8Z5T

human phosphorylase kinase - phosphorylation and Ca2+ bound state

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004689	molecular_function	phosphorylase kinase activity
A	0005516	molecular_function	calmodulin binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0005964	cellular_component	phosphorylase kinase complex
A	0005977	biological_process	glycogen metabolic process
A	0006091	biological_process	generation of precursor metabolites and energy
A	0016020	cellular_component	membrane
A	0045819	biological_process	positive regulation of glycogen catabolic process
B	0005515	molecular_function	protein binding
B	0005516	molecular_function	calmodulin binding
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0005964	cellular_component	phosphorylase kinase complex
B	0005977	biological_process	glycogen metabolic process
B	0006091	biological_process	generation of precursor metabolites and energy
B	0016020	cellular_component	membrane
C	0000166	molecular_function	nucleotide binding
C	0004674	molecular_function	protein serine/threonine kinase activity
C	0004689	molecular_function	phosphorylase kinase activity
C	0005516	molecular_function	calmodulin binding
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005964	cellular_component	phosphorylase kinase complex
C	0005975	biological_process	carbohydrate metabolic process
C	0005977	biological_process	glycogen metabolic process
C	0007165	biological_process	signal transduction
C	0016301	molecular_function	kinase activity
C	0016740	molecular_function	transferase activity
C	0019899	molecular_function	enzyme binding
C	0106310	molecular_function	protein serine kinase activity
D	0000086	biological_process	G2/M transition of mitotic cell cycle
D	0000922	cellular_component	spindle pole
D	0001975	biological_process	response to amphetamine
D	0002027	biological_process	regulation of heart rate
D	0005246	molecular_function	calcium channel regulator activity
D	0005509	molecular_function	calcium ion binding
D	0005513	biological_process	detection of calcium ion
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005813	cellular_component	centrosome
D	0005819	cellular_component	spindle
D	0005856	cellular_component	cytoskeleton
D	0005876	cellular_component	spindle microtubule
D	0005886	cellular_component	plasma membrane
D	0007186	biological_process	G protein-coupled receptor signaling pathway
D	0008076	cellular_component	voltage-gated potassium channel complex
D	0008179	molecular_function	adenylate cyclase binding
D	0010856	molecular_function	adenylate cyclase activator activity
D	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
D	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
D	0016020	cellular_component	membrane
D	0019901	molecular_function	protein kinase binding
D	0019904	molecular_function	protein domain specific binding
D	0021762	biological_process	substantia nigra development
D	0030017	cellular_component	sarcomere
D	0030235	molecular_function	nitric-oxide synthase regulator activity
D	0030426	cellular_component	growth cone
D	0030672	cellular_component	synaptic vesicle membrane
D	0031432	molecular_function	titin binding
D	0031800	molecular_function	type 3 metabotropic glutamate receptor binding
D	0031966	cellular_component	mitochondrial membrane
D	0031982	cellular_component	vesicle
D	0032465	biological_process	regulation of cytokinesis
D	0032991	cellular_component	protein-containing complex
D	0034704	cellular_component	calcium channel complex
D	0043209	cellular_component	myelin sheath
D	0043539	molecular_function	protein serine/threonine kinase activator activity
D	0043548	molecular_function	phosphatidylinositol 3-kinase binding
D	0044305	cellular_component	calyx of Held
D	0044325	molecular_function	transmembrane transporter binding
D	0046872	molecular_function	metal ion binding
D	0048306	molecular_function	calcium-dependent protein binding
D	0050848	biological_process	regulation of calcium-mediated signaling
D	0050998	molecular_function	nitric-oxide synthase binding
D	0051412	biological_process	response to corticosterone
D	0051592	biological_process	response to calcium ion
D	0055117	biological_process	regulation of cardiac muscle contraction
D	0060291	biological_process	long-term synaptic potentiation
D	0072542	molecular_function	protein phosphatase activator activity
D	0090150	biological_process	establishment of protein localization to membrane
D	0090151	biological_process	establishment of protein localization to mitochondrial membrane
D	0097225	cellular_component	sperm midpiece
D	0097720	biological_process	calcineurin-mediated signaling
D	0098685	cellular_component	Schaffer collateral - CA1 synapse
D	0098901	biological_process	regulation of cardiac muscle cell action potential
D	0099523	cellular_component	presynaptic cytosol
D	0099524	cellular_component	postsynaptic cytosol
