Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

9ATU

Bifunctional Inhibition of Neutrophil Elastase by Eap4 from S. aureus

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0001878biological_processresponse to yeast
A0002020molecular_functionprotease binding
A0002438biological_processacute inflammatory response to antigenic stimulus
A0002523biological_processleukocyte migration involved in inflammatory response
A0002812biological_processbiosynthetic process of antibacterial peptides active against Gram-negative bacteria
A0003714molecular_functiontranscription corepressor activity
A0004175molecular_functionendopeptidase activity
A0004252molecular_functionserine-type endopeptidase activity
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006508biological_processproteolysis
A0006874biological_processintracellular calcium ion homeostasis
A0006909biological_processphagocytosis
A0008201molecular_functionheparin binding
A0008233molecular_functionpeptidase activity
A0008236molecular_functionserine-type peptidase activity
A0009411biological_processresponse to UV
A0009986cellular_componentcell surface
A0017053cellular_componenttranscription repressor complex
A0019955molecular_functioncytokine binding
A0022617biological_processextracellular matrix disassembly
A0030141cellular_componentsecretory granule
A0030163biological_processprotein catabolic process
A0031410cellular_componentcytoplasmic vesicle
A0032496biological_processresponse to lipopolysaccharide
A0032682biological_processnegative regulation of chemokine production
A0032717biological_processnegative regulation of interleukin-8 production
A0032757biological_processpositive regulation of interleukin-8 production
A0035578cellular_componentazurophil granule lumen
A0035580cellular_componentspecific granule lumen
A0042742biological_processdefense response to bacterium
A0043406biological_processpositive regulation of MAP kinase activity
A0045335cellular_componentphagocytic vesicle
A0048661biological_processpositive regulation of smooth muscle cell proliferation
A0050728biological_processnegative regulation of inflammatory response
A0050778biological_processpositive regulation of immune response
A0050832biological_processdefense response to fungus
A0050900biological_processleukocyte migration
A0050922biological_processnegative regulation of chemotaxis
A0062023cellular_componentcollagen-containing extracellular matrix
A0070062cellular_componentextracellular exosome
A0070269biological_processpyroptotic inflammatory response
A0070945biological_processneutrophil-mediated killing of gram-negative bacterium
A0070947biological_processneutrophil-mediated killing of fungus
A1903238biological_processpositive regulation of leukocyte tethering or rolling
C0000122biological_processnegative regulation of transcription by RNA polymerase II
C0001878biological_processresponse to yeast
C0002020molecular_functionprotease binding
C0002438biological_processacute inflammatory response to antigenic stimulus
C0002523biological_processleukocyte migration involved in inflammatory response
C0002812biological_processbiosynthetic process of antibacterial peptides active against Gram-negative bacteria
C0003714molecular_functiontranscription corepressor activity
C0004175molecular_functionendopeptidase activity
C0004252molecular_functionserine-type endopeptidase activity
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006508biological_processproteolysis
C0006874biological_processintracellular calcium ion homeostasis
C0006909biological_processphagocytosis
C0008201molecular_functionheparin binding
C0008233molecular_functionpeptidase activity
C0008236molecular_functionserine-type peptidase activity
C0009411biological_processresponse to UV
C0009986cellular_componentcell surface
C0017053cellular_componenttranscription repressor complex
C0019955molecular_functioncytokine binding
C0022617biological_processextracellular matrix disassembly
C0030141cellular_componentsecretory granule
C0030163biological_processprotein catabolic process
C0031410cellular_componentcytoplasmic vesicle
C0032496biological_processresponse to lipopolysaccharide
C0032682biological_processnegative regulation of chemokine production
C0032717biological_processnegative regulation of interleukin-8 production
C0032757biological_processpositive regulation of interleukin-8 production
C0035578cellular_componentazurophil granule lumen
C0035580cellular_componentspecific granule lumen
C0042742biological_processdefense response to bacterium
C0043406biological_processpositive regulation of MAP kinase activity
C0045335cellular_componentphagocytic vesicle
C0048661biological_processpositive regulation of smooth muscle cell proliferation
C0050728biological_processnegative regulation of inflammatory response
C0050778biological_processpositive regulation of immune response
C0050832biological_processdefense response to fungus
C0050900biological_processleukocyte migration
C0050922biological_processnegative regulation of chemotaxis
C0062023cellular_componentcollagen-containing extracellular matrix
C0070062cellular_componentextracellular exosome
C0070269biological_processpyroptotic inflammatory response
C0070945biological_processneutrophil-mediated killing of gram-negative bacterium
C0070947biological_processneutrophil-mediated killing of fungus
C1903238biological_processpositive regulation of leukocyte tethering or rolling
D0000122biological_processnegative regulation of transcription by RNA polymerase II
D0001878biological_processresponse to yeast
D0002020molecular_functionprotease binding
D0002438biological_processacute inflammatory response to antigenic stimulus
D0002523biological_processleukocyte migration involved in inflammatory response
D0002812biological_processbiosynthetic process of antibacterial peptides active against Gram-negative bacteria
D0003714molecular_functiontranscription corepressor activity
D0004175molecular_functionendopeptidase activity
