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9AS2

Global reconstruction of 5-HT2AR bound to DMT in complex with a mini-Gq protein and scFv16 obtained by cryo-electron microscopy (cryoEM)

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
A0001587molecular_functionGq/11-coupled serotonin receptor activity
A0001618molecular_functionvirus receptor activity
A0001659biological_processtemperature homeostasis
A0002720biological_processpositive regulation of cytokine production involved in immune response
A0004930molecular_functionG protein-coupled receptor activity
A0004993molecular_functionG protein-coupled serotonin receptor activity
A0005515molecular_functionprotein binding
A0005883cellular_componentneurofilament
A0005886cellular_componentplasma membrane
A0005901cellular_componentcaveola
A0006096biological_processglycolytic process
A0006874biological_processintracellular calcium ion homeostasis
A0007165biological_processsignal transduction
A0007186biological_processG protein-coupled receptor signaling pathway
A0007187biological_processG protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
A0007204biological_processpositive regulation of cytosolic calcium ion concentration
A0007208biological_processphospholipase C-activating serotonin receptor signaling pathway
A0007210biological_processserotonin receptor signaling pathway
A0007268biological_processchemical synaptic transmission
A0007613biological_processmemory
A0008284biological_processpositive regulation of cell population proliferation
A0009410biological_processresponse to xenobiotic stimulus
A0010513biological_processpositive regulation of phosphatidylinositol biosynthetic process
A0014059biological_processregulation of dopamine secretion
A0014824biological_processartery smooth muscle contraction
A0014832biological_processurinary bladder smooth muscle contraction
A0016020cellular_componentmembrane
A0030296molecular_functionprotein tyrosine kinase activator activity
A0030424cellular_componentaxon
A0030425cellular_componentdendrite
A0030594molecular_functionneurotransmitter receptor activity
A0031410cellular_componentcytoplasmic vesicle
A0031652biological_processpositive regulation of heat generation
A0042220biological_processresponse to cocaine
A0042734cellular_componentpresynaptic membrane
A0042802molecular_functionidentical protein binding
A0042995cellular_componentcell projection
A0043025cellular_componentneuronal cell body
A0043198cellular_componentdendritic shaft
A0043267biological_processnegative regulation of potassium ion transport
A0043525biological_processpositive regulation of neuron apoptotic process
A0044380biological_processprotein localization to cytoskeleton
A0044877molecular_functionprotein-containing complex binding
A0045202cellular_componentsynapse
A0045211cellular_componentpostsynaptic membrane
A0045600biological_processpositive regulation of fat cell differentiation
A0045821biological_processpositive regulation of glycolytic process
A0045907biological_processpositive regulation of vasoconstriction
A0046718biological_processsymbiont entry into host cell
A0046960biological_processsensitization
A0048148biological_processbehavioral response to cocaine
A0050729biological_processpositive regulation of inflammatory response
A0050951biological_processsensory perception of temperature stimulus
A0050965biological_processdetection of temperature stimulus involved in sensory perception of pain
A0050966biological_processdetection of mechanical stimulus involved in sensory perception of pain
A0051209biological_processrelease of sequestered calcium ion into cytosol
A0051378molecular_functionserotonin binding
A0051967biological_processnegative regulation of synaptic transmission, glutamatergic
A0070374biological_processpositive regulation of ERK1 and ERK2 cascade
A0070852cellular_componentcell body fiber
A0071886molecular_function1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding
A0098664biological_processG protein-coupled serotonin receptor signaling pathway
A0098666cellular_componentG protein-coupled serotonin receptor complex
A0098793cellular_componentpresynapse
A0098978cellular_componentglutamatergic synapse
A0099171biological_processpresynaptic modulation of chemical synaptic transmission
A0099589molecular_functionserotonin receptor activity
A1900119biological_processpositive regulation of execution phase of apoptosis
A1901731biological_processpositive regulation of platelet aggregation
A2000573biological_processpositive regulation of DNA biosynthetic process
C0001750cellular_componentphotoreceptor outer segment
C0003924molecular_functionGTPase activity
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005765cellular_componentlysosomal membrane
C0005829cellular_componentcytosol
C0005834cellular_componentheterotrimeric G-protein complex
C0005886cellular_componentplasma membrane
C0007165biological_processsignal transduction
C0007186biological_processG protein-coupled receptor signaling pathway
C0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
C0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
C0007213biological_processG protein-coupled acetylcholine receptor signaling pathway
C0007265biological_processRas protein signal transduction
C0008283biological_processcell population proliferation
C0016020cellular_componentmembrane
C0030159molecular_functionsignaling receptor complex adaptor activity
C0044877molecular_functionprotein-containing complex binding
C0045202cellular_componentsynapse
C0050909biological_processsensory perception of taste
C0051020molecular_functionGTPase binding
C0060041biological_processretina development in camera-type eye
C0070062cellular_componentextracellular exosome
C0071380biological_processcellular response to prostaglandin E stimulus
C0071870biological_processcellular response to catecholamine stimulus
C0097381cellular_componentphotoreceptor disc membrane
C1903561cellular_componentextracellular vesicle
D0005515molecular_functionprotein binding
D0005834cellular_componentheterotrimeric G-protein complex
D0005886cellular_componentplasma membrane
D0007165biological_processsignal transduction
D0007186biological_processG protein-coupled receptor signaling pathway
D0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
D0016020cellular_componentmembrane
D0031681molecular_functionG-protein beta-subunit binding
D0045202cellular_componentsynapse
D0048144biological_processfibroblast proliferation
D0070062cellular_componentextracellular exosome
D0071380biological_processcellular response to prostaglandin E stimulus
D0071870biological_processcellular response to catecholamine stimulus
Functional Information from PROSITE/UniProt
site_idPS00237
Number of Residues17
DetailsG_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASImHLCAISLDRYVaI
ChainResidueDetails
AALA161-ILE177