D	0140238	biological_process	presynaptic endocytosis
D	0141110	molecular_function	transporter inhibitor activity
D	1900242	biological_process	regulation of synaptic vesicle endocytosis
D	1901842	biological_process	negative regulation of high voltage-gated calcium channel activity
D	1901844	biological_process	regulation of cell communication by electrical coupling involved in cardiac conduction
D	1902494	cellular_component	catalytic complex
D	1905913	biological_process	negative regulation of calcium ion export across plasma membrane
D	2000300	biological_process	regulation of synaptic vesicle exocytosis
E	0004689	molecular_function	phosphorylase kinase activity
E	0005516	molecular_function	calmodulin binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005886	cellular_component	plasma membrane
E	0005964	cellular_component	phosphorylase kinase complex
E	0005977	biological_process	glycogen metabolic process
E	0006091	biological_process	generation of precursor metabolites and energy
E	0016020	cellular_component	membrane
E	0045819	biological_process	positive regulation of glycogen catabolic process
F	0005515	molecular_function	protein binding
F	0005516	molecular_function	calmodulin binding
F	0005829	cellular_component	cytosol
F	0005886	cellular_component	plasma membrane
F	0005964	cellular_component	phosphorylase kinase complex
F	0005977	biological_process	glycogen metabolic process
F	0006091	biological_process	generation of precursor metabolites and energy
F	0016020	cellular_component	membrane
G	0000166	molecular_function	nucleotide binding
G	0004674	molecular_function	protein serine/threonine kinase activity
G	0004689	molecular_function	phosphorylase kinase activity
G	0005516	molecular_function	calmodulin binding
G	0005524	molecular_function	ATP binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0005964	cellular_component	phosphorylase kinase complex
G	0005975	biological_process	carbohydrate metabolic process
G	0005977	biological_process	glycogen metabolic process
G	0007165	biological_process	signal transduction
G	0016301	molecular_function	kinase activity
G	0016740	molecular_function	transferase activity
G	0019899	molecular_function	enzyme binding
G	0106310	molecular_function	protein serine kinase activity
H	0000086	biological_process	G2/M transition of mitotic cell cycle
H	0000922	cellular_component	spindle pole
H	0001975	biological_process	response to amphetamine
H	0002027	biological_process	regulation of heart rate
H	0005246	molecular_function	calcium channel regulator activity
H	0005509	molecular_function	calcium ion binding
H	0005513	biological_process	detection of calcium ion
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0005739	cellular_component	mitochondrion
H	0005813	cellular_component	centrosome
H	0005819	cellular_component	spindle
H	0005856	cellular_component	cytoskeleton
H	0005876	cellular_component	spindle microtubule
H	0005886	cellular_component	plasma membrane
H	0007186	biological_process	G protein-coupled receptor signaling pathway
H	0008076	cellular_component	voltage-gated potassium channel complex
H	0008179	molecular_function	adenylate cyclase binding
H	0010856	molecular_function	adenylate cyclase activator activity
H	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
H	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
H	0016020	cellular_component	membrane
H	0019901	molecular_function	protein kinase binding
H	0019904	molecular_function	protein domain specific binding
H	0021762	biological_process	substantia nigra development
H	0030017	cellular_component	sarcomere
H	0030235	molecular_function	nitric-oxide synthase regulator activity
H	0030426	cellular_component	growth cone
H	0030672	cellular_component	synaptic vesicle membrane
H	0031432	molecular_function	titin binding
H	0031800	molecular_function	type 3 metabotropic glutamate receptor binding
H	0031966	cellular_component	mitochondrial membrane
H	0031982	cellular_component	vesicle
H	0032465	biological_process	regulation of cytokinesis
H	0032991	cellular_component	protein-containing complex
H	0034704	cellular_component	calcium channel complex
H	0043209	cellular_component	myelin sheath
H	0043539	molecular_function	protein serine/threonine kinase activator activity
H	0043548	molecular_function	phosphatidylinositol 3-kinase binding
H	0044305	cellular_component	calyx of Held
H	0044325	molecular_function	transmembrane transporter binding
H	0046872	molecular_function	metal ion binding
H	0048306	molecular_function	calcium-dependent protein binding
H	0050848	biological_process	regulation of calcium-mediated signaling
H	0050998	molecular_function	nitric-oxide synthase binding
H	0051412	biological_process	response to corticosterone
H	0051592	biological_process	response to calcium ion
H	0055117	biological_process	regulation of cardiac muscle contraction
