8YYZ

Crystal structure of Sonic hedgehog in complex with antibody 5E1 mutant H-R102A in the absence of metals

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0007267	biological_process	cell-cell signaling
A	0007275	biological_process	multicellular organism development

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH

Chain	Residue	Details
H	TYR200-HIS206
L	TYR192-HIS198

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20504762","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29954986","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31127104","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31548691","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35231446","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3MXW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6DMY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6N7G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6N7H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6N7K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RVD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7RHQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20504762","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29954986","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30139912","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31127104","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31548691","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35231446","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3MXW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6DMY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6E1H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6N7G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6N7H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6N7K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RVD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7RHQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20504762","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31548691","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35231446","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3MXW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RVD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7RHQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20504762","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30139912","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31548691","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35231446","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3MXW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6E1H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RVD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7RHQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20504762","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31548691","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3MXW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RVD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10753901","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20504762","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29954986","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30139912","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31127104","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31548691","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31555730","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35231446","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3M1N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3MXW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6DMY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6E1H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6N7G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6N7H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6N7K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RMG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RVD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7RHQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---