site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS
ChainResidueDetails
CLEU70-SER84
CILE157-ILE171
CLEU285-ALA299

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: N-acetylalanine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22814378
ChainResidueDetails
DALA2
AGLY138-LYS146
AGLN216-ASP232
ACYS349-ASP356

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Cysteine methyl ester => ECO:0000250|UniProtKB:P63212
ChainResidueDetails
DCYS68

site_idSWS_FT_FI3
Number of Residues1
DetailsLIPID: S-geranylgeranyl cysteine => ECO:0000250|UniProtKB:P63212
ChainResidueDetails
DCYS68
AASP172-LYS191
ALYS259-CYS322
APHE383-VAL471

site_idSWS_FT_FI4
Number of Residues25
DetailsTRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:36171289, ECO:0007744|PDB:7RAN
ChainResidueDetails
APHE112-TYR137

site_idSWS_FT_FI5
Number of Residues24
DetailsTRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:36171289, ECO:0007744|PDB:7RAN
ChainResidueDetails
ALEU147-LEU171

site_idSWS_FT_FI6
Number of Residues23
DetailsTRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:36171289, ECO:0007744|PDB:7RAN
ChainResidueDetails
AALA192-LEU215

site_idSWS_FT_FI7
Number of Residues25
DetailsTRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:36171289, ECO:0007744|PDB:7RAN
ChainResidueDetails
AASN233-ILE258

site_idSWS_FT_FI8
Number of Residues25
DetailsTRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:36171289, ECO:0007744|PDB:7RAN
ChainResidueDetails
ALYS323-ILE348

site_idSWS_FT_FI9
Number of Residues25
DetailsTRANSMEM: Helical; Name=7 => ECO:0000269|PubMed:36171289, ECO:0007744|PDB:7RAN
ChainResidueDetails
AVAL357-LEU382

site_idSWS_FT_FI10
Number of Residues1
DetailsBINDING: BINDING => ECO:0000269|PubMed:35084960, ECO:0007744|PDB:7WC4
ChainResidueDetails
AASP155

site_idSWS_FT_FI11
Number of Residues1
DetailsBINDING: BINDING => ECO:0000305|PubMed:35084960, ECO:0007744|PDB:7WC4
ChainResidueDetails
AASN343

site_idSWS_FT_FI12
Number of Residues1
DetailsSITE: Hydrophobic barrier that decreases the speed of ligand binding and dissociation => ECO:0000269|PubMed:28129538
ChainResidueDetails
ALEU229

site_idSWS_FT_FI13
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:24637012
ChainResidueDetails
ASER280

site_idSWS_FT_FI14
Number of Residues5
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN8
AASN38
AASN44
AASN51
AASN54

236371

PDB entries from 2025-05-21

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