
Z0008017molecular_functionmicrotubule binding
Z0010288biological_processresponse to lead ion
Z0010506biological_processregulation of autophagy
Z0010629biological_processnegative regulation of gene expression
Z0010917biological_processnegative regulation of mitochondrial membrane potential
Z0015630cellular_componentmicrotubule cytoskeleton
Z0016020cellular_componentmembrane
Z0016072biological_processrRNA metabolic process
Z0017124molecular_functionSH3 domain binding
Z0019896biological_processaxonal transport of mitochondrion
Z0019899molecular_functionenzyme binding
Z0019901molecular_functionprotein kinase binding
Z0021954biological_processcentral nervous system neuron development
Z0030424cellular_componentaxon
Z0030425cellular_componentdendrite
Z0030426cellular_componentgrowth cone
Z0030673cellular_componentaxolemma
Z0030674molecular_functionprotein-macromolecule adaptor activity
Z0031110biological_processregulation of microtubule polymerization or depolymerization
Z0031113biological_processregulation of microtubule polymerization
Z0031116biological_processpositive regulation of microtubule polymerization
Z0031122biological_processcytoplasmic microtubule organization
Z0031175biological_processneuron projection development
Z0032930biological_processpositive regulation of superoxide anion generation
Z0033044biological_processregulation of chromosome organization
Z0034063biological_processstress granule assembly
Z0034185molecular_functionapolipoprotein binding
Z0034399cellular_componentnuclear periphery
Z0034452molecular_functiondynactin binding
Z0034605biological_processcellular response to heat
Z0034614biological_processcellular response to reactive oxygen species
Z0035091molecular_functionphosphatidylinositol binding
Z0036464cellular_componentcytoplasmic ribonucleoprotein granule
Z0036477cellular_componentsomatodendritic compartment
Z0042802molecular_functionidentical protein binding
Z0042995cellular_componentcell projection
Z0043005cellular_componentneuron projection
Z0043025cellular_componentneuronal cell body
Z0043197cellular_componentdendritic spine
Z0043565molecular_functionsequence-specific DNA binding
Z0044297cellular_componentcell body
Z0044304cellular_componentmain axon
Z0045121cellular_componentmembrane raft
Z0045298cellular_componenttubulin complex
Z0045773biological_processpositive regulation of axon extension
Z0046785biological_processmicrotubule polymerization
Z0048143biological_processastrocyte activation
Z0048167biological_processregulation of synaptic plasticity
Z0048312biological_processintracellular distribution of mitochondria
Z0048699biological_processgeneration of neurons
Z0050808biological_processsynapse organization
Z0050848biological_processregulation of calcium-mediated signaling
Z0051087molecular_functionprotein-folding chaperone binding
Z0051258biological_processprotein polymerization
Z0051721molecular_functionprotein phosphatase 2A binding
Z0051879molecular_functionHsp90 protein binding
Z0061564biological_processaxon development
Z0070507biological_processregulation of microtubule cytoskeleton organization
Z0071813molecular_functionlipoprotein particle binding
Z0072386biological_processplus-end-directed organelle transport along microtubule
Z0090140biological_processregulation of mitochondrial fission
Z0090258biological_processnegative regulation of mitochondrial fission
Z0097386cellular_componentglial cell projection
Z0097418cellular_componentneurofibrillary tangle
Z0097435biological_processsupramolecular fiber organization
Z0098930biological_processaxonal transport
Z0099077molecular_functionhistone-dependent DNA binding
Z0099609molecular_functionmicrotubule lateral binding
Z1900034biological_processregulation of cellular response to heat
Z1900452biological_processregulation of long-term synaptic depression
Z1902474biological_processpositive regulation of protein localization to synapse
Z1902936molecular_functionphosphatidylinositol bisphosphate binding
Z1902988biological_processneurofibrillary tangle assembly
Z1903748biological_processnegative regulation of establishment of protein localization to mitochondrion
Z1903829biological_processpositive regulation of protein localization
Z1904115cellular_componentaxon cytoplasm
Z1904428biological_processnegative regulation of tubulin deacetylation
Z1990000biological_processamyloid fibril formation
Z1990090biological_processcellular response to nerve growth factor stimulus
Z1990416biological_processcellular response to brain-derived neurotrophic factor stimulus
Functional Information from PROSITE/UniProt
site_idPS00229
Number of Residues13
DetailsTAU_MAP_1 Tau and MAP proteins tubulin-binding repeat signature. GSteNlkHqPGGG
ChainResidueDetails
AGLY261-GLY273
AGLY292-GLY304
AGLY323-GLY335
AGLY355-GLY367

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues360
DetailsRepeat: {"description":"Tau/MAP 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00824","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"7706316","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues372
DetailsRepeat: {"description":"Tau/MAP 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00824","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"7706316","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues96
DetailsSite: {"description":"Not glycated","evidences":[{"source":"PubMed","id":"9326300","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues12
DetailsModified residue: {"description":"Phosphoserine; by PHK","evidences":[{"source":"PubMed","id":"7706316","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8999860","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues84
DetailsModified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P10637","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues24
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"7706316","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues12
DetailsModified residue: {"description":"Omega-N-methylarginine","evidences":[{"source":"UniProtKB","id":"P10637","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI8
Number of Residues12
DetailsModified residue: {"description":"Phosphoserine; by PHK","evidences":[{"source":"PubMed","id":"8999860","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI9
Number of Residues36
DetailsGlycosylation: {"description":"N-linked (Glc) (glycation) lysine; in PHF-tau; in vitro","evidences":[{"source":"PubMed","id":"9326300","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI10
Number of Residues24
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); in PHF-tau","evidences":[{"source":"PubMed","id":"16443603","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI11
Number of Residues24
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"UniProtKB","id":"P10637","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI12
Number of Residues72
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"UniProtKB","id":"P10637","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

239803

PDB entries from 2025-08-06

PDB statisticsPDBj update infoContact PDBjnumon