9B0T

Cryo-EM structure of E227Q variant of uMtCK1 in complex with transition state analog

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003824	molecular_function	catalytic activity
A	0004111	molecular_function	creatine kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005739	cellular_component	mitochondrion
A	0005743	cellular_component	mitochondrial inner membrane
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0016772	molecular_function	transferase activity, transferring phosphorus-containing groups
A	0046314	biological_process	phosphocreatine biosynthetic process
B	0000166	molecular_function	nucleotide binding
B	0003824	molecular_function	catalytic activity
B	0004111	molecular_function	creatine kinase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005739	cellular_component	mitochondrion
B	0005743	cellular_component	mitochondrial inner membrane
B	0016301	molecular_function	kinase activity
B	0016740	molecular_function	transferase activity
B	0016772	molecular_function	transferase activity, transferring phosphorus-containing groups
B	0046314	biological_process	phosphocreatine biosynthetic process
C	0000166	molecular_function	nucleotide binding
C	0003824	molecular_function	catalytic activity
C	0004111	molecular_function	creatine kinase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005739	cellular_component	mitochondrion
C	0005743	cellular_component	mitochondrial inner membrane
C	0016301	molecular_function	kinase activity
C	0016740	molecular_function	transferase activity
C	0016772	molecular_function	transferase activity, transferring phosphorus-containing groups
C	0046314	biological_process	phosphocreatine biosynthetic process
D	0000166	molecular_function	nucleotide binding
D	0003824	molecular_function	catalytic activity
D	0004111	molecular_function	creatine kinase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005739	cellular_component	mitochondrion
D	0005743	cellular_component	mitochondrial inner membrane
D	0016301	molecular_function	kinase activity
D	0016740	molecular_function	transferase activity
D	0016772	molecular_function	transferase activity, transferring phosphorus-containing groups
D	0046314	biological_process	phosphocreatine biosynthetic process
E	0000166	molecular_function	nucleotide binding
E	0003824	molecular_function	catalytic activity
E	0004111	molecular_function	creatine kinase activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005739	cellular_component	mitochondrion
E	0005743	cellular_component	mitochondrial inner membrane
E	0016301	molecular_function	kinase activity
E	0016740	molecular_function	transferase activity
E	0016772	molecular_function	transferase activity, transferring phosphorus-containing groups
E	0046314	biological_process	phosphocreatine biosynthetic process
F	0000166	molecular_function	nucleotide binding
F	0003824	molecular_function	catalytic activity
F	0004111	molecular_function	creatine kinase activity
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005739	cellular_component	mitochondrion
F	0005743	cellular_component	mitochondrial inner membrane
F	0016301	molecular_function	kinase activity
F	0016740	molecular_function	transferase activity
F	0016772	molecular_function	transferase activity, transferring phosphorus-containing groups
F	0046314	biological_process	phosphocreatine biosynthetic process
G	0000166	molecular_function	nucleotide binding
G	0003824	molecular_function	catalytic activity
G	0004111	molecular_function	creatine kinase activity
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0005739	cellular_component	mitochondrion
G	0005743	cellular_component	mitochondrial inner membrane
G	0016301	molecular_function	kinase activity
G	0016740	molecular_function	transferase activity
G	0016772	molecular_function	transferase activity, transferring phosphorus-containing groups
G	0046314	biological_process	phosphocreatine biosynthetic process
H	0000166	molecular_function	nucleotide binding
H	0003824	molecular_function	catalytic activity
H	0004111	molecular_function	creatine kinase activity
H	0005515	molecular_function	protein binding
H	0005524	molecular_function	ATP binding
H	0005739	cellular_component	mitochondrion
H	0005743	cellular_component	mitochondrial inner membrane
H	0016301	molecular_function	kinase activity
H	0016740	molecular_function	transferase activity
H	0016772	molecular_function	transferase activity, transferring phosphorus-containing groups
H	0046314	biological_process	phosphocreatine biosynthetic process

Functional Information from PROSITE/UniProt

site_id	PS00112
Number of Residues	7
Details	PHOSPHAGEN_KINASE Phosphagen kinase active site signature. CP.SNLGT

Chain	Residue	Details
A	CYS278-THR284

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	688
Details	Domain: {"description":"Phosphagen kinase N-terminal","evidences":[{"source":"PROSITE-ProRule","id":"PRU00842","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	104
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00843","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	16
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P25809","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P00564","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P30275","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	8
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P07310","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---