8ZEM
Crystal Structure of NLRP3 NACHT domain in complex with NP3-1
This is a non-PDB format compatible entry.
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:35254907, ECO:0000305|PubMed:36142182, ECO:0000305|PubMed:36442502, ECO:0007744|PDB:7VTP, ECO:0007744|PDB:7ZGU, ECO:0007744|PDB:8EJ4 |
| Chain | Residue | Details |
| A | THR169 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00136, ECO:0000269|PubMed:17483456, ECO:0000305|PubMed:34687713, ECO:0000305|PubMed:35114687, ECO:0000305|PubMed:35254907, ECO:0000305|PubMed:36142182, ECO:0000305|PubMed:36442502, ECO:0007744|PDB:7ALV, ECO:0007744|PDB:7PZC, ECO:0007744|PDB:7VTP, ECO:0007744|PDB:7ZGU, ECO:0007744|PDB:8EJ4 |
| Chain | Residue | Details |
| A | GLY226 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:34687713, ECO:0000305|PubMed:35114687, ECO:0000305|PubMed:35254907, ECO:0000305|PubMed:36142182, ECO:0007744|PDB:7ALV, ECO:0007744|PDB:7PZC, ECO:0007744|PDB:7VTP, ECO:0007744|PDB:7ZGU |
| Chain | Residue | Details |
| A | HIS522 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphotyrosine; by BTK => ECO:0000269|PubMed:34554188 |
| Chain | Residue | Details |
| A | TYR136 | |
| A | TYR140 | |
| A | TYR143 | |
| A | TYR168 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q8R4B8 |
| Chain | Residue | Details |
| A | SER161 | |
| A | SER295 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:28943315 |
| Chain | Residue | Details |
| A | SER163 | |
| A | SER334 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by MAPK8 => ECO:0000269|PubMed:35114687 |
| Chain | Residue | Details |
| A | SER198 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:35114687 |
| Chain | Residue | Details |
| A | SER201 |