H	0060291	biological_process	long-term synaptic potentiation
H	0072542	molecular_function	protein phosphatase activator activity
H	0090150	biological_process	establishment of protein localization to membrane
H	0090151	biological_process	establishment of protein localization to mitochondrial membrane
H	0097225	cellular_component	sperm midpiece
H	0097720	biological_process	calcineurin-mediated signaling
H	0098685	cellular_component	Schaffer collateral - CA1 synapse
H	0098901	biological_process	regulation of cardiac muscle cell action potential
H	0099523	cellular_component	presynaptic cytosol
H	0099524	cellular_component	postsynaptic cytosol
H	0140238	biological_process	presynaptic endocytosis
H	0141110	molecular_function	transporter inhibitor activity
H	1900242	biological_process	regulation of synaptic vesicle endocytosis
H	1901842	biological_process	negative regulation of high voltage-gated calcium channel activity
H	1901844	biological_process	regulation of cell communication by electrical coupling involved in cardiac conduction
H	1902494	cellular_component	catalytic complex
H	1905913	biological_process	negative regulation of calcium ion export across plasma membrane
H	2000300	biological_process	regulation of synaptic vesicle exocytosis
I	0004689	molecular_function	phosphorylase kinase activity
I	0005516	molecular_function	calmodulin binding
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0005886	cellular_component	plasma membrane
I	0005964	cellular_component	phosphorylase kinase complex
I	0005977	biological_process	glycogen metabolic process
I	0006091	biological_process	generation of precursor metabolites and energy
I	0016020	cellular_component	membrane
I	0045819	biological_process	positive regulation of glycogen catabolic process
J	0005515	molecular_function	protein binding
J	0005516	molecular_function	calmodulin binding
J	0005829	cellular_component	cytosol
J	0005886	cellular_component	plasma membrane
J	0005964	cellular_component	phosphorylase kinase complex
J	0005977	biological_process	glycogen metabolic process
J	0006091	biological_process	generation of precursor metabolites and energy
J	0016020	cellular_component	membrane
K	0000166	molecular_function	nucleotide binding
K	0004674	molecular_function	protein serine/threonine kinase activity
K	0004689	molecular_function	phosphorylase kinase activity
K	0005516	molecular_function	calmodulin binding
K	0005524	molecular_function	ATP binding
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0005964	cellular_component	phosphorylase kinase complex
K	0005975	biological_process	carbohydrate metabolic process
K	0005977	biological_process	glycogen metabolic process
K	0007165	biological_process	signal transduction
K	0016301	molecular_function	kinase activity
K	0016740	molecular_function	transferase activity
K	0019899	molecular_function	enzyme binding
K	0106310	molecular_function	protein serine kinase activity
L	0000086	biological_process	G2/M transition of mitotic cell cycle
L	0000922	cellular_component	spindle pole
L	0001975	biological_process	response to amphetamine
L	0002027	biological_process	regulation of heart rate
L	0005246	molecular_function	calcium channel regulator activity
L	0005509	molecular_function	calcium ion binding
L	0005513	biological_process	detection of calcium ion
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005737	cellular_component	cytoplasm
L	0005739	cellular_component	mitochondrion
L	0005813	cellular_component	centrosome
L	0005819	cellular_component	spindle
L	0005856	cellular_component	cytoskeleton
L	0005876	cellular_component	spindle microtubule
L	0005886	cellular_component	plasma membrane
L	0007186	biological_process	G protein-coupled receptor signaling pathway
L	0008076	cellular_component	voltage-gated potassium channel complex
L	0008179	molecular_function	adenylate cyclase binding
L	0010856	molecular_function	adenylate cyclase activator activity
L	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
L	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
L	0016020	cellular_component	membrane
L	0019901	molecular_function	protein kinase binding
L	0019904	molecular_function	protein domain specific binding
L	0021762	biological_process	substantia nigra development
L	0030017	cellular_component	sarcomere
L	0030235	molecular_function	nitric-oxide synthase regulator activity
L	0030426	cellular_component	growth cone
L	0030672	cellular_component	synaptic vesicle membrane
L	0031432	molecular_function	titin binding
L	0031800	molecular_function	type 3 metabotropic glutamate receptor binding
L	0031966	cellular_component	mitochondrial membrane
L	0031982	cellular_component	vesicle
L	0032465	biological_process	regulation of cytokinesis
L	0032991	cellular_component	protein-containing complex
L	0034704	cellular_component	calcium channel complex
