Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8ZAR

EmrAB-TolC MFS-type tripartite multidrug efflux pump FA

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005886	cellular_component	plasma membrane
A	0009636	biological_process	response to toxic substance
A	0015125	molecular_function	bile acid transmembrane transporter activity
A	0015721	biological_process	bile acid and bile salt transport
A	0030288	cellular_component	outer membrane-bounded periplasmic space
A	0042802	molecular_function	identical protein binding
A	0042910	molecular_function	xenobiotic transmembrane transporter activity
A	0046677	biological_process	response to antibiotic
A	0048545	biological_process	response to steroid hormone
A	0098567	cellular_component	periplasmic side of plasma membrane
A	0140330	biological_process	xenobiotic detoxification by transmembrane export across the cell outer membrane
A	1990961	biological_process	xenobiotic detoxification by transmembrane export across the plasma membrane
B	0005515	molecular_function	protein binding
B	0005886	cellular_component	plasma membrane
B	0009636	biological_process	response to toxic substance
B	0015125	molecular_function	bile acid transmembrane transporter activity
B	0015721	biological_process	bile acid and bile salt transport
B	0030288	cellular_component	outer membrane-bounded periplasmic space
B	0042802	molecular_function	identical protein binding
B	0042910	molecular_function	xenobiotic transmembrane transporter activity
B	0046677	biological_process	response to antibiotic
B	0048545	biological_process	response to steroid hormone
B	0098567	cellular_component	periplasmic side of plasma membrane
B	0140330	biological_process	xenobiotic detoxification by transmembrane export across the cell outer membrane
B	1990961	biological_process	xenobiotic detoxification by transmembrane export across the plasma membrane
C	0005515	molecular_function	protein binding
C	0005886	cellular_component	plasma membrane
C	0009636	biological_process	response to toxic substance
C	0015125	molecular_function	bile acid transmembrane transporter activity
C	0015721	biological_process	bile acid and bile salt transport
C	0030288	cellular_component	outer membrane-bounded periplasmic space
C	0042802	molecular_function	identical protein binding
C	0042910	molecular_function	xenobiotic transmembrane transporter activity
C	0046677	biological_process	response to antibiotic
C	0048545	biological_process	response to steroid hormone
C	0098567	cellular_component	periplasmic side of plasma membrane
C	0140330	biological_process	xenobiotic detoxification by transmembrane export across the cell outer membrane
C	1990961	biological_process	xenobiotic detoxification by transmembrane export across the plasma membrane
D	0005515	molecular_function	protein binding
D	0005886	cellular_component	plasma membrane
D	0009636	biological_process	response to toxic substance
D	0015125	molecular_function	bile acid transmembrane transporter activity
D	0015721	biological_process	bile acid and bile salt transport
D	0030288	cellular_component	outer membrane-bounded periplasmic space
D	0042802	molecular_function	identical protein binding
D	0042910	molecular_function	xenobiotic transmembrane transporter activity
D	0046677	biological_process	response to antibiotic
D	0048545	biological_process	response to steroid hormone
D	0098567	cellular_component	periplasmic side of plasma membrane
D	0140330	biological_process	xenobiotic detoxification by transmembrane export across the cell outer membrane
D	1990961	biological_process	xenobiotic detoxification by transmembrane export across the plasma membrane
E	0005515	molecular_function	protein binding
E	0005886	cellular_component	plasma membrane
E	0009636	biological_process	response to toxic substance
E	0015125	molecular_function	bile acid transmembrane transporter activity
E	0015721	biological_process	bile acid and bile salt transport
E	0030288	cellular_component	outer membrane-bounded periplasmic space
E	0042802	molecular_function	identical protein binding
E	0042910	molecular_function	xenobiotic transmembrane transporter activity
E	0046677	biological_process	response to antibiotic
E	0048545	biological_process	response to steroid hormone
E	0098567	cellular_component	periplasmic side of plasma membrane
E	0140330	biological_process	xenobiotic detoxification by transmembrane export across the cell outer membrane
E	1990961	biological_process	xenobiotic detoxification by transmembrane export across the plasma membrane
F	0005515	molecular_function	protein binding
F	0005886	cellular_component	plasma membrane
F	0009636	biological_process	response to toxic substance
F	0015125	molecular_function	bile acid transmembrane transporter activity
F	0015721	biological_process	bile acid and bile salt transport
F	0030288	cellular_component	outer membrane-bounded periplasmic space
F	0042802	molecular_function	identical protein binding
F	0042910	molecular_function	xenobiotic transmembrane transporter activity
F	0046677	biological_process	response to antibiotic
F	0048545	biological_process	response to steroid hormone
F	0098567	cellular_component	periplasmic side of plasma membrane
F	0140330	biological_process	xenobiotic detoxification by transmembrane export across the cell outer membrane
F	1990961	biological_process	xenobiotic detoxification by transmembrane export across the plasma membrane
G	0015562	molecular_function	efflux transmembrane transporter activity
G	0019867	cellular_component	outer membrane
G	0055085	biological_process	transmembrane transport
H	0015562	molecular_function	efflux transmembrane transporter activity
H	0019867	cellular_component	outer membrane
H	0055085	biological_process	transmembrane transport
I	0015562	molecular_function	efflux transmembrane transporter activity
I	0019867	cellular_component	outer membrane
I	0055085	biological_process	transmembrane transport
J	0005506	molecular_function	iron ion binding
J	0005515	molecular_function	protein binding
J	0005886	cellular_component	plasma membrane
J	0009055	molecular_function	electron transfer activity
J	0009636	biological_process	response to toxic substance
J	0015125	molecular_function	bile acid transmembrane transporter activity
J	0015721	biological_process	bile acid and bile salt transport
J	0016020	cellular_component	membrane
J	0020037	molecular_function	heme binding
J	0022857	molecular_function	transmembrane transporter activity
J	0022900	biological_process	electron transport chain
J	0042597	cellular_component	periplasmic space
J	0046677	biological_process	response to antibiotic
J	0048545	biological_process	response to steroid hormone
J	0055085	biological_process	transmembrane transport
J	0098567	cellular_component	periplasmic side of plasma membrane
J	0140330	biological_process	xenobiotic detoxification by transmembrane export across the cell outer membrane
J	1990961	biological_process	xenobiotic detoxification by transmembrane export across the plasma membrane

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	360
Details	Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	1032
Details	Topological domain: {"description":"Periplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	290
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	101
Details	Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	72
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	630
Details	Topological domain: {"description":"Periplasmic"}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	33
Details	Transmembrane: {"description":"Beta stranded; Name=S1"}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	81
Details	Topological domain: {"description":"Extracellular"}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	39
Details	Transmembrane: {"description":"Beta stranded; Name=S2"}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	30
Details	Transmembrane: {"description":"Beta stranded; Name=S4"}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	30
Details	Transmembrane: {"description":"Beta stranded; Name=S5"}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	621
Details	Repeat: {"description":"1"}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	645
Details	Repeat: {"description":"2"}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	84
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	45
Details	Compositional bias: {"description":"Polar residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		Validation report (PDF)