9AZJ
Structure of ubiquitinated NEMO UBAN K285C-Ub G76C bound to HOIP NZF1
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | SITE: Interacts with activating enzyme |
| Chain | Residue | Details |
| F | ARG54 | |
| C | LYS283 | |
| C | LYS292 | |
| C | LYS302 | |
| D | LYS264 | |
| D | LYS283 | |
| D | LYS292 | |
| D | LYS302 | |
| F | ARG72 | |
| S | ARG54 | |
| S | ARG72 | |
| Z | ARG54 | |
| Z | ARG72 | |
| B | LYS292 | |
| B | LYS302 | |
| C | LYS264 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | SITE: Essential for function |
| Chain | Residue | Details |
| F | HIS68 | |
| S | HIS68 | |
| Z | HIS68 | |
| B | LYS326 | |
| C | LYS326 | |
| D | LYS326 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | MOD_RES: Phosphoserine; by PINK1 => ECO:0000269|PubMed:24660806, ECO:0000269|PubMed:24751536, ECO:0000269|PubMed:24784582, ECO:0000269|PubMed:25527291 |
| Chain | Residue | Details |
| F | SER65 | |
| S | SER65 | |
| Z | SER65 | |
| D | LYS277 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | MOD_RES: (Microbial infection) ADP-ribosylthreonine => ECO:0000269|PubMed:32330457 |
| Chain | Residue | Details |
| F | THR66 | |
| S | THR66 | |
| Z | THR66 | |
| D | CYS285 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | MOD_RES: ADP-ribosylglycine => ECO:0000269|PubMed:28525742 |
| Chain | Residue | Details |
| F | CYS76 | |
| S | CYS76 | |
| Z | CYS76 | |
| D | LYS309 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 3 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603 |
| Chain | Residue | Details |
| F | LYS6 | |
| S | LYS6 | |
| Z | LYS6 | |
| D | LYS321 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 6 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins) |
| Chain | Residue | Details |
| A | LYS325 | |
| F | CYS76 | |
| C | LYS325 | |
| S | CYS76 | |
| Z | CYS76 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 6 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:16543144 |
| Chain | Residue | Details |
| F | LYS11 | |
| F | LYS48 | |
| S | LYS11 | |
| S | LYS48 | |
| Z | LYS11 | |
| Z | LYS48 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 3 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:15466860 |
| Chain | Residue | Details |
| F | LYS27 | |
| S | LYS27 | |
| Z | LYS27 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 3 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:25752573, ECO:0000269|PubMed:25752577, ECO:0000269|PubMed:34239127 |
| Chain | Residue | Details |
| F | LYS29 | |
| S | LYS29 | |
| Z | LYS29 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 3 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:25752577 |
| Chain | Residue | Details |
| F | LYS33 | |
| S | LYS33 | |
| Z | LYS33 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 3 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:18719106 |
| Chain | Residue | Details |
| F | LYS63 | |
| S | LYS63 | |
| Z | LYS63 |