L	0043209	cellular_component	myelin sheath
L	0043539	molecular_function	protein serine/threonine kinase activator activity
L	0043548	molecular_function	phosphatidylinositol 3-kinase binding
L	0044305	cellular_component	calyx of Held
L	0044325	molecular_function	transmembrane transporter binding
L	0046872	molecular_function	metal ion binding
L	0048306	molecular_function	calcium-dependent protein binding
L	0050848	biological_process	regulation of calcium-mediated signaling
L	0050998	molecular_function	nitric-oxide synthase binding
L	0051412	biological_process	response to corticosterone
L	0051592	biological_process	response to calcium ion
L	0055117	biological_process	regulation of cardiac muscle contraction
L	0060291	biological_process	long-term synaptic potentiation
L	0072542	molecular_function	protein phosphatase activator activity
L	0090150	biological_process	establishment of protein localization to membrane
L	0090151	biological_process	establishment of protein localization to mitochondrial membrane
L	0097225	cellular_component	sperm midpiece
L	0097720	biological_process	calcineurin-mediated signaling
L	0098685	cellular_component	Schaffer collateral - CA1 synapse
L	0098901	biological_process	regulation of cardiac muscle cell action potential
L	0099523	cellular_component	presynaptic cytosol
L	0099524	cellular_component	postsynaptic cytosol
L	0140238	biological_process	presynaptic endocytosis
L	0141110	molecular_function	transporter inhibitor activity
L	1900242	biological_process	regulation of synaptic vesicle endocytosis
L	1901842	biological_process	negative regulation of high voltage-gated calcium channel activity
L	1901844	biological_process	regulation of cell communication by electrical coupling involved in cardiac conduction
L	1902494	cellular_component	catalytic complex
L	1905913	biological_process	negative regulation of calcium ion export across plasma membrane
L	2000300	biological_process	regulation of synaptic vesicle exocytosis
M	0004689	molecular_function	phosphorylase kinase activity
M	0005516	molecular_function	calmodulin binding
M	0005737	cellular_component	cytoplasm
M	0005829	cellular_component	cytosol
M	0005886	cellular_component	plasma membrane
M	0005964	cellular_component	phosphorylase kinase complex
M	0005977	biological_process	glycogen metabolic process
M	0006091	biological_process	generation of precursor metabolites and energy
M	0016020	cellular_component	membrane
M	0045819	biological_process	positive regulation of glycogen catabolic process
N	0005515	molecular_function	protein binding
N	0005516	molecular_function	calmodulin binding
N	0005829	cellular_component	cytosol
N	0005886	cellular_component	plasma membrane
N	0005964	cellular_component	phosphorylase kinase complex
N	0005977	biological_process	glycogen metabolic process
N	0006091	biological_process	generation of precursor metabolites and energy
N	0016020	cellular_component	membrane
O	0000166	molecular_function	nucleotide binding
O	0004674	molecular_function	protein serine/threonine kinase activity
O	0004689	molecular_function	phosphorylase kinase activity
O	0005516	molecular_function	calmodulin binding
O	0005524	molecular_function	ATP binding
O	0005737	cellular_component	cytoplasm
O	0005829	cellular_component	cytosol
O	0005964	cellular_component	phosphorylase kinase complex
O	0005975	biological_process	carbohydrate metabolic process
O	0005977	biological_process	glycogen metabolic process
O	0007165	biological_process	signal transduction
O	0016301	molecular_function	kinase activity
O	0016740	molecular_function	transferase activity
O	0019899	molecular_function	enzyme binding
O	0106310	molecular_function	protein serine kinase activity
P	0000086	biological_process	G2/M transition of mitotic cell cycle
P	0000922	cellular_component	spindle pole
P	0001975	biological_process	response to amphetamine
P	0002027	biological_process	regulation of heart rate
P	0005246	molecular_function	calcium channel regulator activity
P	0005509	molecular_function	calcium ion binding
P	0005513	biological_process	detection of calcium ion
P	0005515	molecular_function	protein binding
P	0005634	cellular_component	nucleus
P	0005737	cellular_component	cytoplasm
P	0005739	cellular_component	mitochondrion
P	0005813	cellular_component	centrosome
P	0005819	cellular_component	spindle
P	0005856	cellular_component	cytoskeleton
P	0005876	cellular_component	spindle microtubule
P	0005886	cellular_component	plasma membrane
P	0007186	biological_process	G protein-coupled receptor signaling pathway
P	0008076	cellular_component	voltage-gated potassium channel complex
P	0008179	molecular_function	adenylate cyclase binding
P	0010856	molecular_function	adenylate cyclase activator activity
P	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
P	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
