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8Z6U

SARS-CoV-2 EG.5.1 Spike in complex with CYFN1006-2(S-CYFN1006-2 dimer trimer).

Functional Information from GO Data
ChainGOidnamespacecontents
A0005515molecular_functionprotein binding
A0005886cellular_componentplasma membrane
A0007165biological_processsignal transduction
A0016020cellular_componentmembrane
A0019031cellular_componentviral envelope
A0019062biological_processvirion attachment to host cell
A0019064biological_processfusion of virus membrane with host plasma membrane
A0019081biological_processviral translation
A0020002cellular_componenthost cell plasma membrane
A0033644cellular_componenthost cell membrane
A0039587biological_processsymbiont-mediated-mediated suppression of host tetherin activity
A0039654biological_processfusion of virus membrane with host endosome membrane
A0039660molecular_functionstructural constituent of virion
A0039663biological_processmembrane fusion involved in viral entry into host cell
A0042802molecular_functionidentical protein binding
A0043655cellular_componenthost extracellular space
A0044173cellular_componenthost cell endoplasmic reticulum-Golgi intermediate compartment membrane
A0044228cellular_componenthost cell surface
A0044423cellular_componentvirion component
A0046598biological_processpositive regulation of viral entry into host cell
A0046718biological_processsymbiont entry into host cell
A0046789molecular_functionhost cell surface receptor binding
A0046813biological_processreceptor-mediated virion attachment to host cell
A0048018molecular_functionreceptor ligand activity
A0052170biological_processsymbiont-mediated suppression of host innate immune response
A0055036cellular_componentvirion membrane
A0061025biological_processmembrane fusion
A0075509biological_processendocytosis involved in viral entry into host cell
A0098670biological_processentry receptor-mediated virion attachment to host cell
A0141146biological_processsymbiont-mediated disruption of host tissue
B0005515molecular_functionprotein binding
B0005886cellular_componentplasma membrane
B0007165biological_processsignal transduction
B0016020cellular_componentmembrane
B0019031cellular_componentviral envelope
B0019062biological_processvirion attachment to host cell
B0019064biological_processfusion of virus membrane with host plasma membrane
B0019081biological_processviral translation
B0020002cellular_componenthost cell plasma membrane
B0033644cellular_componenthost cell membrane
B0039587biological_processsymbiont-mediated-mediated suppression of host tetherin activity
B0039654biological_processfusion of virus membrane with host endosome membrane
B0039660molecular_functionstructural constituent of virion
B0039663biological_processmembrane fusion involved in viral entry into host cell
B0042802molecular_functionidentical protein binding
B0043655cellular_componenthost extracellular space
B0044173cellular_componenthost cell endoplasmic reticulum-Golgi intermediate compartment membrane
B0044228cellular_componenthost cell surface
B0044423cellular_componentvirion component
B0046598biological_processpositive regulation of viral entry into host cell
B0046718biological_processsymbiont entry into host cell
B0046789molecular_functionhost cell surface receptor binding
B0046813biological_processreceptor-mediated virion attachment to host cell
B0048018molecular_functionreceptor ligand activity
B0052170biological_processsymbiont-mediated suppression of host innate immune response
B0055036cellular_componentvirion membrane
B0061025biological_processmembrane fusion
B0075509biological_processendocytosis involved in viral entry into host cell
B0098670biological_processentry receptor-mediated virion attachment to host cell
B0141146biological_processsymbiont-mediated disruption of host tissue
C0005515molecular_functionprotein binding
C0005886cellular_componentplasma membrane
C0007165biological_processsignal transduction
C0016020cellular_componentmembrane
C0019031cellular_componentviral envelope
C0019062biological_processvirion attachment to host cell
C0019064biological_processfusion of virus membrane with host plasma membrane
C0019081biological_processviral translation
C0020002cellular_componenthost cell plasma membrane
C0033644cellular_componenthost cell membrane
C0039587biological_processsymbiont-mediated-mediated suppression of host tetherin activity
C0039654biological_processfusion of virus membrane with host endosome membrane
C0039660molecular_functionstructural constituent of virion
C0039663biological_processmembrane fusion involved in viral entry into host cell
C0042802molecular_functionidentical protein binding
C0043655cellular_componenthost extracellular space
C0044173cellular_componenthost cell endoplasmic reticulum-Golgi intermediate compartment membrane
C0044228cellular_componenthost cell surface
C0044423cellular_componentvirion component
C0046598biological_processpositive regulation of viral entry into host cell
C0046718biological_processsymbiont entry into host cell
C0046789molecular_functionhost cell surface receptor binding
C0046813biological_processreceptor-mediated virion attachment to host cell
C0048018molecular_functionreceptor ligand activity
C0052170biological_processsymbiont-mediated suppression of host innate immune response
C0055036cellular_componentvirion membrane
C0061025biological_processmembrane fusion
C0075509biological_processendocytosis involved in viral entry into host cell
C0098670biological_processentry receptor-mediated virion attachment to host cell
C0141146biological_processsymbiont-mediated disruption of host tissue