D0004252molecular_functionserine-type endopeptidase activity
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0006508biological_processproteolysis
D0006874biological_processintracellular calcium ion homeostasis
D0006909biological_processphagocytosis
D0008201molecular_functionheparin binding
D0008233molecular_functionpeptidase activity
D0008236molecular_functionserine-type peptidase activity
D0009411biological_processresponse to UV
D0009986cellular_componentcell surface
D0017053cellular_componenttranscription repressor complex
D0019955molecular_functioncytokine binding
D0022617biological_processextracellular matrix disassembly
D0030141cellular_componentsecretory granule
D0030163biological_processprotein catabolic process
D0031410cellular_componentcytoplasmic vesicle
D0032496biological_processresponse to lipopolysaccharide
D0032682biological_processnegative regulation of chemokine production
D0032717biological_processnegative regulation of interleukin-8 production
D0032757biological_processpositive regulation of interleukin-8 production
D0035578cellular_componentazurophil granule lumen
D0035580cellular_componentspecific granule lumen
D0042742biological_processdefense response to bacterium
D0043406biological_processpositive regulation of MAP kinase activity
D0045335cellular_componentphagocytic vesicle
D0048661biological_processpositive regulation of smooth muscle cell proliferation
D0050728biological_processnegative regulation of inflammatory response
D0050778biological_processpositive regulation of immune response
D0050832biological_processdefense response to fungus
D0050900biological_processleukocyte migration
D0050922biological_processnegative regulation of chemotaxis
D0062023cellular_componentcollagen-containing extracellular matrix
D0070062cellular_componentextracellular exosome
D0070269biological_processpyroptotic inflammatory response
D0070945biological_processneutrophil-mediated killing of gram-negative bacterium
D0070947biological_processneutrophil-mediated killing of fungus
D1903238biological_processpositive regulation of leukocyte tethering or rolling
F0000122biological_processnegative regulation of transcription by RNA polymerase II
F0001878biological_processresponse to yeast
F0002020molecular_functionprotease binding
F0002438biological_processacute inflammatory response to antigenic stimulus
F0002523biological_processleukocyte migration involved in inflammatory response
F0002812biological_processbiosynthetic process of antibacterial peptides active against Gram-negative bacteria
F0003714molecular_functiontranscription corepressor activity
F0004175molecular_functionendopeptidase activity
F0004252molecular_functionserine-type endopeptidase activity
F0005515molecular_functionprotein binding
F0005576cellular_componentextracellular region
F0005615cellular_componentextracellular space
F0005737cellular_componentcytoplasm
F0005829cellular_componentcytosol
F0006508biological_processproteolysis
F0006874biological_processintracellular calcium ion homeostasis
F0006909biological_processphagocytosis
F0008201molecular_functionheparin binding
F0008233molecular_functionpeptidase activity
F0008236molecular_functionserine-type peptidase activity
F0009411biological_processresponse to UV
F0009986cellular_componentcell surface
F0017053cellular_componenttranscription repressor complex
F0019955molecular_functioncytokine binding
F0022617biological_processextracellular matrix disassembly
F0030141cellular_componentsecretory granule
F0030163biological_processprotein catabolic process
F0031410cellular_componentcytoplasmic vesicle
F0032496biological_processresponse to lipopolysaccharide
F0032682biological_processnegative regulation of chemokine production
F0032717biological_processnegative regulation of interleukin-8 production
F0032757biological_processpositive regulation of interleukin-8 production
F0035578cellular_componentazurophil granule lumen
F0035580cellular_componentspecific granule lumen
F0042742biological_processdefense response to bacterium
F0043406biological_processpositive regulation of MAP kinase activity
F0045335cellular_componentphagocytic vesicle
F0048661biological_processpositive regulation of smooth muscle cell proliferation
F0050728biological_processnegative regulation of inflammatory response
F0050778biological_processpositive regulation of immune response
F0050832biological_processdefense response to fungus
F0050900biological_processleukocyte migration
F0050922biological_processnegative regulation of chemotaxis
F0062023cellular_componentcollagen-containing extracellular matrix
F0070062cellular_componentextracellular exosome
F0070269biological_processpyroptotic inflammatory response
F0070945biological_processneutrophil-mediated killing of gram-negative bacterium
F0070947biological_processneutrophil-mediated killing of fungus
F1903238biological_processpositive regulation of leukocyte tethering or rolling
Functional Information from PROSITE/UniProt
site_idPS00134
Number of Residues6
DetailsTRYPSIN_HIS Serine proteases, trypsin family, histidine active site. MSAAHC
ChainResidueDetails
AMET65-CYS70

site_idPS00135
Number of Residues12
DetailsTRYPSIN_SER Serine proteases, trypsin family, serine active site. GVcfGDSGSPLV
ChainResidueDetails
AGLY195-VAL206

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues12
DetailsACT_SITE: Charge relay system => ECO:0000269|PubMed:2911584
ChainResidueDetails
AHIS69
FHIS69
FASP116
FSER201
AASP116
ASER201
CHIS69
CASP116
CSER201
DHIS69
DASP116
DSER201

site_idSWS_FT_FI2
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218
ChainResidueDetails
AASN87
CASN87
DASN87
FASN87

site_idSWS_FT_FI3
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:26274980, ECO:0000269|PubMed:3550808
ChainResidueDetails
AASN123
CASN123
DASN123
FASN123

site_idSWS_FT_FI4
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:3550808
ChainResidueDetails
AASN172
CASN172
DASN172
FASN172

224004

PDB entries from 2024-08-21

PDB statisticsPDBj update infoContact PDBjnumon