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8YYV

A dimeric STAT1-DNA complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0000785cellular_componentchromatin
A0000977molecular_functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
A0000978molecular_functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
A0000979molecular_functionRNA polymerase II core promoter sequence-specific DNA binding
A0000981molecular_functionDNA-binding transcription factor activity, RNA polymerase II-specific
A0001222molecular_functiontranscription corepressor binding
A0001223molecular_functiontranscription coactivator binding
A0001937biological_processnegative regulation of endothelial cell proliferation
A0002053biological_processpositive regulation of mesenchymal cell proliferation
A0002230biological_processpositive regulation of defense response to virus by host
A0003340biological_processnegative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
A0003677molecular_functionDNA binding
A0003690molecular_functiondouble-stranded DNA binding
A0003700molecular_functionDNA-binding transcription factor activity
A0005164molecular_functiontumor necrosis factor receptor binding
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006351biological_processDNA-templated transcription
A0006355biological_processregulation of DNA-templated transcription
A0006357biological_processregulation of transcription by RNA polymerase II
A0006952biological_processdefense response
A0007165biological_processsignal transduction
A0007259biological_processcell surface receptor signaling pathway via JAK-STAT
A0016525biological_processnegative regulation of angiogenesis
A0019899molecular_functionenzyme binding
A0032727biological_processpositive regulation of interferon-alpha production
A0032991cellular_componentprotein-containing complex
A0033209biological_processtumor necrosis factor-mediated signaling pathway
A0034341biological_processresponse to type II interferon
A0035035molecular_functionhistone acetyltransferase binding
A0035456biological_processresponse to interferon-beta
A0035458biological_processcellular response to interferon-beta
A0038111biological_processinterleukin-7-mediated signaling pathway
A0038113biological_processinterleukin-9-mediated signaling pathway
A0042127biological_processregulation of cell population proliferation
A0042393molecular_functionhistone binding
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0042981biological_processregulation of apoptotic process
A0043124biological_processnegative regulation of canonical NF-kappaB signal transduction
A0043434biological_processresponse to peptide hormone
A0043542biological_processendothelial cell migration
A0044389molecular_functionubiquitin-like protein ligase binding
A0045296molecular_functioncadherin binding
A0045648biological_processpositive regulation of erythrocyte differentiation
A0045893biological_processpositive regulation of DNA-templated transcription
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0046725biological_processnegative regulation by virus of viral protein levels in host cell
A0048471cellular_componentperinuclear region of cytoplasm
A0051093biological_processnegative regulation of developmental process
A0051607biological_processdefense response to virus
A0060333biological_processtype II interferon-mediated signaling pathway
A0060337biological_processtype I interferon-mediated signaling pathway
A0061326biological_processrenal tubule development
A0070106biological_processinterleukin-27-mediated signaling pathway
A0070721cellular_componentISGF3 complex
A0071346biological_processcellular response to type II interferon
A0072136biological_processmetanephric mesenchymal cell proliferation involved in metanephros development
A0072162biological_processmetanephric mesenchymal cell differentiation
A0072308biological_processnegative regulation of metanephric nephron tubule epithelial cell differentiation
A0090575cellular_componentRNA polymerase II transcription regulator complex
A0097696biological_processcell surface receptor signaling pathway via STAT
A1990841molecular_functionpromoter-specific chromatin binding
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues97
DetailsDomain: {"description":"SH2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00191","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues6
DetailsModified residue: {"description":"N6-methyllysine","evidences":[{"source":"PubMed","id":"28753426","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues2
DetailsModified residue: {"description":"ADP-ribosyl glutamic acid; by PARP14","evidences":[{"source":"PubMed","id":"27796300","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues1
DetailsModified residue: {"description":"Phosphotyrosine; by JAK1, JAK2 or TYK2","evidences":[{"source":"PubMed","id":"17561467","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19088846","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21135090","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22065572","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26479788","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27796300","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28753426","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38621137","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7657660","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues2
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

246704

PDB entries from 2025-12-24

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