8YZ5

SARS-CoV-2 Delta Spike in complex with Fab of JE-5C

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005886	cellular_component	plasma membrane
A	0007165	biological_process	signal transduction
A	0016020	cellular_component	membrane
A	0019031	cellular_component	viral envelope
A	0019062	biological_process	virion attachment to host cell
A	0019064	biological_process	fusion of virus membrane with host plasma membrane
A	0019081	biological_process	viral translation
A	0020002	cellular_component	host cell plasma membrane
A	0033644	cellular_component	host cell membrane
A	0039587	biological_process	symbiont-mediated-mediated suppression of host tetherin activity
A	0039654	biological_process	fusion of virus membrane with host endosome membrane
A	0039660	molecular_function	structural constituent of virion
A	0039663	biological_process	membrane fusion involved in viral entry into host cell
A	0042802	molecular_function	identical protein binding
A	0043655	cellular_component	host extracellular space
A	0044173	cellular_component	host cell endoplasmic reticulum-Golgi intermediate compartment membrane
A	0044228	cellular_component	host cell surface
A	0044423	cellular_component	virion component
A	0046598	biological_process	positive regulation of viral entry into host cell
A	0046718	biological_process	symbiont entry into host cell
A	0046789	molecular_function	host cell surface receptor binding
A	0046813	biological_process	receptor-mediated virion attachment to host cell
A	0048018	molecular_function	receptor ligand activity
A	0052170	biological_process	symbiont-mediated suppression of host innate immune response
A	0055036	cellular_component	virion membrane
A	0061025	biological_process	membrane fusion
A	0075509	biological_process	endocytosis involved in viral entry into host cell
A	0098670	biological_process	entry receptor-mediated virion attachment to host cell
A	0141146	biological_process	symbiont-mediated disruption of host tissue
C	0005515	molecular_function	protein binding
C	0005886	cellular_component	plasma membrane
C	0007165	biological_process	signal transduction
C	0016020	cellular_component	membrane
C	0019031	cellular_component	viral envelope
C	0019062	biological_process	virion attachment to host cell
C	0019064	biological_process	fusion of virus membrane with host plasma membrane
C	0019081	biological_process	viral translation
C	0020002	cellular_component	host cell plasma membrane
C	0033644	cellular_component	host cell membrane
C	0039587	biological_process	symbiont-mediated-mediated suppression of host tetherin activity
C	0039654	biological_process	fusion of virus membrane with host endosome membrane
C	0039660	molecular_function	structural constituent of virion
C	0039663	biological_process	membrane fusion involved in viral entry into host cell
C	0042802	molecular_function	identical protein binding
C	0043655	cellular_component	host extracellular space
C	0044173	cellular_component	host cell endoplasmic reticulum-Golgi intermediate compartment membrane
C	0044228	cellular_component	host cell surface
C	0044423	cellular_component	virion component
C	0046598	biological_process	positive regulation of viral entry into host cell
C	0046718	biological_process	symbiont entry into host cell
C	0046789	molecular_function	host cell surface receptor binding
C	0046813	biological_process	receptor-mediated virion attachment to host cell
C	0048018	molecular_function	receptor ligand activity
C	0052170	biological_process	symbiont-mediated suppression of host innate immune response
C	0055036	cellular_component	virion membrane
C	0061025	biological_process	membrane fusion
C	0075509	biological_process	endocytosis involved in viral entry into host cell
C	0098670	biological_process	entry receptor-mediated virion attachment to host cell
C	0141146	biological_process	symbiont-mediated disruption of host tissue
D	0005515	molecular_function	protein binding
D	0005886	cellular_component	plasma membrane
D	0007165	biological_process	signal transduction
D	0016020	cellular_component	membrane
D	0019031	cellular_component	viral envelope
D	0019062	biological_process	virion attachment to host cell
D	0019064	biological_process	fusion of virus membrane with host plasma membrane
D	0019081	biological_process	viral translation
D	0020002	cellular_component	host cell plasma membrane
D	0033644	cellular_component	host cell membrane
D	0039587	biological_process	symbiont-mediated-mediated suppression of host tetherin activity
D	0039654	biological_process	fusion of virus membrane with host endosome membrane
D	0039660	molecular_function	structural constituent of virion
D	0039663	biological_process	membrane fusion involved in viral entry into host cell
D	0042802	molecular_function	identical protein binding
D	0043655	cellular_component	host extracellular space
D	0044173	cellular_component	host cell endoplasmic reticulum-Golgi intermediate compartment membrane
D	0044228	cellular_component	host cell surface
D	0044423	cellular_component	virion component
D	0046598	biological_process	positive regulation of viral entry into host cell
D	0046718	biological_process	symbiont entry into host cell
D	0046789	molecular_function	host cell surface receptor binding
D	0046813	biological_process	receptor-mediated virion attachment to host cell
D	0048018	molecular_function	receptor ligand activity
D	0052170	biological_process	symbiont-mediated suppression of host innate immune response
D	0055036	cellular_component	virion membrane
D	0061025	biological_process	membrane fusion
D	0075509	biological_process	endocytosis involved in viral entry into host cell
D	0098670	biological_process	entry receptor-mediated virion attachment to host cell
D	0141146	biological_process	symbiont-mediated disruption of host tissue