D0005515molecular_functionprotein binding
D0005886cellular_componentplasma membrane
D0007165biological_processsignal transduction
D0016020cellular_componentmembrane
D0019031cellular_componentviral envelope
D0019062biological_processvirion attachment to host cell
D0019064biological_processfusion of virus membrane with host plasma membrane
D0019081biological_processviral translation
D0020002cellular_componenthost cell plasma membrane
D0033644cellular_componenthost cell membrane
D0039587biological_processsymbiont-mediated-mediated suppression of host tetherin activity
D0039654biological_processfusion of virus membrane with host endosome membrane
D0039660molecular_functionstructural constituent of virion
D0039663biological_processmembrane fusion involved in viral entry into host cell
D0042802molecular_functionidentical protein binding
D0043655cellular_componenthost extracellular space
D0044173cellular_componenthost cell endoplasmic reticulum-Golgi intermediate compartment membrane
D0044228cellular_componenthost cell surface
D0044423cellular_componentvirion component
D0046598biological_processpositive regulation of viral entry into host cell
D0046718biological_processsymbiont entry into host cell
D0046789molecular_functionhost cell surface receptor binding
D0046813biological_processreceptor-mediated virion attachment to host cell
D0048018molecular_functionreceptor ligand activity
D0052170biological_processsymbiont-mediated suppression of host innate immune response
D0055036cellular_componentvirion membrane
D0061025biological_processmembrane fusion
D0075509biological_processendocytosis involved in viral entry into host cell
D0098670biological_processentry receptor-mediated virion attachment to host cell
D0141146biological_processsymbiont-mediated disruption of host tissue
E0005515molecular_functionprotein binding
E0005886cellular_componentplasma membrane
E0007165biological_processsignal transduction
E0016020cellular_componentmembrane
E0019031cellular_componentviral envelope
E0019062biological_processvirion attachment to host cell
E0019064biological_processfusion of virus membrane with host plasma membrane
E0019081biological_processviral translation
E0020002cellular_componenthost cell plasma membrane
E0033644cellular_componenthost cell membrane
E0039587biological_processsymbiont-mediated-mediated suppression of host tetherin activity
E0039654biological_processfusion of virus membrane with host endosome membrane
E0039660molecular_functionstructural constituent of virion
E0039663biological_processmembrane fusion involved in viral entry into host cell
E0042802molecular_functionidentical protein binding
E0043655cellular_componenthost extracellular space
E0044173cellular_componenthost cell endoplasmic reticulum-Golgi intermediate compartment membrane
E0044228cellular_componenthost cell surface
E0044423cellular_componentvirion component
E0046598biological_processpositive regulation of viral entry into host cell
E0046718biological_processsymbiont entry into host cell
E0046789molecular_functionhost cell surface receptor binding
E0046813biological_processreceptor-mediated virion attachment to host cell
E0048018molecular_functionreceptor ligand activity
E0052170biological_processsymbiont-mediated suppression of host innate immune response
E0055036cellular_componentvirion membrane
E0061025biological_processmembrane fusion
E0075509biological_processendocytosis involved in viral entry into host cell
E0098670biological_processentry receptor-mediated virion attachment to host cell
E0141146biological_processsymbiont-mediated disruption of host tissue
F0005515molecular_functionprotein binding
F0005886cellular_componentplasma membrane
F0007165biological_processsignal transduction
F0016020cellular_componentmembrane
F0019031cellular_componentviral envelope
F0019062biological_processvirion attachment to host cell
F0019064biological_processfusion of virus membrane with host plasma membrane
F0019081biological_processviral translation
F0020002cellular_componenthost cell plasma membrane
F0033644cellular_componenthost cell membrane
F0039587biological_processsymbiont-mediated-mediated suppression of host tetherin activity
F0039654biological_processfusion of virus membrane with host endosome membrane
F0039660molecular_functionstructural constituent of virion
F0039663biological_processmembrane fusion involved in viral entry into host cell
F0042802molecular_functionidentical protein binding
F0043655cellular_componenthost extracellular space
F0044173cellular_componenthost cell endoplasmic reticulum-Golgi intermediate compartment membrane
F0044228cellular_componenthost cell surface
F0044423cellular_componentvirion component
F0046598biological_processpositive regulation of viral entry into host cell
F0046718biological_processsymbiont entry into host cell
F0046789molecular_functionhost cell surface receptor binding
F0046813biological_processreceptor-mediated virion attachment to host cell
F0048018molecular_functionreceptor ligand activity
F0052170biological_processsymbiont-mediated suppression of host innate immune response
F0055036cellular_componentvirion membrane
F0061025biological_processmembrane fusion
F0075509biological_processendocytosis involved in viral entry into host cell
F0098670biological_processentry receptor-mediated virion attachment to host cell
F0141146biological_processsymbiont-mediated disruption of host tissue
Functional Information from PROSITE/UniProt
site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YSCQVTH
ChainResidueDetails
JTYR212-HIS218
GTYR209-HIS215

