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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8ZU3

Human PIEZO1-MDFIC

Functional Information from GO Data
ChainGOidnamespacecontents
A0005261molecular_functionmonoatomic cation channel activity
A0005515molecular_functionprotein binding
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0005886cellular_componentplasma membrane
A0006811biological_processmonoatomic ion transport
A0006812biological_processmonoatomic cation transport
A0008381molecular_functionmechanosensitive monoatomic ion channel activity
A0010831biological_processpositive regulation of myotube differentiation
A0016020cellular_componentmembrane
A0031258cellular_componentlamellipodium membrane
A0032420cellular_componentstereocilium
A0032437cellular_componentcuticular plate
A0033116cellular_componentendoplasmic reticulum-Golgi intermediate compartment membrane
A0033625biological_processpositive regulation of integrin activation
A0033634biological_processpositive regulation of cell-cell adhesion mediated by integrin
A0034220biological_processmonoatomic ion transmembrane transport
A0042391biological_processregulation of membrane potential
A0050982biological_processdetection of mechanical stimulus
A0071260biological_processcellular response to mechanical stimulus
A0098655biological_processmonoatomic cation transmembrane transport
A0140135molecular_functionmechanosensitive monoatomic cation channel activity
B0005261molecular_functionmonoatomic cation channel activity
B0005515molecular_functionprotein binding
B0005783cellular_componentendoplasmic reticulum
B0005789cellular_componentendoplasmic reticulum membrane
B0005886cellular_componentplasma membrane
B0006811biological_processmonoatomic ion transport
B0006812biological_processmonoatomic cation transport
B0008381molecular_functionmechanosensitive monoatomic ion channel activity
B0010831biological_processpositive regulation of myotube differentiation
B0016020cellular_componentmembrane
B0031258cellular_componentlamellipodium membrane
B0032420cellular_componentstereocilium
B0032437cellular_componentcuticular plate
B0033116cellular_componentendoplasmic reticulum-Golgi intermediate compartment membrane
B0033625biological_processpositive regulation of integrin activation
B0033634biological_processpositive regulation of cell-cell adhesion mediated by integrin
B0034220biological_processmonoatomic ion transmembrane transport
B0042391biological_processregulation of membrane potential
B0050982biological_processdetection of mechanical stimulus
B0071260biological_processcellular response to mechanical stimulus
B0098655biological_processmonoatomic cation transmembrane transport
B0140135molecular_functionmechanosensitive monoatomic cation channel activity
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005730cellular_componentnucleolus
C0005737cellular_componentcytoplasm
C0006351biological_processDNA-templated transcription
C0010468biological_processregulation of gene expression
C0030111biological_processregulation of Wnt signaling pathway
C0030332molecular_functioncyclin binding
C0030957molecular_functionTat protein binding
C0042308biological_processnegative regulation of protein import into nucleus
C0045892biological_processnegative regulation of DNA-templated transcription
C0045893biological_processpositive regulation of DNA-templated transcription
C0046328biological_processregulation of JNK cascade
C0050434biological_processpositive regulation of viral transcription
C0140297molecular_functionDNA-binding transcription factor binding
D0005261molecular_functionmonoatomic cation channel activity
D0005515molecular_functionprotein binding
D0005783cellular_componentendoplasmic reticulum
D0005789cellular_componentendoplasmic reticulum membrane
D0005886cellular_componentplasma membrane
D0006811biological_processmonoatomic ion transport
D0006812biological_processmonoatomic cation transport
D0008381molecular_functionmechanosensitive monoatomic ion channel activity
D0010831biological_processpositive regulation of myotube differentiation
D0016020cellular_componentmembrane
D0031258cellular_componentlamellipodium membrane
D0032420cellular_componentstereocilium
D0032437cellular_componentcuticular plate
D0033116cellular_componentendoplasmic reticulum-Golgi intermediate compartment membrane
D0033625biological_processpositive regulation of integrin activation
D0033634biological_processpositive regulation of cell-cell adhesion mediated by integrin
D0034220biological_processmonoatomic ion transmembrane transport
D0042391biological_processregulation of membrane potential
D0050982biological_processdetection of mechanical stimulus
D0071260biological_processcellular response to mechanical stimulus
D0098655biological_processmonoatomic cation transmembrane transport
D0140135molecular_functionmechanosensitive monoatomic cation channel activity
E0005515molecular_functionprotein binding
E0005576cellular_componentextracellular region
E0005634cellular_componentnucleus
E0005654cellular_componentnucleoplasm
E0005730cellular_componentnucleolus
E0005737cellular_componentcytoplasm
E0006351biological_processDNA-templated transcription
E0010468biological_processregulation of gene expression
E0030111biological_processregulation of Wnt signaling pathway
E0030332molecular_functioncyclin binding
E0030957molecular_functionTat protein binding
E0042308biological_processnegative regulation of protein import into nucleus
E0045892biological_processnegative regulation of DNA-templated transcription
E0045893biological_processpositive regulation of DNA-templated transcription
E0046328biological_processregulation of JNK cascade
E0050434biological_processpositive regulation of viral transcription
E0140297molecular_functionDNA-binding transcription factor binding
F0005515molecular_functionprotein binding
