Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

9B29

Cryo-EM structure of the mouse TRPM3 alpha 2 channel in complex with cholesteryl hemisuccinate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005216	molecular_function	monoatomic ion channel activity
A	0005261	molecular_function	monoatomic cation channel activity
A	0005262	molecular_function	calcium channel activity
A	0005385	molecular_function	zinc ion transmembrane transporter activity
A	0005516	molecular_function	calmodulin binding
A	0005546	molecular_function	phosphatidylinositol-4,5-bisphosphate binding
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006812	biological_process	monoatomic cation transport
A	0016020	cellular_component	membrane
A	0031683	molecular_function	G-protein beta/gamma-subunit complex binding
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0051262	biological_process	protein tetramerization
A	0051289	biological_process	protein homotetramerization
A	0055085	biological_process	transmembrane transport
A	0070588	biological_process	calcium ion transmembrane transport
A	0071577	biological_process	zinc ion transmembrane transport
A	0097603	molecular_function	temperature-gated ion channel activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0005261	molecular_function	monoatomic cation channel activity
B	0005262	molecular_function	calcium channel activity
B	0005385	molecular_function	zinc ion transmembrane transporter activity
B	0005516	molecular_function	calmodulin binding
B	0005546	molecular_function	phosphatidylinositol-4,5-bisphosphate binding
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0006812	biological_process	monoatomic cation transport
B	0016020	cellular_component	membrane
B	0031683	molecular_function	G-protein beta/gamma-subunit complex binding
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0051262	biological_process	protein tetramerization
B	0051289	biological_process	protein homotetramerization
B	0055085	biological_process	transmembrane transport
B	0070588	biological_process	calcium ion transmembrane transport
B	0071577	biological_process	zinc ion transmembrane transport
B	0097603	molecular_function	temperature-gated ion channel activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0005261	molecular_function	monoatomic cation channel activity
C	0005262	molecular_function	calcium channel activity
C	0005385	molecular_function	zinc ion transmembrane transporter activity
C	0005516	molecular_function	calmodulin binding
C	0005546	molecular_function	phosphatidylinositol-4,5-bisphosphate binding
C	0005886	cellular_component	plasma membrane
C	0006811	biological_process	monoatomic ion transport
C	0006812	biological_process	monoatomic cation transport
C	0016020	cellular_component	membrane
C	0031683	molecular_function	G-protein beta/gamma-subunit complex binding
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0051262	biological_process	protein tetramerization
C	0051289	biological_process	protein homotetramerization
C	0055085	biological_process	transmembrane transport
C	0070588	biological_process	calcium ion transmembrane transport
C	0071577	biological_process	zinc ion transmembrane transport
C	0097603	molecular_function	temperature-gated ion channel activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0005261	molecular_function	monoatomic cation channel activity
D	0005262	molecular_function	calcium channel activity
D	0005385	molecular_function	zinc ion transmembrane transporter activity
D	0005516	molecular_function	calmodulin binding
D	0005546	molecular_function	phosphatidylinositol-4,5-bisphosphate binding
D	0005886	cellular_component	plasma membrane
D	0006811	biological_process	monoatomic ion transport
D	0006812	biological_process	monoatomic cation transport
D	0016020	cellular_component	membrane
D	0031683	molecular_function	G-protein beta/gamma-subunit complex binding
D	0034220	biological_process	monoatomic ion transmembrane transport
D	0051262	biological_process	protein tetramerization
D	0051289	biological_process	protein homotetramerization
D	0055085	biological_process	transmembrane transport
D	0070588	biological_process	calcium ion transmembrane transport
D	0071577	biological_process	zinc ion transmembrane transport
D	0097603	molecular_function	temperature-gated ion channel activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6064
Details	TOPO_DOM: Cytoplasmic => ECO:0000305

Chain	Residue	Details
A	MET1-LEU894
C	ILE949-ASP964
C	VAL1014-ARG1028
C	HIS1141-HIS1735
D	MET1-LEU894
D	ILE949-ASP964
D	VAL1014-ARG1028
D	HIS1141-HIS1735
A	ILE949-ASP964
A	VAL1014-ARG1028
A	HIS1141-HIS1735
B	MET1-LEU894
B	ILE949-ASP964
B	VAL1014-ARG1028
B	HIS1141-HIS1735
C	MET1-LEU894

site_id	SWS_FT_FI2
Number of Residues	92
Details	TRANSMEM: Helical; Name=1 => ECO:0000269\|PubMed:36283409

Chain	Residue	Details
A	VAL895-GLU918
B	VAL895-GLU918
C	VAL895-GLU918
D	VAL895-GLU918

site_id	SWS_FT_FI3
Number of Residues	136
Details	TOPO_DOM: Extracellular => ECO:0000305

Chain	Residue	Details
A	LYS919-MET925
C	LEU986-ILE989
C	GLU1057-ARG1073
C	ALA1102-ILE1111
D	LYS919-MET925
D	LEU986-ILE989
D	GLU1057-ARG1073
D	ALA1102-ILE1111
A	LEU986-ILE989
A	GLU1057-ARG1073
A	ALA1102-ILE1111
B	LYS919-MET925
B	LEU986-ILE989
B	GLU1057-ARG1073
B	ALA1102-ILE1111
C	LYS919-MET925

site_id	SWS_FT_FI4
Number of Residues	88
Details	TRANSMEM: Helical; Name=2 => ECO:0000269\|PubMed:36283409

Chain	Residue	Details
A	SER926-LEU948
B	SER926-LEU948
C	SER926-LEU948
D	SER926-LEU948

site_id	SWS_FT_FI5
Number of Residues	80
Details	TRANSMEM: Helical; Name=3 => ECO:0000269\|PubMed:36283409

Chain	Residue	Details
A	GLN965-ARG985
B	GLN965-ARG985
C	GLN965-ARG985
D	GLN965-ARG985

site_id	SWS_FT_FI6
Number of Residues	92
Details	TRANSMEM: Helical; Name=4 => ECO:0000269\|PubMed:36283409

Chain	Residue	Details
A	PHE990-PHE1013
B	PHE990-PHE1013
C	PHE990-PHE1013
D	PHE990-PHE1013

site_id	SWS_FT_FI7
Number of Residues	108
Details	TRANSMEM: Helical; Name=5 => ECO:0000269\|PubMed:36283409

Chain	Residue	Details
A	GLN1029-GLY1056
B	GLN1029-GLY1056
C	GLN1029-GLY1056
D	GLN1029-GLY1056

site_id	SWS_FT_FI8
Number of Residues	108
Details	INTRAMEM: Pore-forming => ECO:0000305\|PubMed:32780479

Chain	Residue	Details
A	GLU1074-VAL1101
B	GLU1074-VAL1101
C	GLU1074-VAL1101
D	GLU1074-VAL1101

site_id	SWS_FT_FI9
Number of Residues	100
Details	TRANSMEM: Helical; Name=6 => ECO:0000269\|PubMed:36283409

Chain	Residue	Details
A	ALA1112-ILE1137
B	ALA1112-ILE1137
C	ALA1112-ILE1137
D	ALA1112-ILE1137

site_id	SWS_FT_FI10
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:36283409, ECO:0007744\|PDB:8DDU

Chain	Residue	Details
A	ASP796
B	ASP796
C	ASP796
D	ASP796

site_id	SWS_FT_FI11
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269\|PubMed:36283409, ECO:0007744\|PDB:8DDT, ECO:0007744\|PDB:8DDU

Chain	Residue	Details
A	MET1017
A	LEU1018
B	MET1017
B	LEU1018
C	MET1017
C	LEU1018
D	MET1017
D	LEU1018

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)