8Z50

Crystal structure of the ASF1-H3T-H4 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0000781	cellular_component	chromosome, telomeric region
B	0000786	cellular_component	nucleosome
B	0003677	molecular_function	DNA binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005694	cellular_component	chromosome
B	0006325	biological_process	chromatin organization
B	0006334	biological_process	nucleosome assembly
B	0070062	cellular_component	extracellular exosome
C	0000781	cellular_component	chromosome, telomeric region
C	0000786	cellular_component	nucleosome
C	0003677	molecular_function	DNA binding
C	0003723	molecular_function	RNA binding
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005694	cellular_component	chromosome
C	0006325	biological_process	chromatin organization
C	0006334	biological_process	nucleosome assembly
C	0016020	cellular_component	membrane
C	0030527	molecular_function	structural constituent of chromatin
C	0032200	biological_process	telomere organization
C	0032991	cellular_component	protein-containing complex
C	0043505	cellular_component	CENP-A containing nucleosome
C	0045653	biological_process	negative regulation of megakaryocyte differentiation
C	0061644	biological_process	protein localization to CENP-A containing chromatin
C	0070062	cellular_component	extracellular exosome

Functional Information from PROSITE/UniProt

site_id	PS00047
Number of Residues	5
Details	HISTONE_H4 Histone H4 signature. GAKRH

Chain	Residue	Details
C	GLY14-HIS18

---

site_id	PS00322
Number of Residues	7
Details	HISTONE_H3_1 Histone H3 signature 1. KAPRKQL

Chain	Residue	Details
B	LYS14-LEU20

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	DNA_BIND:

Chain	Residue	Details
C	LYS16-LYS20
B	ARG17

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:17967882

Chain	Residue	Details
C	SER1

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Symmetric dimethylarginine; by PRMT5 and PRMT7; alternate => ECO:0000250|UniProtKB:P62806

Chain	Residue	Details
C	ARG3
B	LYS18
B	LYS23
B	LYS36
B	LYS64

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: N6-lactoyllysine; alternate => ECO:0000269|PubMed:31645732

Chain	Residue	Details
C	LYS5

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	MOD_RES: N6-propionyllysine; alternate => ECO:0000269|PubMed:17267393

Chain	Residue	Details
C	LYS8
C	LYS16
C	LYS44

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000269|PubMed:22389435

Chain	Residue	Details
C	LYS12
C	LYS31
C	LYS77
C	LYS91

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:12086618, ECO:0000269|PubMed:15964846, ECO:0000269|PubMed:17967882, ECO:0000269|PubMed:27338793

Chain	Residue	Details
C	LYS20
B	LYS27

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	MOD_RES: Phosphoserine; by PAK2 => ECO:0000269|PubMed:21724829, ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
C	SER47

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:15592455, ECO:0007744|PubMed:20068231

Chain	Residue	Details
C	TYR51
B	LYS56
B	LYS79
B	LYS122

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	MOD_RES: N6-glutaryllysine; alternate => ECO:0000269|PubMed:31542297

Chain	Residue	Details
C	LYS59

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P62806

Chain	Residue	Details
C	LYS79

---

site_id	SWS_FT_FI12
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P62806

Chain	Residue	Details
C	THR80

---

site_id	SWS_FT_FI13
Number of Residues	1
Details	MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:24275569

Chain	Residue	Details
C	TYR88

---

site_id	SWS_FT_FI14
Number of Residues	1
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:25218447

Chain	Residue	Details
C	LYS12

---

site_id	SWS_FT_FI15
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000269|PubMed:19818714

Chain	Residue	Details
B	THR80
C	LYS91

---

site_id	SWS_FT_FI16
Number of Residues	3
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:28112733

Chain	Residue	Details
C	LYS20
C	LYS59
C	LYS79

---

site_id	SWS_FT_FI17
Number of Residues	1
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in UFM1); alternate => ECO:0000269|PubMed:30886146

Chain	Residue	Details
C	LYS31

---

site_id	SWS_FT_FI18
Number of Residues	1
Details	MOD_RES: N6-glutaryllysine; alternate => ECO:0000250|UniProtKB:P84243

Chain	Residue	Details
B	LYS115

---