F0005576cellular_componentextracellular region
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0005730cellular_componentnucleolus
F0005737cellular_componentcytoplasm
F0006351biological_processDNA-templated transcription
F0010468biological_processregulation of gene expression
F0030111biological_processregulation of Wnt signaling pathway
F0030332molecular_functioncyclin binding
F0030957molecular_functionTat protein binding
F0042308biological_processnegative regulation of protein import into nucleus
F0045892biological_processnegative regulation of DNA-templated transcription
F0045893biological_processpositive regulation of DNA-templated transcription
F0046328biological_processregulation of JNK cascade
F0050434biological_processpositive regulation of viral transcription
F0140297molecular_functionDNA-binding transcription factor binding
Functional Information from PROSITE/UniProt
site_idPS00022
Number of Residues12
DetailsEGF_1 EGF-like domain signature 1. CcCcgDemGDdC
ChainResidueDetails
CCYS202-CYS213
site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YQCVAAH
ChainResidueDetails
ATYR1680-HIS1686
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues60
DetailsTransmembrane: {"description":"Helical; Name=13"}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues3
DetailsTopological domain: {"description":"Extracellular"}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues60
DetailsTransmembrane: {"description":"Helical; Name=14"}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues27
DetailsTopological domain: {"description":"Cytoplasmic"}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues48
DetailsTransmembrane: {"description":"Helical; Name=16"}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues33
DetailsTransmembrane: {"description":"Helical; Name=17","evidences":[{"source":"UniProtKB","id":"E2JF22","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues30
DetailsTopological domain: {"description":"Extracellular","evidences":[{"source":"UniProtKB","id":"E2JF22","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues39
DetailsTransmembrane: {"description":"Helical; Name=18","evidences":[{"source":"UniProtKB","id":"E2JF22","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues672
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"source":"UniProtKB","id":"E2JF22","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues42
DetailsTransmembrane: {"description":"Helical; Name=19","evidences":[{"source":"UniProtKB","id":"E2JF22","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues81
DetailsTransmembrane: {"description":"Helical; Name=20","evidences":[{"source":"UniProtKB","id":"E2JF22","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues45
DetailsTransmembrane: {"description":"Helical; Name=21","evidences":[{"source":"UniProtKB","id":"E2JF22","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues45
DetailsTransmembrane: {"description":"Helical; Name=22","evidences":[{"source":"UniProtKB","id":"E2JF22","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues45
DetailsTransmembrane: {"description":"Helical; Name=23","evidences":[{"source":"UniProtKB","id":"E2JF22","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues63
DetailsTransmembrane: {"description":"Helical; Name=24","evidences":[{"source":"UniProtKB","id":"E2JF22","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues78
DetailsTransmembrane: {"description":"Helical; Name=25","evidences":[{"source":"UniProtKB","id":"E2JF22","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues54
DetailsTransmembrane: {"description":"Helical; Name=26","evidences":[{"source":"UniProtKB","id":"E2JF22","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues48
DetailsTransmembrane: {"description":"Helical; Name=28","evidences":[{"source":"UniProtKB","id":"E2JF22","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues129
DetailsTransmembrane: {"description":"Helical; Name=29","evidences":[{"source":"UniProtKB","id":"E2JF22","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues45
DetailsTransmembrane: {"description":"Helical; Name=30","evidences":[{"source":"UniProtKB","id":"E2JF22","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues54
DetailsTransmembrane: {"description":"Helical; Name=31","evidences":[{"source":"UniProtKB","id":"E2JF22","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues63
DetailsTransmembrane: {"description":"Helical; Name=32","evidences":[{"source":"UniProtKB","id":"E2JF22","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues57
DetailsTransmembrane: {"description":"Helical; Name=33","evidences":[{"source":"UniProtKB","id":"E2JF22","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI24
Number of Residues48
DetailsTransmembrane: {"description":"Helical; Name=34","evidences":[{"source":"UniProtKB","id":"E2JF22","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI25
Number of Residues45
DetailsTransmembrane: {"description":"Helical; Name=36","evidences":[{"source":"UniProtKB","id":"E2JF22","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI26
Number of Residues60
DetailsTransmembrane: {"description":"Helical; Name=37","evidences":[{"source":"UniProtKB","id":"E2JF22","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI27
Number of Residues60
DetailsTransmembrane: {"description":"Helical; Name=38","evidences":[{"source":"UniProtKB","id":"E2JF22","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI28
Number of Residues87
DetailsCoiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI29
Number of Residues3
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI30
Number of Residues3
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19349973","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

246704

PDB entries from 2025-12-24

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