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	SITE: Cleavage; by host furin => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32142651, ECO:0000269|PubMed:32362314, ECO:0000269|PubMed:32703818, ECO:0000269|PubMed:34159616

Chain	Residue	Details
C	VAL687
A	VAL687
D	VAL687

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	SITE: Cleavage; by host TMPRSS2 or CTSL => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32703818, ECO:0000269|PubMed:34159616

Chain	Residue	Details
C	PHE817
A	PHE817
D	PHE817

---

site_id	SWS_FT_FI3
Number of Residues	9
Details	CARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942

Chain	Residue	Details
C	ASN17
C	THR1160
C	SER1175
A	ASN17
A	THR1160
A	SER1175
D	ASN17
D	THR1160
D	SER1175

---

site_id	SWS_FT_FI4
Number of Residues	15
Details	CARBOHYD: N-linked (GlcNAc...) (hybrid) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942

Chain	Residue	Details
C	ASN61
A	THR1076
D	ASN61
D	ASN122
D	THR719
D	SER803
D	THR1076
C	ASN122
C	THR719
C	SER803
C	THR1076
A	ASN61
A	ASN122
A	THR719
A	SER803

---

site_id	SWS_FT_FI5
Number of Residues	9
Details	CARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942

Chain	Residue	Details
C	ASN74
C	ASN151
C	SER1196
A	ASN74
A	ASN151
A	SER1196
D	ASN74
D	ASN149
D	SER1196

---

site_id	SWS_FT_FI6
Number of Residues	21
Details	CARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942

Chain	Residue	Details
C	THR167
A	THR333
A	THR345
A	THR618
A	SER659
A	THR1100
D	THR167
D	THR284
D	THR333
D	THR345
D	THR618
C	THR284
D	SER659
D	THR1100
C	THR333
C	THR345
C	THR618
C	SER659
C	THR1100
A	THR167
A	THR284

---

site_id	SWS_FT_FI7
Number of Residues	6
Details	CARBOHYD: N-linked (GlcNAc...) (high mannose) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32363391, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942

Chain	Residue	Details
C	THR236
C	SER711
A	THR236
A	SER711
D	THR236
D	SER711

---

site_id	SWS_FT_FI8
Number of Residues	3
Details	CARBOHYD: O-linked (GalNAc) threonine; by host => ECO:0000269|PubMed:32363391

Chain	Residue	Details
C	SER325
A	SER325
D	SER325

---

site_id	SWS_FT_FI9
Number of Residues	3
Details	CARBOHYD: O-linked (HexNAc...) serine; by host => ECO:0000269|PubMed:32363391

Chain	Residue	Details
C	VAL327
A	VAL327
D	VAL327

---

site_id	SWS_FT_FI10
Number of Residues	3
Details	CARBOHYD: N-linked (GlcNAc...) (hybrid) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942

Chain	Residue	Details
C	SER605
A	SER605
D	SER605

---

site_id	SWS_FT_FI11
Number of Residues	6
Details	CARBOHYD: O-linked (GlcNAc...) threonine; by host GALNT1 => ECO:0000269|PubMed:34732583

Chain	Residue	Details
C	THR678
C	SER680
A	THR678
A	SER680
D	THR678
D	SER680

---

site_id	SWS_FT_FI12
Number of Residues	3
Details	CARBOHYD: N-linked (GlcNAc...) (complex) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04099, ECO:0000269|PubMed:32155444, ECO:0000269|PubMed:32366695, ECO:0000269|PubMed:32979942

Chain	Residue	Details
C	THR1136
A	THR1136
D	THR1136

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