P	0016020	cellular_component	membrane
P	0019901	molecular_function	protein kinase binding
P	0019904	molecular_function	protein domain specific binding
P	0021762	biological_process	substantia nigra development
P	0030017	cellular_component	sarcomere
P	0030235	molecular_function	nitric-oxide synthase regulator activity
P	0030426	cellular_component	growth cone
P	0030672	cellular_component	synaptic vesicle membrane
P	0031432	molecular_function	titin binding
P	0031800	molecular_function	type 3 metabotropic glutamate receptor binding
P	0031966	cellular_component	mitochondrial membrane
P	0031982	cellular_component	vesicle
P	0032465	biological_process	regulation of cytokinesis
P	0032991	cellular_component	protein-containing complex
P	0034704	cellular_component	calcium channel complex
P	0043209	cellular_component	myelin sheath
P	0043539	molecular_function	protein serine/threonine kinase activator activity
P	0043548	molecular_function	phosphatidylinositol 3-kinase binding
P	0044305	cellular_component	calyx of Held
P	0044325	molecular_function	transmembrane transporter binding
P	0046872	molecular_function	metal ion binding
P	0048306	molecular_function	calcium-dependent protein binding
P	0050848	biological_process	regulation of calcium-mediated signaling
P	0050998	molecular_function	nitric-oxide synthase binding
P	0051412	biological_process	response to corticosterone
P	0051592	biological_process	response to calcium ion
P	0055117	biological_process	regulation of cardiac muscle contraction
P	0060291	biological_process	long-term synaptic potentiation
P	0072542	molecular_function	protein phosphatase activator activity
P	0090150	biological_process	establishment of protein localization to membrane
P	0090151	biological_process	establishment of protein localization to mitochondrial membrane
P	0097225	cellular_component	sperm midpiece
P	0097720	biological_process	calcineurin-mediated signaling
P	0098685	cellular_component	Schaffer collateral - CA1 synapse
P	0098901	biological_process	regulation of cardiac muscle cell action potential
P	0099523	cellular_component	presynaptic cytosol
P	0099524	cellular_component	postsynaptic cytosol
P	0140238	biological_process	presynaptic endocytosis
P	0141110	molecular_function	transporter inhibitor activity
P	1900242	biological_process	regulation of synaptic vesicle endocytosis
P	1901842	biological_process	negative regulation of high voltage-gated calcium channel activity
P	1901844	biological_process	regulation of cell communication by electrical coupling involved in cardiac conduction
P	1902494	cellular_component	catalytic complex
P	1905913	biological_process	negative regulation of calcium ion export across plasma membrane
P	2000300	biological_process	regulation of synaptic vesicle exocytosis

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DKDGDGTITtkEL

Chain	Residue	Details
D	ASP21-LEU33
D	ASP57-PHE69
D	ASP94-LEU106
D	ASP130-PHE142

---

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGRGVSSVVRrCihkptsqe..........YAVK

Chain	Residue	Details
C	LEU26-LYS49

---

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IvHrDLKpeNILL

Chain	Residue	Details
C	ILE146-LEU158

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	512
Details	Region: {"description":"Calmodulin-binding","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine; by autocatalysis","evidences":[{"source":"UniProtKB","id":"P18688","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine; by PKA","evidences":[{"source":"UniProtKB","id":"P18688","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	8
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P18688","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P12798","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	1072
Details	Domain: {"description":"Protein kinase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	96
Details	Region: {"description":"Calmodulin-binding (domain-N)"}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	96
Details	Region: {"description":"Calmodulin-binding (domain-C)"}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	4
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	36
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	140
Details	Domain: {"description":"EF-hand 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	140
Details	Domain: {"description":"EF-hand 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	56
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"1474585","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine; by CaMK4","evidences":[{"source":"UniProtKB","id":"P0DP31","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	4
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	8
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"UniProtKB","id":"P62157","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---