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsSITE: Cleavage; by host furin => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32142651, ECO:0000269|PubMed:32362314, ECO:0000269|PubMed:32703818, ECO:0000269|PubMed:34159616
ChainResidueDetails
BSER689
ASER689
CSER689
ESER689
DSER689
FSER689

site_idSWS_FT_FI2
Number of Residues6
DetailsSITE: Cleavage; by host TMPRSS2 or CTSL => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32703818, ECO:0000269|PubMed:34159616
ChainResidueDetails
BGLU819
AGLU819
CGLU819
EGLU819
DGLU819
FGLU819

site_idSWS_FT_FI3
Number of Residues18
DetailsCARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942
ChainResidueDetails
BASN21
EASN21
EPRO1162
EVAL1177
DASN21
DPRO1162
DVAL1177
FASN21
FPRO1162
FVAL1177
BPRO1162
BVAL1177
AASN21
APRO1162
AVAL1177
CASN21
CPRO1162
CVAL1177

site_idSWS_FT_FI4
Number of Residues30
DetailsCARBOHYD: N-linked (GlcNAc...) (hybrid) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942
ChainResidueDetails
BTRP65
AALA1078
CTRP65
CASN126
CSER721
CILE805
CALA1078
ETRP65
EASN126
ESER721
EILE805
BASN126
EALA1078
DTRP65
DASN126
DSER721
DILE805
DALA1078
FTRP65
FASN126
FSER721
FILE805
BSER721
FALA1078
BILE805
BALA1078
ATRP65
AASN126
ASER721
AILE805

site_idSWS_FT_FI5
Number of Residues18
DetailsCARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942
ChainResidueDetails
BLYS78
ELYS78
EMET153
EILE1198
DLYS78
DMET153
DILE1198
FLYS78
FMET153
FILE1198
BMET153
BILE1198
ALYS78
AMET153
AILE1198
CLYS78
CMET153
CILE1198

site_idSWS_FT_FI6
Number of Residues42
DetailsCARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942
ChainResidueDetails
BGLU169
ALEU335
APHE347
AVAL620
AGLU661
ATRP1102
CGLU169
CTHR286
CLEU335
CPHE347
CVAL620
BTHR286
CGLU661
CTRP1102
EGLU169
ETHR286
ELEU335
EPHE347
EVAL620
EGLU661
ETRP1102
DGLU169
BLEU335
DTHR286
DLEU335
DPHE347
DVAL620
DGLU661
DTRP1102
FGLU169
FTHR286
FLEU335
FPHE347
BPHE347
FVAL620
FGLU661
FTRP1102
BVAL620
BGLU661
BTRP1102
AGLU169
ATHR286

site_idSWS_FT_FI7
Number of Residues12
DetailsCARBOHYD: N-linked (GlcNAc...) (high mannose) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942
ChainResidueDetails
BPHE238
DALA713
FPHE238
FALA713
BALA713
APHE238
AALA713
CPHE238
CALA713
EPHE238
EALA713
DPHE238

site_idSWS_FT_FI8
Number of Residues6
DetailsCARBOHYD: O-linked (GalNAc) threonine; by host => ECO:0000269|PubMed:32363391
ChainResidueDetails
BVAL327
AVAL327
CVAL327
EVAL327
DVAL327
FVAL327

site_idSWS_FT_FI9
Number of Residues6
DetailsCARBOHYD: O-linked (HexNAc...) serine; by host => ECO:0000269|PubMed:32363391
ChainResidueDetails
BPHE329
APHE329
CPHE329
EPHE329
DPHE329
FPHE329

site_idSWS_FT_FI10
Number of Residues6
DetailsCARBOHYD: N-linked (GlcNAc...) (hybrid) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942
ChainResidueDetails
BGLN607
AGLN607
CGLN607
EGLN607
DGLN607
FGLN607

site_idSWS_FT_FI11
Number of Residues12
DetailsCARBOHYD: O-linked (GlcNAc...) threonine; by host GALNT1 => ECO:0000269|PubMed:34732583
ChainResidueDetails
BSER680
DGLY682
FSER680
FGLY682
BGLY682
ASER680
AGLY682
CSER680
CGLY682
ESER680
EGLY682
DSER680

site_idSWS_FT_FI12
Number of Residues6
DetailsCARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942
ChainResidueDetails
BTYR1138
ATYR1138
CTYR1138
ETYR1138
DTYR1138
FTYR1138

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PDB entries from 2025-06-18

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